GO:0035255

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Name ionotropic glutamate receptor binding
Categary Function
Go Slim No
Go Link GO:0035255
Unique Molecular Interactions 403
Total Molecular Interactions 592
Total Single Events 4204
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor binding. They are ordered first by their pain relevance and then by number of times they were reported for ionotropic glutamate receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
3 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
4 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
5 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
6 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
7 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
8 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
9 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
10 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
11 INT229094 Binding of IL1RN and Il1r1 1 0.01 1.9 1.5
12 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
13 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
14 INT246519 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.25 0.08 1.42
15 INT293200 Positive_regulation of Grin1 Positive_regulation of Phosphorylation of Grin2b 1 0.24 0.4 1.39
16 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
17 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
18 INT154518 Binding of Ephb6 and Grin2b 1 0.21 0.24 1.28
19 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
20 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
21 INT112105 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2b 2 0.40 0.89 1.2
22 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
23 INT256295 Binding of Creb1 and Grin2b 1 0.11 1.21 1.19
24 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
25 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
26 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
27 INT122268 Binding of Grin2b and Grm5 1 0.40 0.52 1.1
28 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
29 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06
30 INT256293 Binding of Grin2b and Insrr 1 0.01 1.06 1.05
31 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04
32 INT346835 Gene_expression of Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.27 1.07 1.03
33 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
34 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
35 INT344389 Ephb2 Positive_regulation of Phosphorylation of Grin2b 1 0.16 1.46 0.98
36 INT156380 Regulation of Binding of Grin1 and Dlg4 1 0.29 0.32 0.97
37 INT281375 Il1r1 Negative_regulation of Gene_expression of Fos 1 0.47 0.61 0.97
38 INT344381 Olfr360 Negative_regulation of Gene_expression of Grin2b 1 0.01 1.17 0.93
39 INT344390 Olfr360 Negative_regulation of Phosphorylation of Grin2b 1 0.01 1.17 0.93
40 INT344388 Efnb1 Positive_regulation of Phosphorylation of Grin2b 1 0.40 1.45 0.92
41 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
42 INT251152 Dlg2 Positive_regulation of Localization of Grin2b 1 0.43 0.6 0.92
43 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92
44 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
45 INT108438 Grin2b Regulation of Pdyn 1 0.16 0.25 0.9
46 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
47 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
48 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
49 INT42865 Binding of Adrb2 and Man2a2 1 0.23 1.03 0.85
50 INT42864 Regulation of Binding of Adrb2 and Man2a2 1 0.28 1.03 0.85
51 INT120820 Binding of ASIC3 and Dlg4 3 0.02 0.11 0.84
52 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
53 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
54 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
55 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
56 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
57 INT152945 Dlg4 Regulation of Cap1 1 0.11 0.18 0.76
58 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
59 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
60 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
61 INT152944 Dlg4 Regulation of Gpr88 1 0.12 0.18 0.75
62 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
63 INT296285 Binding of Car1 and Grin2b 1 0.14 0.32 0.72
64 INT186160 Negative_regulation of Grin2b Negative_regulation of Grin1 1 0.37 0.5 0.72
65 INT296282 Grin2b Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
66 INT296295 Binding of Grin1 and Grin2b 1 0.16 0.31 0.71
67 INT296298 Grin2b Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
68 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
69 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
70 INT249485 Trib3 Negative_regulation of Phosphorylation of Grin2b 1 0.02 0.64 0.68
71 INT250084 Negative_regulation of Grin2b Negative_regulation of Positive_regulation of Ltp 1 0.18 0.07 0.66
72 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
73 INT250078 Negative_regulation of Grin2b Negative_regulation of Ltp 1 0.18 0.07 0.66
74 INT168205 Binding of Dlg4 and Pik3cd 1 0.11 0.37 0.65
75 INT302441 Binding of GRIN1 and Grin2b 1 0.10 1.27 0.63
76 INT186159 Grin2d Negative_regulation of Grin2b 1 0.21 0.82 0.62
77 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
78 INT249484 Trib3 Positive_regulation of Phosphorylation of Grin2b 1 0.01 0.57 0.61
79 INT261372 Gsk3b Regulation of Gene_expression of Ifi205 1 0.00 0.24 0.58
80 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
81 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
82 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
83 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
84 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
85 INT251143 Binding of Grin2b and Dlg3 1 0.22 0.32 0.55
86 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54
87 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
88 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
89 INT249497 Efnb2 Positive_regulation of Phosphorylation of Grin2b 1 0.02 0.51 0.54
90 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
91 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
92 INT155406 Binding of Adrb2 and Ngf 1 0.05 0.39 0.53
93 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
94 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
95 INT3218 Adrb2 Positive_regulation of Localization of Ins1 1 0.10 0 0.52
96 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
97 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
98 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
99 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
100 INT66188 Binding of ADRB2 and CDSN 1 0.01 0 0.51
101 INT229095 Binding of IL1R1 and Il1r1 1 0.00 0.64 0.5
102 INT250080 Grin2b Positive_regulation of Ltp 1 0.22 0.19 0.49
103 INT208119 Grin2b Positive_regulation of Positive_regulation of Ltp 1 0.16 0.21 0.49
104 INT263746 Binding of Dlg4 and Neto1 1 0.27 0 0.48
105 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
106 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
107 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46
108 INT35167 Adrb2 Positive_regulation of Trh 1 0.05 0 0.45
109 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
110 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
111 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
112 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
113 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
114 INT92744 Binding of ADRB2 and NF2 1 0.00 0.1 0.41
115 INT105733 Grin2b Negative_regulation of Gene_expression of Grin2a 1 0.22 0.09 0.41
116 INT296296 Binding of Grin2b and Kcnip3 1 0.24 0 0.4
117 INT279620 Negative_regulation of Binding of Grin2a and Grin2b 1 0.18 0.99 0.4
118 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
119 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
120 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
121 INT288545 Gsk3b Negative_regulation of gr 1 0.25 0.38 0.38
122 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
123 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
124 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
125 INT150196 Grm5 Regulation of Grin2b 1 0.45 0 0.36
126 INT120821 Dlg4 Positive_regulation of ASIC3 1 0.02 0 0.36
127 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
128 INT249492 Trib3 Regulation of Phosphorylation of Grin2b 1 0.01 0.23 0.35
129 INT66369 Pomc Regulation of Positive_regulation of Gsk3b 1 0.07 0 0.35
130 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
131 INT272602 Binding of Dlg4 and Gria2 3 0.09 0.19 0.34
132 INT120817 Binding of Dlg4 and Lin7b 1 0.00 0 0.34
133 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
134 INT296465 Binding of Dlg4 and Rbm39 1 0.00 0.05 0.34
135 INT236006 HTR1A Regulation of Grin2b 1 0.00 0 0.33
136 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
137 INT321366 Gsk3b Regulation of Gene_expression of CYP8B1 1 0.01 0.21 0.33
138 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
139 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
140 INT263974 Binding of ADRB2 and NR4A3 1 0.01 0.5 0.32
141 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
142 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
143 INT263979 Binding of ADRB2 and ATF3 1 0.01 0.5 0.32
144 INT198779 Binding of Dlg4 and Psd 10 0.25 0.09 0.31
145 INT296459 Binding of Dlg1 and Gria1 1 0.02 0.23 0.31
146 INT342810 Binding of Adarb1 and Gsk3b 1 0.00 0.36 0.3
147 INT263749 Binding of Grin2b and Neto1 1 0.38 0 0.3
148 INT250079 Grin2b Regulation of Ltp 1 0.18 0.31 0.29
149 INT135425 Binding of Dlg4 and Dlg3 1 0.29 0.07 0.28
150 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
151 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
152 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
153 INT325530 Positive_regulation of Gsk3b Negative_regulation of Gene_expression of Wnt2 1 0.03 0.63 0.28
154 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
155 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
156 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
157 INT296450 Cacng2 Regulation of Gria2 1 0.13 0.24 0.26
158 INT346745 Binding of Cacng2 and Grip2 1 0.01 0 0.25
159 INT274939 Binding of Dlg4 and Ephb6 1 0.12 0 0.25
160 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
161 INT274942 Binding of Dlg1 and Ephb6 1 0.05 0 0.25
162 INT296470 Binding of Cacng2 and Myo18a 1 0.00 0.22 0.24
163 INT263787 Binding of GRIN1 and Dlg4 3 0.18 0.05 0.23
164 INT296467 Binding of Cacng2 and Gria1 1 0.12 0.25 0.23
165 INT296464 Binding of Cacng2 and Tinagl1 1 0.06 0.25 0.23
166 INT198776 Binding of Dlg4 and Psds1 1 0.11 0.05 0.23
167 INT296474 Binding of Cacng2 and Gria2 1 0.18 0.26 0.23
168 INT29099 Binding of ADRB2 and PPAP2A 1 0.03 0.77 0.22
169 INT273237 Cdk5 Positive_regulation of Protein_catabolism of Grin2b 1 0.45 1.31 0.22
170 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
171 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
172 INT208123 Hpcal1 Regulation of Grin2b 1 0.10 0 0.21
173 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
174 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
175 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
176 INT250074 Grin2b Positive_regulation of Gene_expression of Hpcal4 1 0.04 0.3 0.2
177 INT273099 Bdnf Positive_regulation of Localization of Dlg4 1 0.21 0.07 0.18
178 INT132265 Binding of SGCG and Canx 1 0.04 0.24 0.18
179 INT261401 Binding of Gsk3b and ADHD1 1 0.00 1.62 0.18
180 INT195114 Gene_expression of Il1r1 Positive_regulation of Positive_regulation of F2r 1 0.38 1.67 0.18
181 INT256985 Binding of Dlg1 and Cd81 1 0.39 0.2 0.17
182 INT349659 PYCARD Positive_regulation of ADRB2 1 0.06 0.19 0.17
183 INT148563 Ngf Positive_regulation of GNAS 1 0.06 0.07 0.16
184 INT296469 Gene_expression of Cacng2 Positive_regulation of Gria2 1 0.15 0 0.16
185 INT296461 Gene_expression of Cacng2 Positive_regulation of Rbm39 1 0.00 0 0.16
186 INT354968 Shank3 Positive_regulation of Gene_expression of Gria2 1 0.05 0 0.15
187 INT128705 Binding of Adrb2 and Ahsg 1 0.00 0.23 0.15
188 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
189 INT272605 Binding of Dlg4 and Nsf 1 0.36 0.41 0.14
190 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
191 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
192 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
193 INT312893 Gsk3b Positive_regulation of Hdac6 1 0.07 0.65 0.13
194 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
195 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
196 INT263318 Akt1 Regulation of Gsk3b 1 0.02 0.75 0.13
197 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
198 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
199 INT354327 Gsk3b Positive_regulation of Gene_expression of Ide 1 0.17 0.33 0.13
200 INT354705 Binding of ASIC2 and Dlg4 1 0.00 0.11 0.12

Single Events

The table below shows the top 100 pain related interactions that have been reported for ionotropic glutamate receptor binding. They are ordered first by their pain relevance and then by number of times they were reported in ionotropic glutamate receptor binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
2 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
3 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
4 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
5 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
6 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
7 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
8 INT13501 Binding of Drd2 65 0.48 23.76 35.6
9 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
10 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
11 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
12 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
13 INT93033 Negative_regulation of Grin2b 48 0.58 20.94 28.54
14 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
15 INT107577 Negative_regulation of Grin2b 32 0.59 12.35 24.88
16 INT12484 Binding of Drd2 45 0.48 15.17 24.72
17 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
18 INT102281 Positive_regulation of Gene_expression of Grin2b 27 0.70 10.38 20.84
19 INT49774 Binding of DRD2 48 0.48 17.42 20.73
20 INT93037 Regulation of Grin2b 26 0.57 11.9 16.92
21 INT92514 Regulation of Grin2b 22 0.50 11.07 16.92
22 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
23 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
24 INT97100 Negative_regulation of Dlg4 16 0.58 6.18 14.36
25 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
26 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
27 INT103996 Negative_regulation of Phosphorylation of Grin2b 11 0.58 7.81 12.85
28 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74
29 INT122117 Negative_regulation of Gene_expression of Grin2b 20 0.59 11.3 12.55
30 INT130475 Positive_regulation of Phosphorylation of Grin2b 8 0.47 11.52 10.96
31 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
32 INT80006 Regulation of Gene_expression of Grin2b 8 0.57 3.75 9.62
33 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
34 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
35 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
36 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32
37 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
38 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
39 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
40 INT29411 Positive_regulation of ADRB2 13 0.65 5.42 8.78
41 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58
42 INT112104 Binding of Grin2b 21 0.44 6.78 8.16
43 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
44 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
45 INT7883 Binding of ADRB2 18 0.47 5.49 7.37
46 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
47 INT97099 Positive_regulation of Dlg4 13 0.60 3.04 6.98
48 INT88786 Binding of Dlg4 11 0.46 2.73 6.58
49 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
50 INT24460 Localization of Drd2 12 0.73 2.96 6.46
51 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
52 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
53 INT86772 Localization of Drd2 14 0.80 1.93 6.17
54 INT100658 Negative_regulation of Positive_regulation of Grin2b 7 0.41 1.39 6.17
55 INT74593 Transcription of Grin2b 10 0.66 1.21 5.98
56 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
57 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
58 INT130472 Negative_regulation of Phosphorylation of Grin2b 4 0.40 4.4 5.78
59 INT1243 Regulation of ADRB2 16 0.54 1.84 5.66
60 INT124370 Positive_regulation of Gene_expression of Gsk3b 47 0.67 24.56 5.4
61 INT127353 Regulation of Phosphorylation of Grin2b 5 0.45 1.6 5.29
62 INT130478 Localization of Grin2b 11 0.75 2.49 5.28
63 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
64 INT92541 Localization of Grin2b 11 0.75 2.85 5.14
65 INT13885 Positive_regulation of Adrb2 9 0.49 1.11 5.12
66 INT36030 Gene_expression of Il1r1 16 0.68 11.42 4.87
67 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
68 INT135374 Binding of Gsk3b 46 0.48 24.36 4.75
69 INT88790 Negative_regulation of Gene_expression of Dlg4 6 0.59 1.53 4.66
70 INT79505 Binding of Grin2b 9 0.36 1.43 4.61
71 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
72 INT24930 Binding of Adrb2 6 0.26 4.18 4.44
73 INT145532 Localization of Dlg4 25 0.79 1.97 4.36
74 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
75 INT98357 Binding of Gnas 11 0.41 1.87 4.35
76 INT66366 Positive_regulation of Gsk3b 15 0.68 6.56 4.27
77 INT170348 Regulation of Gene_expression of Grin2b 8 0.60 2.29 4.25
78 INT112100 Negative_regulation of Gene_expression of Grin2b 6 0.42 3.71 4.24
79 INT167284 Phosphorylation of Gsk3b 88 0.82 36.03 4.21
80 INT88787 Transcription of Dlg4 4 0.69 0.83 4.09
81 INT32933 Gene_expression of GNAS 57 0.32 10.58 4.03
82 INT120810 Binding of Dlg4 38 0.41 3.55 4.03
83 INT484 Negative_regulation of ADRB2 13 0.59 2.85 3.94
84 INT116642 Negative_regulation of Gsk3b 13 0.57 7.16 3.83
85 INT163500 Transcription of Grin2b 3 0.67 3.63 3.8
86 INT139646 Positive_regulation of Positive_regulation of Grin2b 4 0.42 3.89 3.74
87 INT6882 Binding of Adrb2 5 0.47 1.97 3.55
88 INT135373 Regulation of Gsk3b 35 0.62 18.11 3.53
89 INT16626 Positive_regulation of Adrb2 10 0.30 2.41 3.4
90 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
91 INT66367 Gene_expression of Gsk3b 16 0.45 9.75 3.07
92 INT41474 Gene_expression of ADRB2 10 0.75 1.56 2.94
93 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
94 INT33480 Gene_expression of Adrb2 4 0.66 1.96 2.77
95 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
96 INT101055 Regulation of GRIN2B 4 0.61 1.39 2.5
97 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46
98 INT36029 Negative_regulation of Il1r1 9 0.41 4.64 2.3
99 INT3531 Regulation of Adrb2 7 0.44 1.48 2.25
100 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
101 INT70725 Negative_regulation of Binding of ADRB2 3 0.57 0.4 2.14
102 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12
103 INT179311 Transcription of GNAS 2 0.10 0.67 2.08
104 INT108903 Negative_regulation of GNAS 7 0.57 1.58 2.04
105 INT246518 Regulation of Negative_regulation of Grin2b 1 0.38 0.07 1.99
106 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
107 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
108 INT151942 Regulation of Negative_regulation of Grin2b 2 0.41 0.41 1.92
109 INT124559 Gene_expression of Il1r1 4 0.54 2.14 1.89
110 INT204018 Localization of Gsk3b 27 0.71 13.67 1.87
111 INT198748 Regulation of Gene_expression of Dlg4 10 0.44 2.16 1.85
112 INT40832 Localization of ADRB2 5 0.73 2.21 1.81
113 INT74594 Regulation of Transcription of Grin2b 1 0.42 0.17 1.8
114 INT130440 Phosphorylation of GRIN2B 2 0.79 2.93 1.79
115 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
116 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
117 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
118 INT119219 Localization of Dlg4 3 0.64 0.16 1.5
119 INT152939 Regulation of Dlg4 9 0.60 1.09 1.49
120 INT52873 Localization of Il1r1 4 0.56 1.28 1.48
121 INT107379 Localization of GRIN2B 2 0.73 0.86 1.48
122 INT121347 Binding of GNAS 8 0.13 3.99 1.47
123 INT134873 Phosphorylation of Dlg4 3 0.80 0.5 1.42
124 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
125 INT162308 Phosphorylation of GNAS 3 0.01 1.71 1.4
126 INT296265 Regulation of Phosphorylation of Grin2b 2 0.44 1.06 1.4
127 INT148562 Positive_regulation of GNAS 13 0.16 5.31 1.32
128 INT97098 Regulation of Negative_regulation of Dlg4 3 0.45 0.97 1.3
129 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
130 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
131 INT249527 Positive_regulation of Positive_regulation of Grin2b 2 0.37 1.12 1.22
132 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
133 INT77216 Localization of DRD2 3 0.75 0 1.19
134 INT95347 Negative_regulation of GRIN2B 1 0.57 0 1.19
135 INT167283 Negative_regulation of Phosphorylation of Gsk3b 12 0.59 7.94 1.16
136 INT128413 Positive_regulation of Shank1 2 0.70 0.61 1.16
137 INT134036 Regulation of Gsk3b 4 0.60 1.42 1.15
138 INT124560 Negative_regulation of Il1r1 2 0.07 0.77 1.14
139 INT41475 Positive_regulation of Localization of ADRB2 2 0.49 0.18 1.12
140 INT32545 Localization of Gsk3b 9 0.07 2.88 1.11
141 INT208536 Positive_regulation of Positive_regulation of Gsk3b 6 0.30 4.83 1.11
142 INT143091 Positive_regulation of Negative_regulation of Grin2b 2 0.44 0.9 1.09
143 INT291961 Negative_regulation of Regulation of Grin2b 1 0.30 1.65 1.09
144 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
145 INT98489 Binding of Il1r1 3 0.36 1.46 1.06
146 INT209218 Gene_expression of Dlg1 3 0.54 0.42 1.03
147 INT198750 Positive_regulation of Gene_expression of Dlg4 5 0.68 0.6 1.02
148 INT49796 Positive_regulation of Binding of Adrb2 1 0.00 0 1.02
149 INT52186 Positive_regulation of Positive_regulation of ADRB2 1 0.14 0 1.02
150 INT49795 Negative_regulation of Binding of Adrb2 1 0.00 0 1.02
151 INT155543 Binding of Rapsn 1 0.32 1.7 1.02
152 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
153 INT116646 Regulation of Negative_regulation of Gsk3b 2 0.44 0.39 0.99
154 INT138548 Negative_regulation of Gene_expression of Adrb2 1 0.41 0.85 0.96
155 INT128411 Regulation of Shank1 2 0.45 0.81 0.95
156 INT134876 Negative_regulation of Phosphorylation of Dlg4 1 0.35 0.27 0.93
157 INT134878 Negative_regulation of Negative_regulation of Dlg4 1 0.35 0.27 0.93
158 INT261360 Binding of Gsk3b 5 0.36 2.85 0.9
159 INT101056 Positive_regulation of GRIN2B 1 0.23 0.32 0.9
160 INT135422 Binding of Dlg3 3 0.35 0.48 0.88
161 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
162 INT14976 Negative_regulation of Adrb2 3 0.24 0.75 0.86
163 INT70726 Positive_regulation of Negative_regulation of ADRB2 1 0.49 0.2 0.86
164 INT186168 Negative_regulation of Negative_regulation of Grin2b 2 0.35 0.54 0.85
165 INT42863 Regulation of Adrb2 1 0.11 1.02 0.85
166 INT42862 Regulation of Binding of Adrb2 1 0.15 1.03 0.85
167 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
168 INT143092 Negative_regulation of Negative_regulation of Grin2b 1 0.27 0.33 0.83
169 INT167285 Positive_regulation of Phosphorylation of Gsk3b 17 0.50 5.92 0.82
170 INT156945 Positive_regulation of Negative_regulation of Gsk3b 6 0.38 4.58 0.82
171 INT36028 Positive_regulation of Gene_expression of Il1r1 4 0.40 1.82 0.81
172 INT66365 Positive_regulation of Gene_expression of Gsk3b 2 0.07 0.95 0.81
173 INT151626 Negative_regulation of Gene_expression of Il1r1 1 0.20 1.33 0.8
174 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
175 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
176 INT116644 Phosphorylation of Gsk3b 4 0.61 0.68 0.78
177 INT112947 Regulation of Il1r1 2 0.24 0.36 0.78
178 INT33481 Positive_regulation of Gene_expression of Adrb2 2 0.48 0.38 0.78
179 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
180 INT204002 Negative_regulation of Gene_expression of Gsk3b 15 0.55 8.57 0.77
181 INT112945 Transcription of Il1r1 1 0.39 0.32 0.76
182 INT215783 Localization of Gnas 1 0.12 1.64 0.76
183 INT169844 Positive_regulation of Localization of Dlg4 2 0.49 0.07 0.75
184 INT165578 Regulation of Positive_regulation of Grin2b 3 0.41 1.07 0.74
185 INT114524 Binding of GRIN2B 3 0.36 0.44 0.74
186 INT31778 Negative_regulation of Adrb2 2 0.07 1.34 0.72
187 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
188 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
189 INT353369 Regulation of Localization of Dlg4 1 0.23 0 0.69
190 INT195104 Positive_regulation of Il1r1 4 0.40 2.18 0.68
191 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
192 INT67452 Positive_regulation of Regulation of ADRB2 1 0.41 0.26 0.68
193 INT242137 Negative_regulation of Positive_regulation of Gsk3b 7 0.39 2.99 0.67
194 INT139895 Positive_regulation of Gene_expression of GRIN2B 2 0.49 0.9 0.65
195 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
196 INT156376 Negative_regulation of Transcription of Dlg4 1 0.56 0.16 0.65
197 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
198 INT147397 Negative_regulation of Binding of Grin2b 1 0.16 0.87 0.63
199 INT122116 Negative_regulation of Transcription of Grin2b 1 0.43 0.34 0.62
200 INT204006 Negative_regulation of Localization of Gsk3b 6 0.40 1.66 0.6
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