GO:0034976

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Name response to endoplasmic reticulum stress
Categary Process
Go Slim No
Go Link GO:0034976
Unique Molecular Interactions 103
Total Molecular Interactions 133
Total Single Events 818
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to endoplasmic reticulum stress. They are ordered first by their pain relevance and then by number of times they were reported for response to endoplasmic reticulum stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
2 INT119887 Binding of Atf4 and Usf1 1 0.21 0.15 1.05
3 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
4 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
5 INT118568 Binding of Ddit3 and Atf6 1 0.33 0.85 0.66
6 INT165844 Binding of ATF4 and HSP90AB1 1 0.15 0.34 0.61
7 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
8 INT151558 ERLEC1 Regulation of Atp2a1 1 0.00 0.64 0.53
9 INT151557 NARG2 Regulation of Atp2a1 1 0.01 0.64 0.53
10 INT177791 PDCD2 Positive_regulation of ATF4 1 0.06 0.76 0.46
11 INT177781 BUB1B Positive_regulation of ATF4 1 0.07 0.76 0.46
12 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
13 INT156640 ATF4 Regulation of Gene_expression of S100P 1 0.44 0.88 0.28
14 INT107189 Atp2a2 Negative_regulation of Atp2a1 1 0.27 0 0.26
15 INT103280 PGR Negative_regulation of Positive_regulation of ATF4 1 0.02 0.31 0.26
16 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
17 INT130689 CA2 Positive_regulation of ATF4 1 0.13 0.59 0.24
18 INT318678 Atf4 Positive_regulation of Gene_expression of Ddit3 1 0.53 0.77 0.23
19 INT318679 Atf4 Positive_regulation of Gene_expression of Xbp1 1 0.53 0.77 0.23
20 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
21 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2
22 INT318682 Atf4 Positive_regulation of Ddit3 1 0.73 1.71 0.18
23 INT318677 Xbp1 Positive_regulation of Ddit3 1 0.73 1.72 0.18
24 INT318680 Binding of Cebpg and Ddit3 1 0.39 1.73 0.18
25 INT320260 Binding of Atf4 and Creb1 1 0.15 0.36 0.17
26 INT320256 Binding of Atf4 and Rorb 1 0.06 0.36 0.17
27 INT130690 Gene_expression of HSPA5 Negative_regulation of Positive_regulation of DDIT3 1 0.21 0.58 0.17
28 INT320263 Binding of Ntrk2 and Atf4 1 0.01 0.38 0.17
29 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
30 INT199667 Cep290 Regulation of Atf4 1 0.04 1.96 0.09
31 INT215884 Eif2ak3 Positive_regulation of Gene_expression of Musd1 1 0.01 0.96 0.09
32 INT199666 Cntln Regulation of Atf4 1 0.00 1.95 0.09
33 INT140610 SNAR-I Negative_regulation of Gene_expression of ATF4 1 0.05 0.74 0.08
34 INT140606 PMEL Negative_regulation of Gene_expression of ATF4 1 0.01 0.74 0.08
35 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
36 INT140605 PMEL Negative_regulation of Transcription of ATF4 1 0.01 0.74 0.08
37 INT140608 SNAR-I Negative_regulation of Transcription of ATF4 1 0.05 0.74 0.08
38 INT244449 CS Regulation of Gene_expression of ATF4 1 0.15 0.83 0.08
39 INT215879 Ddit3 Regulation of Regulation of Atf4 1 0.26 0.29 0.07
40 INT215874 Positive_regulation of Eif2ak3 Positive_regulation of Positive_regulation of Ddit3 1 0.47 0.31 0.07
41 INT355432 Gene_expression of Pdia3 Negative_regulation of Ddit3 1 0.04 1.29 0.06
42 INT215883 Eif2ak3 Regulation of Musd1 1 0.00 0.8 0.06
43 INT355431 Binding of Pdia3 and Positive_regulation of Gene_expression of Ddit3 1 0.04 1.14 0.06
44 INT215878 Eif2ak3 Positive_regulation of Localization of Ins1 1 0.04 0.96 0.06
45 INT215877 Atf4 Regulation of Eif2ak3 1 0.44 0.21 0.06
46 INT355433 Gene_expression of Pdia3 Negative_regulation of Transcription of Ddit3 1 0.03 1.79 0.06
47 INT355434 Binding of Pdia3 and Positive_regulation of Transcription of Ddit3 1 0.04 1.14 0.06
48 INT215873 Ddit3 Regulation of Eif2ak3 1 0.39 0.2 0.06
49 INT355438 Gene_expression of Pdia3 Negative_regulation of Gene_expression of Ddit3 1 0.05 4.79 0.06
50 INT355439 Pdia3 Regulation of Gene_expression of Eif2ak3 1 0.01 0.83 0.05
51 INT284447 Il11 Positive_regulation of Atf4 1 0.01 0.42 0.05
52 INT215876 Atf4 Regulation of Hspa5 1 0.22 0.43 0.04
53 INT215871 Atf4 Regulation of Ddit3 1 0.26 0.43 0.04
54 INT5608 Gnl3 Regulation of Eif2ak3 1 0.05 0 0.04
55 INT244464 EIF2AK3 Positive_regulation of Positive_regulation of EIF2S2 1 0.17 0.37 0.04
56 INT244463 EIF2AK3 Regulation of Phosphorylation of EIF2S2 1 0.09 0.37 0.04
57 INT215882 Atf4 Regulation of Xbp1 1 0.28 0.43 0.04
58 INT252818 PPP2R4 Regulation of Positive_regulation of DDIT3 1 0.04 3.07 0.04
59 INT215875 Atf4 Regulation of Mapkap1 1 0.29 0.43 0.04
60 INT355430 Pdia3 Regulation of Gene_expression of Ddit3 1 0.04 1 0.03
61 INT355441 VEGFA Positive_regulation of Gene_expression of Ddit3 1 0.05 0.43 0.03
62 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
63 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
64 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
65 INT177792 Binding of ATF4 and NFE2L2 1 0.06 0.25 0
66 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 0.42 0.24 0
67 INT316774 Hsp90b1 Positive_regulation of Localization of Ddit3 1 0.12 0.17 0
68 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 0.52 0 0
69 INT244454 Binding of EIF2AK3 and SIL1 1 0.05 0.41 0
70 INT355437 Negative_regulation of Pdia3 Positive_regulation of Gene_expression of Ddit3 1 0.04 0.47 0
71 INT316770 Hsp90b1 Positive_regulation of Ddit3 1 0.12 0.17 0
72 INT140607 PMEL Positive_regulation of Gene_expression of DDIT3 1 0.01 0.75 0
73 INT252842 ENOPH1 Positive_regulation of Gene_expression of Ddit3 1 0.06 2.42 0
74 INT206943 Hspa5 Positive_regulation of Atf4 1 0.47 0.62 0
75 INT203853 Eif2ak3 Positive_regulation of Eif2ak1 1 0.05 0.63 0
76 INT355436 Pdia3 Regulation of Transcription of Ddit3 1 0.04 0.59 0
77 INT256705 Binding of Wfs1 and Xbp1 1 0.19 0.39 0
78 INT316772 Calr Positive_regulation of Ddit3 1 0.10 0.12 0
79 INT250152 Binding of APOE and UBE4B 1 0.21 1.2 0
80 INT244466 EIF2AK3 Positive_regulation of Localization of SIL1 1 0.06 0.47 0
81 INT256704 Xbp1 Positive_regulation of Positive_regulation of Wfs1 1 0.26 0.4 0
82 INT292504 Mlph Regulation of EIF2AK3 1 0.00 0.21 0
83 INT256702 Binding of Wfs1 and Tmed4 1 0.01 0.61 0
84 INT316771 Calr Positive_regulation of Localization of Ddit3 1 0.10 0.12 0
85 INT252792 ENOPH1 Positive_regulation of Gene_expression of DDIT3 1 0.03 2.42 0
86 INT174720 Ddit3 Regulation of Gtf3a 1 0.01 0.35 0
87 INT244465 Binding of EIF2AK3 and ATF6 1 0.14 0.69 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to endoplasmic reticulum stress. They are ordered first by their pain relevance and then by number of times they were reported in response to endoplasmic reticulum stress. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
2 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
3 INT128159 Positive_regulation of DDIT3 29 0.67 29.5 8.99
4 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
5 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
6 INT206950 Positive_regulation of Atf4 14 0.45 7.02 5.71
7 INT128161 Gene_expression of DDIT3 20 0.75 17.14 5.13
8 INT116150 Positive_regulation of Ddit3 26 0.67 22.58 5.01
9 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
10 INT118565 Gene_expression of Ddit3 35 0.75 23.62 4.32
11 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
12 INT142483 Positive_regulation of Gene_expression of DDIT3 15 0.67 11.39 3.47
13 INT241623 Gene_expression of Atf4 12 0.74 8.67 2.85
14 INT103282 Positive_regulation of ATF4 12 0.66 7.28 2.65
15 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
16 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
17 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
18 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
19 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
20 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
21 INT141166 Positive_regulation of Gene_expression of Ddit3 15 0.56 10.32 1.92
22 INT173419 Gene_expression of Ddit3 16 0.75 23.31 1.87
23 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
24 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
25 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
26 INT241618 Regulation of Atf4 3 0.43 1.41 1.46
27 INT130704 Gene_expression of ATF4 9 0.78 5.29 1.45
28 INT241627 Regulation of Positive_regulation of Atf4 1 0.29 0.36 1.4
29 INT119870 Binding of Atf4 1 0.45 0.39 1.39
30 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
31 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
32 INT241624 Positive_regulation of Positive_regulation of Atf4 1 0.32 0.72 1.32
33 INT128160 Regulation of DDIT3 3 0.57 2.45 1.29
34 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
35 INT165800 Positive_regulation of Ddit3 17 0.67 11.69 1.21
36 INT116144 Positive_regulation of Positive_regulation of Ddit3 2 0.41 2.95 1.2
37 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
38 INT152407 Negative_regulation of Gene_expression of DDIT3 3 0.40 0.87 1.02
39 INT152408 Binding of DDIT3 3 0.35 2.06 1
40 INT116140 Localization of Ddit3 2 0.57 1.94 0.96
41 INT156649 Positive_regulation of Gene_expression of ATF4 3 0.69 2.79 0.88
42 INT241620 Negative_regulation of Positive_regulation of Atf4 1 0.27 0.85 0.88
43 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
44 INT318665 Negative_regulation of Gene_expression of Atf4 1 0.56 5.16 0.85
45 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
46 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
47 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
48 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
49 INT118566 Gene_expression of Atf4 4 0.64 2.58 0.73
50 INT318666 Negative_regulation of Ddit3 1 0.56 6.86 0.7
51 INT118564 Regulation of Gene_expression of Ddit3 1 0.55 0.89 0.68
52 INT118563 Regulation of Gene_expression of Atf4 1 0.37 0.89 0.68
53 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
54 INT318667 Negative_regulation of Gene_expression of Ddit3 6 0.56 3.16 0.65
55 INT241625 Regulation of Gene_expression of Atf4 2 0.43 0.83 0.59
56 INT147577 Binding of ATF4 1 0.05 0.15 0.54
57 INT147578 Regulation of Binding of ATF4 1 0.07 0.15 0.54
58 INT128162 Negative_regulation of Positive_regulation of DDIT3 4 0.41 4.54 0.53
59 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
60 INT107187 Gene_expression of Atp2a1 1 0.43 0 0.52
61 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
62 INT241626 Negative_regulation of Regulation of Atf4 1 0.28 0.29 0.48
63 INT157308 Regulation of Gene_expression of DDIT3 1 0.44 0.45 0.46
64 INT130712 Negative_regulation of Gene_expression of ATF4 1 0.33 0.75 0.43
65 INT173418 Transcription of Ddit3 6 0.65 7.91 0.41
66 INT140612 Transcription of ATF4 3 0.58 1.73 0.39
67 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
68 INT256681 Regulation of Wfs1 8 0.43 4.72 0.36
69 INT130709 Negative_regulation of Positive_regulation of ATF4 1 0.44 0.75 0.36
70 INT15697 Negative_regulation of EIF2AK3 1 0.41 0 0.33
71 INT164827 Negative_regulation of Atp2a1 1 0.43 0.15 0.32
72 INT15698 Transcription of EIF2AK3 1 0.52 0 0.32
73 INT156648 Positive_regulation of Transcription of ATF4 1 0.42 0.79 0.32
74 INT127902 Negative_regulation of Gene_expression of EIF2AK3 1 0.42 0.47 0.3
75 INT202373 Transcription of Ddit3 6 0.62 5.52 0.29
76 INT154749 Negative_regulation of Gene_expression of Ddit3 2 0.41 1.15 0.27
77 INT239955 Gene_expression of Atp2a1 7 0.29 0.78 0.26
78 INT215850 Regulation of Ddit3 5 0.50 6.15 0.25
79 INT252833 Positive_regulation of Gene_expression of Ddit3 4 0.67 7.58 0.25
80 INT256682 Gene_expression of Wfs1 1 0.74 6.63 0.25
81 INT318676 Negative_regulation of Atf4 3 0.56 1.59 0.23
82 INT157020 Negative_regulation of DDIT3 2 0.42 2.39 0.23
83 INT34862 Gene_expression of UBE4B 7 0.50 4.65 0.18
84 INT256696 Positive_regulation of Wfs1 1 0.66 9.14 0.17
85 INT157019 Regulation of Positive_regulation of DDIT3 2 0.26 2.1 0.16
86 INT157021 Positive_regulation of Positive_regulation of DDIT3 2 0.49 1.78 0.16
87 INT271019 Negative_regulation of Atp2a1 1 0.19 1.75 0.16
88 INT256684 Positive_regulation of Gene_expression of Wfs1 1 0.66 3.62 0.16
89 INT164832 Positive_regulation of Atp2a1 1 0.30 0.07 0.16
90 INT164828 Negative_regulation of Negative_regulation of Atp2a1 1 0.31 0.07 0.16
91 INT215885 Transcription of DDIT3 3 0.69 2.57 0.13
92 INT215886 Positive_regulation of Transcription of DDIT3 2 0.49 2.32 0.13
93 INT215861 Positive_regulation of Negative_regulation of Eif2ak3 1 0.50 1.04 0.13
94 INT215846 Positive_regulation of Atf4 3 0.58 2.03 0.12
95 INT143825 Regulation of Ddit3 3 0.58 2.03 0.11
96 INT318674 Transcription of Atf4 3 0.69 1.26 0.1
97 INT322449 Regulation of Atp2a1 1 0.13 1.22 0.1
98 INT256675 Regulation of Gene_expression of Wfs1 1 0.43 2.33 0.09
99 INT256687 Positive_regulation of Transcription of Wfs1 1 0.44 1.95 0.09
100 INT308642 Localization of UBE4B 1 0.06 0.32 0.09
101 INT173416 Localization of Ddit3 2 0.71 0.98 0.08
102 INT173421 Positive_regulation of Transcription of Ddit3 2 0.47 0.7 0.08
103 INT327269 Regulation of Transcription of Ddit3 1 0.06 1.24 0.08
104 INT174717 Negative_regulation of Transcription of Ddit3 1 0.32 0.5 0.08
105 INT151835 Positive_regulation of UBE4B 1 0.48 0.68 0.08
106 INT256693 Transcription of Wfs1 1 0.68 2.44 0.08
107 INT174709 Positive_regulation of Positive_regulation of Ddit3 1 0.38 0.85 0.08
108 INT263568 Negative_regulation of Positive_regulation of Ddit3 1 0.47 0.98 0.08
109 INT164061 Negative_regulation of ATF4 1 0.59 0.82 0.08
110 INT173420 Regulation of Gene_expression of Ddit3 2 0.37 0.84 0.07
111 INT215869 Regulation of Atf4 1 0.26 0.29 0.07
112 INT279378 Negative_regulation of Ddit3 2 0.30 1.35 0.06
113 INT318669 Localization of Atf4 1 0.72 0.58 0.05
114 INT318672 Positive_regulation of Transcription of Atf4 1 0.48 0.52 0.05
115 INT316762 Binding of Ddit3 1 0.11 0.14 0.04
116 INT241629 Phosphorylation of Atf4 1 0.52 0.08 0.04
117 INT322455 Negative_regulation of Gene_expression of Atp2a1 1 0.12 0.54 0.04
118 INT215856 Positive_regulation of Transcription of Ddit3 2 0.60 2.12 0.03
119 INT244561 Positive_regulation of Positive_regulation of ATF4 1 0.31 0.42 0.03
120 INT271023 Negative_regulation of Negative_regulation of Atp2a1 1 0.19 0.06 0.03
121 INT215843 Negative_regulation of Atf4 1 0.36 0.39 0.03
122 INT186224 Binding of UBE4B 3 0.22 0.32 0
123 INT322446 Negative_regulation of Transcription of Atp2a1 1 0.12 0.21 0
124 INT256676 Regulation of Binding of Wfs1 1 0.43 0.35 0
125 INT320251 Regulation of Transcription of Atf4 1 0.43 0.25 0
126 INT256692 Negative_regulation of Wfs1 1 0.41 0 0
127 INT256671 Regulation of Positive_regulation of Wfs1 1 0.59 1.77 0
128 INT244533 Negative_regulation of Phosphorylation of EIF2AK3 1 0.20 0.39 0
129 INT256686 Binding of Wfs1 1 0.46 0.91 0
130 INT239375 Localization of DDIT3 1 0.38 0.79 0
131 INT256677 Regulation of Transcription of Wfs1 1 0.59 0.5 0
132 INT250156 Negative_regulation of Gene_expression of UBE4B 1 0.29 0.43 0
133 INT322460 Positive_regulation of Atp2a1 1 0.10 0.42 0
134 INT53281 Regulation of Atp2a1 1 0.11 0 0
135 INT322457 Transcription of Atp2a1 1 0.16 0.21 0
136 INT239374 Positive_regulation of Localization of DDIT3 1 0.25 0.8 0
137 INT271085 Positive_regulation of Regulation of Eif2ak3 1 0.03 0.66 0
138 INT256672 Positive_regulation of Positive_regulation of Wfs1 1 0.44 0.24 0
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