GO:0034765

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Name regulation of ion transmembrane transport
Categary Process
Go Slim No
Go Link GO:0034765
Unique Molecular Interactions 242
Total Molecular Interactions 372
Total Single Events 2899
Pain Genes Associated 47

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of ion transmembrane transport. They are ordered first by their pain relevance and then by number of times they were reported for regulation of ion transmembrane transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
3 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
4 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24
5 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
6 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
7 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
8 INT305741 Binding of Kcnk2 and Sort1 1 0.54 1.01 1.8
9 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78
10 INT190981 Binding of Npy and Scn2a1 1 0.10 0 1.75
11 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
12 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
13 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
14 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
15 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
16 INT13756 Binding of Oprd1 and Scn4a 1 0.02 0 1.32
17 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
18 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
19 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
20 INT320021 Prkaca Regulation of Positive_regulation of Kcnma1 1 0.00 0.54 1
21 INT65631 Ufm1 Positive_regulation of Kcna5 1 0.02 0 0.99
22 INT128602 Binding of Kcnma1 and Gtf2ird2 1 0.00 0 0.97
23 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
24 INT296283 Kcnip3 Regulation of Positive_regulation of Cysltr1 1 0.01 0.85 0.94
25 INT112642 Positive_regulation of Kcnma1 Positive_regulation of Nav1 1 0.02 0 0.89
26 INT242621 Gdnf Positive_regulation of Gene_expression of Scn11a 1 0.05 0.12 0.88
27 INT285660 Cnrip1 Negative_regulation of Kcnk3 1 0.00 0.23 0.85
28 INT145646 Binding of Scn2a1 and Scn5a 1 0.36 0 0.76
29 INT190986 Per1 Positive_regulation of Scn2a1 1 0.17 0 0.74
30 INT190979 Per2 Positive_regulation of Scn2a1 1 0.20 0 0.74
31 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
32 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
33 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
34 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7
35 INT42780 Negative_regulation of Scn4a Negative_regulation of Positive_regulation of Prl 1 0.11 0 0.69
36 INT40180 Regulation of Binding of Oprl1 and Scn7a 1 0.02 0 0.67
37 INT40179 Binding of Oprl1 and Scn7a 1 0.03 0 0.67
38 INT42779 Scn4a Positive_regulation of Localization of Gnrhr 1 0.10 0 0.66
39 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
40 INT28845 su Negative_regulation of Positive_regulation of Scn2a1 1 0.27 1.27 0.61
41 INT190987 Abat Regulation of Scn2a1 1 0.03 0.07 0.59
42 INT148172 Mapk1 Positive_regulation of Phosphorylation of Kcnd2 1 0.49 0.55 0.57
43 INT190988 Vip Positive_regulation of Gene_expression of Scn2a1 1 0.16 0.1 0.57
44 INT166863 Kcnj9 Regulation of Kcnj6 1 0.20 0 0.56
45 INT166862 Kcnj6 Positive_regulation of Gene_expression of Oprd1 1 0.15 0 0.52
46 INT152282 Binding of Accn1 and Trpv1 1 0.10 0.42 0.49
47 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
48 INT155958 Binding of Kcnk2 and Akap5 1 0.15 0.64 0.48
49 INT207501 Scn7a Negative_regulation of Gene_expression of ap 1 0.01 0 0.46
50 INT119598 H2-Ab1 Regulation of Scn4a 1 0.00 0.09 0.46
51 INT162954 Sema6a Regulation of Scn7a 1 0.10 0.55 0.46
52 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
53 INT354218 Igfbp7 Positive_regulation of Accn1 1 0.04 0.74 0.44
54 INT29906 Binding of Scn4a and Ap2m1 1 0.09 0 0.43
55 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
56 INT60456 SCN5A Regulation of Scn2a1 1 0.00 0 0.41
57 INT326942 Unc79 Regulation of Nalcn 1 0.20 0.08 0.41
58 INT99122 Binding of Cacna2d3 and DLL1 1 0.02 0 0.41
59 INT190977 Npy Regulation of Scn2a1 1 0.16 0 0.4
60 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
61 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
62 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
63 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
64 INT296300 Binding of Grin1 and Kcnip3 1 0.18 0 0.4
65 INT296301 Binding of Grin2a and Kcnip3 1 0.27 0 0.4
66 INT190739 Adcyap1 Regulation of Gene_expression of Scn2a1 1 0.13 0 0.39
67 INT152431 Regulation of Ghrh Positive_regulation of Scn7a 1 0.02 0.17 0.38
68 INT306694 Nav1 Positive_regulation of Gene_expression of Scn7a 1 0.01 0.07 0.38
69 INT152427 Ghrh Positive_regulation of Scn7a 1 0.03 0.17 0.38
70 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
71 INT140802 Accn2 Regulation of Transcription of Accn1 1 0.24 0 0.36
72 INT334632 Binding of Kcna2 and Eae1 1 0.17 0.87 0.35
73 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
74 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
75 INT269064 Il6 Positive_regulation of Gene_expression of Cybb 1 0.75 0.79 0.31
76 INT207503 Binding of Klkb1 and Scn7a 1 0.02 0 0.3
77 INT239783 Kcnip4 Positive_regulation of Gene_expression of Prh1 1 0.03 0.6 0.29
78 INT190998 ADCYAP1 Positive_regulation of Scn2a1 1 0.07 0.45 0.27
79 INT141314 Gs Regulation of Kcnk4 1 0.19 0.64 0.27
80 INT279828 Binding of Scn1a and Scn9a 1 0.39 1.64 0.26
81 INT296450 Cacng2 Regulation of Gria2 1 0.13 0.24 0.26
82 INT215280 Siglec1 Regulation of Cybb 1 0.01 0.74 0.26
83 INT269060 Il6 Positive_regulation of Cybb 1 0.75 0.65 0.26
84 INT165478 Prok2 Positive_regulation of Positive_regulation of Kcnma1 1 0.02 0 0.25
85 INT346745 Binding of Cacng2 and Grip2 1 0.01 0 0.25
86 INT208037 Binding of Accn1 and Accn3 1 0.15 0.3 0.25
87 INT208036 Binding of Cnga3 and Accn1 1 0.01 0.3 0.25
88 INT296470 Binding of Cacng2 and Myo18a 1 0.00 0.22 0.24
89 INT296467 Binding of Cacng2 and Gria1 1 0.12 0.25 0.23
90 INT326941 Nts Regulation of Nalcn 1 0.04 0.24 0.23
91 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
92 INT328896 Scn2a1 Regulation of hb 1 0.02 0.27 0.23
93 INT296474 Binding of Cacng2 and Gria2 1 0.18 0.26 0.23
94 INT251452 Binding of Car1 and Kcnc1 1 0.11 0 0.22
95 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
96 INT354217 Arc Positive_regulation of Accn1 1 0.01 0.29 0.21
97 INT53902 Atp7b Positive_regulation of Scn7a 1 0.04 0 0.21
98 INT251450 Binding of Dpp6 and Kcnc1 1 0.37 0.18 0.2
99 INT354211 Igfbp7 Positive_regulation of Gene_expression of Accn1 1 0.04 0.29 0.2
100 INT354216 Binding of Accn3 and Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
101 INT354225 Accn3 Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
102 INT354214 Arc Positive_regulation of Gene_expression of Accn1 1 0.01 0.29 0.2
103 INT58013 Binding of Scn4a and Cpt1b 1 0.12 0 0.19
104 INT326940 Chrm3 Positive_regulation of Nalcn 1 0.06 0.21 0.19
105 INT149346 Negative_regulation of Kcnab1 Positive_regulation of Kcna1 1 0.01 0.08 0.18
106 INT251453 Binding of Kcnc1 and Dpp10 1 0.20 0.18 0.18
107 INT149345 Kcnab1 Negative_regulation of Kcna1 1 0.01 0.08 0.18
108 INT149344 Kcnab1 Positive_regulation of Kcna1 1 0.01 0.08 0.18
109 INT149343 Negative_regulation of Kcnab1 Negative_regulation of Kcna1 1 0.01 0.08 0.18
110 INT190985 Vip Regulation of Scn2a1 1 0.09 0 0.18
111 INT156970 Negative_regulation of Kcnip3 Positive_regulation of Transcription of Creb1 1 0.47 0.45 0.17
112 INT216487 Ca2 Negative_regulation of Kcnma1 1 0.00 0.1 0.17
113 INT156971 Kcnip3 Negative_regulation of Creb1 1 0.48 0.46 0.17
114 INT296469 Gene_expression of Cacng2 Positive_regulation of Gria2 1 0.15 0 0.16
115 INT296276 Binding of Preb and Kcnip3 1 0.02 0.06 0.16
116 INT296461 Gene_expression of Cacng2 Positive_regulation of Rbm39 1 0.00 0 0.16
117 INT296294 Binding of Kcnip3 and Dre 1 0.13 0.06 0.16
118 INT279829 Scn1a Regulation of Gene_expression of Scn9a 1 0.42 1.52 0.15
119 INT151393 Binding of Kcna4 and Kcnip4 1 0.00 0.09 0.14
120 INT269054 Positive_regulation of Il6 Positive_regulation of Cybb 1 0.54 0.3 0.14
121 INT269070 Regulation of Il6 Positive_regulation of Cybb 1 0.29 0.3 0.14
122 INT114811 Kcna7 Regulation of KCNQ2 1 0.00 0.69 0.13
123 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13
124 INT325998 Negative_regulation of Cybb Negative_regulation of Gene_expression of Ros1 1 0.06 1.3 0.11
125 INT296468 Cacng2 Regulation of Regulation of Gria2 1 0.10 0 0.11
126 INT208983 Binding of Ca2 and Kcnma1 2 0.01 0.28 0.1
127 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
128 INT190982 Avp Positive_regulation of Scn2a1 1 0.17 0.17 0.1
129 INT305733 Gtf3a Positive_regulation of Gene_expression of Kcnk2 1 0.01 0.12 0.1
130 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
131 INT324583 Hspg2 Positive_regulation of Trpm5 1 0.19 0 0.09
132 INT269069 Binding of Cyba and Cybb 1 0.18 0.18 0.09
133 INT269056 Positive_regulation of Binding of Cyba and Cybb 1 0.24 0.18 0.09
134 INT221258 Negative_regulation of Binding of VDAC1 and Crk 1 0.00 0.22 0.08
135 INT221255 Binding of VDAC1 and Crk 1 0.00 0.22 0.08
136 INT150446 Binding of Clcn1 and Scn4a 1 0.26 0.65 0.08
137 INT236531 Binding of Cacna1f and Flna 1 0.08 0 0.07
138 INT269063 Gene_expression of Il6 Positive_regulation of Cybb 1 0.47 0.33 0.07
139 INT111933 Cacna1c Positive_regulation of PENK 1 0.01 0 0.07
140 INT216570 Gene_expression of cx Positive_regulation of Kcnma1 1 0.00 0.25 0.06
141 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
142 INT196137 Trpm5 Negative_regulation of Gene_expression of Trpc3 1 0.33 0.08 0.06
143 INT216545 Gene_expression of Cftr Negative_regulation of Kcnma1 1 0.00 0.59 0.06
144 INT285381 Scn11a Positive_regulation of Localization of Chst10 1 0.12 0.08 0.06
145 INT167271 Binding of Ezr and Clic5 1 0.54 0.07 0.06
146 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
147 INT196136 Trpm5 Negative_regulation of Trpc3 1 0.33 0.08 0.06
148 INT190976 Binding of Scn2a1 and Gal 1 0.06 0 0.05
149 INT311296 Akt1 Positive_regulation of Gene_expression of Clcn1 1 0.11 0 0.05
150 INT133989 Pdx1 Regulation of Kcnip3 1 0.07 0 0.04
151 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
152 INT133988 Kcnip3 Regulation of Meis1 1 0.02 0 0.04
153 INT133991 Kcnip3 Regulation of Pou2f1 1 0.03 0 0.04
154 INT288595 Binding of CYTIP and Kcnma1 1 0.00 0 0.04
155 INT323286 CYP4A11 Positive_regulation of Kcnma1 1 0.01 0.45 0.04
156 INT133985 Kcnip3 Regulation of Pou1f1 1 0.02 0 0.04
157 INT133995 Meis1 Regulation of Kcnip3 1 0.02 0 0.04
158 INT269065 Il6 Regulation of Gene_expression of Cybb 1 0.66 0.12 0.04
159 INT133979 Pou1f1 Regulation of Kcnip3 1 0.02 0 0.04
160 INT134001 Kcnip3 Regulation of Pdx1 1 0.07 0 0.04
161 INT133980 Kcnip3 Regulation of Gene_expression of Npff 1 0.23 0 0.04
162 INT133984 Pou2f1 Regulation of Kcnip3 1 0.03 0 0.04
163 INT269058 Positive_regulation of Il6 Positive_regulation of Gene_expression of Cybb 1 0.50 0.06 0.03
164 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
165 INT272597 Binding of Dlg4 and Kcna4 1 0.17 0 0.03
166 INT322667 Binding of Vdac1 and Pbrm1 1 0.15 0.79 0.03
167 INT315034 Ass1 Positive_regulation of Cacna1f 1 0.00 0 0.03
168 INT346742 Binding of Cacng2 and Dlg4 1 0.03 0 0
169 INT311295 Gopc Positive_regulation of Gene_expression of Clcn1 1 0.07 0.29 0
170 INT235693 Binding of Clcn1 and Gab2 1 0.19 2.96 0
171 INT100747 Kcnma1 Positive_regulation of sar 1 0.03 0 0
172 INT288584 Cav1 Regulation of Gene_expression of Kcnma1 1 0.14 0 0
173 INT288594 Regulation of Binding of CAV1 and Kcnma1 1 0.01 0 0
174 INT325589 Nppa Regulation of Cacna1c 1 0.05 0 0
175 INT307417 Binding of Cybb and Cxam 1 0.00 1.22 0
176 INT215349 Binding of VDAC1 and Tspo 1 0.00 0.63 0
177 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
178 INT204480 Fmr1 Negative_regulation of Positive_regulation of Scn10a 1 0.17 0.74 0
179 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
180 INT325997 Binding of Cybb and Ncf1 1 0.18 0.77 0
181 INT269940 Binding of Sox17 and Scn4a 1 0.17 0.15 0
182 INT288587 Cav1 Regulation of Binding of Kcnma1 1 0.14 0 0
183 INT288597 Binding of CAV1 and Kcnma1 1 0.01 0.17 0
184 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
185 INT235697 Binding of Clcn1 and Syn1 1 0.00 0.48 0
186 INT346746 Binding of Cacng2 and Gria2 1 0.21 0.18 0
187 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
188 INT288596 Positive_regulation of Binding of CAV1 and Kcnma1 1 0.01 0.1 0
189 INT330155 Pcsk1n Regulation of Gene_expression of Scn2a1 1 0.15 0 0
190 INT109574 Binding of Kcnk3 and Ncl-ps1 1 0.01 0 0
191 INT288593 Cav1 Positive_regulation of Binding of Kcnma1 1 0.15 0 0
192 INT307420 Binding of PRRX1 and Cybb 1 0.12 0.41 0
193 INT315029 Binding of Calm3 and Cacna1f 1 0.04 0 0
194 INT215344 Binding of Sp1 and Vdac1 1 0.02 0.1 0
195 INT269921 Binding of Smad3 and Scn4a 1 0.12 0 0
196 INT325999 Binding of Cybb and Ncf2 1 0.18 0.77 0
197 INT262515 Positive_regulation of Kcnj6 Positive_regulation of Binding of Bcl2 1 0.00 0.48 0
198 INT208051 Binding of SNRNP70 and Accn1 1 0.01 1.81 0
199 INT204490 Binding of Fmr1 and Scn10a 1 0.15 0 0
200 INT279694 Hc Negative_regulation of Catsper1 1 0.05 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of ion transmembrane transport. They are ordered first by their pain relevance and then by number of times they were reported in regulation of ion transmembrane transport. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT72252 Gene_expression of Kcnma1 63 0.64 20.47 29.56
4 INT85395 Gene_expression of Scn11a 62 0.78 17.97 26.89
5 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
6 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19
7 INT20003 Gene_expression of Scn2a1 125 0.71 8.78 23.94
8 INT89657 Gene_expression of Kcnj9 24 0.77 15.15 18.86
9 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
10 INT48540 Gene_expression of Kcna5 37 0.77 14.04 16.07
11 INT69311 Gene_expression of Scn10a 31 0.78 15.54 14.64
12 INT13752 Binding of Scn4a 24 0.36 5.68 14.16
13 INT99116 Binding of Cacna2d3 15 0.48 7.33 13.58
14 INT142941 Negative_regulation of Scn11a 14 0.43 12.2 13.38
15 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
16 INT68290 Gene_expression of Accn1 32 0.73 7.36 11.23
17 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
18 INT65627 Negative_regulation of Kcna5 19 0.59 7.82 10.79
19 INT28843 Positive_regulation of Scn2a1 31 0.68 5.35 10.7
20 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4
21 INT43009 Gene_expression of Scn7a 45 0.68 7.85 10.29
22 INT62997 Gene_expression of Kcnj6 17 0.77 2.16 9.44
23 INT21502 Gene_expression of Scn4a 22 0.78 4.47 7.97
24 INT20705 Positive_regulation of Scn4a 18 0.68 4.34 7.85
25 INT17028 Positive_regulation of Scn7a 35 0.41 9.83 7.44
26 INT65630 Regulation of Kcna5 11 0.62 6.61 7.22
27 INT116428 Gene_expression of Cybb 68 0.76 35.81 7.07
28 INT17029 Regulation of Scn7a 23 0.45 3.89 7.02
29 INT17674 Localization of Scn2a1 32 0.61 1.73 6.79
30 INT48541 Positive_regulation of Kcna5 12 0.69 5.51 6.35
31 INT133971 Binding of Kcnip3 4 0.42 5.54 6.12
32 INT101008 Gene_expression of Scn5a 5 0.75 26.93 6.06
33 INT124960 Regulation of Scn11a 9 0.52 8.39 5.49
34 INT13370 Negative_regulation of Scn4a 11 0.57 4.05 5.47
35 INT149217 Gene_expression of Kcnip3 2 0.63 6.31 5.26
36 INT20703 Regulation of Scn4a 5 0.35 0.38 5.17
37 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
38 INT13051 Regulation of Kcnma1 12 0.12 2.09 5.06
39 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
40 INT90957 Positive_regulation of Kcnj9 6 0.69 2 4.79
41 INT86488 Gene_expression of Kcnc1 34 0.66 3.58 4.72
42 INT81086 Positive_regulation of Accn1 8 0.65 7.51 4.62
43 INT77148 Gene_expression of Kcna1 20 0.73 4.08 4.46
44 INT8624 Positive_regulation of Scn11a 7 0.46 3.56 4.41
45 INT137810 Regulation of Kcnk2 5 0.62 3.52 4.4
46 INT56159 Regulation of Scn2a1 17 0.51 3.23 4.27
47 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
48 INT107415 Regulation of Kcnj9 6 0.62 1 3.87
49 INT66473 Negative_regulation of Kcnj6 6 0.50 1.26 3.87
50 INT47992 Gene_expression of Scn8a 14 0.78 4.15 3.83
51 INT190722 Positive_regulation of Gene_expression of Scn2a1 15 0.36 0.5 3.78
52 INT28844 Negative_regulation of Scn2a1 15 0.37 3.84 3.65
53 INT29832 Negative_regulation of Scn7a 20 0.37 5.91 3.63
54 INT46208 Negative_regulation of Scn10a 6 0.58 7.16 3.46
55 INT48122 Regulation of Cacna1h 5 0.42 3 3.37
56 INT142701 Gene_expression of Kcnj6 8 0.78 0.34 3.25
57 INT100591 Regulation of Kcnip3 3 0.50 2.51 3.17
58 INT126116 Gene_expression of Kcna7 16 0.16 4.67 3.14
59 INT69313 Regulation of Scn10a 5 0.60 4.45 3.14
60 INT118247 Positive_regulation of Positive_regulation of Scn4a 1 0.06 0.82 3.1
61 INT162835 Positive_regulation of Cybb 38 0.68 16.09 3.02
62 INT65628 Regulation of Gene_expression of Kcna5 4 0.61 1.66 2.98
63 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
64 INT100344 Regulation of Gene_expression of Scn11a 4 0.44 1.6 2.82
65 INT65629 Positive_regulation of Gene_expression of Kcna5 5 0.69 2.48 2.76
66 INT116215 Transcription of Kcna5 6 0.53 3.62 2.75
67 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74
68 INT72253 Positive_regulation of Accn1 8 0.63 2.64 2.73
69 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
70 INT116216 Negative_regulation of Gene_expression of Kcna5 4 0.43 3.11 2.64
71 INT75551 Localization of Accn1 6 0.68 1.75 2.58
72 INT62998 Regulation of Kcnj6 4 0.39 0.5 2.57
73 INT91471 Positive_regulation of Gene_expression of Kcnma1 4 0.22 2.88 2.56
74 INT99800 Binding of Kcna5 4 0.47 0.96 2.55
75 INT140200 Regulation of Cacna2d3 4 0.45 1.48 2.53
76 INT82730 Transcription of Scn10a 3 0.69 2.5 2.53
77 INT145946 Negative_regulation of Kcnk2 3 0.59 2.65 2.52
78 INT72254 Gene_expression of Accn1 9 0.71 3.24 2.46
79 INT131831 Negative_regulation of Kcnj9 2 0.43 0.66 2.42
80 INT29901 Localization of Scn4a 3 0.68 0.07 2.41
81 INT13753 Transcription of Scn4a 4 0.70 0 2.39
82 INT17559 Localization of Scn7a 13 0.28 4.47 2.37
83 INT107414 Positive_regulation of Gene_expression of Kcnj9 1 0.50 2.61 2.34
84 INT69481 Negative_regulation of Kcna1 5 0.28 0.38 2.33
85 INT80733 Binding of Scn2a1 11 0.30 1.09 2.3
86 INT136190 Transcription of Accn1 5 0.61 2.75 2.24
87 INT48120 Positive_regulation of Cacna1h 5 0.34 1.2 2.22
88 INT70522 Binding of Kcna1 2 0.36 0.73 2.22
89 INT99119 Gene_expression of Cacna2d3 7 0.65 1.41 2.21
90 INT169533 Positive_regulation of Gene_expression of Cybb 16 0.68 8.62 2.14
91 INT100590 Negative_regulation of Kcnip3 5 0.58 2.39 2.13
92 INT99951 Regulation of Accn1 5 0.26 2.65 2.1
93 INT9429 Positive_regulation of Clcn1 18 0.58 10.03 2.07
94 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
95 INT165083 Positive_regulation of Positive_regulation of Accn1 1 0.47 3.91 2.07
96 INT157927 Gene_expression of Scn1a 5 0.64 6.55 2.02
97 INT134894 Phosphorylation of Kcnc1 2 0.56 1.38 2.02
98 INT233112 Gene_expression of Kcnk2 15 0.78 0.9 2.01
99 INT64075 Positive_regulation of Positive_regulation of Kcnma1 2 0.02 0.55 1.96
100 INT117396 Binding of Kcnj6 1 0.35 1.58 1.95
101 INT34860 Negative_regulation of Gene_expression of Scn2a1 8 0.30 0.97 1.94
102 INT134896 Regulation of Kcnc1 6 0.37 1.14 1.9
103 INT8623 Transcription of Scn11a 5 0.58 2.42 1.82
104 INT81827 Positive_regulation of Kcnk2 7 0.70 0.42 1.79
105 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
106 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
107 INT105567 Negative_regulation of Positive_regulation of Kcnj9 2 0.42 0.31 1.78
108 INT263066 Negative_regulation of Negative_regulation of Scn11a 1 0.42 2.77 1.78
109 INT66469 Negative_regulation of Gene_expression of Kcnj6 3 0.58 0.32 1.77
110 INT131751 Localization of Kcna5 1 0.71 0 1.7
111 INT148853 Transcription of Kcnj6 1 0.72 0 1.66
112 INT19467 Localization of Clcn1 7 0.66 2.84 1.59
113 INT132677 Regulation of Kcnk3 3 0.45 1.32 1.57
114 INT123076 Gene_expression of Cacna1c 7 0.37 1.91 1.56
115 INT65601 Negative_regulation of Kcnab1 4 0.42 1.64 1.56
116 INT29904 Negative_regulation of Binding of Scn4a 4 0.41 1.21 1.56
117 INT81828 Positive_regulation of Kcnk3 7 0.45 1.43 1.54
118 INT115082 Negative_regulation of Gene_expression of Scn4a 2 0.42 0.34 1.53
119 INT99117 Transcription of Cacna2d3 1 0.69 0 1.52
120 INT42250 Binding of Scn7a 7 0.33 0.51 1.48
121 INT79001 Positive_regulation of Localization of Scn2a1 3 0.36 0.22 1.48
122 INT15048 Regulation of Cacna1c 4 0.29 3.26 1.47
123 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
124 INT16178 Gene_expression of Clcn1 20 0.69 8.67 1.46
125 INT126121 Transcription of Kcnj6 1 0.65 0 1.45
126 INT65452 Negative_regulation of Cacna1c 8 0.09 0.8 1.44
127 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
128 INT159464 Negative_regulation of Accn1 4 0.37 1.07 1.41
129 INT83528 Localization of Scn11a 6 0.75 1.51 1.4
130 INT46206 Positive_regulation of Scn10a 11 0.60 6.57 1.38
131 INT8622 Positive_regulation of Transcription of Scn11a 2 0.45 1.45 1.37
132 INT83606 Negative_regulation of Gene_expression of Scn10a 1 0.43 0.51 1.36
133 INT143451 Negative_regulation of Gene_expression of Scn5a 2 0.43 4.63 1.34
134 INT77752 Binding of Cacna1c 3 0.22 0.22 1.31
135 INT120521 Negative_regulation of Gene_expression of Scn11a 2 0.42 2.12 1.3
136 INT48121 Negative_regulation of Cacna1h 3 0.11 1.86 1.28
137 INT72250 Binding of Accn1 3 0.44 2.87 1.27
138 INT92848 Gene_expression of Scn5a 3 0.73 0.23 1.25
139 INT82728 Positive_regulation of Transcription of Scn10a 1 0.49 1.07 1.25
140 INT82732 Positive_regulation of Transcription of Scn7a 1 0.17 1.07 1.25
141 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
142 INT116242 Negative_regulation of Cybb 11 0.57 8.57 1.24
143 INT91914 Binding of Accn1 3 0.36 0.44 1.24
144 INT151822 Gene_expression of Catsper1 2 0.62 2.62 1.24
145 INT82726 Transcription of Scn7a 1 0.24 1.05 1.24
146 INT117398 Gene_expression of Nalcn 2 0.50 1.58 1.23
147 INT148171 Phosphorylation of Kcnd2 1 0.80 1.09 1.23
148 INT19466 Negative_regulation of Clcn1 6 0.52 3.39 1.22
149 INT86486 Negative_regulation of Gene_expression of Kcna1 4 0.55 1.74 1.21
150 INT158269 Gene_expression of Trpm5 18 0.76 2.06 1.2
151 INT134895 Positive_regulation of Kcnc1 3 0.43 0.66 1.18
152 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
153 INT218609 Localization of Kcna1 1 0.78 0 1.15
154 INT228648 Binding of Scn1a 1 0.27 1.95 1.15
155 INT70521 Regulation of Kcna1 2 0.50 0.54 1.11
156 INT148851 Regulation of Transcription of Kcnj6 1 0.62 0 1.11
157 INT141116 Transcription of Scn2a1 9 0.45 1.1 1.1
158 INT66452 Positive_regulation of Cacna1c 6 0.19 2.56 1.08
159 INT140201 Positive_regulation of Binding of Cacna2d3 1 0.69 0.62 1.07
160 INT69482 Positive_regulation of Kcna1 4 0.32 0.27 1.06
161 INT72591 Gene_expression of Scn4a 2 0.64 0.65 1.05
162 INT150630 Positive_regulation of Positive_regulation of Scn10a 1 0.24 0.69 1.04
163 INT86489 Regulation of Gene_expression of Kcna1 1 0.42 0.27 1.03
164 INT190964 Regulation of Gene_expression of Scn2a1 7 0.29 1.29 1.02
165 INT129360 Positive_regulation of Gene_expression of Scn11a 2 0.10 0.49 1.01
166 INT72255 Binding of Kcnma1 4 0.02 0.2 0.99
167 INT78935 Localization of Cacna1c 3 0.48 1.25 0.97
168 INT114136 Binding of Vdac1 3 0.47 2.02 0.97
169 INT262479 Phosphorylation of Scn7a 2 0.06 1.04 0.96
170 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
171 INT103166 Positive_regulation of Nalcn 1 0.06 0.5 0.95
172 INT148852 Regulation of Kcnj6 1 0.27 0 0.91
173 INT99801 Regulation of Binding of Kcna5 1 0.26 0.14 0.9
174 INT207496 Regulation of Gene_expression of Scn7a 8 0.04 1.1 0.89
175 INT143450 Negative_regulation of Scn5a 3 0.43 2.71 0.88
176 INT7457 Localization of Kcnma1 3 0.60 2.75 0.85
177 INT29902 Regulation of Binding of Scn4a 1 0.08 0 0.85
178 INT33430 Regulation of Localization of Scn7a 1 0.07 0 0.85
179 INT139928 Negative_regulation of Kcnma1 6 0.37 1.19 0.84
180 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83
181 INT68289 Positive_regulation of Gene_expression of Accn1 2 0.45 0.34 0.83
182 INT109570 Gene_expression of Kcnk3 3 0.75 2.18 0.81
183 INT77610 Gene_expression of Cacna1h 6 0.65 0.47 0.8
184 INT144789 Negative_regulation of Hcn2 2 0.53 0.24 0.8
185 INT109568 Negative_regulation of Kcnk3 2 0.37 0.86 0.8
186 INT204461 Localization of Scn10a 4 0.31 2.58 0.79
187 INT143673 Regulation of Gene_expression of Accn1 4 0.43 0.81 0.78
188 INT236517 Gene_expression of Cacna1f 8 0.65 5.18 0.77
189 INT117570 Positive_regulation of Gene_expression of Scn7a 7 0.43 1.4 0.77
190 INT76487 Localization of Cacna1h 3 0.48 0.98 0.77
191 INT51778 Negative_regulation of Positive_regulation of Scn7a 2 0.26 0.69 0.77
192 INT296263 Localization of Kcnip3 1 0.69 0.34 0.76
193 INT69771 Positive_regulation of Kcnma1 6 0.52 0.31 0.74
194 INT199071 Negative_regulation of Gene_expression of Cybb 6 0.55 3.52 0.74
195 INT123075 Positive_regulation of Gene_expression of Cacna1c 1 0.05 0.73 0.73
196 INT37012 Binding of Clcn1 11 0.33 4.83 0.7
197 INT220695 Positive_regulation of Gene_expression of Scn10a 2 0.10 2.06 0.7
198 INT126114 Regulation of Kcna7 5 0.07 2.08 0.69
199 INT282365 Positive_regulation of Trpm5 4 0.68 0.53 0.69
200 INT207494 Positive_regulation of Positive_regulation of Scn7a 1 0.03 0 0.69
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