GO:0035326

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Name enhancer binding
Categary Function
Go Slim No
Go Link GO:0035326
Unique Molecular Interactions 83
Total Molecular Interactions 102
Total Single Events 632
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for enhancer binding. They are ordered first by their pain relevance and then by number of times they were reported for enhancer binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT157540 Binding of SP1 and YY1 1 0.41 2.55 1.42
2 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
3 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
4 INT77254 Binding of gr and Sp1 1 0.04 0.4 0.9
5 INT103611 Mdk Negative_regulation of Phosphorylation of Sp1 1 0.01 0.28 0.88
6 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83
7 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78
8 INT157539 Binding of SP1 and Regulation of Gene_expression of OPRM1 1 0.36 1.2 0.72
9 INT98956 Positive_regulation of Binding of NR5A2 and SP1 1 0.00 0 0.7
10 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
11 INT98958 Binding of NR5A2 and SP1 1 0.00 0 0.7
12 INT207547 Sp1 Regulation of Qsox1 1 0.05 0.06 0.67
13 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
14 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62
15 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61
16 INT237453 Binding of STAR and MESP1 1 0.00 0.47 0.42
17 INT89332 Binding of SP1 and SP3 1 0.30 0.76 0.39
18 INT167558 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.03 0.07 0.36
19 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
20 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
21 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
22 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
23 INT96787 SP1 Positive_regulation of GDF15 1 0.08 0.27 0.27
24 INT125515 SP1 Regulation of GDF15 1 0.14 0.47 0.26
25 INT169837 Sp1 Positive_regulation of Gene_expression of Kcnq3 1 0.04 0.08 0.26
26 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26
27 INT169836 Sp1 Positive_regulation of Gene_expression of Kcnq2 1 0.05 0.08 0.26
28 INT260739 Mapk14 Regulation of Positive_regulation of Sp1 1 0.01 1.06 0.25
29 INT189196 RASGRP1 Positive_regulation of SP1 1 0.05 0.63 0.21
30 INT136462 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Sp1 1 0.01 0.65 0.19
31 INT253564 Binding of Lpl and Sp1 1 0.13 0.9 0.14
32 INT200315 Binding of Sp1 and Sp3 1 0.29 0 0.12
33 INT68802 Sp1 Regulation of Gene_expression of Pebp1 1 0.24 0 0.12
34 INT253572 Binding of Csnk2a2 and Sp1 1 0.17 0 0.11
35 INT171163 Creb1 Regulation of Sp1 1 0.03 0.62 0.1
36 INT194822 Negative_regulation of MAPK1 Negative_regulation of Binding of Sp1 1 0.04 0.05 0.1
37 INT253571 Positive_regulation of Binding of Lpl and Sp1 1 0.17 0.42 0.09
38 INT253579 Negative_regulation of Binding of Lpl and Sp1 1 0.15 0.42 0.09
39 INT313509 Binding of ALOX5 and SP1 1 0.07 1.51 0.08
40 INT253577 Csnk2a2 Positive_regulation of Phosphorylation of Sp1 1 0.17 0.37 0.06
41 INT295718 Binding of PTGER2 and Positive_regulation of Positive_regulation of SP1 1 0.02 0.58 0.04
42 INT322891 Sox9 Regulation of Transcription of Col2a1 1 0.10 0.12 0.04
43 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03
44 INT289101 Binding of KCNA1 and LEF1 1 0.00 2.58 0.03
45 INT210260 Sox9 Negative_regulation of Cdx2 1 0.20 0 0.03
46 INT314052 Binding of VEGFA and Sp1 1 0.02 1.25 0.03
47 INT253566 Sp1 Positive_regulation of Lpl 1 0.18 0 0.03
48 INT337402 LEF1 Positive_regulation of E2F1 1 0.11 0 0
49 INT320029 Gene_expression of SOX9 Positive_regulation of Gene_expression of COL7A1 1 0.03 0 0
50 INT245726 SOX9 Regulation of SGCG 1 0.00 0.29 0
51 INT333879 Shc1 Positive_regulation of SOX9 1 0.01 0 0
52 INT225570 Ncoa6 Regulation of Sox9 1 0.16 0.72 0
53 INT183648 Binding of Lef1 and Ctnnd2 1 0.07 1.05 0
54 INT337415 Negative_regulation of MIR203 Positive_regulation of Positive_regulation of LEF1 1 0.03 0.25 0
55 INT337405 MIR203 Regulation of LEF1 1 0.02 0.31 0
56 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0
57 INT337411 Negative_regulation of MIR203 Positive_regulation of Gene_expression of LEF1 1 0.04 0.25 0
58 INT289102 KCNA1 Negative_regulation of Gene_expression of LEF1 1 0.00 0.44 0
59 INT289098 KCNA1 Regulation of LEF1 1 0.00 0.67 0
60 INT215344 Binding of Sp1 and Vdac1 1 0.02 0.1 0
61 INT337417 MIR203 Negative_regulation of LEF1 1 0.04 0.57 0
62 INT220822 Binding of Myc and LEF1 1 0.26 0.08 0
63 INT220766 Binding of MAX and LEF1 1 0.40 0.08 0
64 INT292143 Binding of HIVEP1 and SP1 1 0.01 0.33 0
65 INT245829 Binding of VEGFA and Sp1 1 0.04 0.65 0
66 INT292149 Binding of GTF2B and SP1 1 0.03 0.4 0
67 INT289100 KCNA1 Regulation of Gene_expression of LEF1 1 0.00 0.68 0
68 INT245735 SOX9 Regulation of COL5A2 1 0.07 0.29 0
69 INT215341 Binding of Htt and Sp1 1 0.03 0.25 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for enhancer binding. They are ordered first by their pain relevance and then by number of times they were reported in enhancer binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT41558 Localization of Sp1 9 0.48 0.56 14.9
2 INT24082 Negative_regulation of Sp1 13 0.40 1.19 13.11
3 INT48555 Binding of SP1 30 0.46 11.38 6.53
4 INT41604 Negative_regulation of Localization of Sp1 2 0.30 0.32 5.86
5 INT123411 Gene_expression of Sp1 15 0.69 4.2 3.79
6 INT41559 Positive_regulation of Sp1 7 0.45 2.65 3.24
7 INT123409 Binding of Sp1 20 0.39 3.18 3.15
8 INT103607 Binding of Sp1 7 0.42 1.26 2.92
9 INT93213 Phosphorylation of Sp1 5 0.67 0.93 2.84
10 INT24902 Gene_expression of SP1 17 0.71 8.11 2.58
11 INT23998 Positive_regulation of Sp1 4 0.40 0.51 2.56
12 INT103609 Transcription of Sp1 1 0.11 0.97 2.42
13 INT103608 Negative_regulation of Binding of Sp1 4 0.35 0.69 2.1
14 INT41495 Regulation of Sp1 7 0.42 2.96 2.05
15 INT41557 Gene_expression of Sp1 5 0.68 1.17 2.04
16 INT24906 Negative_regulation of SP1 8 0.40 4.48 1.77
17 INT41605 Positive_regulation of Localization of Sp1 1 0.05 0 1.58
18 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54
19 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47
20 INT123414 Transcription of Sp1 5 0.48 2.2 1.38
21 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31
22 INT94692 Positive_regulation of Gene_expression of Sp1 3 0.17 0.39 1.28
23 INT24000 Regulation of Sp1 2 0.22 1.25 1.27
24 INT134663 Gene_expression of SOX9 40 0.75 9.07 1.2
25 INT48554 Positive_regulation of SP1 12 0.49 3.64 1.2
26 INT93216 Negative_regulation of Phosphorylation of Sp1 2 0.14 0.4 1.13
27 INT237456 Gene_expression of MESP1 1 0.03 1.33 1.12
28 INT123408 Positive_regulation of Gene_expression of Sp1 2 0.62 0.9 0.96
29 INT123407 Negative_regulation of Binding of Sp1 6 0.47 0.72 0.93
30 INT200272 Localization of Sp1 3 0.57 0.06 0.93
31 INT166715 Gene_expression of Sox9 16 0.65 6.39 0.92
32 INT123410 Negative_regulation of Gene_expression of Sp1 3 0.38 1.01 0.82
33 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82
34 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8
35 INT98967 Localization of SP1 2 0.60 0.15 0.66
36 INT24905 Negative_regulation of Gene_expression of SP1 4 0.39 2.05 0.65
37 INT184222 Negative_regulation of SOX9 7 0.41 2.68 0.58
38 INT157103 Transcription of SOX9 6 0.59 1.2 0.58
39 INT126899 Regulation of SP1 5 0.43 2.53 0.57
40 INT157104 Positive_regulation of SOX9 6 0.66 1.66 0.52
41 INT157105 Positive_regulation of Transcription of SOX9 4 0.58 0.88 0.51
42 INT89334 Negative_regulation of Binding of SP1 2 0.47 1.05 0.5
43 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46
44 INT126896 Positive_regulation of Protein_catabolism of SP1 1 0.13 0.99 0.44
45 INT237457 Positive_regulation of Gene_expression of MESP1 1 0.02 0.45 0.4
46 INT126895 Protein_catabolism of SP1 3 0.96 3.59 0.38
47 INT98963 Positive_regulation of Binding of SP1 1 0.43 0 0.37
48 INT166959 Positive_regulation of Positive_regulation of SP1 3 0.46 2.23 0.35
49 INT111230 Transcription of LEF1 3 0.30 1.72 0.33
50 INT136460 Negative_regulation of Sp1 2 0.30 0.99 0.3
51 INT93215 Positive_regulation of Phosphorylation of Sp1 1 0.11 0.09 0.27
52 INT253556 Phosphorylation of Sp1 6 0.44 2.93 0.24
53 INT145303 Regulation of Sox9 2 0.28 0.71 0.22
54 INT245763 Regulation of SOX9 4 0.43 1.68 0.21
55 INT136457 Negative_regulation of Negative_regulation of Sp1 1 0.30 0.65 0.2
56 INT253542 Positive_regulation of Phosphorylation of Sp1 1 0.27 1.16 0.2
57 INT134662 Positive_regulation of Gene_expression of SOX9 9 0.48 1.69 0.19
58 INT178673 Positive_regulation of Gene_expression of SP1 1 0.08 0.14 0.16
59 INT211949 Negative_regulation of Sox9 1 0.31 0.83 0.12
60 INT173632 Transcription of SP1 7 0.41 1.42 0.09
61 INT184220 Negative_regulation of Gene_expression of SOX9 4 0.36 0.58 0.09
62 INT322523 Regulation of Transcription of SP1 1 0.11 0.15 0.09
63 INT211948 Regulation of Gene_expression of Sox9 2 0.33 0.94 0.08
64 INT210242 Positive_regulation of Sox9 3 0.43 0.35 0.06
65 INT211939 Regulation of Sox9 1 0.33 0.35 0.06
66 INT220802 Binding of LEF1 7 0.36 3.86 0.04
67 INT289116 Positive_regulation of Localization of LEF1 2 0.22 1.19 0.04
68 INT289110 Localization of LEF1 2 0.32 1.19 0.04
69 INT194474 Positive_regulation of Binding of Sp1 1 0.03 0.6 0.04
70 INT194476 Regulation of Binding of Sp1 1 0.02 0.6 0.04
71 INT225365 Binding of Sox9 2 0.28 0.48 0.03
72 INT145302 Positive_regulation of Sox9 2 0.48 1.42 0.03
73 INT162339 Regulation of Gene_expression of SOX9 4 0.32 0.42 0
74 INT245757 Localization of SOX9 4 0.62 0.8 0
75 INT211945 Negative_regulation of Gene_expression of Sox9 3 0.44 0.63 0
76 INT173623 Positive_regulation of Transcription of SP1 3 0.30 0.95 0
77 INT289127 Positive_regulation of LEF1 2 0.22 0.76 0
78 INT322883 Regulation of Transcription of Sox9 1 0.43 0.18 0
79 INT173637 Negative_regulation of Positive_regulation of SP1 1 0.05 0.27 0
80 INT136453 Protein_catabolism of Sp1 1 0.70 0.15 0
81 INT337456 Positive_regulation of Binding of LEF1 1 0.22 0 0
82 INT292205 Phosphorylation of SP1 1 0.21 0.07 0
83 INT234916 Gene_expression of Lef1 1 0.04 0.25 0
84 INT211943 Transcription of Sox9 1 0.50 0.3 0
85 INT323815 Negative_regulation of Transcription of SOX9 1 0.41 0.18 0
86 INT289129 Positive_regulation of Gene_expression of LEF1 1 0.13 0.76 0
87 INT322886 Transcription of Sox9 1 0.50 0.25 0
88 INT145307 Positive_regulation of Positive_regulation of Sox9 1 0.48 0.07 0
89 INT337461 Positive_regulation of Transcription of LEF1 1 0.22 0.26 0
90 INT245752 Positive_regulation of Binding of SOX9 1 0.41 0.48 0
91 INT289108 Negative_regulation of Transcription of LEF1 1 0.11 0.32 0
92 INT245765 Binding of SOX9 1 0.31 0.87 0
93 INT312245 Positive_regulation of Localization of SOX9 1 0.10 0 0
94 INT136455 Positive_regulation of Protein_catabolism of Sp1 1 0.49 0.15 0
95 INT220775 Binding of Lef1 1 0.20 0.06 0
96 INT352010 Protein_catabolism of Sox9 1 0.22 0.07 0
97 INT308349 Positive_regulation of Gene_expression of Sox9 1 0.40 0.69 0
98 INT78107 Regulation of Positive_regulation of SP1 1 0.32 0.1 0
99 INT289124 Negative_regulation of Positive_regulation of LEF1 1 0.11 0.34 0
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