GO:0035235

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Name ionotropic glutamate receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0035235
Unique Molecular Interactions 1289
Total Molecular Interactions 1816
Total Single Events 17919
Pain Genes Associated 33

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for ionotropic glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
2 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
3 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
4 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
5 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
6 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
7 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
8 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
9 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
10 INT156799 Gria1 Regulation of Grm8 1 0.11 1.29 2.45
11 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
12 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
13 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
14 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
15 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
16 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
17 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
18 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
19 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
20 INT332773 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.04 0.73 1.75
21 INT139156 Binding of Gria1 and Gria2 1 0.23 0.64 1.72
22 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
23 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
24 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
25 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
26 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
27 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
28 INT136843 Binding of Camk2a and Nrgn 1 0.47 0 1.47
29 INT140329 Grin1 Negative_regulation of Ltp 1 0.04 0.64 1.46
30 INT161871 Mors1 Positive_regulation of GRIN1 1 0.01 0.12 1.46
31 INT161858 OPRM1 Positive_regulation of GRIN1 1 0.50 0.12 1.45
32 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42
33 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
34 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
35 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
36 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29
37 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
38 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
39 INT197231 Grik1 Regulation of Gabrg1 1 0.19 0.13 1.22
40 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2
41 INT281077 Binding of Gria2 and Gria3 2 0.24 0.35 1.19
42 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
43 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
44 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
45 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14
46 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
47 INT317553 Binding of Car2 and Grin1 1 0.07 0 1.14
48 INT123387 Binding of Camk2a and Gria2 1 0.13 0.32 1.14
49 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
50 INT163799 Binding of GRIN1 and Rvm 1 0.16 0.96 1.13
51 INT332776 FSCN1 Positive_regulation of Grin1 1 0.02 0.21 1.12
52 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
53 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
54 INT269191 Binding of Grin1 and Grin3a 2 0.32 1.05 1.09
55 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
56 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
57 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
58 INT296458 Binding of Gria2 and Pick1 3 0.24 1.86 1.07
59 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
60 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
61 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
62 INT296460 Binding of Gria2 and Myo18a 1 0.01 1.49 1.06
63 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
64 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06
65 INT317531 Regulation of Binding of Grin1 and Mors1 1 0.08 0.06 1.05
66 INT317534 Regulation of Binding of Camk2a and Grin1 1 0.20 0.06 1.05
67 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
68 INT269199 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.03 0.56 1.05
69 INT317535 Binding of Grin1 and Mors1 1 0.07 0.06 1.04
70 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
71 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
72 INT157142 OPA1 Positive_regulation of Gene_expression of Camk2a 1 0.02 0.3 1.02
73 INT269194 Ceacam3 Positive_regulation of Phosphorylation of Grin1 1 0.09 0.55 1.02
74 INT131889 gr Regulation of Gene_expression of Grin1 1 0.02 0 1.01
75 INT186161 Prkaca Positive_regulation of Phosphorylation of Grin1 1 0.11 1.05 1.01
76 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
77 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
78 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
79 INT156510 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.03 0.98 0.98
80 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
81 INT156508 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.22 0.98 0.98
82 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98
83 INT156380 Regulation of Binding of Grin1 and Dlg4 1 0.29 0.32 0.97
84 INT281085 Binding of Gria2 and Nsf 2 0.26 0.4 0.94
85 INT338893 TNFSF14 Positive_regulation of Gene_expression of Gria1 1 0.07 0.59 0.94
86 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93
87 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93
88 INT271635 Negative_regulation of GRIN1 Negative_regulation of Positive_regulation of Ltp 1 0.00 0.65 0.93
89 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92
90 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
91 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
92 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92
93 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
94 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92
95 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92
96 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
97 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91
98 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
99 INT281082 Binding of Gria2 and Ltp 1 0.24 0.6 0.9
100 INT281089 Binding of Gria1 and Ltp 1 0.25 0.6 0.9
101 INT108647 Binding of Grin2a and Camk1d 1 0.33 0.78 0.9
102 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9
103 INT142129 Nrgn Regulation of Camk2a 1 0.48 0.25 0.89
104 INT165540 NGF Positive_regulation of GRIN1 1 0.07 0.17 0.88
105 INT223867 Camk2a Positive_regulation of Positive_regulation of Ltp 1 0.25 0 0.87
106 INT315769 GRIN1 Negative_regulation of Plbd1 1 0.00 0.57 0.87
107 INT52195 Sigmar1 Positive_regulation of Positive_regulation of Grin1 1 0.15 0 0.87
108 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
109 INT127545 Gria1 Positive_regulation of Gene_expression of Gnptab 1 0.00 0.7 0.83
110 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83
111 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83
112 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
113 INT98479 Lif Regulation of Gene_expression of Grin1 1 0.04 0.35 0.82
114 INT150681 Pomc Positive_regulation of Camk2a 1 0.47 0.07 0.8
115 INT100559 Binding of Grin1 and LOC502940 1 0.13 0.61 0.8
116 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
117 INT54800 Grin1 Regulation of Gene_expression of Gh 1 0.01 0 0.79
118 INT150679 Pomc Regulation of Gene_expression of Camk2a 1 0.30 0.07 0.79
119 INT214876 Ap3d1 Negative_regulation of Gria1 1 0.00 0.4 0.78
120 INT261413 Positive_regulation of GRIN1 Positive_regulation of Positive_regulation of Creb1 1 0.00 0.81 0.77
121 INT147913 Phosphorylation of Camk2a Positive_regulation of Binding of Lpl 1 0.10 0 0.77
122 INT232621 Binding of Gria1 and Psd 1 0.10 0.29 0.77
123 INT164996 Ins1 Regulation of Gria2 1 0.05 0.05 0.76
124 INT116805 Phosphorylation of Camk2b Positive_regulation of Camk2a 1 0.07 0 0.76
125 INT311525 Binding of Gria1 and Ltp 1 0.00 0.1 0.73
126 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72
127 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72
128 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
129 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72
130 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
131 INT296290 Binding of Car1 and Grin1 1 0.11 0.32 0.72
132 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
133 INT197234 Grik1 Positive_regulation of Localization of Gabrg1 1 0.15 0.82 0.71
134 INT296295 Binding of Grin1 and Grin2b 1 0.16 0.31 0.71
135 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
136 INT190984 Binding of Scn2a1 and Gria1 1 0.03 0.08 0.71
137 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
138 INT51433 Gria1 Positive_regulation of Eif3g 1 0.03 0 0.7
139 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
140 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
141 INT71595 Camk2a Regulation of Negative_regulation of Oprm1 1 0.04 0 0.69
142 INT102344 Grin1 Regulation of Localization of C3orf52 1 0.00 0 0.68
143 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
144 INT114036 Binding of Grin1 and Psd 1 0.24 0.45 0.68
145 INT162224 Grin1 Positive_regulation of Gene_expression of Gria1 1 0.27 0.07 0.66
146 INT162223 Grin1 Positive_regulation of Localization of Gria2 1 0.23 0.07 0.66
147 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
148 INT250084 Negative_regulation of Grin2b Negative_regulation of Positive_regulation of Ltp 1 0.18 0.07 0.66
149 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
150 INT250078 Negative_regulation of Grin2b Negative_regulation of Ltp 1 0.18 0.07 0.66
151 INT281083 Binding of Gria1 and Gipc1 1 0.01 0 0.65
152 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
153 INT197238 Grik1 Regulation of Gene_expression of Gabrg1 1 0.17 0.13 0.64
154 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
155 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63
156 INT236003 Binding of HTR1A and Grin1 1 0.01 0.7 0.63
157 INT2700 Binding of App and Cpe 1 0.00 0 0.63
158 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
159 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
160 INT186429 Camk2a Regulation of Regulation of Creb1 1 0.09 0.09 0.62
161 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
162 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
163 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
164 INT86405 MMD Positive_regulation of GRIN1 1 0.54 0 0.62
165 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
166 INT197239 Grik1 Regulation of Localization of Gabrg1 1 0.10 0.56 0.61
167 INT281079 Binding of Nsf and Gria3 1 0.19 0.05 0.61
168 INT201294 Negative_regulation of Grik1 Negative_regulation of Gabrg1 1 0.30 0 0.6
169 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
170 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
171 INT296463 Binding of Gria1 and Pick1 1 0.16 0.32 0.59
172 INT157141 Cpox Positive_regulation of Gene_expression of Camk2a 1 0.19 0.13 0.58
173 INT281093 GRIN1 Positive_regulation of Positive_regulation of Ltp 1 0.30 0 0.58
174 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57
175 INT296472 Camk2a Positive_regulation of Prkaca 1 0.09 0.32 0.57
176 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
177 INT296456 Gria1 Negative_regulation of Rbm39 1 0.00 0.45 0.57
178 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
179 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
180 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
181 INT296446 Binding of Gria2 and Gria4 1 0.13 0.55 0.57
182 INT134530 Grin1 Regulation of Gria1 1 0.12 0 0.56
183 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56
184 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
185 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
186 INT281087 Binding of Gria1 and Hmmr 1 0.04 0 0.55
187 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
188 INT343597 Gys1 Regulation of Transcription of Gria2 1 0.00 0 0.55
189 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
190 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
191 INT312751 Phosphorylation of Gria1 Positive_regulation of GRIA1 1 0.18 0.22 0.55
192 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55
193 INT259184 Binding of Gria2 and Gria1 2 0.26 0.28 0.54
194 INT263776 Grin1 Positive_regulation of Ltp 2 0.17 0.17 0.54
195 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54
196 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54
197 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54
198 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
199 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
200 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54

Single Events

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in ionotropic glutamate receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
2 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
3 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
4 INT65500 Gene_expression of App 605 0.78 429.94 98.31
5 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
6 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
7 INT29708 Gene_expression of Gria1 177 0.78 56.36 77.37
8 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
9 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
10 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
11 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
12 INT119528 Positive_regulation of Camk2a 135 0.70 26.13 54.7
13 INT8071 Positive_regulation of Gria1 102 0.70 26.61 53.37
14 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
15 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
16 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
17 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
18 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
19 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
20 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38
21 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
22 INT11246 Binding of Grin1 65 0.48 14.53 36.93
23 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
24 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
25 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
26 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24
27 INT114729 Phosphorylation of Camk2a 110 0.82 15.49 33.19
28 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6
29 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
30 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
31 INT114173 Phosphorylation of Gria1 27 0.82 33.73 31.24
32 INT49001 Regulation of Gria1 51 0.56 18.28 31.22
33 INT64918 Gene_expression of Gria2 108 0.74 29.95 29.67
34 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28
35 INT106540 Negative_regulation of Phosphorylation of Grin1 15 0.58 9.32 29.13
36 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
37 INT56525 Gene_expression of Gria2 74 0.75 23.15 28.6
38 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
39 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15
40 INT32794 Gene_expression of Grin2d 81 0.68 20.87 26.99
41 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
42 INT61664 Regulation of GRIN1 38 0.60 16.45 25.35
43 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88
44 INT101225 Positive_regulation of Gria2 62 0.64 28.1 23.93
45 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
46 INT123386 Negative_regulation of Camk2a 48 0.58 12.57 23.78
47 INT76249 Gene_expression of Gria1 67 0.75 15.07 22.78
48 INT49623 Negative_regulation of Gria1 39 0.59 12.4 21.59
49 INT129987 Phosphorylation of Gria1 63 0.80 20.65 21.02
50 INT11625 Localization of App 98 0.78 55.46 20.86
51 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
52 INT16794 Binding of App 103 0.48 64.87 19.79
53 INT65502 Regulation of App 77 0.62 52.05 19.44
54 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13
55 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
56 INT50420 Transcription of Grin1 30 0.71 13.21 18.28
57 INT29709 Positive_regulation of Gene_expression of Gria1 36 0.69 9.43 17.83
58 INT63928 Negative_regulation of Grin1 51 0.56 11.81 17.57
59 INT16624 Localization of Grin1 38 0.79 8.46 17.15
60 INT95930 Negative_regulation of Gria2 63 0.56 18.37 17.04
61 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
62 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92
63 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
64 INT88356 Negative_regulation of Positive_regulation of Grin1 16 0.58 4.72 16.58
65 INT197210 Positive_regulation of Grik1 24 0.69 3.15 16.24
66 INT62861 Regulation of Gria2 45 0.60 13.35 16.07
67 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73
68 INT143276 Phosphorylation of Gria2 42 0.80 16.07 15.2
69 INT18513 Binding of GRIN1 32 0.47 9.44 15.08
70 INT114172 Positive_regulation of Phosphorylation of Gria1 8 0.63 15.73 14.99
71 INT114510 Positive_regulation of Gria2 36 0.57 14.91 14.85
72 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8
73 INT54052 Gene_expression of App 33 0.78 25.08 14.7
74 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44
75 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3
76 INT92513 Regulation of Grin1 26 0.59 9.12 13.94
77 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78
78 INT7342 Positive_regulation of Positive_regulation of Grin1 18 0.50 9.22 13.76
79 INT49538 Binding of Gria1 22 0.47 2.66 13.35
80 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
81 INT119089 Regulation of Phosphorylation of Grin1 17 0.61 3.1 12.82
82 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
83 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
84 INT29745 Binding of APP 47 0.48 26.49 12.4
85 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
86 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2
87 INT112103 Binding of Grin1 28 0.48 4.21 12.08
88 INT111948 Positive_regulation of Gria1 23 0.61 7.55 12.03
89 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
90 INT48883 Negative_regulation of GRIN3B 19 0.54 14.53 11.5
91 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
92 INT116347 Positive_regulation of Positive_regulation of GRIN1 12 0.49 3.63 11.44
93 INT86544 Positive_regulation of Camk2a 20 0.47 4.59 11.37
94 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
95 INT259165 Phosphorylation of Gria2 4 0.65 11.65 11.07
96 INT57069 Regulation of Gria2 28 0.44 10.11 11.06
97 INT130475 Positive_regulation of Phosphorylation of Grin2b 8 0.47 11.52 10.96
98 INT79556 Gene_expression of GRIN3B 16 0.77 7.71 10.75
99 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
100 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
101 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31
102 INT8072 Localization of Gria1 17 0.75 2.62 10.04
103 INT115614 Binding of Gria2 25 0.43 8.97 9.91
104 INT6065 Localization of GRIN1 15 0.74 3.15 9.81
105 INT96298 Negative_regulation of Gria1 25 0.57 10.61 9.7
106 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62
107 INT41569 Regulation of APP 32 0.62 17.15 9.4
108 INT259169 Positive_regulation of Phosphorylation of Gria2 3 0.40 9.98 9.34
109 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
110 INT119527 Regulation of Camk2a 26 0.60 5.55 9.01
111 INT119529 Positive_regulation of Phosphorylation of Camk2a 16 0.60 1.49 8.94
112 INT121987 Phosphorylation of Grin1 11 0.80 4.73 8.88
113 INT71590 Gene_expression of Camk2a 17 0.78 2.3 8.63
114 INT119525 Negative_regulation of Positive_regulation of Camk2a 14 0.43 5.15 8.45
115 INT112104 Binding of Grin2b 21 0.44 6.78 8.16
116 INT78766 Negative_regulation of Gria2 20 0.52 6.27 8.12
117 INT117642 Regulation of Gene_expression of Grin1 18 0.53 7.09 8.08
118 INT135113 Localization of Grin1 18 0.73 3.73 7.69
119 INT48882 Binding of GRIN3B 9 0.46 5.12 7.66
120 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
121 INT110705 Positive_regulation of Positive_regulation of Grin1 11 0.69 4.7 7.33
122 INT114509 Transcription of Gria2 10 0.58 0.75 7.27
123 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
124 INT57023 Negative_regulation of Gene_expression of Gria1 20 0.58 6.92 7.17
125 INT139149 Binding of Gria1 22 0.37 5.71 6.88
126 INT197216 Localization of Grik1 9 0.80 0.39 6.78
127 INT132468 Positive_regulation of Positive_regulation of Camk2a 20 0.70 2.76 6.7
128 INT120298 Negative_regulation of Phosphorylation of Gria1 6 0.57 8.99 6.68
129 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41
130 INT153959 Phosphorylation of GRIN1 8 0.80 4.07 6.18
131 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17
132 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98
133 INT94927 Transcription of Gria1 12 0.69 3.14 5.94
134 INT130472 Negative_regulation of Phosphorylation of Grin2b 4 0.40 4.4 5.78
135 INT121988 Negative_regulation of Gene_expression of Camk2a 8 0.59 4.76 5.72
136 INT67693 Binding of Grin2a 9 0.38 1.74 5.68
137 INT80344 Regulation of Camk2a 9 0.56 0.99 5.66
138 INT112102 Regulation of Gene_expression of Gria2 14 0.55 5.4 5.55
139 INT57068 Regulation of Gene_expression of Gria2 12 0.36 3.76 5.44
140 INT135473 Negative_regulation of Gene_expression of Grin1 14 0.47 5.47 5.36
141 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
142 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29
143 INT130478 Localization of Grin2b 11 0.75 2.49 5.28
144 INT208108 Localization of Grin2a 19 0.70 1.5 5.22
145 INT134468 Gene_expression of Cdk5r1 26 0.48 27.09 5.2
146 INT135998 Localization of Gria2 18 0.72 3.14 5.15
147 INT92541 Localization of Grin2b 11 0.75 2.85 5.14
148 INT259167 Negative_regulation of Phosphorylation of Gria2 2 0.34 5.24 5.13
149 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
150 INT19549 Binding of Grin2a 12 0.45 1.24 5.09
151 INT85946 Localization of Gria2 10 0.61 1.23 5.09
152 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
153 INT26042 Binding of Gria2 20 0.40 4.88 5.04
154 INT135474 Negative_regulation of Gene_expression of Grin2a 7 0.39 6.94 4.89
155 INT147898 Binding of Camk2a 16 0.37 4.01 4.87
156 INT111947 Positive_regulation of Gene_expression of Grin2a 7 0.68 1.75 4.84
157 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
158 INT114511 Positive_regulation of Gene_expression of Gria2 14 0.41 3.9 4.71
159 INT49060 Negative_regulation of Camk2a 10 0.45 2.59 4.67
160 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67
161 INT79505 Binding of Grin2b 9 0.36 1.43 4.61
162 INT151350 Regulation of Gene_expression of Camk2a 1 0.62 0.79 4.57
163 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
164 INT197230 Regulation of Positive_regulation of Grik1 4 0.45 0 4.42
165 INT93035 Negative_regulation of Transcription of Grin1 6 0.41 2.29 4.39
166 INT71594 Positive_regulation of Gene_expression of Camk2a 8 0.47 1.07 4.35
167 INT111404 Regulation of Positive_regulation of Grin1 5 0.56 2.49 4.31
168 INT170348 Regulation of Gene_expression of Grin2b 8 0.60 2.29 4.25
169 INT109219 Negative_regulation of Cdk5r1 5 0.43 1.22 4.25
170 INT112100 Negative_regulation of Gene_expression of Grin2b 6 0.42 3.71 4.24
171 INT58003 Localization of APP 32 0.80 13.75 4.2
172 INT92902 Negative_regulation of Positive_regulation of Gria1 6 0.57 1.06 4.1
173 INT115354 Regulation of Binding of Grin1 2 0.43 1.15 4.08
174 INT88156 Regulation of Gria1 12 0.54 2.5 4.06
175 INT224807 Gene_expression of Gria4 35 0.78 4.63 4.02
176 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
177 INT103999 Positive_regulation of Phosphorylation of Grin2a 5 0.38 3.12 3.94
178 INT129990 Positive_regulation of Phosphorylation of Gria1 11 0.61 3.44 3.87
179 INT163500 Transcription of Grin2b 3 0.67 3.63 3.8
180 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
181 INT92516 Positive_regulation of Gene_expression of Grin1 8 0.45 2.53 3.77
182 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74
183 INT84593 Positive_regulation of Binding of Grin1 6 0.48 2.74 3.72
184 INT121986 Phosphorylation of Grin2a 5 0.76 0.83 3.71
185 INT131969 Regulation of Grik1 6 0.61 0.57 3.69
186 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
187 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
188 INT197207 Negative_regulation of Grik1 5 0.43 1.91 3.5
189 INT209221 Regulation of Gene_expression of Grin2a 5 0.24 2.81 3.45
190 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
191 INT132888 Negative_regulation of Phosphorylation of Grin1 3 0.57 1.18 3.43
192 INT231293 Negative_regulation of Grin2d 4 0.45 3.95 3.38
193 INT102276 Gene_expression of Grin2d 10 0.71 4.74 3.37
194 INT84564 Regulation of Positive_regulation of Gria1 2 0.33 1.86 3.3
195 INT51427 Positive_regulation of Positive_regulation of Gria1 11 0.45 1.33 3.28
196 INT170351 Positive_regulation of Gene_expression of Gria2 13 0.67 3.67 3.27
197 INT80007 Transcription of GRIN1 5 0.67 2.36 3.26
198 INT170343 Positive_regulation of Gene_expression of Gria1 10 0.61 2.77 3.09
199 INT132887 Positive_regulation of Phosphorylation of Grin1 3 0.49 1.73 3.08
200 INT71588 Phosphorylation of Camk2a 7 0.65 0.32 3.03
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