GO:0035359

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Name negative regulation of peroxisome proliferator activated receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0035359
Unique Molecular Interactions 67
Total Molecular Interactions 84
Total Single Events 701
Pain Genes Associated 2

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of peroxisome proliferator activated receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of peroxisome proliferator activated receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48881 TWIST1 Positive_regulation of Localization of Abat 1 0.02 0.44 1.29
2 INT275097 Twist1 Regulation of Ltp 1 0.01 0.37 0.96
3 INT142709 Binding of TWIST1 and CEBPZ 2 0.17 1.16 0.95
4 INT243626 Twist1 Regulation of Hand1 1 0.15 1.55 0.72
5 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
6 INT102864 Prkaca Regulation of Twist1 1 0.48 0.05 0.58
7 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47
8 INT117531 Twist1 Regulation of CSAD 1 0.00 0.85 0.47
9 INT102862 Prkaca Regulation of Phosphorylation of Twist1 1 0.19 0.1 0.42
10 INT152158 NENF Regulation of TWIST1 1 0.01 0.33 0.4
11 INT243627 Twist1 Regulation of Gene_expression of Ik 1 0.01 0.13 0.34
12 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
13 INT243641 Twist1 Positive_regulation of Socs1 1 0.14 0.13 0.31
14 INT243634 Twist1 Regulation of Socs1 1 0.14 0.13 0.31
15 INT243625 Stat4 Positive_regulation of Gene_expression of Twist1 1 0.39 0.75 0.3
16 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
17 INT275092 Twist1 Regulation of stm 1 0.00 0 0.25
18 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
19 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
20 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16
21 INT219601 Pde4a Negative_regulation of Twist1 1 0.10 0 0.16
22 INT219598 Pde4a Negative_regulation of Gene_expression of Twist1 1 0.10 0 0.16
23 INT208458 TWIST1 Positive_regulation of Localization of Bdnf 1 0.01 0.19 0.15
24 INT301414 Binding of Enpp2 and Twist1 1 0.08 1.26 0.13
25 INT243642 Binding of Nfatc1 and Twist1 1 0.08 0.23 0.12
26 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1
27 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1
28 INT340505 Binding of Twist1 and Mgat4b 1 0.01 0.45 0.08
29 INT350909 Binding of Pcsk4 and Twist1 1 0.02 1.91 0.08
30 INT350908 Binding of Bcl2 and Twist1 1 0.04 1.9 0.08
31 INT273372 IL6 Regulation of Regulation of TWIST1 1 0.10 0.1 0.07
32 INT273366 IL6 Regulation of TWIST1 1 0.06 0.1 0.07
33 INT84751 Binding of HRAS and TWIST1 1 0.29 2.6 0.07
34 INT349886 Negative_regulation of Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
35 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
36 INT349887 Binding of Pcyt1a and Twist1 1 0.02 1.21 0.06
37 INT273353 Pde4d Regulation of Gene_expression of Twist1 1 0.26 0.25 0.05
38 INT243633 Il23a Positive_regulation of Gene_expression of Twist1 1 0.14 0.11 0.05
39 INT233849 Twist1 Positive_regulation of Snai2 1 0.07 0.58 0.04
40 INT233852 Twist1 Positive_regulation of Snai1 1 0.02 0.58 0.04
41 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
42 INT233851 Twist1 Positive_regulation of Zeb1 1 0.06 0.58 0.04
43 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
44 INT233854 Twist1 Positive_regulation of Itk 1 0.03 0.58 0.04
45 INT243636 Stat1 Positive_regulation of Gene_expression of Twist1 1 0.46 0.05 0.03
46 INT301413 Positive_regulation of Binding of Enpp2 and Twist1 1 0.11 0.18 0.03
47 INT301415 Positive_regulation of Binding of Twist1 and IL19 1 0.11 0.18 0.03
48 INT301416 Binding of Twist1 and IL19 1 0.08 0.18 0.03
49 INT301408 Positive_regulation of Binding of Enpp1 and Twist1 1 0.06 0.18 0.03
50 INT301406 Binding of Enpp1 and Twist1 1 0.04 0.18 0.03
51 INT235800 Twist1 Positive_regulation of VEGFA 1 0.02 0.62 0.03
52 INT209580 Twist1 Positive_regulation of Localization of VEGFA 1 0.05 0.53 0
53 INT280164 Twist1 Negative_regulation of Mod2 1 0.06 1.76 0
54 INT273770 VEGFA Negative_regulation of Localization of Twist1 1 0.07 0.58 0
55 INT350906 Twist1 Positive_regulation of Gene_expression of Cd4 1 0.10 1.49 0
56 INT286988 Twist1 Positive_regulation of EGFR 1 0.17 2.01 0
57 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
58 INT121479 Twist1 Negative_regulation of Ins1 1 0.10 0 0
59 INT286188 Twist1 Positive_regulation of Serpina5 1 0.02 0 0
60 INT350907 Twist1 Positive_regulation of Gene_expression of Cd7 1 0.05 1.49 0
61 INT280166 Binding of MAPK8 and Twist1 1 0.19 0.78 0
62 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
63 INT243624 Stat6 Negative_regulation of Gene_expression of Twist1 1 0.30 0 0
64 INT280167 Twist1 Positive_regulation of MAPK8 1 0.29 0.94 0
65 INT280163 Twist1 Positive_regulation of Mod2 1 0.07 1.67 0
66 INT326726 Twist1 Regulation of Itk 1 0.02 0.84 0
67 INT260529 Twist1 Positive_regulation of Gene_expression of Vegfa 1 0.04 0.54 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of peroxisome proliferator activated receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of peroxisome proliferator activated receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT79395 Gene_expression of Twist1 193 0.77 100.06 26.34
2 INT10874 Negative_regulation of Twist1 89 0.50 36.84 11.32
3 INT43820 Positive_regulation of Twist1 75 0.59 42.15 8.47
4 INT136664 Positive_regulation of Gene_expression of Twist1 49 0.69 25.91 5.41
5 INT94028 Regulation of Twist1 37 0.44 22.41 5.33
6 INT64766 Gene_expression of TWIST1 41 0.76 37.89 3.4
7 INT116540 Binding of Twist1 35 0.48 16.32 2.85
8 INT48880 Positive_regulation of TWIST1 15 0.59 8.6 1.98
9 INT102861 Phosphorylation of Twist1 6 0.70 0.86 1.81
10 INT180238 Regulation of Gene_expression of Twist1 13 0.61 4.87 1.59
11 INT102860 Positive_regulation of Phosphorylation of Twist1 1 0.35 0.15 1.42
12 INT10873 Localization of Twist1 21 0.74 10.43 1.37
13 INT219579 Negative_regulation of Gene_expression of Twist1 12 0.43 9.07 1.36
14 INT243621 Transcription of Twist1 13 0.71 4.08 1.23
15 INT141475 Negative_regulation of Gene_expression of TWIST1 5 0.41 3.94 0.97
16 INT243616 Positive_regulation of Transcription of Twist1 6 0.69 2.09 0.6
17 INT140436 Binding of TWIST1 5 0.39 2.34 0.47
18 INT231199 Positive_regulation of Localization of Twist1 3 0.50 1.45 0.38
19 INT121475 Regulation of Negative_regulation of Twist1 3 0.14 2.43 0.24
20 INT135054 Negative_regulation of Negative_regulation of Twist1 2 0.42 0.46 0.17
21 INT102354 Localization of TWIST1 3 0.75 0.17 0.15
22 INT186632 Regulation of TWIST1 4 0.37 5.28 0.14
23 INT273333 Negative_regulation of Regulation of Twist1 1 0.18 0.3 0.12
24 INT350900 Protein_catabolism of Twist1 1 0.22 0.78 0.05
25 INT273406 Positive_regulation of Gene_expression of TWIST1 4 0.57 8.42 0.04
26 INT141476 Regulation of Gene_expression of TWIST1 2 0.50 2.57 0.04
27 INT149440 Negative_regulation of TWIST1 4 0.41 1.5 0
28 INT263106 Positive_regulation of Binding of Twist1 3 0.35 1.21 0
29 INT280152 Positive_regulation of Positive_regulation of Twist1 3 0.43 1.95 0
30 INT304047 Positive_regulation of Transcription of TWIST1 1 0.10 0.57 0
31 INT338245 Positive_regulation of Positive_regulation of TWIST1 1 0.38 2.95 0
32 INT280151 Positive_regulation of Regulation of Twist1 1 0.41 0.67 0
33 INT349880 Regulation of Binding of Twist1 1 0.31 0.98 0
34 INT349873 Regulation of Regulation of Twist1 1 0.31 0.97 0
35 INT275080 Positive_regulation of Negative_regulation of Twist1 1 0.05 0.11 0
36 INT243609 Negative_regulation of Transcription of Twist1 1 0.42 0 0
37 INT243602 Regulation of Localization of Twist1 1 0.45 0 0
38 INT273393 Phosphorylation of TWIST1 1 0.16 0.4 0
39 INT304055 Transcription of TWIST1 1 0.14 0.57 0
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