GO:0035033

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Name histone deacetylase regulator activity
Categary Function
Go Slim No
Go Link GO:0035033
Unique Molecular Interactions 432
Total Molecular Interactions 516
Total Single Events 4060
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone deacetylase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported for histone deacetylase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT139723 PROC Positive_regulation of MAPK8 1 0.01 2.98 2.33
3 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
4 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
5 INT167427 Mapk8 Regulation of Regulation of Tnf 1 0.26 2.83 1.7
6 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6
7 INT134679 FSCN1 Positive_regulation of MAPK8 1 0.01 0.56 1.39
8 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
9 INT167429 Negative_regulation of Mapk8 Negative_regulation of RYBP 1 0.01 1.11 1.09
10 INT139703 Tnf Positive_regulation of Mapk8 1 0.32 0.73 1.08
11 INT223875 Negative_regulation of Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.31 0 1.07
12 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
13 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
14 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
15 INT97057 Bcl2l1 Regulation of Gene_expression of Trp53 1 0.36 0.51 0.83
16 INT97058 Cpz Regulation of Gene_expression of Trp53 1 0.27 0.57 0.83
17 INT222024 Mapk8 Regulation of Mapk14 2 0.17 0.83 0.79
18 INT158684 MAPK8 Positive_regulation of Gene_expression of BCL2L11 1 0.51 0.44 0.78
19 INT152234 Mapk8 Positive_regulation of Localization of Nfkb1 1 0.33 0.26 0.78
20 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
21 INT98179 Aap Positive_regulation of Mapk8 1 0.01 0.75 0.74
22 INT168420 Positive_regulation of Mapk8 Positive_regulation of Phosphorylation of Jun 1 0.30 0.88 0.74
23 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
24 INT223873 Mapk8 Regulation of Positive_regulation of Ltp 1 0.24 0 0.71
25 INT223869 Mapk8 Negative_regulation of Positive_regulation of Ltp 1 0.20 0 0.68
26 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
27 INT110458 Binding of Atf2 and Mapk8 1 0.35 0 0.66
28 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
29 INT158685 ROS1 Regulation of Positive_regulation of MAPK8 1 0.21 0.39 0.64
30 INT100030 TNF Positive_regulation of Mapk8 1 0.12 1.57 0.63
31 INT169295 PTPLA Positive_regulation of MAPK8 1 0.10 0.15 0.63
32 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
33 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
34 INT178437 Mapk8 Positive_regulation of Jun 3 0.40 2.69 0.58
35 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56
36 INT200913 Dio1 Positive_regulation of Mapk8 1 0.00 0 0.53
37 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52
38 INT171909 MAPK8 Positive_regulation of Gene_expression of MAPK1 1 0.08 1.55 0.52
39 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
40 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46
41 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46
42 INT278950 MAPK8 Negative_regulation of Localization of EPHB2 1 0.25 0.47 0.43
43 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
44 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43
45 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
46 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
47 INT116938 Positive_regulation of GLI2 Positive_regulation of MAPK8 1 0.10 0.07 0.41
48 INT319312 Socs4 Positive_regulation of Mapk8 1 0.05 0.68 0.41
49 INT179938 Negative_regulation of Mapk8 Negative_regulation of TNF 1 0.02 1.09 0.37
50 INT187233 Positive_regulation of Mapk8 Positive_regulation of Jun 1 0.12 0.92 0.37
51 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
52 INT309120 Edc4 Negative_regulation of Positive_regulation of Mapk8 1 0.01 1.03 0.36
53 INT308653 Proc Regulation of Gene_expression of Mapk8 1 0.00 1.48 0.36
54 INT330106 Racgap1 Positive_regulation of Positive_regulation of Mapk8 1 0.01 1.32 0.35
55 INT330105 Rac1 Positive_regulation of Mapk8 1 0.15 1.47 0.34
56 INT330103 Rac1 Positive_regulation of Positive_regulation of Mapk8 1 0.14 1.24 0.32
57 INT91814 Binding of TNF and TP53 1 0.14 2.2 0.32
58 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
59 INT110461 Binding of Mapk8 and Gtf3a 1 0.03 0 0.32
60 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
61 INT282421 Mapk8 Negative_regulation of Ins1 1 0.06 2.48 0.31
62 INT166396 IFI27 Regulation of Gene_expression of TP53 1 0.19 0.41 0.31
63 INT253153 TNF Positive_regulation of Mapk8 1 0.18 0.61 0.31
64 INT167983 Mapk8 Negative_regulation of gr 1 0.02 0.5 0.31
65 INT253155 TNF Positive_regulation of Positive_regulation of Mapk8 1 0.19 0.62 0.31
66 INT333917 MDM2 Positive_regulation of Protein_catabolism of Trp53 1 0.01 1.23 0.3
67 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
68 INT112795 Positive_regulation of CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.3
69 INT163761 MDM2 Positive_regulation of Gene_expression of TP53 1 0.40 0.86 0.3
70 INT112803 CASP1 Positive_regulation of MAPK8 1 0.02 0.16 0.29
71 INT159964 Tnf Positive_regulation of Phosphorylation of Mapk8 1 0.11 0.94 0.29
72 INT226505 Il1rl1 Positive_regulation of Mapk8 1 0.04 0.4 0.29
73 INT226509 Il1rl1 Positive_regulation of Gene_expression of Mapk8 1 0.05 0.4 0.29
74 INT166952 LYRM4 Positive_regulation of Gene_expression of TP53 1 0.05 0.75 0.28
75 INT309122 Edc4 Positive_regulation of Phosphorylation of Mapk8 1 0.02 0.73 0.28
76 INT237679 IRF6 Positive_regulation of MAPK8 1 0.00 0.56 0.28
77 INT286042 Binding of Tp53 and Wwox 1 0.04 2.05 0.28
78 INT216127 EGR1 Regulation of Transcription of TP53 1 0.06 0.21 0.28
79 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28
80 INT306267 Binding of INCENP and TP53 1 0.02 0.83 0.27
81 INT132368 Mapk8 Positive_regulation of Nfkb1 1 0.17 0.11 0.27
82 INT132369 Mapk8 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.27
83 INT216128 EGR1 Regulation of TP53 1 0.11 0.21 0.27
84 INT132366 Lgals1 Positive_regulation of Mapk8 1 0.38 0.13 0.27
85 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
86 INT352931 Prkaca Regulation of TP53 1 0.13 1.01 0.26
87 INT352930 Prkaca Regulation of Phosphorylation of TP53 1 0.13 1.02 0.26
88 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
89 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26
90 INT171907 MAPK8 Positive_regulation of Gene_expression of MAPK14 1 0.06 0.77 0.26
91 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
92 INT352893 PTGDS Regulation of TP53 1 0.16 1.02 0.26
93 INT125516 TP53 Regulation of GDF15 1 0.10 0.47 0.26
94 INT171913 MAPK8 Positive_regulation of MAPK9 1 0.07 0.78 0.26
95 INT337086 Mif Negative_regulation of Localization of Trp53 1 0.16 1.64 0.25
96 INT337091 Mif Negative_regulation of Positive_regulation of Trp53 1 0.16 1.64 0.25
97 INT156879 Gene_expression of TP53 Negative_regulation of Positive_regulation of PDF 1 0.45 0.9 0.24
98 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
99 INT330053 Binding of Ros1 and Mapk8 1 0.02 0.88 0.24
100 INT156881 TP53 Positive_regulation of Positive_regulation of PDF 1 0.49 0.89 0.24
101 INT95741 Creb1 Regulation of Mapk8 1 0.39 0 0.23
102 INT292554 MAP3K5 Positive_regulation of MAPK8 1 0.08 0 0.23
103 INT229177 IFRD1 Regulation of TP53 1 0.13 0.68 0.23
104 INT309124 Dlat Negative_regulation of Positive_regulation of Mapk8 1 0.02 0.27 0.22
105 INT226902 Padi3 Regulation of Trp53 1 0.06 0.69 0.22
106 INT309116 Edc4 Negative_regulation of Mapk8 1 0.01 0.43 0.22
107 INT112802 IL4I1 Positive_regulation of Positive_regulation of MAPK8 1 0.04 0 0.22
108 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
109 INT223828 Binding of GSTP1 and MAPK8 1 0.06 1.8 0.21
110 INT156882 Binding of TP53 and PDF 1 0.39 0.77 0.21
111 INT330051 Mapk8 Positive_regulation of Bcl2l11 1 0.13 0.46 0.21
112 INT156880 TP53 Positive_regulation of Gene_expression of PDF 1 0.49 0.75 0.21
113 INT131718 Mapk8 Regulation of Penk 1 0.46 0.16 0.2
114 INT210887 Sst Positive_regulation of Gene_expression of Trp53 1 0.33 0.93 0.2
115 INT266414 Binding of HMGB1 and Mapk8 1 0.03 0.91 0.2
116 INT179935 Binding of Jun and Mapk8 1 0.04 0.61 0.19
117 INT193787 Positive_regulation of CXCR4 Positive_regulation of Positive_regulation of TP53 1 0.03 0.71 0.19
118 INT142853 Binding of TP53 and WISP2 1 0.33 1.43 0.19
119 INT209934 IL1B Positive_regulation of MAPK8 1 0.06 0.37 0.19
120 INT222023 Gpx3 Regulation of Mapk8 1 0.01 1.43 0.18
121 INT299370 Binding of Mapk8 and Life1 1 0.04 0.73 0.18
122 INT284445 Dep1 Positive_regulation of Mapk8 1 0.00 0.58 0.17
123 INT148103 MAPK8 Positive_regulation of STK24 1 0.47 1.82 0.17
124 INT102804 NFKB1 Regulation of TP53 1 0.35 0.77 0.17
125 INT102803 NFKB1 Regulation of Gene_expression of TP53 1 0.35 0.77 0.17
126 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
127 INT91812 Binding of FASLG and TP53 1 0.04 1.1 0.16
128 INT91811 Binding of FAS and TP53 1 0.21 1.1 0.16
129 INT255736 Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.14 2.31 0.16
130 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
131 INT329168 MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.56 0.15
132 INT266377 Binding of S100a11 and Trp53 1 0.02 0.89 0.15
133 INT179934 Mapk8 Regulation of Gene_expression of Mmp9 1 0.06 0.48 0.15
134 INT329172 Phosphorylation of MAPK8 Positive_regulation of Localization of JUN 1 0.12 0.62 0.15
135 INT311666 Binding of BCL2 and TP53 1 0.19 1.26 0.14
136 INT177914 PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.02 1.07 0.14
137 INT177911 PRKG1 Positive_regulation of MAPK8 1 0.02 1.07 0.14
138 INT134400 Positive_regulation of PRKG1 Positive_regulation of Phosphorylation of MAPK8 1 0.30 1.13 0.14
139 INT103557 Binding of ERCC2 and TP53 1 0.40 1 0.13
140 INT132148 LTF Positive_regulation of TP53 1 0.44 0.56 0.13
141 INT103561 Binding of TP53 and Mc1r 1 0.03 1 0.13
142 INT266531 Mapk8 Positive_regulation of Phosphorylation of Olr447 1 0.00 0 0.13
143 INT342311 Binding of Tp53 and Positive_regulation of Gene_expression of BCL2 1 0.08 1.25 0.13
144 INT344314 PDPN Positive_regulation of Phosphorylation of MAPK8 1 0.35 0.67 0.13
145 INT134399 Negative_regulation of MAPK3 Positive_regulation of Phosphorylation of MAPK8 1 0.39 1.14 0.13
146 INT182886 Ros1 Positive_regulation of Mapk8 3 0.09 2.3 0.12
147 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
148 INT352467 Dusp1 Negative_regulation of Mapk8 1 0.02 0.23 0.12
149 INT83370 Binding of HRAS and TP53 1 0.30 0.59 0.11
150 INT348786 Tlr4 Positive_regulation of Mapk8 1 0.33 1.09 0.11
151 INT291251 Map3k8 Regulation of Gene_expression of MAPK8 1 0.05 0.52 0.11
152 INT143648 Negative_regulation of Mapk8 Negative_regulation of Gene_expression of Fas 1 0.39 0.21 0.11
153 INT266904 Plat Positive_regulation of Positive_regulation of Mapk8 1 0.03 0.6 0.11
154 INT181076 Map4k4 Positive_regulation of Mapk8 1 0.11 0.47 0.11
155 INT240903 Mapk8 Positive_regulation of Ros1 2 0.09 1.01 0.1
156 INT266386 Binding of S100a1 and Trp53 1 0.03 0.64 0.1
157 INT181569 Binding of Edn1 and Mapk8 1 0.09 2.7 0.1
158 INT348042 Positive_regulation of Mapk8 Regulation of Gene_expression of VEGFA 1 0.03 0.85 0.1
159 INT193782 Binding of TP53 and SDF2L1 1 0.00 0.67 0.1
160 INT223827 MAPK8 Positive_regulation of Gene_expression of GSTP1 1 0.12 0.88 0.1
161 INT262522 Binding of Trp53 and Foxo4 1 0.05 0.7 0.1
162 INT310743 TP53 Regulation of BAX 1 0.09 1.11 0.1
163 INT326126 Binding of S100A1 and TP53 1 0.04 1.34 0.09
164 INT292555 Binding of MAPK8 and GTPBP4 1 0.00 0.36 0.09
165 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
166 INT302168 YWHAQ Regulation of TP53 1 0.01 0.41 0.09
167 INT265466 CSPG4 Regulation of Phosphorylation of TP53 1 0.09 0.15 0.09
168 INT246625 Sirt1 Positive_regulation of Negative_regulation of Trp53 1 0.10 0.96 0.08
169 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
170 INT348025 Mapk8 Regulation of Gene_expression of Proc 1 0.00 0.58 0.08
171 INT301631 Gene_expression of Mapk8 Positive_regulation of Phosphorylation of Irs1 1 0.09 0.72 0.08
172 INT266394 Binding of S100a4 and Trp53 1 0.03 0.59 0.08
173 INT301659 Gene_expression of Mapk8 Positive_regulation of Positive_regulation of Srebf1 1 0.33 0.8 0.08
174 INT266390 Binding of S100a6 and Trp53 1 0.04 0.51 0.07
175 INT325274 IL1RAP Positive_regulation of Mapk8 1 0.14 0 0.07
176 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
177 INT245296 Trp53 Regulation of Gadd45a 1 0.05 0.43 0.07
178 INT266398 Binding of S100b and Trp53 1 0.06 0.92 0.07
179 INT173660 Map2k6 Positive_regulation of MAPK8 1 0.15 0.27 0.07
180 INT173659 Map2k3 Positive_regulation of MAPK8 1 0.15 0.28 0.07
181 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
182 INT302155 TP53 Regulation of Positive_regulation of CASP9 1 0.02 0.7 0.06
183 INT266388 S100a6 Negative_regulation of Mapk8 1 0.03 0.49 0.06
184 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
185 INT140291 ROS1 Positive_regulation of TP53 1 0.52 1.27 0.06
186 INT178438 Mapk8 Positive_regulation of Plau 1 0.06 0.52 0.06
187 INT348030 Mapk8 Regulation of Re 1 0.17 0.95 0.06
188 INT223825 GSTP1 Negative_regulation of MAPK8 1 0.11 1.53 0.06
189 INT265459 Phosphorylation of TP53 Positive_regulation of Localization of CASP9 1 0.17 1.16 0.05
190 INT218676 Mapk8 Regulation of Mapk14 1 0.00 0.33 0.05
191 INT181571 Binding of Mapk8 and Mapk1 1 0.04 1.24 0.05
192 INT352618 Tpt1 Regulation of Trp53 1 0.06 0.54 0.05
193 INT218703 Mapk8 Regulation of EPHB2 1 0.04 0.33 0.05
194 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
195 INT286049 Binding of MAPK8 and Wwox 1 0.31 0.26 0.05
196 INT286768 Binding of Trp53 and Tusc2 1 0.07 1.1 0.05
197 INT341542 Binding of DUSP4 and MAPK8 1 0.04 0.28 0.05
198 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
199 INT181601 Binding of TP53 and WT1 1 0.30 0.9 0.05
200 INT265454 Phosphorylation of TP53 Positive_regulation of CASP9 1 0.17 1.16 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone deacetylase regulator activity. They are ordered first by their pain relevance and then by number of times they were reported in histone deacetylase regulator activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75
2 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98
3 INT95734 Phosphorylation of Mapk8 108 0.82 49.92 33.52
4 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2
5 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
6 INT99068 Gene_expression of Mapk8 62 0.78 33.57 21.25
7 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53
8 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24
9 INT104493 Negative_regulation of Mapk8 56 0.53 27.76 16.86
10 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
11 INT93361 Gene_expression of Trp53 208 0.78 175.35 16.65
12 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54
13 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
14 INT95738 Positive_regulation of Phosphorylation of Mapk8 40 0.70 23.46 13.88
15 INT80685 Gene_expression of MAPK8 90 0.72 51.91 13.36
16 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65
17 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44
18 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
19 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83
20 INT111998 Positive_regulation of Positive_regulation of Mapk8 23 0.69 9.33 8.97
21 INT104481 Regulation of Mapk8 21 0.50 13.87 8.41
22 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14
23 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63
24 INT99071 Positive_regulation of Gene_expression of Mapk8 16 0.55 9.87 7.58
25 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
26 INT97055 Positive_regulation of Gene_expression of Trp53 51 0.70 45.7 7.25
27 INT93359 Positive_regulation of Trp53 90 0.70 69.77 6.24
28 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
29 INT128922 Negative_regulation of Gene_expression of Mapk8 6 0.34 3.93 5.36
30 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23
31 INT60585 Regulation of TP53 59 0.59 54.55 5.21
32 INT135291 Positive_regulation of Positive_regulation of Mapk8 24 0.64 19.37 5.16
33 INT131717 Positive_regulation of Gene_expression of Mapk8 18 0.55 14.25 5.02
34 INT109972 Phosphorylation of Trp53 13 0.80 6.15 4.68
35 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
36 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
37 INT75523 Regulation of MAPK8 21 0.33 11.18 4.28
38 INT109935 Positive_regulation of Phosphorylation of MAPK8 35 0.68 13.13 4.18
39 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06
40 INT132103 Positive_regulation of Gene_expression of MAPK8 26 0.46 16.54 3.94
41 INT71602 Negative_regulation of Trp53 84 0.59 67.77 3.68
42 INT21569 Binding of Mapk8 8 0.48 5.55 3.44
43 INT163529 Negative_regulation of Positive_regulation of Mapk8 14 0.43 8.37 3.2
44 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98
45 INT8103 Binding of TP53 46 0.44 40.2 2.96
46 INT95735 Regulation of Phosphorylation of Mapk8 7 0.50 1.88 2.69
47 INT109969 Positive_regulation of Phosphorylation of Trp53 1 0.45 2.18 2.66
48 INT95739 Negative_regulation of Phosphorylation of Mapk8 11 0.42 6.77 2.61
49 INT109968 Positive_regulation of Positive_regulation of Trp53 6 0.47 3.57 2.51
50 INT55952 Transcription of TP53 16 0.61 12.14 2.36
51 INT109908 Localization of MAPK8 10 0.73 3.86 2.14
52 INT156270 Regulation of Positive_regulation of Mapk8 3 0.41 2.31 2.08
53 INT152696 Negative_regulation of Negative_regulation of Mapk8 1 0.32 0.35 2
54 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
55 INT109313 Binding of Mapk8 6 0.48 1.78 1.98
56 INT96916 Negative_regulation of Phosphorylation of Mapk8 16 0.52 9.68 1.97
57 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
58 INT65855 Localization of TP53 18 0.76 17.08 1.89
59 INT164864 Positive_regulation of Negative_regulation of Mapk8 1 0.31 1.33 1.82
60 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
61 INT299365 Transcription of Mapk8 9 0.72 5.91 1.75
62 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62
63 INT64233 Regulation of Trp53 35 0.62 27.11 1.53
64 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
65 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
66 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
67 INT172953 Binding of Trp53 33 0.37 20.76 1.41
68 INT93357 Regulation of Gene_expression of Trp53 15 0.62 13.4 1.41
69 INT162462 Protein_catabolism of TP53 8 0.86 7.89 1.41
70 INT145221 Binding of Tp53 10 0.37 8.59 1.37
71 INT125079 Negative_regulation of Gene_expression of MAPK8 9 0.39 4.87 1.25
72 INT154048 Negative_regulation of Gene_expression of Mapk8 5 0.43 4.43 1.22
73 INT174156 Localization of Trp53 16 0.72 13.52 1.18
74 INT116436 Negative_regulation of Phosphorylation of TP53 2 0.40 0.94 1.16
75 INT134661 Negative_regulation of Tp53 11 0.43 10.91 1.13
76 INT97052 Transcription of Trp53 12 0.64 6.52 1.01
77 INT200900 Localization of Mapk8 9 0.40 5.76 0.84
78 INT93356 Negative_regulation of Gene_expression of Trp53 28 0.53 20.61 0.8
79 INT182293 Binding of MAPK8 11 0.34 4.6 0.77
80 INT165104 Negative_regulation of Negative_regulation of Mapk8 5 0.43 4.21 0.77
81 INT165105 Localization of Mapk8 7 0.69 4.45 0.76
82 INT102813 Regulation of Gene_expression of TP53 25 0.59 25.95 0.75
83 INT168245 Positive_regulation of Transcription of Tp53 2 0.70 2.63 0.75
84 INT164489 Regulation of Gene_expression of Mapk8 2 0.44 0.65 0.74
85 INT162470 Negative_regulation of Protein_catabolism of TP53 1 0.32 1.24 0.74
86 INT237709 Negative_regulation of Negative_regulation of MAPK8 6 0.25 2.09 0.72
87 INT177936 Positive_regulation of Negative_regulation of MAPK8 3 0.50 2.1 0.63
88 INT93358 Negative_regulation of Positive_regulation of Trp53 9 0.41 3.95 0.6
89 INT53950 Phosphorylation of Tp53 8 0.61 9.4 0.6
90 INT158689 Positive_regulation of Regulation of MAPK8 1 0.46 0.41 0.6
91 INT327658 Regulation of Ncor1 1 0.13 0 0.56
92 INT109926 Positive_regulation of Localization of MAPK8 4 0.49 0.87 0.52
93 INT224486 Regulation of Phosphorylation of MAPK8 2 0.33 0.52 0.52
94 INT286035 Negative_regulation of Gene_expression of Tp53 5 0.32 6.2 0.49
95 INT301056 Transcription of Mapk8 1 0.06 1.22 0.45
96 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43
97 INT139976 Regulation of Tp53 7 0.44 6.49 0.39
98 INT187209 Negative_regulation of Localization of Mapk8 1 0.22 0.93 0.39
99 INT301047 Negative_regulation of Transcription of Mapk8 1 0.12 0.65 0.36
100 INT145220 Negative_regulation of Binding of Tp53 1 0.20 0.75 0.36
101 INT63268 Negative_regulation of Ncor1 5 0.32 0.51 0.34
102 INT261685 Regulation of Gene_expression of MAPK8 3 0.26 1.45 0.34
103 INT109915 Protein_catabolism of MAPK8 3 0.86 1.92 0.34
104 INT93355 Negative_regulation of Negative_regulation of Trp53 2 0.41 0.92 0.3
105 INT179089 Protein_catabolism of Trp53 8 0.90 6.52 0.29
106 INT166960 Positive_regulation of Negative_regulation of TP53 2 0.25 1.65 0.26
107 INT291227 Protein_catabolism of Mapk8 1 0.64 0.26 0.26
108 INT314729 Regulation of Localization of TP53 1 0.30 2.5 0.25
109 INT109905 Positive_regulation of Protein_catabolism of MAPK8 1 0.49 0.14 0.24
110 INT257786 Localization of NCOR1 1 0.68 0.36 0.24
111 INT178399 Regulation of Positive_regulation of Mapk8 4 0.44 3.4 0.23
112 INT179088 Positive_regulation of Regulation of Trp53 3 0.38 3.23 0.23
113 INT156886 Positive_regulation of Localization of TP53 1 0.48 0.87 0.23
114 INT299366 Positive_regulation of Transcription of Mapk8 2 0.70 1.29 0.22
115 INT63271 Regulation of Ncor1 2 0.26 0.8 0.18
116 INT300284 Regulation of Phosphorylation of Tp53 1 0.16 1.51 0.17
117 INT337078 Negative_regulation of Localization of Trp53 1 0.20 1.3 0.17
118 INT63270 Gene_expression of Ncor1 7 0.56 0.65 0.15
119 INT179086 Positive_regulation of Negative_regulation of Trp53 5 0.50 4.78 0.15
120 INT125081 Positive_regulation of Binding of TP53 2 0.46 1.2 0.15
121 INT207805 Negative_regulation of Phosphorylation of Trp53 2 0.18 0.98 0.15
122 INT286749 Regulation of Localization of Trp53 1 0.06 1.39 0.15
123 INT168244 Regulation of Transcription of Tp53 1 0.33 0.57 0.13
124 INT222016 Regulation of Negative_regulation of Mapk8 1 0.44 0.79 0.12
125 INT109312 Regulation of Gene_expression of Mapk8 3 0.44 1.55 0.1
126 INT297456 Protein_catabolism of Tp53 1 0.11 0.72 0.1
127 INT111139 Localization of Tp53 4 0.45 2.4 0.09
128 INT352605 Regulation of Negative_regulation of Trp53 1 0.45 0.72 0.07
129 INT171527 Gene_expression of NCOR1 3 0.51 0.49 0.06
130 INT354439 Positive_regulation of NCOR1 1 0.35 0.15 0.06
131 INT171421 Regulation of Positive_regulation of TP53 1 0.48 0.45 0.05
132 INT315213 Negative_regulation of Binding of Trp53 1 0.32 0.11 0.05
133 INT182282 Negative_regulation of Binding of MAPK8 2 0.39 0.29 0.04
134 INT311668 Regulation of Regulation of TP53 2 0.36 3.58 0.04
135 INT178388 Positive_regulation of Localization of Mapk8 1 0.40 0.75 0.04
136 INT305536 Positive_regulation of Binding of Trp53 1 0.35 0.32 0.04
137 INT210871 Transcription of Ncor1 3 0.50 0 0.03
138 INT217802 Regulation of Transcription of TP53 2 0.37 0.81 0.03
139 INT259061 Negative_regulation of Regulation of TP53 2 0.10 2.23 0.03
140 INT218945 Localization of Ncor1 1 0.32 0.15 0.03
141 INT342653 Regulation of Transcription of Ncor1 1 0.31 0 0.03
142 INT178927 Regulation of Gene_expression of Tp53 6 0.26 2.23 0
143 INT333669 Positive_regulation of Transcription of Trp53 3 0.45 2.33 0
144 INT292587 Regulation of Negative_regulation of MAPK8 3 0.23 1.45 0
145 INT250698 Positive_regulation of Transcription of TP53 3 0.18 3.68 0
146 INT63269 Positive_regulation of Ncor1 2 0.66 0.05 0
147 INT113348 Negative_regulation of Binding of TP53 2 0.28 1.49 0
148 INT214913 Positive_regulation of Positive_regulation of Tp53 2 0.08 2.47 0
149 INT217820 Regulation of Negative_regulation of TP53 2 0.37 1.92 0
150 INT261486 Protein_catabolism of Mapk8 1 0.27 0 0
151 INT204059 Positive_regulation of Phosphorylation of Tp53 1 0.07 0.76 0
152 INT333668 Regulation of Protein_catabolism of Trp53 1 0.24 1.58 0
153 INT342659 Positive_regulation of Gene_expression of Ncor1 1 0.35 0 0
154 INT332921 Localization of Ncor1 1 0.04 0.05 0
155 INT210872 Regulation of Gene_expression of Ncor1 1 0.06 0 0
156 INT333671 Regulation of Transcription of Trp53 1 0.24 0.83 0
157 INT332828 Gene_expression of Ncor1 1 0.50 0.16 0
158 INT332848 Negative_regulation of Binding of Ncor1 1 0.32 0.36 0
159 INT179076 Negative_regulation of Protein_catabolism of Trp53 1 0.32 0.43 0
160 INT332842 Binding of Ncor1 1 0.36 0.91 0
161 INT179957 Positive_regulation of Binding of Tp53 1 0.08 0.48 0
162 INT333663 Positive_regulation of Protein_catabolism of Trp53 1 0.45 0.84 0
163 INT333662 Negative_regulation of Transcription of Trp53 1 0.53 1.15 0
164 INT223765 Negative_regulation of Positive_regulation of Tp53 1 0.07 1.69 0
165 INT240837 Positive_regulation of Negative_regulation of Mapk8 1 0.26 0.13 0
166 INT305295 Regulation of Binding of TP53 1 0.39 1.09 0
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