GO:0035095

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Name behavioral response to nicotine
Categary Process
Go Slim No
Go Link GO:0035095
Unique Molecular Interactions 48
Total Molecular Interactions 51
Total Single Events 515
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for behavioral response to nicotine. They are ordered first by their pain relevance and then by number of times they were reported for behavioral response to nicotine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
2 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
3 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
4 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
5 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
6 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
7 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
8 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
9 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
10 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
11 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
12 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
13 INT85037 Binding of Cct2 and Chrna3 1 0.00 0.15 0.38
14 INT46788 Chrna7 Positive_regulation of G6pd 1 0.50 0 0.33
15 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
16 INT59682 Hps6 Positive_regulation of Binding of Chrna7 1 0.02 0 0.29
17 INT59683 Binding of Chrna7 and Evi2a 1 0.03 0 0.25
18 INT143972 Chrna7 Negative_regulation of Gene_expression of Trpv1 1 0.01 0.18 0.24
19 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
20 INT143974 Chrna7 Positive_regulation of Vti1b 1 0.17 0.16 0.2
21 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
22 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
23 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
24 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17
25 INT101725 Binding of ITGA4 and Chrna7 1 0.00 0 0.16
26 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15
27 INT207683 Chrnb4 Positive_regulation of Htr3b 1 0.26 0.31 0.1
28 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
29 INT207682 Chrnb4 Positive_regulation of Hcn4 1 0.35 0.29 0.1
30 INT207681 Chrnb4 Positive_regulation of Scn2b 1 0.02 0.32 0.1
31 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
32 INT207684 Chrnb4 Positive_regulation of Htr3a 1 0.22 0.3 0.1
33 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
34 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
35 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08
36 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
37 INT352062 Binding of SV2A and Chrna7 1 0.00 0.7 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for behavioral response to nicotine. They are ordered first by their pain relevance and then by number of times they were reported in behavioral response to nicotine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
2 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
3 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
4 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
5 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
6 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
7 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
8 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
9 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
10 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
11 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
12 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
13 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
14 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
15 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
16 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
17 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
18 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
19 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
20 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
21 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
22 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
23 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
24 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63
25 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57
26 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
27 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2
28 INT24197 Regulation of Binding of Chrna7 2 0.11 0 1.14
29 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76
30 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
31 INT85033 Positive_regulation of Chrna3 2 0.06 0.35 0.67
32 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67
33 INT133004 Gene_expression of Chrna3 2 0.58 0.63 0.66
34 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
35 INT99329 Binding of Chrna4 3 0.37 0.45 0.6
36 INT123256 Regulation of Localization of Chrna4 1 0.27 0.28 0.58
37 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
38 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
39 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
40 INT281775 Regulation of Positive_regulation of Chrna4 1 0.02 0.98 0.41
41 INT169388 Transcription of Chrna7 2 0.69 0.27 0.36
42 INT169386 Regulation of Transcription of Chrna7 1 0.45 0.05 0.36
43 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
44 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
45 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23
46 INT538 Protein_catabolism of Chrna7 2 0.57 1.01 0.19
47 INT174049 Positive_regulation of Negative_regulation of Htr2c 1 0.01 0 0.19
48 INT174053 Phosphorylation of Htr2c 1 0.01 0.06 0.18
49 INT95662 Binding of Chrna3 1 0.00 0.17 0.17
50 INT261645 Positive_regulation of CHRNA5 1 0.37 0.69 0.14
51 INT261639 Positive_regulation of CHRNA3 1 0.38 0.68 0.14
52 INT272355 Regulation of Regulation of Htr2c 1 0.44 1.1 0.14
53 INT1796 Phosphorylation of Chrna7 1 0.82 0 0.12
54 INT43207 Regulation of Positive_regulation of Chrna7 1 0.01 0 0.11
55 INT139554 Positive_regulation of Gene_expression of Chrna4 2 0.25 0 0.1
56 INT139553 Transcription of Chrna4 1 0.27 0 0.1
57 INT139555 Positive_regulation of Positive_regulation of Chrna4 1 0.25 0 0.1
58 INT261641 Localization of CHRNA5 1 0.64 0.91 0.09
59 INT261646 Localization of CHRNA3 1 0.65 0.91 0.09
60 INT174050 Binding of Htr2c 1 0.01 0 0.06
61 INT211025 Regulation of Gene_expression of Htr2c 1 0.43 1.01 0.06
62 INT207668 Binding of Chrnb4 1 0.27 0 0.05
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