GO:0035313

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Name wound healing, spreading of epidermal cells
Categary Process
Go Slim No
Go Link GO:0035313
Unique Molecular Interactions 58
Total Molecular Interactions 67
Total Single Events 715
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for wound healing, spreading of epidermal cells. They are ordered first by their pain relevance and then by number of times they were reported for wound healing, spreading of epidermal cells. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
2 INT144661 Dnm1 Negative_regulation of Binding of Hbegf 1 0.24 0 1.01
3 INT190165 MMP12 Positive_regulation of MMP2 1 0.13 0.72 0.85
4 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
5 INT190182 JUN Positive_regulation of MMP12 1 0.34 0.08 0.8
6 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
7 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
8 INT219685 Binding of MMP12 and COPD 1 0.27 5.59 0.74
9 INT190174 TNF Positive_regulation of MMP12 1 0.27 0.08 0.74
10 INT190169 Regulation of JUN Positive_regulation of Localization of MMP12 1 0.30 0.07 0.74
11 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
12 INT190172 Gene_expression of IL13 Regulation of MMP12 1 0.12 0.05 0.68
13 INT190164 Gene_expression of IL4 Regulation of MMP12 1 0.11 0.05 0.68
14 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
15 INT190211 Adm Regulation of MMP12 1 0.29 0 0.65
16 INT190180 IL4 Regulation of MMP12 1 0.11 0 0.6
17 INT190166 IL13 Regulation of MMP12 1 0.12 0 0.59
18 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
19 INT259637 Binding of Mmp12 and COPD 2 0.02 1.71 0.4
20 INT219684 Binding of MMP12 and GOPC 1 0.09 3.11 0.38
21 INT150351 Binding of EXT1 and MMP12 1 0.04 3.68 0.29
22 INT272928 Positive_regulation of Binding of Mmp12 and COPD 1 0.01 0.79 0.29
23 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
24 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
25 INT115875 Col5a1 Positive_regulation of Localization of Gcg 1 0.08 0 0.23
26 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
27 INT259627 Cxcl10 Positive_regulation of Gene_expression of Mmp12 1 0.02 0.64 0.15
28 INT317071 KCNC4 Regulation of SCNN1G 1 0.03 0.17 0.13
29 INT273185 PDE4A Regulation of Gene_expression of Mmp12 1 0.08 0.57 0.13
30 INT117136 NPEPPS Positive_regulation of Hbegf 1 0.00 0 0.12
31 INT294608 Binding of Serpinh1 and Col5a1 1 0.03 0.45 0.09
32 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
33 INT231676 Binding of CD47 and ITGA5 1 0.02 0.08 0.07
34 INT196624 TNF Negative_regulation of Transcription of SCNN1G 1 0.02 0.07 0.07
35 INT262214 Binding of Msx2 and Nr1i2 1 0.19 0.55 0.06
36 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
37 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
38 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
39 INT317072 SCNN1G Regulation of NA 1 0.00 0.08 0.04
40 INT259621 Serpinc1 Regulation of Gene_expression of Mmp12 1 0.01 0.89 0.03
41 INT196617 TNF Negative_regulation of Gene_expression of SCNN1G 1 0.02 0.08 0.03
42 INT196625 TNF Negative_regulation of Positive_regulation of SCNN1G 1 0.02 0.14 0.03
43 INT196607 IFNG Regulation of Gene_expression of SCNN1G 1 0.03 0.08 0.03
44 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
45 INT317075 Binding of NA and SCNN1G 1 0.00 0 0
46 INT262172 Nr1i2 Regulation of Msx2 1 0.12 0.53 0
47 INT91832 CD81 Negative_regulation of Gene_expression of Hbegf 1 0.01 0.07 0
48 INT317074 CA2 Regulation of SCNN1G 1 0.01 0.08 0
49 INT285396 Binding of Adam17 and R3hcc1 1 0.15 0.93 0
50 INT310187 Acvrl1 Regulation of Gene_expression of Bmpr2 1 0.04 0 0
51 INT257547 HBEGF Positive_regulation of Phosphorylation of CDCP1 1 0.00 0.36 0
52 INT310189 Binding of Acvrl1 and Gdf2 1 0.01 0 0
53 INT310192 Tgfbr1 Positive_regulation of Regulation of Acvrl1 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for wound healing, spreading of epidermal cells. They are ordered first by their pain relevance and then by number of times they were reported in wound healing, spreading of epidermal cells. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12
2 INT23635 Positive_regulation of MMP12 31 0.59 28.19 17.95
3 INT49379 Localization of MMP12 26 0.77 13.07 16.93
4 INT190204 Positive_regulation of Gene_expression of MMP12 22 0.67 31.31 13.69
5 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
6 INT71716 Binding of Hbegf 21 0.28 6.54 4.51
7 INT74684 Gene_expression of Mmp12 8 0.31 5.69 3.68
8 INT20493 Regulation of MMP12 3 0.52 0.89 3.65
9 INT58532 Negative_regulation of MMP12 4 0.37 2.61 3.2
10 INT71717 Negative_regulation of Hbegf 15 0.39 3.63 3.18
11 INT190189 Positive_regulation of Localization of MMP12 4 0.58 2.87 3.18
12 INT190202 Negative_regulation of Localization of MMP12 1 0.36 1.29 3.12
13 INT77333 Binding of Hbegf 5 0.32 2.39 3.07
14 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
15 INT190188 Regulation of Localization of MMP12 1 0.44 0.39 2.8
16 INT91825 Binding of HBEGF 4 0.31 2.39 2.52
17 INT124862 Gene_expression of Col5a1 4 0.17 2.05 2.32
18 INT179659 Gene_expression of Mmp12 13 0.52 11.56 2.23
19 INT190186 Negative_regulation of Gene_expression of MMP12 5 0.38 5.37 2.17
20 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
21 INT190210 Regulation of Positive_regulation of MMP12 1 0.38 1.4 1.79
22 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
23 INT87454 Gene_expression of Hbegf 11 0.66 2.1 1.67
24 INT179663 Localization of Mmp12 8 0.51 4.97 1.53
25 INT129099 Negative_regulation of Hbegf 4 0.36 1.2 1.46
26 INT190184 Regulation of Gene_expression of MMP12 2 0.44 4.41 1.42
27 INT74683 Positive_regulation of Gene_expression of Mmp12 3 0.23 2.02 1.41
28 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
29 INT196687 Positive_regulation of SCNN1G 6 0.06 3.85 1.32
30 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
31 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
32 INT136991 Localization of HBEGF 5 0.59 3.62 1.28
33 INT124861 Positive_regulation of Col5a1 2 0.09 0.75 1.27
34 INT74680 Positive_regulation of Mmp12 3 0.23 2.33 1.16
35 INT117134 Localization of Hbegf 5 0.50 0.37 1.12
36 INT85941 Binding of MMP12 3 0.31 4.91 1.12
37 INT87452 Negative_regulation of Binding of Hbegf 4 0.32 1.94 1.11
38 INT23636 Protein_catabolism of MMP12 3 0.84 0.58 1.05
39 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
40 INT120696 Gene_expression of SCNN1G 9 0.43 5.46 1.03
41 INT259601 Positive_regulation of Mmp12 8 0.48 5.67 1.03
42 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
43 INT190203 Negative_regulation of Positive_regulation of MMP12 1 0.36 1.5 1.02
44 INT78014 Negative_regulation of ITGA5 1 0.01 1.71 0.98
45 INT78561 Gene_expression of Hbegf 4 0.56 2.65 0.97
46 INT87453 Regulation of Hbegf 3 0.20 1.05 0.94
47 INT86458 Positive_regulation of Hbegf 4 0.41 2 0.93
48 INT179662 Negative_regulation of Mmp12 2 0.33 3.04 0.93
49 INT120697 Negative_regulation of SCNN1G 6 0.32 3.53 0.92
50 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
51 INT87455 Positive_regulation of Gene_expression of Hbegf 5 0.59 1.01 0.86
52 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
53 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
54 INT170156 Phosphorylation of MMP12 3 0.68 0.83 0.75
55 INT190201 Positive_regulation of Phosphorylation of MMP12 1 0.42 0 0.75
56 INT259610 Negative_regulation of Gene_expression of Mmp12 2 0.37 2.22 0.66
57 INT124858 Negative_regulation of Positive_regulation of Col5a1 1 0.01 0.75 0.64
58 INT91831 Gene_expression of HBEGF 2 0.63 1.93 0.6
59 INT117133 Positive_regulation of Localization of Hbegf 3 0.43 0.38 0.59
60 INT179668 Positive_regulation of Gene_expression of Mmp12 6 0.47 4.08 0.58
61 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
62 INT144660 Negative_regulation of Negative_regulation of Hbegf 1 0.21 0 0.53
63 INT91828 Negative_regulation of Gene_expression of HBEGF 1 0.47 0.45 0.52
64 INT190192 Positive_regulation of Transcription of MMP12 1 0.42 0 0.52
65 INT190196 Transcription of MMP12 1 0.58 0 0.51
66 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
67 INT91827 Negative_regulation of Binding of HBEGF 1 0.34 0.44 0.5
68 INT91826 Negative_regulation of HBEGF 1 0.47 0.44 0.5
69 INT86459 Positive_regulation of Positive_regulation of Hbegf 1 0.13 0.1 0.46
70 INT271477 Negative_regulation of Localization of Mmp12 1 0.31 1.71 0.42
71 INT236948 Positive_regulation of Gene_expression of Col5a1 1 0.10 1.15 0.41
72 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
73 INT23637 Negative_regulation of Protein_catabolism of MMP12 1 0.38 0 0.34
74 INT209502 Positive_regulation of HBEGF 1 0.03 2.48 0.33
75 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
76 INT131134 Regulation of Col5a1 1 0.06 0 0.32
77 INT193609 Protein_catabolism of HBEGF 4 0.30 2.77 0.3
78 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
79 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
80 INT86463 Regulation of Gene_expression of Hbegf 1 0.05 0.59 0.26
81 INT78865 Localization of Adam17 1 0.43 0.34 0.23
82 INT115873 Negative_regulation of Col5a1 1 0.06 0 0.22
83 INT120694 Negative_regulation of Gene_expression of SCNN1G 3 0.32 2.08 0.19
84 INT317078 Regulation of SCNN1G 1 0.04 0.58 0.18
85 INT179669 Positive_regulation of Localization of Mmp12 1 0.25 1.09 0.17
86 INT71718 Positive_regulation of Hbegf 4 0.59 0.63 0.16
87 INT189590 Positive_regulation of ACVRL1 3 0.08 1.3 0.16
88 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
89 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
90 INT129100 Negative_regulation of Positive_regulation of Hbegf 1 0.36 0.64 0.14
91 INT196671 Positive_regulation of Positive_regulation of SCNN1G 2 0.04 1.04 0.13
92 INT210224 Localization of Acvrl1 1 0.03 0.33 0.12
93 INT273173 Regulation of Gene_expression of Mmp12 1 0.18 0.56 0.12
94 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
95 INT196674 Transcription of SCNN1G 1 0.04 0.22 0.1
96 INT196692 Positive_regulation of Gene_expression of SCNN1G 2 0.06 0.35 0.09
97 INT120695 Regulation of Gene_expression of SCNN1G 1 0.22 0.77 0.08
98 INT326308 Regulation of Gene_expression of HBEGF 1 0.01 1.48 0.08
99 INT271476 Regulation of Mmp12 1 0.28 0.08 0.08
100 INT196680 Negative_regulation of Positive_regulation of SCNN1G 1 0.04 0.28 0.07
101 INT72601 Gene_expression of ITGA5 3 0.32 0.51 0.06
102 INT271472 Positive_regulation of Positive_regulation of Mmp12 1 0.31 0.32 0.06
103 INT179660 Protein_catabolism of Mmp12 1 0.50 0.75 0.05
104 INT317082 Positive_regulation of Negative_regulation of SCNN1G 1 0.04 0 0.03
105 INT259600 Regulation of Gene_expression of Mmp12 1 0.16 0.88 0.03
106 INT206911 Gene_expression of Msx2 4 0.71 1.26 0
107 INT265340 Binding of Acvrl1 3 0.30 0.46 0
108 INT206909 Negative_regulation of Gene_expression of Msx2 2 0.53 0.29 0
109 INT206916 Positive_regulation of Gene_expression of Msx2 1 0.40 0.36 0
110 INT310166 Regulation of Acvrl1 1 0.07 0 0
111 INT220772 Transcription of Msx2 1 0.46 0.08 0
112 INT310163 Positive_regulation of Positive_regulation of Acvrl1 1 0.08 0 0
113 INT189611 Negative_regulation of Gene_expression of ACVRL1 1 0.06 0.29 0
114 INT317079 Negative_regulation of Binding of SCNN1G 1 0.04 0 0
115 INT297259 Regulation of ACVRL1 1 0.18 0.55 0
116 INT72602 Positive_regulation of Gene_expression of ITGA5 1 0.03 0.16 0
117 INT317080 Binding of SCNN1G 1 0.03 0 0
118 INT72600 Positive_regulation of ITGA5 1 0.03 0.16 0
119 INT91822 Negative_regulation of Gene_expression of Hbegf 1 0.35 0 0
120 INT285394 Binding of Adam17 1 0.31 0.93 0
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