GO:0035137

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Name hindlimb morphogenesis
Categary Process
Go Slim No
Go Link GO:0035137
Unique Molecular Interactions 109
Total Molecular Interactions 142
Total Single Events 814
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for hindlimb morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported for hindlimb morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT274948 Binding of Dh and Ltp 1 0.11 0.55 1.23
2 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
3 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
4 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
5 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
6 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
7 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
8 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
9 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
10 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
11 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
12 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
13 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
14 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
15 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
16 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
17 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
18 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
19 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
20 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
21 INT5874 Pitx1 Positive_regulation of Ina 1 0.17 0 0.21
22 INT5873 Pitx1 Negative_regulation of Ina 1 0.15 0 0.21
23 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
24 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
25 INT244843 Lbx1 Negative_regulation of Hoxd10 1 0.02 0.09 0.16
26 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
27 INT244844 Lbx1 Negative_regulation of Hoxd9 1 0.01 0.09 0.16
28 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
29 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
30 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
31 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
32 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
33 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
34 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
35 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
36 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
37 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
38 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
39 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
40 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
41 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
42 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
43 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
44 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
45 INT261964 fc Positive_regulation of Sall3 1 0.01 1.17 0.04
46 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
47 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
48 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
49 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
50 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
51 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
52 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
53 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
54 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
55 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
56 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
57 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
58 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
59 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
60 INT343744 mn Negative_regulation of Regulation of Wnt7a 1 0.01 0.1 0
61 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
62 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
63 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
64 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
65 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
66 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
67 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
68 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
69 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
70 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
71 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
72 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
73 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
74 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
75 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
76 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
77 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
78 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
79 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
80 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
81 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
82 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
83 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
84 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
85 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
86 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
87 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
88 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
89 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
90 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
91 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
92 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
93 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
94 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
95 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
96 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
97 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
98 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
99 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
100 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
101 INT274705 Binding of TXNRD1 and Dh 1 0.00 0 0
102 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
103 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
104 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0
105 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
106 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0
107 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for hindlimb morphogenesis. They are ordered first by their pain relevance and then by number of times they were reported in hindlimb morphogenesis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
3 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
4 INT65803 Gene_expression of Dh 10 0.32 1.24 8.07
5 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
6 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
7 INT54002 Negative_regulation of Dh 6 0.20 3.05 5.06
8 INT116540 Binding of Twist1 35 0.48 16.32 2.85
9 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
10 INT55090 Positive_regulation of Wnt7a 13 0.37 2.25 2.2
11 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
12 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
13 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
14 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
15 INT10873 Localization of Twist1 21 0.74 10.43 1.37
16 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
17 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
18 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
19 INT97695 Positive_regulation of Dh 3 0.33 1.44 1.1
20 INT127647 Regulation of Wnt7a 3 0.07 1.28 1.01
21 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
22 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
23 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
24 INT105947 Binding of Dh 3 0.35 0.79 0.72
25 INT131240 Gene_expression of Sall3 5 0.65 0.32 0.68
26 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
27 INT28958 Negative_regulation of Wnt7a 3 0.45 0.49 0.65
28 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
29 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
30 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
31 INT127648 Gene_expression of Wnt7a 2 0.13 1.11 0.56
32 INT125381 Regulation of Dh 3 0.29 1.07 0.49
33 INT85854 Binding of SALL1 5 0.36 1.4 0.41
34 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
35 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
36 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
37 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
38 INT131243 Positive_regulation of Sall3 2 0.45 1.34 0.2
39 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
40 INT244795 Positive_regulation of Hoxd10 2 0.42 0.09 0.17
41 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
42 INT244740 Positive_regulation of Hoxd9 1 0.01 0.09 0.17
43 INT55089 Positive_regulation of Positive_regulation of Wnt7a 2 0.27 0.06 0.16
44 INT131242 Positive_regulation of Gene_expression of Sall3 1 0.49 0.19 0.16
45 INT192060 Gene_expression of Hoxd9 2 0.54 0.25 0.12
46 INT244773 Gene_expression of Hoxd10 2 0.50 0.13 0.12
47 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
48 INT329940 Gene_expression of Sall1 1 0.02 0 0.1
49 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
50 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
51 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
52 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
53 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
54 INT224825 Regulation of Gene_expression of SALL1 1 0.37 0.07 0.07
55 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
56 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
57 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
58 INT159426 Positive_regulation of Gene_expression of Wnt7a 1 0.10 0.51 0.05
59 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
60 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
61 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
62 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
63 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
64 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
65 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
66 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
67 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
68 INT279810 Negative_regulation of Positive_regulation of SALL1 1 0.03 0.07 0
69 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
70 INT280151 Positive_regulation of Regulation of Twist1 1 0.41 0.67 0
71 INT266460 Positive_regulation of Binding of Wnt7a 1 0.04 0.06 0
72 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0
73 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0
74 INT260089 Localization of PTCH1 1 0.70 0.37 0
75 INT266459 Binding of Wnt7a 1 0.03 0.06 0
76 INT275080 Positive_regulation of Negative_regulation of Twist1 1 0.05 0.11 0
77 INT243609 Negative_regulation of Transcription of Twist1 1 0.42 0 0
78 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
79 INT243602 Regulation of Localization of Twist1 1 0.45 0 0
80 INT343743 Negative_regulation of Regulation of Wnt7a 1 0.04 0.1 0
81 INT301453 Positive_regulation of Sall1 1 0.04 0.08 0
82 INT297392 Positive_regulation of Binding of SALL1 1 0.49 0 0
83 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
84 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
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