GO:0035098

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Name ESC/E(Z) complex
Categary Component
Go Slim No
Go Link GO:0035098
Unique Molecular Interactions 51
Total Molecular Interactions 60
Total Single Events 503
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ESC/E(Z) complex. They are ordered first by their pain relevance and then by number of times they were reported for ESC/E(Z) complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT289525 Sirt1 Negative_regulation of Negative_regulation of Ucp2 1 0.32 0.86 0.15
2 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
3 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
4 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
5 INT289539 Negative_regulation of Sirt1 Negative_regulation of Gene_expression of Agrp 1 0.29 0.47 0.09
6 INT289536 Sirt1 Negative_regulation of Localization of Pparg 1 0.13 0.43 0.08
7 INT289603 Sirt1 Negative_regulation of Localization of PPARG 1 0.02 0.43 0.08
8 INT289540 Sirt1 Negative_regulation of Localization of Ins1 1 0.03 0.43 0.08
9 INT289533 Sirt1 Negative_regulation of Pparg 1 0.18 0.42 0.07
10 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
11 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
12 INT289602 Sirt1 Negative_regulation of PPARG 1 0.02 0.37 0.07
13 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
14 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
15 INT289541 Sirt1 Regulation of Gene_expression of Agrp 1 0.41 0.52 0.04
16 INT289538 Sirt1 Positive_regulation of Stat3 1 0.34 0.37 0.04
17 INT289542 Sirt1 Negative_regulation of Stat3 1 0.32 0.31 0.03
18 INT289526 Binding of Arc and Sirt1 1 0.08 0.55 0.03
19 INT289599 Sirt1 Positive_regulation of Ppargc1a 1 0.51 0.36 0.03
20 INT348584 EZH2 Regulation of Gene_expression of PPARG 1 0.30 0.43 0
21 INT289600 Negative_regulation of Binding of Sirt1 and Sirt1 1 0.47 1.17 0
22 INT204325 Binding of PPARGC1A and SIRT1 1 0.39 0.19 0
23 INT339096 Ezh2 Regulation of Rcc1 1 0.02 1.1 0
24 INT348588 MECP2 Positive_regulation of Gene_expression of EZH2 1 0.28 0.42 0
25 INT289534 Sirt1 Regulation of Regulation of Pomc 1 0.04 0.15 0
26 INT348596 EZH2 Positive_regulation of Gene_expression of MECP2 1 0.28 0.42 0
27 INT318218 SIRT1 Positive_regulation of Binding of FOXO3 1 0.44 0.51 0
28 INT289518 Arc Regulation of Sirt1 1 0.10 0.56 0
29 INT289537 Lep Negative_regulation of Sirt1 1 0.20 0.05 0
30 INT318219 SIRT1 Regulation of TBK1 1 0.03 0.43 0
31 INT348591 EZH2 Regulation of Negative_regulation of MECP2 1 0.15 0.73 0
32 INT289517 Sirt1 Regulation of Prkag1 1 0.02 0.08 0
33 INT204326 SIRT1 Positive_regulation of PPARGC1A 1 0.51 0.19 0
34 INT318221 SIRT1 Positive_regulation of FOXO3 1 0.41 0.63 0
35 INT337637 SIRT1 Negative_regulation of TP53 1 0.23 1.49 0
36 INT289598 Binding of Sirt1 and Sirt1 1 0.41 1.15 0
37 INT300307 Binding of Tp53 and Sirt1 1 0.24 0.98 0
38 INT289519 Sirt1 Regulation of Rps6kb1 1 0.25 0.13 0
39 INT289530 Sirt1 Regulation of Foxo1 1 0.25 0.42 0
40 INT289523 Binding of Foxo1 and Positive_regulation of Sirt1 1 0.36 0.13 0
41 INT204321 NOS3 Regulation of SIRT1 1 0.23 0.1 0
42 INT289531 Acsm3 Positive_regulation of Sirt1 1 0.01 0.27 0
43 INT348585 EZH2 Regulation of PPARG 1 0.41 0.73 0
44 INT318216 SIRT1 Positive_regulation of Gene_expression of FOXO3 1 0.36 0.52 0
45 INT318217 SIRT1 Regulation of TP53 1 0.07 0.43 0
46 INT304013 Binding of SUZ12 and JAZF1 1 0.30 1.89 0
47 INT204319 SIRT1 Regulation of Gene_expression of PPARGC1A 1 0.50 0.12 0
48 INT289535 Negative_regulation of Sirt1 Negative_regulation of Binding of Foxo1 1 0.29 0.14 0
49 INT289529 Lep Regulation of Sirt1 1 0.28 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ESC/E(Z) complex. They are ordered first by their pain relevance and then by number of times they were reported in ESC/E(Z) complex. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
2 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
3 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
4 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
5 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
6 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
7 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
8 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
9 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
10 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
11 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
12 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
13 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
14 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
15 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
16 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
17 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
18 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
19 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
20 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
21 INT204365 Positive_regulation of Gene_expression of SIRT1 8 0.68 2.9 0.13
22 INT289543 Regulation of Gene_expression of Sirt1 3 0.45 1.81 0.11
23 INT289547 Positive_regulation of Positive_regulation of Sirt1 2 0.69 0.76 0.11
24 INT332681 Regulation of Positive_regulation of Sirt1 1 0.16 0.69 0.11
25 INT289567 Regulation of Negative_regulation of Sirt1 1 0.45 0.74 0.09
26 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
27 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
28 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
29 INT289574 Negative_regulation of Positive_regulation of Sirt1 1 0.42 0.42 0.07
30 INT339991 Localization of SIRT1 1 0.34 0.3 0.06
31 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
32 INT318236 Negative_regulation of Gene_expression of SIRT1 1 0.42 0.59 0.05
33 INT339094 Gene_expression of Ezh2 1 0.78 67.79 0.05
34 INT289587 Negative_regulation of Negative_regulation of Sirt1 1 0.42 0.65 0.05
35 INT289584 Binding of Sirt1 3 0.48 1.35 0.03
36 INT348609 Negative_regulation of EZH2 1 0.29 1.33 0.03
37 INT348611 Localization of EZH2 1 0.50 0.35 0.03
38 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
39 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
40 INT204367 Positive_regulation of SIRT1 13 0.68 4.17 0
41 INT204349 Regulation of SIRT1 8 0.61 1.99 0
42 INT204353 Transcription of SIRT1 3 0.68 0.67 0
43 INT337478 Binding of HDAC2 1 0.14 0.07 0
44 INT339087 Binding of Ezh2 1 0.37 1.14 0
45 INT204361 Negative_regulation of SIRT1 1 0.42 0.18 0
46 INT289569 Transcription of Sirt1 1 0.71 0.25 0
47 INT348622 Binding of EZH2 1 0.21 0.39 0
48 INT300287 Localization of Sirt1 1 0.66 1.46 0
49 INT304050 Gene_expression of SUZ12 1 0.54 6.53 0
50 INT289583 Regulation of Transcription of Sirt1 1 0.27 0.25 0
51 INT348618 Gene_expression of EZH2 1 0.51 2.32 0
52 INT204371 Positive_regulation of Transcription of SIRT1 1 0.49 0.13 0
53 INT318239 Regulation of Transcription of SIRT1 1 0.26 0.45 0
54 INT348612 Regulation of Gene_expression of EZH2 1 0.30 0.65 0
55 INT289594 Regulation of Regulation of Sirt1 1 0.45 0.15 0
56 INT350520 Phosphorylation of SIRT1 1 0.25 0.72 0
57 INT204356 Regulation of Gene_expression of SIRT1 1 0.61 0.29 0
58 INT339090 Positive_regulation of Ezh2 1 0.47 0.82 0
59 INT348624 Positive_regulation of EZH2 1 0.31 0.42 0
60 INT304070 Regulation of SUZ12 1 0.22 1 0
61 INT338716 Negative_regulation of SUZ12 1 0.08 0.78 0
62 INT204331 Binding of SIRT1 1 0.47 0.39 0
63 INT339091 Positive_regulation of Gene_expression of Ezh2 1 0.70 11.65 0
64 INT339095 Negative_regulation of Gene_expression of Ezh2 1 0.59 4.48 0
65 INT339089 Regulation of Gene_expression of Ezh2 1 0.45 3.76 0
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