GO:0034742

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Name APC-Axin-1-beta-catenin complex
Categary Component
Go Slim No
Go Link GO:0034742
Unique Molecular Interactions 87
Total Molecular Interactions 115
Total Single Events 817
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for APC-Axin-1-beta-catenin complex. They are ordered first by their pain relevance and then by number of times they were reported for APC-Axin-1-beta-catenin complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
2 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
3 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
4 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
5 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
6 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
7 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
8 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
9 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
10 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
11 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
12 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
13 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
14 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
15 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
16 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
17 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
18 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
19 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
20 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
21 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
22 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
23 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
24 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
25 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
26 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
27 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
28 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
29 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
30 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
31 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
32 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
33 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
34 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
35 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
36 INT262255 Binding of APC and F2R 1 0.05 3 0.1
37 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
38 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
39 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
40 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
41 INT120574 Binding of Apc and Egfr 1 0.27 1.02 0.05
42 INT334107 Binding of APC and APCS 1 0.16 1.52 0.04
43 INT213034 Hdl1 Positive_regulation of Apc 1 0.08 1.21 0
44 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
45 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
46 INT341502 Negative_regulation of Binding of Apc and Pdcd1 1 0.00 0.53 0
47 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
48 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
49 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
50 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
51 INT301675 Binding of APC and HLA-E 1 0.01 1.48 0
52 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
53 INT286112 Binding of Apc and Afap1 1 0.05 0.71 0
54 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
55 INT213007 Hdl1 Regulation of Regulation of Apc 1 0.08 1.24 0
56 INT236724 Binding of AXIN1 and Ctnnd2 1 0.39 1.03 0
57 INT301674 Binding of APC and CD80 1 0.01 0.53 0
58 INT220821 Binding of MAX and Ctnnb1 1 0.09 0.13 0
59 INT195661 Binding of APC and PROC 1 0.23 0.89 0
60 INT253019 APC Positive_regulation of Protein_catabolism of Pttg1 1 0.06 0 0
61 INT253012 APC Positive_regulation of Binding of Pttg1 1 0.06 0 0
62 INT268342 Binding of APC and ANKS1B 1 0.01 0.92 0
63 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
64 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
65 INT286561 Binding of Ctnnb1 and Cdh2 1 0.00 1.06 0
66 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
67 INT268395 Binding of APC and Kras 1 0.04 1.21 0
68 INT286567 Prkd1 Regulation of Ctnnb1 1 0.01 0.39 0
69 INT213009 Hdl1 Positive_regulation of Positive_regulation of Apc 1 0.09 1.14 0
70 INT80660 INS Positive_regulation of APC 1 0.32 0.65 0
71 INT283362 AXIN2 Negative_regulation of APC 1 0.10 1.67 0
72 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
73 INT195659 APC Positive_regulation of Gene_expression of PROC 1 0.26 0.31 0
74 INT213025 Vtn Positive_regulation of Apc 1 0.01 1.19 0
75 INT213054 Hdl1 Regulation of Apc 1 0.05 1.24 0
76 INT286572 Binding of Ctnnb1 and Pkd1 1 0.02 0.96 0
77 INT80659 Positive_regulation of INS Positive_regulation of APC 1 0.32 0.65 0
78 INT236721 Binding of Apc and Ctnnd2 1 0.25 1.03 0
79 INT252909 FZR1 Positive_regulation of APC 1 0.06 0.08 0
80 INT341501 Binding of Apc and Pdcd1 1 0.00 0.52 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for APC-Axin-1-beta-catenin complex. They are ordered first by their pain relevance and then by number of times they were reported in APC-Axin-1-beta-catenin complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
2 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
3 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
4 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
5 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
6 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
7 INT63121 Binding of APC 29 0.41 23.02 3.8
8 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
9 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
10 INT3818 Regulation of Apc 13 0.39 12.52 1.68
11 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
12 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
13 INT220177 Binding of Apc 21 0.37 15.34 1.37
14 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
15 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
16 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
17 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
18 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
19 INT242134 Localization of Apc 8 0.74 4.83 0.88
20 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
21 INT57062 Regulation of APC 24 0.58 14.3 0.7
22 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
23 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
24 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
25 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
26 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
27 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
28 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
29 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
30 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
31 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
32 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
33 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
34 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
35 INT118243 Transcription of APC 4 0.45 3.33 0.33
36 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
37 INT225667 Transcription of Apc 3 0.52 3.73 0.32
38 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
39 INT195672 Localization of APC 7 0.74 3.76 0.3
40 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
41 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
42 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
43 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
44 INT99392 Negative_regulation of Localization of Ctnnb1 2 0.59 1.43 0.17
45 INT151721 Negative_regulation of Localization of Ctnnb1 1 0.23 0.96 0.17
46 INT325506 Positive_regulation of Localization of Ctnnb1 1 0.05 0.28 0.17
47 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
48 INT210123 Localization of Axin1 1 0.04 0.84 0.17
49 INT66933 Binding of AXIN1 6 0.32 1.8 0.16
50 INT263410 Negative_regulation of Axin1 1 0.01 0 0.14
51 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
52 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
53 INT130374 Transcription of Ctnnb1 1 0.19 0 0.13
54 INT242140 Regulation of Localization of Apc 1 0.12 0.12 0.11
55 INT242819 Negative_regulation of Gene_expression of Apc 4 0.37 5.6 0.1
56 INT268372 Phosphorylation of APC 3 0.81 3.39 0.09
57 INT294014 Regulation of AXIN1 3 0.24 1.04 0.08
58 INT145364 Negative_regulation of AXIN1 2 0.33 0.52 0.08
59 INT195679 Positive_regulation of Positive_regulation of APC 6 0.50 4.43 0.05
60 INT235057 Positive_regulation of Negative_regulation of Apc 2 0.30 0.66 0.05
61 INT244699 Positive_regulation of AXIN1 1 0.02 0 0.05
62 INT242139 Protein_catabolism of Apc 1 0.17 0.27 0.03
63 INT195681 Positive_regulation of Negative_regulation of APC 5 0.47 3.9 0
64 INT76959 Binding of Ctnnb1 2 0.34 0.69 0
65 INT294025 Phosphorylation of AXIN1 2 0.38 0.47 0
66 INT230651 Phosphorylation of Ctnnb1 1 0.10 0 0
67 INT230674 Positive_regulation of Phosphorylation of Ctnnb1 1 0.06 0 0
68 INT326137 Protein_catabolism of Ctnnb1 1 0.02 1.08 0
69 INT287932 Negative_regulation of Binding of AXIN1 1 0.12 0 0
70 INT337657 Negative_regulation of Negative_regulation of APC 1 0.37 0.99 0
71 INT104591 Negative_regulation of Negative_regulation of Apc 1 0.04 0.16 0
72 INT355576 Negative_regulation of Negative_regulation of Ctnnb1 1 0.02 1.14 0
73 INT337673 Regulation of Positive_regulation of APC 1 0.38 1.44 0
74 INT220769 Positive_regulation of Positive_regulation of Ctnnb1 1 0.10 0 0
75 INT191087 Regulation of Regulation of Apc 1 0.06 1.02 0
76 INT283365 Positive_regulation of Binding of APC 1 0.50 1.43 0
77 INT337667 Regulation of Transcription of APC 1 0.23 1 0
78 INT286093 Regulation of Binding of Apc 1 0.39 1.08 0
79 INT287935 Positive_regulation of Binding of AXIN1 1 0.14 0 0
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