GO:0035173

From wiki-pain
Jump to: navigation, search
Name histone kinase activity
Categary Function
Go Slim No
Go Link GO:0035173
Unique Molecular Interactions 36
Total Molecular Interactions 59
Total Single Events 296
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for histone kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
2 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
3 INT164265 TGM7 Negative_regulation of CDK2 1 0.26 1.08 0.53
4 INT164264 TGM7 Negative_regulation of CCNB1 1 0.07 1.08 0.53
5 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
6 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
7 INT306274 Binding of CCNB1 and CDK1 1 0.19 0.13 0.09
8 INT320267 CCNA2 Positive_regulation of CDK1 1 0.12 1.08 0.08
9 INT88411 Positive_regulation of PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
10 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
11 INT88408 PDGFA Positive_regulation of CDK2 1 0.11 0 0.07
12 INT316489 Stat3 Positive_regulation of Transcription of Ccnb1 1 0.02 1.27 0.04
13 INT237206 LGALS4 Regulation of Gene_expression of Ccnb1 1 0.05 0 0.03
14 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
15 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
16 INT289608 Binding of CDK2 and CCNE2 5 0.06 4.89 0
17 INT219412 CDK2 Regulation of PCNA 1 0.20 0.11 0
18 INT182397 NFYA Regulation of CCNB1 1 0.00 0.09 0
19 INT268316 Cdk1 Positive_regulation of Mcm3 1 0.28 0.25 0
20 INT325156 CDKN1B Negative_regulation of CDK2 1 0.49 0.11 0
21 INT182402 E2F2 Regulation of CCNB1 1 0.00 0.09 0
22 INT182399 E2F2 Regulation of CDK1 1 0.00 0.09 0
23 INT268318 Cdk1 Positive_regulation of Orc2 1 0.29 0.25 0
24 INT182406 NFYA Regulation of CDK1 1 0.00 0.09 0
25 INT219426 CDK2 Regulation of HNF4A 1 0.01 0.11 0
26 INT268319 Cdk1 Positive_regulation of Cdc20 1 0.32 0.25 0
27 INT314688 Binding of CCNE1 and CDK2 1 0.04 1.41 0
28 INT219413 CDK2 Regulation of SKP2 1 0.23 0.11 0
29 INT268317 Cdk1 Positive_regulation of Mcm7 1 0.33 0.25 0
30 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
31 INT322544 Binding of CDK2 and Ccne1 1 0.16 0 0
32 INT322503 Negative_regulation of Binding of CDK2 and CCNE2 1 0.01 0.25 0
33 INT268315 Cdk1 Positive_regulation of Mcm5 1 0.33 0.25 0
34 INT271998 Cdk1 Positive_regulation of Phosphorylation of Tsc1 1 0.17 0.3 0
35 INT219419 CDK2 Regulation of E2F2 1 0.23 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in histone kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT88414 Negative_regulation of CDK2 30 0.57 18.4 3.96
2 INT88412 Positive_regulation of CDK2 17 0.57 8.49 1.66
3 INT70138 Positive_regulation of Ccnb1 7 0.41 4.31 1.26
4 INT106735 Phosphorylation of CDK2 11 0.79 4.03 1.02
5 INT113841 Gene_expression of CCNB1 11 0.75 3.46 0.86
6 INT98784 Gene_expression of Ccnb1 11 0.59 4.53 0.75
7 INT258791 Positive_regulation of CDK1 14 0.45 5.73 0.74
8 INT62273 Gene_expression of CDK1 19 0.75 8.43 0.68
9 INT105330 Gene_expression of CDK2 31 0.63 13.7 0.67
10 INT113846 Negative_regulation of Positive_regulation of CDK2 1 0.48 0.39 0.6
11 INT163285 Negative_regulation of Phosphorylation of CDK2 2 0.32 0.52 0.48
12 INT62272 Negative_regulation of CDK1 9 0.57 6.46 0.46
13 INT127451 Positive_regulation of Cdk1 1 0.20 0.27 0.4
14 INT271922 Phosphorylation of Cdk1 2 0.44 0.37 0.39
15 INT237161 Regulation of Ccnb1 5 0.17 2.71 0.32
16 INT106733 Regulation of CDK2 6 0.44 4.76 0.23
17 INT98783 Negative_regulation of Gene_expression of Ccnb1 1 0.26 0.69 0.21
18 INT94166 Phosphorylation of CDK1 10 0.79 4.75 0.2
19 INT163284 Negative_regulation of Gene_expression of CDK2 5 0.32 1.6 0.16
20 INT173184 Regulation of CDK1 4 0.30 2.97 0.15
21 INT196421 Negative_regulation of Cdk1 2 0.24 1.17 0.15
22 INT62271 Negative_regulation of Gene_expression of CDK1 2 0.42 1.32 0.14
23 INT201462 Binding of CDK2 12 0.39 5.2 0.12
24 INT167436 Localization of CDK1 2 0.14 0.41 0.1
25 INT201460 Positive_regulation of Gene_expression of CDK2 5 0.52 2.8 0.09
26 INT169428 Regulation of Gene_expression of CDK2 4 0.46 1.03 0.09
27 INT186055 Binding of CDK1 3 0.35 1.43 0.09
28 INT106732 Regulation of Phosphorylation of CDK2 2 0.44 0.8 0.09
29 INT302272 Localization of CDK2 2 0.30 1.09 0.09
30 INT306284 Binding of CCNB1 1 0.28 0.13 0.09
31 INT226414 Negative_regulation of Ccnb1 2 0.02 2.16 0.08
32 INT326819 Negative_regulation of Cdk1 1 0.16 0.39 0.08
33 INT113842 Negative_regulation of CCNB1 1 0.40 0.53 0.06
34 INT176238 Gene_expression of Cdk1 5 0.46 0.94 0.04
35 INT316438 Transcription of Ccnb1 1 0.02 1.24 0.04
36 INT94160 Positive_regulation of Phosphorylation of CDK1 2 0.49 0.93 0.03
37 INT309477 Positive_regulation of Cdk1 2 0.35 0.21 0.03
38 INT201468 Negative_regulation of Binding of CDK2 2 0.17 1.1 0.03
39 INT94161 Negative_regulation of Phosphorylation of CDK1 1 0.41 0.93 0.03
40 INT332373 Binding of Ccnb1 1 0.34 0 0.03
41 INT329787 Regulation of CCNB1 1 0.08 1.21 0.03
42 INT169427 Transcription of CDK2 2 0.09 0.42 0
43 INT249788 Positive_regulation of Gene_expression of Ccnb1 2 0.44 0.51 0
44 INT236691 Regulation of Cdk1 2 0.20 0.46 0
45 INT285901 Regulation of Transcription of CDK2 1 0.03 0.7 0
46 INT289866 Protein_catabolism of CDK1 1 0.46 0 0
47 INT289873 Negative_regulation of Gene_expression of CCNB1 1 0.15 0 0
48 INT289863 Negative_regulation of Positive_regulation of CDK1 1 0.31 0 0
49 INT289864 Positive_regulation of CCNB1 1 0.25 0 0
50 INT341855 Positive_regulation of Positive_regulation of CDK2 1 0.06 0.51 0
51 INT289862 Positive_regulation of Gene_expression of CDK1 1 0.26 0 0
52 INT289859 Localization of CCNB1 1 0.24 0.27 0
53 INT289620 Regulation of Binding of CDK2 1 0.28 0.22 0
54 INT289869 Positive_regulation of Protein_catabolism of CDK1 1 0.26 0 0
55 INT289860 Negative_regulation of Positive_regulation of CCNB1 1 0.15 0 0
56 INT289871 Positive_regulation of Gene_expression of CCNB1 1 0.25 0.41 0
57 INT268284 Gene_expression of Cdk1 1 0.26 0.25 0
58 INT256925 Protein_catabolism of Ccnb1 1 0.24 0.74 0
59 INT325169 Regulation of Negative_regulation of CDK2 1 0.34 0.05 0
60 INT256906 Regulation of Gene_expression of Ccnb1 1 0.17 0.39 0
61 INT225187 Positive_regulation of Binding of CDK2 1 0.56 0.87 0
62 INT331145 Phosphorylation of Ccnb1 1 0.17 0.58 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox