GO:0035418

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Name protein localization to synapse
Categary Process
Go Slim No
Go Link GO:0035418
Unique Molecular Interactions 166
Total Molecular Interactions 291
Total Single Events 1110
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein localization to synapse. They are ordered first by their pain relevance and then by number of times they were reported for protein localization to synapse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT296275 Binding of Dlg4 and Kcnip3 1 0.39 3.58 5.6
2 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
3 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
4 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
5 INT156380 Regulation of Binding of Grin1 and Dlg4 1 0.29 0.32 0.97
6 INT120820 Binding of ASIC3 and Dlg4 3 0.02 0.11 0.84
7 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
8 INT152947 Dlg4 Regulation of Sgk1 1 0.09 0.18 0.76
9 INT152945 Dlg4 Regulation of Cap1 1 0.11 0.18 0.76
10 INT152949 Homer1 Regulation of Sgk1 1 0.28 0.18 0.76
11 INT152946 Homer1 Regulation of Cap1 1 0.32 0.18 0.76
12 INT152948 Homer1 Regulation of Gpr88 1 0.36 0.18 0.75
13 INT152944 Dlg4 Regulation of Gpr88 1 0.12 0.18 0.75
14 INT168205 Binding of Dlg4 and Pik3cd 1 0.11 0.37 0.65
15 INT251141 Binding of Dlg4 and Grin2b 1 0.14 0.32 0.55
16 INT152282 Binding of Accn1 and Trpv1 1 0.10 0.42 0.49
17 INT81064 Negative_regulation of Nts Negative_regulation of Gene_expression of Homer1 1 0.01 0 0.48
18 INT263746 Binding of Dlg4 and Neto1 1 0.27 0 0.48
19 INT198931 Binding of Dlg4 and Lrp8 1 0.06 0.23 0.46
20 INT354218 Igfbp7 Positive_regulation of Accn1 1 0.04 0.74 0.44
21 INT296477 Binding of Cacng2 and Dlg4 1 0.04 0.22 0.42
22 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42
23 INT283714 Positive_regulation of Binding of Id2 and Homer1 1 0.08 1.34 0.42
24 INT283713 Binding of Id2 and Homer1 1 0.06 1.34 0.42
25 INT120821 Dlg4 Positive_regulation of ASIC3 1 0.02 0 0.36
26 INT140802 Accn2 Regulation of Transcription of Accn1 1 0.24 0 0.36
27 INT272602 Binding of Dlg4 and Gria2 3 0.09 0.19 0.34
28 INT120817 Binding of Dlg4 and Lin7b 1 0.00 0 0.34
29 INT296465 Binding of Dlg4 and Rbm39 1 0.00 0.05 0.34
30 INT283841 Dlg4 Negative_regulation of Insrr 1 0.01 0.95 0.33
31 INT198779 Binding of Dlg4 and Psd 10 0.25 0.09 0.31
32 INT135425 Binding of Dlg4 and Dlg3 1 0.29 0.07 0.28
33 INT274944 Binding of Dlg4 and Pick1 1 0.04 0 0.28
34 INT274939 Binding of Dlg4 and Ephb6 1 0.12 0 0.25
35 INT208037 Binding of Accn1 and Accn3 1 0.15 0.3 0.25
36 INT208036 Binding of Cnga3 and Accn1 1 0.01 0.3 0.25
37 INT263787 Binding of GRIN1 and Dlg4 3 0.18 0.05 0.23
38 INT198776 Binding of Dlg4 and Psds1 1 0.11 0.05 0.23
39 INT150582 Creb1 Positive_regulation of Gene_expression of Homer1 1 0.00 0 0.22
40 INT354217 Arc Positive_regulation of Accn1 1 0.01 0.29 0.21
41 INT174679 Homer1 Regulation of Luc7l3 1 0.02 0.67 0.21
42 INT354211 Igfbp7 Positive_regulation of Gene_expression of Accn1 1 0.04 0.29 0.2
43 INT354216 Binding of Accn3 and Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
44 INT354225 Accn3 Positive_regulation of Gene_expression of Accn1 1 0.06 0.29 0.2
45 INT354214 Arc Positive_regulation of Gene_expression of Accn1 1 0.01 0.29 0.2
46 INT273099 Bdnf Positive_regulation of Localization of Dlg4 1 0.21 0.07 0.18
47 INT261518 Binding of DLG4 and HTR4 1 0.01 0 0.16
48 INT58179 Gtf3a Positive_regulation of Gene_expression of Homer1 1 0.07 0.1 0.16
49 INT261520 Binding of DLG4 and HTR2A 1 0.06 0 0.14
50 INT272605 Binding of Dlg4 and Nsf 1 0.36 0.41 0.14
51 INT303172 Binding of Dlgap1 and Trim3 1 0.22 0.13 0.13
52 INT354705 Binding of ASIC2 and Dlg4 1 0.00 0.11 0.12
53 INT265982 Homer1 Regulation of Grm5 1 0.04 0.38 0.12
54 INT354698 Binding of Dlg4 and Gopc 1 0.02 0.11 0.12
55 INT354717 Binding of ASIC1 and Dlg4 1 0.02 0 0.11
56 INT303179 Binding of Dlgap1 and Shank1 1 0.22 0.31 0.1
57 INT101880 Oxt Positive_regulation of Gene_expression of Homer1 1 0.23 0.14 0.1
58 INT303166 Binding of Dlgap1 and Psd 1 0.08 0.31 0.1
59 INT272265 Binding of Dlg4 and Grip2 1 0.02 0 0.09
60 INT265981 Homer1 Regulation of Localization of Grm5 1 0.04 0.06 0.09
61 INT303180 Trim3 Negative_regulation of Shank1 1 0.40 0 0.09
62 INT263764 Dlg4 Regulation of Localization of Grin2a 1 0.16 0.17 0.07
63 INT263741 Grin2b Regulation of Localization of Dlg4 1 0.17 0.17 0.07
64 INT263784 Dlg4 Regulation of Localization of Grin1 1 0.17 0.17 0.07
65 INT272595 Binding of Dlg4 and Dnahc8 1 0.03 0.21 0.07
66 INT265983 Homer1 Regulation of Ryr1 1 0.37 0.15 0.07
67 INT263734 Dlg4 Regulation of Localization of Vamp2 1 0.15 0.17 0.07
68 INT263742 Grin1 Regulation of Localization of Dlg4 1 0.19 0.17 0.07
69 INT303176 Gene_expression of Trim3 Positive_regulation of Protein_catabolism of Shank1 1 0.44 0 0.07
70 INT244022 Binding of Nrxn1 and Nlgn4l 1 0.00 0.21 0.07
71 INT263771 Grin2a Regulation of Localization of Dlg4 1 0.19 0.17 0.07
72 INT263722 Dlg4 Regulation of Localization of Grin2b 1 0.15 0.17 0.07
73 INT263740 Dlg4 Regulation of Localization of Gria2 1 0.11 0.17 0.07
74 INT263724 Positive_regulation of Binding of Dlg4 and Neto1 1 0.28 0 0.06
75 INT346754 Binding of Dlg4 and Gria2 1 0.02 0 0.06
76 INT263751 Binding of Dlg4 and Spna1 1 0.03 0 0.05
77 INT303177 Trim3 Positive_regulation of Protein_catabolism of Dlgap1 1 0.41 0.13 0.05
78 INT263778 Localization of Neto1 Regulation of Localization of Dlg4 1 0.26 0.18 0.05
79 INT303249 Binding of LILRA3 and Dlgap1 1 0.01 0.13 0.05
80 INT272598 Dlg4 Positive_regulation of Gene_expression of Gria2 1 0.03 0.53 0.04
81 INT272593 Dlg4 Positive_regulation of Clc 1 0.11 0.54 0.04
82 INT354963 Binding of Cttn and Shank1 1 0.12 0 0.04
83 INT354971 Binding of HOMER1 and Shank1 1 0.01 0 0.04
84 INT272591 Dlg4 Positive_regulation of Gene_expression of Clybl 1 0.09 0.53 0.04
85 INT272590 Dlg4 Positive_regulation of Clybl 1 0.09 0.52 0.04
86 INT272599 Dlg4 Positive_regulation of Gene_expression of Clc 1 0.11 0.54 0.04
87 INT303170 Gene_expression of Trim3 Negative_regulation of Shank1 1 0.40 0.12 0.04
88 INT272603 Binding of Dlg4 and Nlgn2 1 0.23 0 0.03
89 INT272600 Binding of Dlg4 and Grik5 1 0.20 0 0.03
90 INT272597 Binding of Dlg4 and Kcna4 1 0.17 0 0.03
91 INT263788 Positive_regulation of Binding of GRIN1 and Dlg4 1 0.24 0 0.03
92 INT272596 Binding of Dlg4 and Lrp1 1 0.16 0 0.03
93 INT272606 Binding of Dlg4 and Grin2c 1 0.18 0 0.03
94 INT272604 Binding of Dlg4 and Nlgn3 1 0.17 0 0.03
95 INT272601 Binding of Dlg4 and Grik2 1 0.22 0 0.03
96 INT272594 Binding of Dlg4 and Shank1 1 0.20 0 0.03
97 INT272609 Binding of Cit and Dlg4 1 0.11 0 0.03
98 INT198780 Regulation of Binding of Dlg4 and Psd 1 0.14 0 0.03
99 INT303159 Trim3 Negative_regulation of Gene_expression of Shank1 1 0.40 0 0
100 INT346742 Binding of Cacng2 and Dlg4 1 0.03 0 0
101 INT263791 Binding of DLG3 and Dlg4 1 0.20 0 0
102 INT303181 Trim3 Negative_regulation of Gene_expression of Dlgap1 1 0.26 0 0
103 INT272592 Binding of Dlg4 and Sh3 1 0.11 0.13 0
104 INT132849 Homer1 Regulation of Srf 1 0.01 0.15 0
105 INT287609 Fmr1 Regulation of Protein_catabolism of Dlg4 1 0.05 0.06 0
106 INT303158 Trim3 Positive_regulation of Dlgap1 1 0.28 0 0
107 INT263726 Binding of Dlg1 and Dlg4 1 0.04 0 0
108 INT303251 HMBS Positive_regulation of Protein_catabolism of Dlgap1 1 0.01 0 0
109 INT303185 Binding of Shank1 and Trim3 1 0.35 0 0
110 INT303164 Trim3 Regulation of Gene_expression of Dlgap1 1 0.37 0 0
111 INT303162 Trim3 Positive_regulation of Regulation of Dlgap1 1 0.41 0.07 0
112 INT303174 Trim3 Regulation of Binding of Dlgap1 1 0.27 0 0
113 INT272610 Binding of NA and Dlg4 1 0.41 0.13 0
114 INT287077 Chrm2 Positive_regulation of Homer1 1 0.05 0.08 0
115 INT303175 Trim3 Positive_regulation of Negative_regulation of Dlgap1 1 0.28 0 0
116 INT303157 Trim3 Regulation of Dlgap1 1 0.32 0.22 0
117 INT303161 Gene_expression of Trim3 Positive_regulation of Shank1 1 0.44 0 0
118 INT354966 Binding of Rapsn and Dlgap1 1 0.01 0.09 0
119 INT313272 Binding of DLG4 and GRIN1 1 0.09 0.06 0
120 INT354967 Binding of Psd and Dlgap1 1 0.15 0.09 0
121 INT303245 Rnf123 Positive_regulation of Protein_catabolism of Dlgap1 1 0.01 0 0
122 INT346747 Binding of Dlg4 and Shisa9 1 0.01 0 0
123 INT303178 Trim3 Negative_regulation of Dlgap1 1 0.35 0 0
124 INT208051 Binding of SNRNP70 and Accn1 1 0.01 1.81 0
125 INT303169 Trim3 Regulation of Gene_expression of Shank1 1 0.42 0 0
126 INT272264 Dlg4 Regulation of Psd 1 0.22 0.09 0
127 INT346744 Binding of Dlg4 and Tinagl1 1 0.03 0 0
128 INT303171 Binding of Myo5b and Dlgap1 1 0.08 0 0
129 INT303250 Binding of DYNC1LI1 and Dlgap1 1 0.00 0 0
130 INT303168 Binding of Myc and Dlgap1 1 0.10 0 0
131 INT287619 Fmr1 Regulation of Dlg4 1 0.12 0.06 0
132 INT303163 Shank1 Positive_regulation of Trim3 1 0.47 0 0
133 INT303173 Negative_regulation of Trim3 Negative_regulation of Shank1 1 0.40 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein localization to synapse. They are ordered first by their pain relevance and then by number of times they were reported in protein localization to synapse. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67
2 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98
3 INT47818 Positive_regulation of Homer1 48 0.70 11.11 24.05
4 INT97100 Negative_regulation of Dlg4 16 0.58 6.18 14.36
5 INT88789 Gene_expression of Dlg4 26 0.78 4.41 12.74
6 INT68290 Gene_expression of Accn1 32 0.73 7.36 11.23
7 INT60995 Negative_regulation of Positive_regulation of Homer1 9 0.38 1.63 9.63
8 INT15242 Regulation of Gene_expression of Homer1 14 0.62 4.33 9.28
9 INT108643 Gene_expression of Dlg4 61 0.76 8.63 8.58
10 INT97099 Positive_regulation of Dlg4 13 0.60 3.04 6.98
11 INT88786 Binding of Dlg4 11 0.46 2.73 6.58
12 INT53974 Regulation of Homer1 14 0.39 4.71 4.9
13 INT88790 Negative_regulation of Gene_expression of Dlg4 6 0.59 1.53 4.66
14 INT81086 Positive_regulation of Accn1 8 0.65 7.51 4.62
15 INT145532 Localization of Dlg4 25 0.79 1.97 4.36
16 INT88787 Transcription of Dlg4 4 0.69 0.83 4.09
17 INT120810 Binding of Dlg4 38 0.41 3.55 4.03
18 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77
19 INT60714 Regulation of Positive_regulation of Homer1 3 0.04 0.64 3.46
20 INT58173 Negative_regulation of Homer1 5 0.43 1 2.79
21 INT72253 Positive_regulation of Accn1 8 0.63 2.64 2.73
22 INT82278 Positive_regulation of Positive_regulation of Homer1 5 0.13 2.32 2.73
23 INT75551 Localization of Accn1 6 0.68 1.75 2.58
24 INT72254 Gene_expression of Accn1 9 0.71 3.24 2.46
25 INT136190 Transcription of Accn1 5 0.61 2.75 2.24
26 INT134874 Regulation of Dlg4 3 0.58 0.28 2.12
27 INT99951 Regulation of Accn1 5 0.26 2.65 2.1
28 INT165083 Positive_regulation of Positive_regulation of Accn1 1 0.47 3.91 2.07
29 INT198748 Regulation of Gene_expression of Dlg4 10 0.44 2.16 1.85
30 INT61845 Transcription of Homer1 9 0.72 2.28 1.85
31 INT63520 Localization of Homer1 4 0.75 0.38 1.63
32 INT119219 Localization of Dlg4 3 0.64 0.16 1.5
33 INT152939 Regulation of Dlg4 9 0.60 1.09 1.49
34 INT134873 Phosphorylation of Dlg4 3 0.80 0.5 1.42
35 INT159464 Negative_regulation of Accn1 4 0.37 1.07 1.41
36 INT82279 Regulation of Negative_regulation of Homer1 1 0.02 0 1.36
37 INT97098 Regulation of Negative_regulation of Dlg4 3 0.45 0.97 1.3
38 INT72250 Binding of Accn1 3 0.44 2.87 1.27
39 INT91914 Binding of Accn1 3 0.36 0.44 1.24
40 INT128413 Positive_regulation of Shank1 2 0.70 0.61 1.16
41 INT198750 Positive_regulation of Gene_expression of Dlg4 5 0.68 0.6 1.02
42 INT128411 Regulation of Shank1 2 0.45 0.81 0.95
43 INT134876 Negative_regulation of Phosphorylation of Dlg4 1 0.35 0.27 0.93
44 INT134878 Negative_regulation of Negative_regulation of Dlg4 1 0.35 0.27 0.93
45 INT9797 Binding of Homer1 2 0.48 1.14 0.9
46 INT68289 Positive_regulation of Gene_expression of Accn1 2 0.45 0.34 0.83
47 INT143673 Regulation of Gene_expression of Accn1 4 0.43 0.81 0.78
48 INT169844 Positive_regulation of Localization of Dlg4 2 0.49 0.07 0.75
49 INT353369 Regulation of Localization of Dlg4 1 0.23 0 0.69
50 INT156376 Negative_regulation of Transcription of Dlg4 1 0.56 0.16 0.65
51 INT76505 Positive_regulation of Transcription of Homer1 3 0.21 0.48 0.59
52 INT84854 Regulation of Transcription of Homer1 1 0.00 0.15 0.57
53 INT327689 Regulation of Dlgap1 1 0.21 0 0.56
54 INT198749 Negative_regulation of Dlg4 8 0.53 2.14 0.54
55 INT198744 Negative_regulation of Gene_expression of Dlg4 6 0.42 1.73 0.54
56 INT243864 Gene_expression of DLG4 5 0.34 0.22 0.54
57 INT153321 Positive_regulation of Gene_expression of Dlg4 3 0.49 0.31 0.53
58 INT92523 Phosphorylation of Homer1 3 0.63 0.15 0.52
59 INT156377 Regulation of Binding of Dlg4 1 0.43 0.17 0.51
60 INT198755 Positive_regulation of Dlg4 7 0.59 0.6 0.5
61 INT208024 Negative_regulation of Binding of Accn1 1 0.39 1.26 0.5
62 INT166767 Negative_regulation of Gene_expression of Accn1 1 0.12 0.13 0.44
63 INT303211 Gene_expression of Shank1 1 0.64 0.48 0.4
64 INT140798 Localization of Accn1 3 0.76 0.24 0.34
65 INT303237 Positive_regulation of Gene_expression of Dlgap1 1 0.27 0.45 0.34
66 INT119656 Regulation of Accn1 1 0.31 0.2 0.33
67 INT140800 Negative_regulation of Gene_expression of Accn1 1 0.40 0.08 0.33
68 INT296258 Negative_regulation of Localization of Dlg4 1 0.32 0 0.32
69 INT285182 Negative_regulation of Accn1 1 0.04 1.06 0.31
70 INT303203 Gene_expression of Dlgap1 1 0.41 0.32 0.3
71 INT91915 Negative_regulation of Binding of Accn1 1 0.19 0 0.25
72 INT272255 Regulation of Positive_regulation of Dlg4 1 0.39 0.06 0.19
73 INT243875 Positive_regulation of Gene_expression of DLG4 1 0.30 0.22 0.19
74 INT272253 Negative_regulation of Regulation of Dlg4 1 0.37 0 0.18
75 INT303213 Binding of Dlgap1 1 0.26 0 0.17
76 INT303216 Protein_catabolism of Shank1 1 0.83 0 0.15
77 INT243883 Negative_regulation of DLG4 1 0.19 0.07 0.15
78 INT198738 Protein_catabolism of Dlg4 5 0.97 0.06 0.12
79 INT243912 Gene_expression of Nlgn2 2 0.37 0.22 0.12
80 INT303223 Protein_catabolism of Dlgap1 1 0.53 0.12 0.11
81 INT303217 Binding of Shank1 1 0.36 0 0.11
82 INT303233 Negative_regulation of Gene_expression of Shank1 1 0.49 0.07 0.1
83 INT272257 Positive_regulation of Localization of Dlg4 1 0.43 0 0.1
84 INT251222 Localization of Nlgn2 1 0.20 0 0.1
85 INT303212 Positive_regulation of Protein_catabolism of Shank1 1 0.42 0 0.08
86 INT156437 Binding of DLG4 2 0.35 0.29 0.07
87 INT208021 Positive_regulation of Gene_expression of Accn1 1 0.63 0.21 0.07
88 INT303152 Protein_catabolism of Dlgap1 1 0.28 0 0.07
89 INT243988 Binding of Nrxn1 1 0.01 0.21 0.07
90 INT272574 Gene_expression of Shank1 2 0.61 0.22 0.06
91 INT303195 Positive_regulation of Gene_expression of Shank1 1 0.42 0.08 0.06
92 INT243932 Gene_expression of Nrxn1 1 0.02 0.28 0.06
93 INT79048 Positive_regulation of Localization of Accn1 2 0.46 0.45 0.05
94 INT100988 Regulation of Gene_expression of Dlg4 1 0.36 0.06 0.05
95 INT303230 Negative_regulation of Dlgap1 1 0.23 0.07 0.05
96 INT303234 Regulation of Dlgap1 1 0.33 0.21 0.05
97 INT303214 Positive_regulation of Dlgap1 1 0.37 0.31 0.04
98 INT198746 Regulation of Protein_catabolism of Dlg4 1 0.26 0 0.04
99 INT303204 Negative_regulation of Shank1 1 0.42 0.11 0.04
100 INT303210 Positive_regulation of Positive_regulation of Dlgap1 1 0.22 0.06 0.04
101 INT272252 Regulation of Phosphorylation of Dlg4 1 0.44 0 0.04
102 INT263696 Transcription of Dlg4 2 0.68 0.07 0
103 INT303227 Regulation of Negative_regulation of Shank1 1 0.26 0 0
104 INT354950 Gene_expression of Dlgap1 1 0.47 0.29 0
105 INT354940 Negative_regulation of Gene_expression of Dlgap1 1 0.30 0.57 0
106 INT272578 Phosphorylation of Dlg4 1 0.69 0 0
107 INT348166 Localization of DLG4 1 0.11 1.13 0
108 INT303221 Negative_regulation of Negative_regulation of Dlgap1 1 0.23 0 0
109 INT303225 Negative_regulation of Gene_expression of Dlgap1 1 0.23 0 0
110 INT198741 Negative_regulation of Binding of Dlg4 1 0.36 0 0
111 INT303202 Negative_regulation of Protein_catabolism of Shank1 1 0.49 0 0
112 INT303224 Positive_regulation of Protein_catabolism of Dlgap1 1 0.37 0 0
113 INT303209 Positive_regulation of Positive_regulation of Shank1 1 0.34 0 0
114 INT303218 Positive_regulation of Negative_regulation of Dlgap1 1 0.25 0 0
115 INT263677 Positive_regulation of Binding of Dlg4 1 0.21 0 0
116 INT198745 Regulation of Binding of Dlg4 1 0.44 0 0
117 INT303207 Regulation of Protein_catabolism of Dlgap1 1 0.14 0 0
118 INT303201 Phosphorylation of Dlgap1 1 0.44 0 0
119 INT303193 Localization of Shank1 1 0.62 0.19 0
120 INT303199 Regulation of Gene_expression of Shank1 1 0.23 0 0
121 INT208022 Regulation of Gene_expression of Accn1 1 0.41 0.13 0
122 INT354939 Positive_regulation of Gene_expression of Shank1 1 0.45 0.14 0
123 INT303232 Regulation of Protein_catabolism of Shank1 1 0.38 0 0
124 INT303205 Positive_regulation of Phosphorylation of Dlgap1 1 0.37 0 0
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