GO:0035174

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Name histone serine kinase activity
Categary Function
Go Slim No
Go Link GO:0035174
Unique Molecular Interactions 72
Total Molecular Interactions 95
Total Single Events 568
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for histone serine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for histone serine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT28119 Atm Negative_regulation of Cck 1 0.42 0 0.56
2 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
3 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
4 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
5 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
6 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
7 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
8 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
9 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
10 INT157264 PPARA Positive_regulation of PRKAA1 1 0.03 0.92 0.08
11 INT157271 Adipor1 Positive_regulation of PRKAA1 1 0.01 0.89 0.08
12 INT253377 Lep Negative_regulation of Phosphorylation of Prkaa2 1 0.24 1.24 0.06
13 INT253413 ATIC Positive_regulation of Gene_expression of Prkaa2 1 0.02 0 0.04
14 INT253417 ATIC Positive_regulation of Prkaa2 1 0.02 0.31 0.04
15 INT253363 Lep Regulation of Prkaa2 1 0.15 0.08 0.04
16 INT253365 Il6 Negative_regulation of Prkaa2 1 0.23 0 0.04
17 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
18 INT253415 ATIC Regulation of Phosphorylation of Prkaa2 1 0.03 0 0.03
19 INT253418 ATIC Regulation of Prkaa2 1 0.02 0 0.03
20 INT253370 Lep Negative_regulation of Prkaa2 1 0.29 0.18 0.03
21 INT253359 Positive_regulation of Prkaa2 Negative_regulation of Mtor 1 0.26 0.27 0
22 INT207817 Negative_regulation of Parp1 Positive_regulation of Atm 1 0.53 0.2 0
23 INT253368 Positive_regulation of Lep Positive_regulation of Prkaa2 1 0.26 0.19 0
24 INT207815 Parp1 Negative_regulation of Phosphorylation of Atm 1 0.42 0.15 0
25 INT207816 Parp1 Regulation of Positive_regulation of Atm 1 0.51 0.21 0
26 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
27 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
28 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
29 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
30 INT253382 Il6 Positive_regulation of Prkaa2 1 0.42 0.19 0
31 INT253361 Il6 Negative_regulation of Phosphorylation of Prkaa2 1 0.26 0.16 0
32 INT330226 Positive_regulation of Prkaa2 Positive_regulation of Trib3 1 0.00 0.07 0
33 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
34 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
35 INT253369 Prkaa2 Negative_regulation of Mtor 1 0.24 0.27 0
36 INT228109 Binding of Atm and Chrm2 1 0.09 0.21 0
37 INT330225 Binding of Tmprss5 and Positive_regulation of Positive_regulation of Prkaa2 1 0.01 0.18 0
38 INT330224 Tmprss5 Positive_regulation of Prkaa2 1 0.01 0 0
39 INT253379 Lep Positive_regulation of Prkaa2 1 0.39 0.19 0
40 INT253373 Binding of Mtor and Prkaa2 1 0.20 0.26 0
41 INT253372 Prkaa2 Regulation of Mtor 1 0.13 0.09 0
42 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
43 INT253381 Il6 Regulation of Prkaa2 1 0.16 0 0
44 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
45 INT207813 Atm Regulation of Gene_expression of Parp1 1 0.44 0.31 0
46 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
47 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
48 INT207814 Negative_regulation of Parp1 Positive_regulation of Positive_regulation of Atm 1 0.53 0.08 0
49 INT207812 Binding of Parp1 and Atm 1 0.54 0.99 0
50 INT330223 Binding of Tmprss5 and Positive_regulation of Prkaa2 1 0.01 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for histone serine kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in histone serine kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
2 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
3 INT71747 Positive_regulation of Prkaa2 19 0.46 8.76 0.98
4 INT28118 Binding of Atm 13 0.38 12.24 0.68
5 INT48212 Binding of ATM 5 0.47 3.89 0.57
6 INT160778 Transcription of ATM 1 0.40 1.03 0.57
7 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
8 INT228570 Phosphorylation of Prkaa2 24 0.61 7.9 0.5
9 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
10 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
11 INT144275 Negative_regulation of Atm 9 0.59 8.48 0.36
12 INT71752 Negative_regulation of Prkaa2 17 0.39 2.81 0.3
13 INT71750 Regulation of Prkaa2 12 0.41 2.98 0.29
14 INT226115 Positive_regulation of PRKAA1 2 0.15 0.45 0.29
15 INT167438 Localization of ATM 3 0.55 1.61 0.27
16 INT197121 Positive_regulation of Atm 24 0.69 6.81 0.25
17 INT35719 Gene_expression of Atm 34 0.78 15.75 0.24
18 INT187504 Gene_expression of Prkaa2 5 0.65 1.3 0.22
19 INT253395 Negative_regulation of Phosphorylation of Prkaa2 9 0.39 1.35 0.2
20 INT253401 Positive_regulation of Positive_regulation of Prkaa2 2 0.33 1.39 0.15
21 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
22 INT167440 Regulation of ATM 2 0.20 0.68 0.12
23 INT187495 Positive_regulation of Gene_expression of Prkaa2 1 0.49 0.09 0.11
24 INT253404 Positive_regulation of Phosphorylation of Prkaa2 3 0.29 1.23 0.09
25 INT207804 Negative_regulation of Gene_expression of Atm 2 0.59 6.22 0.09
26 INT253390 Negative_regulation of Positive_regulation of Prkaa2 4 0.28 0.76 0.08
27 INT207806 Phosphorylation of Atm 8 0.81 3.07 0.06
28 INT253387 Negative_regulation of Regulation of Prkaa2 1 0.28 0.08 0.05
29 INT212459 Positive_regulation of Binding of Atm 1 0.40 0.88 0.04
30 INT207803 Regulation of Atm 3 0.41 1.15 0.03
31 INT207807 Localization of Atm 4 0.74 0.21 0
32 INT253402 Binding of Prkaa2 2 0.24 0.43 0
33 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
34 INT252642 Transcription of Atm 1 0.53 0.18 0
35 INT253408 Positive_regulation of Negative_regulation of Prkaa2 1 0.33 0.44 0
36 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
37 INT330234 Localization of Prkaa2 1 0.21 0 0
38 INT252645 Positive_regulation of Gene_expression of Atm 1 0.50 2.35 0
39 INT253394 Negative_regulation of Negative_regulation of Prkaa2 1 0.28 0.33 0
40 INT252644 Regulation of Gene_expression of Atm 1 0.27 0.39 0
41 INT207808 Positive_regulation of Positive_regulation of Atm 1 0.50 0.08 0
42 INT252643 Negative_regulation of Positive_regulation of Atm 1 0.38 0.6 0
43 INT238857 Phosphorylation of PRKAA1 1 0.01 1.73 0
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