GO:0034983

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Name peptidyl-lysine deacetylation
Categary Process
Go Slim No
Go Link GO:0034983
Unique Molecular Interactions 82
Total Molecular Interactions 101
Total Single Events 884
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptidyl-lysine deacetylation. They are ordered first by their pain relevance and then by number of times they were reported for peptidyl-lysine deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
2 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
3 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
4 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
5 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49
6 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
7 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34
8 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
9 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
10 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
11 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
12 INT190628 Negative_regulation of Binding of Rab7 and Sirt1 1 0.33 0.62 0.17
13 INT190638 Binding of Rab7 and Sirt1 1 0.29 0.62 0.17
14 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
15 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
16 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
17 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
18 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
19 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13
20 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
21 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
22 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
23 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
24 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08
25 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
26 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
27 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
28 INT256160 Positive_regulation of Binding of Pgc and Sirt1 1 0.55 0.21 0.07
29 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
30 INT256161 Binding of Pgc and Sirt1 1 0.38 0.21 0.07
31 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05
32 INT340293 Binding of Ins1 and Sirt1 1 0.25 1.25 0.05
33 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
34 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
35 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
36 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
37 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
38 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
39 INT180040 Binding of D7Cwr3P and Sirt1 1 0.00 0 0
40 INT300696 Sirt1 Regulation of Cyb5r3 1 0.03 0 0
41 INT299444 Foxl2 Positive_regulation of Sirt1 1 0.24 0.31 0
42 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
43 INT299458 Gene_expression of Sirt1 Negative_regulation of Foxl2 1 0.25 0.32 0
44 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
45 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
46 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
47 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
48 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0
49 INT256165 Binding of Sirt6 and Sirt1 1 0.13 0.58 0
50 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
51 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
52 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
53 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
54 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
55 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
56 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
57 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
58 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
59 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
60 INT265383 Hsp90aa1 Negative_regulation of HDAC9 1 0.06 0.7 0
61 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
62 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
63 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
64 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
65 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
66 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
67 INT355201 Binding of HDAC9 and Gopc 1 0.01 0.06 0
68 INT314132 Sirt1 Positive_regulation of Ppargc1a 1 0.50 2.3 0
69 INT200650 HDAC4 Regulation of Gene_expression of AKT1 1 0.16 0.66 0
70 INT326197 Negative_regulation of HDAC9 Negative_regulation of EPHB2 1 0.17 0.15 0
71 INT299451 Foxl2 Negative_regulation of Gene_expression of Sirt1 1 0.25 0.32 0
72 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
73 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
74 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
75 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
76 INT200724 HDAC9 Positive_regulation of TP53 1 0.36 0.27 0
77 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0
78 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
79 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
80 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptidyl-lysine deacetylation. They are ordered first by their pain relevance and then by number of times they were reported in peptidyl-lysine deacetylation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
2 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36
3 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
4 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
5 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11
6 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
7 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18
8 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
9 INT191154 Binding of HDAC9 20 0.36 14.12 1.83
10 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
11 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
12 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
13 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44
14 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
15 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23
16 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
17 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
18 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
19 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
20 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
21 INT333910 Positive_regulation of Gene_expression of HDAC4 2 0.07 1.5 0.49
22 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
23 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48
24 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
25 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
26 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
27 INT333915 Negative_regulation of Binding of HDAC9 1 0.21 0.83 0.41
28 INT277579 Binding of Hdac4 1 0.37 3.84 0.38
29 INT277604 Negative_regulation of Hdac4 4 0.51 2.89 0.36
30 INT277598 Regulation of Gene_expression of Hdac4 1 0.45 0.91 0.36
31 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
32 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
33 INT333912 Regulation of Positive_regulation of HDAC9 1 0.19 0.63 0.31
34 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
35 INT312879 Regulation of Hdac6 1 0.55 0.76 0.29
36 INT124568 Regulation of HDAC4 5 0.24 3.03 0.27
37 INT234466 Regulation of Negative_regulation of HDAC9 2 0.25 1.82 0.26
38 INT312887 Gene_expression of Hdac6 1 0.60 1.28 0.25
39 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24
40 INT312883 Regulation of Regulation of Hdac6 1 0.40 0.38 0.24
41 INT277584 Negative_regulation of Gene_expression of Hdac4 1 0.43 0.85 0.21
42 INT277594 Positive_regulation of Localization of Hdac4 1 0.50 1.71 0.21
43 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
44 INT277593 Localization of Hdac4 1 0.75 2.07 0.2
45 INT277600 Positive_regulation of Gene_expression of Hdac4 1 0.60 0.48 0.2
46 INT191155 Binding of HDAC4 5 0.08 2.79 0.17
47 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
48 INT133646 Positive_regulation of Regulation of HDAC9 1 0.49 0.83 0.17
49 INT277601 Positive_regulation of Positive_regulation of Hdac4 1 0.50 0.18 0.16
50 INT312881 Positive_regulation of Hdac6 1 0.45 0.67 0.15
51 INT256111 Regulation of Gene_expression of Sirt1 1 0.32 0.73 0.14
52 INT277582 Regulation of Hdac4 1 0.45 0.36 0.14
53 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
54 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
55 INT234460 Negative_regulation of Gene_expression of HDAC4 2 0.04 1.55 0.11
56 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
57 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
58 INT234465 Regulation of Negative_regulation of HDAC4 1 0.04 0.74 0.11
59 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
60 INT346968 Positive_regulation of Transcription of HDAC9 1 0.22 0.21 0.07
61 INT346969 Transcription of HDAC9 1 0.23 0.21 0.07
62 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
63 INT256136 Negative_regulation of Binding of Sirt1 1 0.30 0.5 0.07
64 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
65 INT256137 Positive_regulation of Regulation of Sirt1 1 0.36 0.32 0.05
66 INT191153 Negative_regulation of Negative_regulation of HDAC9 1 0.09 0.57 0.05
67 INT312877 Positive_regulation of Negative_regulation of Hdac6 1 0.45 0 0.05
68 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
69 INT277599 Phosphorylation of Hdac4 1 0.82 3.24 0.05
70 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
71 INT256129 Negative_regulation of Gene_expression of Sirt1 1 0.31 0.4 0.05
72 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
73 INT270038 Positive_regulation of Positive_regulation of Sirt1 2 0.43 0.44 0.03
74 INT246622 Phosphorylation of Sirt1 2 0.74 0.56 0.03
75 INT326227 Phosphorylation of HDAC9 1 0.22 2.32 0.03
76 INT259662 Positive_regulation of Regulation of HDAC4 1 0.03 0.77 0.03
77 INT312888 Phosphorylation of Hdac6 1 0.73 0 0.03
78 INT332926 Localization of HDAC4 1 0.10 0.11 0.03
79 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
80 INT204349 Regulation of SIRT1 8 0.61 1.99 0
81 INT256134 Localization of Sirt1 5 0.50 2.99 0
82 INT204353 Transcription of SIRT1 3 0.68 0.67 0
83 INT277612 Localization of HDAC9 3 0.45 0.55 0
84 INT265379 Positive_regulation of Binding of HDAC9 2 0.19 1.06 0
85 INT200682 Phosphorylation of HDAC4 2 0.44 1.24 0
86 INT312873 Negative_regulation of Gene_expression of Hdac6 1 0.38 0 0
87 INT312885 Binding of Hdac6 1 0.43 0 0
88 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
89 INT289569 Transcription of Sirt1 1 0.71 0.25 0
90 INT300686 Regulation of Binding of Sirt1 1 0.44 0.06 0
91 INT312874 Regulation of Phosphorylation of Hdac6 1 0.40 0 0
92 INT277580 Regulation of Localization of Hdac4 1 0.39 0 0
93 INT300287 Localization of Sirt1 1 0.66 1.46 0
94 INT326229 Regulation of Phosphorylation of HDAC9 1 0.07 0.48 0
95 INT200668 Regulation of Phosphorylation of HDAC4 1 0.24 0.71 0
96 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
97 INT326233 Negative_regulation of Phosphorylation of HDAC9 1 0.11 0 0
98 INT300683 Positive_regulation of Negative_regulation of Sirt1 1 0.45 0 0
99 INT312876 Negative_regulation of Transcription of Hdac6 1 0.38 0 0
100 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
101 INT277577 Transcription of Hdac4 1 0.69 0 0
102 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
103 INT240932 Negative_regulation of Transcription of Sirt1 1 0.34 0.29 0
104 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
105 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
106 INT239368 Negative_regulation of Binding of HDAC4 1 0.06 1.44 0
107 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
108 INT355200 Regulation of Gene_expression of HDAC9 1 0.14 1.77 0
109 INT312875 Transcription of Hdac6 1 0.61 0 0
110 INT338233 Regulation of Gene_expression of HDAC4 1 0.03 0.18 0
111 INT277603 Negative_regulation of Phosphorylation of Hdac4 1 0.43 0.39 0
112 INT204331 Binding of SIRT1 1 0.47 0.39 0
113 INT312878 Protein_catabolism of Hdac6 1 0.88 0 0
114 INT300685 Positive_regulation of Binding of Sirt1 1 0.67 0 0
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