GO:0035556

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Name intracellular signal transduction
Categary Process
Go Slim No
Go Link GO:0035556
Unique Molecular Interactions 3368
Total Molecular Interactions 4364
Total Single Events 34747
Pain Genes Associated 214

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for intracellular signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for intracellular signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73
2 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
3 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
4 INT296484 Binding of Gria2 and GRIP1 1 0.04 4.52 4.59
5 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
6 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16
7 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
8 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
9 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
10 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
11 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
12 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47
13 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
14 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
15 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
16 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
17 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08
18 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
19 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
20 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
21 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
22 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
23 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
24 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
25 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
26 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
27 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
28 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
29 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
30 INT111787 Cck Regulation of Gene_expression of Npr1 1 0.22 1.68 2.57
31 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5
32 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
33 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
34 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
35 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
36 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
37 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
38 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33
39 INT211748 Binding of Pag1 and Mors1 2 0.07 0.2 2.26
40 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
41 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
42 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
43 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
44 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
45 INT33756 Akr1d1 Positive_regulation of Npr1 3 0.01 0 2.05
46 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
47 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
48 INT21261 Penk Negative_regulation of Npr1 1 0.02 0 2
49 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
50 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
51 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
52 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
53 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
54 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
55 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
56 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
57 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86
58 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
59 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
60 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
61 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
62 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
63 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
64 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
65 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
66 INT68709 Positive_regulation of Crh Regulation of Npr1 1 0.03 0 1.71
67 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
68 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
69 INT68710 Crh Regulation of Npr1 1 0.03 0 1.7
70 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
71 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
72 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
73 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
74 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
75 INT96296 Oprm1 Negative_regulation of Npr1 2 0.05 0.32 1.65
76 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
77 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
78 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
79 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
80 INT33757 Hmmr Positive_regulation of Npr1 1 0.01 0 1.59
81 INT111076 Psen1 Regulation of Psenen 1 0.17 0.76 1.58
82 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
83 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
84 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
85 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
86 INT151849 IL10 Negative_regulation of Gene_expression of IL8 4 0.14 3.26 1.54
87 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
88 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
89 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
90 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
91 INT166676 Binding of PRKCA and UGT1A6 1 0.30 0 1.5
92 INT93781 Racgap1 Positive_regulation of Positive_regulation of Gnptab 1 0.02 0.07 1.49
93 INT112033 Gabrb3 Positive_regulation of Plcg1 1 0.05 0.18 1.49
94 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
95 INT93782 Racgap1 Positive_regulation of Rgs9 1 0.55 0.07 1.49
96 INT93783 Racgap1 Positive_regulation of Gnptab 1 0.02 0.07 1.49
97 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
98 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
99 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
100 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
101 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47
102 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
103 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
104 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
105 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
106 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
107 INT169801 Binding of Adrbk1 and Rapgef3 1 0.34 1.04 1.43
108 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
109 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
110 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
111 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
112 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
113 INT96262 Positive_regulation of Pik3cd Positive_regulation of Plcg1 1 0.03 0 1.39
114 INT140021 Avp Positive_regulation of Pag1 1 0.03 0.85 1.38
115 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 0.04 0.85 1.38
116 INT140020 Avp Positive_regulation of Localization of Pag1 1 0.03 0.85 1.38
117 INT6466 Binding of Npr1 and Oprd1 1 0.01 0 1.37
118 INT122430 Negative_regulation of Binding of Ighm and Prkci 1 0.00 0 1.36
119 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
120 INT14827 Binding of Gabrd and Pag1 1 0.07 0.95 1.33
121 INT131888 gr Positive_regulation of Gene_expression of Prkcg 1 0.00 0 1.32
122 INT120929 Prkcg Regulation of Gene_expression of Fos 2 0.50 0.34 1.31
123 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
124 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
125 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
126 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
127 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
128 INT34393 Oprd1 Negative_regulation of Adcy1 1 0.36 0 1.27
129 INT143620 Ltp Positive_regulation of Npr1 1 0.01 0.16 1.26
130 INT211743 Positive_regulation of Binding of Pag1 and Mors1 1 0.09 0.1 1.25
131 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
132 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25
133 INT236835 Binding of CISH and CSF2 1 0.06 1.43 1.25
134 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
135 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
136 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
137 INT42554 Oprl1 Regulation of Npr1 2 0.06 0 1.22
138 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
139 INT153215 Htr5b Positive_regulation of Pag1 1 0.01 0.57 1.22
140 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
141 INT96261 Positive_regulation of Pik3cd Positive_regulation of Plcg2 1 0.02 0 1.21
142 INT70288 Negative_regulation of Atxn2l Positive_regulation of Racgap1 1 0.02 0.3 1.19
143 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
144 INT25660 Binding of Penk and Pag1 1 0.01 0.67 1.19
145 INT169802 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Rapgef3 1 0.44 0.75 1.19
146 INT65203 OPRL1 Negative_regulation of ADCY1 1 0.19 0 1.19
147 INT139736 Htr1a Positive_regulation of Mapk3 1 0.54 0.13 1.19
148 INT49955 OPRM1 Positive_regulation of ADCY1 1 0.21 0.31 1.19
149 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
150 INT150835 Gper Positive_regulation of Localization of Prkce 1 0.15 0.62 1.18
151 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
152 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
153 INT140022 Avp Regulation of Localization of Pag1 1 0.01 0.57 1.17
154 INT25112 RYBP Negative_regulation of Binding of PLEKHM1 1 0.01 0 1.17
155 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
156 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
157 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16
158 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
159 INT144153 Socs6 Positive_regulation of Gene_expression of Gabrg1 1 0.07 0 1.16
160 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
161 INT25109 Negative_regulation of COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.16
162 INT76378 Binding of Cit and Flvcr2 1 0.09 0.17 1.15
163 INT25114 COL7A1 Positive_regulation of PLEKHM1 1 0.01 0 1.15
164 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
165 INT107029 Cpox Regulation of Pag1 1 0.01 1.24 1.15
166 INT70289 Atxn2l Positive_regulation of Racgap1 1 0.04 0.29 1.15
167 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
168 INT65204 PNOC Negative_regulation of ADCY1 1 0.07 0 1.14
169 INT13204 Binding of Npr1 and Akr1d1 1 0.00 0 1.14
170 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
171 INT68157 Alox5 Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.13
172 INT196812 Ppp1r1b Negative_regulation of Ppp1cc 3 0.07 0.13 1.12
173 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
174 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
175 INT130471 Prkcg Regulation of Regulation of Fos 1 0.45 0.27 1.12
176 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
177 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
178 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
179 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
180 INT68165 Alox5 Positive_regulation of Pdpk1 1 0.01 0.63 1.12
181 INT147660 Positive_regulation of Prkce Positive_regulation of TRPV1 1 0.04 0.69 1.12
182 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
183 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
184 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
185 INT62381 ADCY10 Positive_regulation of Localization of IGHG3 1 0.04 0.36 1.11
186 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
187 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
188 INT62380 ADCY10 Positive_regulation of IGHG3 1 0.03 0.36 1.11
189 INT99691 Pdpk1 Positive_regulation of Positive_regulation of VEGFA 1 0.01 0.72 1.11
190 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
191 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1
192 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
193 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
194 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
195 INT53847 Pag1 Regulation of Gabrd 1 0.01 1 1.08
196 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
197 INT96905 Plxna3 Regulation of Regulation of Prkce 1 0.18 0.71 1.07
198 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
199 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
200 INT122432 Prkci Regulation of Negative_regulation of Oprd1 1 0.01 0 1.06

Single Events

The table below shows the top 100 pain related interactions that have been reported for intracellular signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in intracellular signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
2 INT10832 Gene_expression of IL8 1050 0.78 698.72 270
3 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87
4 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
5 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
6 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
7 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78
8 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
9 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
10 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11
11 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
12 INT12339 Localization of IL8 437 0.81 251.87 117.39
13 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
14 INT10838 Positive_regulation of IL8 381 0.70 295.51 101.62
15 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76
16 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
17 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
18 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
19 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
20 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
21 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
22 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
23 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34
24 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
25 INT6926 Regulation of Pag1 72 0.39 55.79 65.09
26 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
27 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23
28 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
29 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
30 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
31 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
32 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
33 INT7800 Localization of Pag1 51 0.56 33.06 53.74
34 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
35 INT1232 Positive_regulation of Pdpk1 78 0.42 24.33 50.17
36 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
37 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
38 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
39 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
40 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
41 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
42 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
43 INT18992 Negative_regulation of Pdpk1 53 0.42 19.02 40.95
44 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
45 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
46 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
47 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
48 INT48222 Positive_regulation of Localization of IL8 123 0.59 78.04 37.2
49 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
50 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
51 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
52 INT48924 Positive_regulation of Mapk3 107 0.67 50.53 34.05
53 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
54 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
55 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
56 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
57 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
58 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
59 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
60 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
61 INT72375 Phosphorylation of Mapk3 87 0.80 43.66 30.27
62 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21
63 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
64 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
65 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
66 INT52712 Negative_regulation of PRKCA 64 0.57 23.11 28.43
67 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
68 INT9296 Negative_regulation of PLEK 100 0.57 36.65 27.52
69 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
70 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
71 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
72 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
73 INT10836 Negative_regulation of IL8 95 0.59 52.59 24.71
74 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
75 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26
76 INT10835 Regulation of IL8 79 0.49 53.04 24.14
77 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
78 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
79 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
80 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
81 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
82 INT106720 Positive_regulation of Adcy1 30 0.50 22.05 22.68
83 INT10481 Phosphorylation of Ppp1r1b 29 0.82 2.46 21.59
84 INT117527 Binding of Prkca 25 0.48 6.43 21.05
85 INT19580 Binding of Pag1 24 0.30 15.13 20.88
86 INT52106 Negative_regulation of Localization of IL8 57 0.52 22.81 20.8
87 INT79805 Phosphorylation of PRKCA 57 0.81 23.33 20.41
88 INT48769 Regulation of Pdpk1 20 0.35 9.78 20.36
89 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
90 INT7017 Regulation of Npr1 45 0.52 3.38 20.05
91 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
92 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
93 INT4260 Negative_regulation of Positive_regulation of Npr1 29 0.43 4.39 19.57
94 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
95 INT12725 Positive_regulation of Racgap1 66 0.68 32.74 19.29
96 INT99058 Regulation of PAG1 18 0.45 21.62 18.5
97 INT10833 Regulation of Gene_expression of IL8 68 0.62 38.74 18.46
98 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
99 INT6461 Gene_expression of Npr1 35 0.75 10.38 17.58
100 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
101 INT65211 Binding of Prkcg 38 0.48 14.75 16.92
102 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87
103 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
104 INT9299 Positive_regulation of Positive_regulation of Npr1 32 0.53 6.65 16.72
105 INT10834 Binding of IL8 65 0.48 41.66 16.53
106 INT112908 Phosphorylation of Ppp1r1b 65 0.77 1.27 16.42
107 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
108 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26
109 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18
110 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
111 INT52107 Transcription of IL8 63 0.72 41.66 16.06
112 INT12617 Regulation of ADCY1 41 0.61 7.38 15.94
113 INT111073 Gene_expression of Psen1 167 0.76 78.65 15.83
114 INT79458 Localization of Prkca 30 0.81 11.13 15.78
115 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
116 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
117 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
118 INT124371 Negative_regulation of Gsk3b 170 0.55 87.92 15.51
119 INT61172 Gene_expression of PRKCA 34 0.77 8.89 15.47
120 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
121 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
122 INT75908 Regulation of LEP 77 0.60 60.16 15.19
123 INT63553 Binding of PAG1 14 0.48 12.51 14.76
124 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
125 INT8989 Binding of Npr1 25 0.36 5.52 14.58
126 INT124372 Gene_expression of Gsk3b 164 0.75 95.64 14.35
127 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15
128 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
129 INT26733 Gene_expression of Pdpk1 17 0.48 5.74 13.91
130 INT111529 Phosphorylation of Mapk3 41 0.80 21.14 13.72
131 INT52714 Regulation of PRKCA 28 0.61 7.73 13.66
132 INT130424 Negative_regulation of Adcy1 19 0.58 16.31 13.6
133 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
134 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
135 INT132178 Binding of CD80 41 0.47 15.55 12.98
136 INT48927 Regulation of Mapk3 25 0.60 14.06 12.82
137 INT73641 Regulation of Lep 45 0.62 26.2 12.59
138 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
139 INT12135 Gene_expression of PLEK 62 0.75 34.13 12.47
140 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
141 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36
142 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
143 INT118905 Positive_regulation of Positive_regulation of PAG1 8 0.40 7.55 12.25
144 INT42459 Positive_regulation of Gene_expression of Pag1 19 0.25 13.49 12.22
145 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
146 INT26973 Gene_expression of Tenc1 59 0.66 27.19 12
147 INT92686 Gene_expression of Ctgf 51 0.77 34.4 11.93
148 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93
149 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
150 INT72221 Localization of PRKCA 17 0.81 1.23 11.47
151 INT21934 Negative_regulation of Negative_regulation of Pag1 11 0.39 7.91 11.37
152 INT5630 Localization of Pdpk1 10 0.45 5.21 11.36
153 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33
154 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
155 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16
156 INT96259 Positive_regulation of Plcg1 11 0.49 3.01 11.15
157 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
158 INT111264 Gene_expression of Rgs9 16 0.76 1.96 10.94
159 INT18412 Binding of PLEK 49 0.47 17.82 10.72
160 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
161 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
162 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
163 INT87451 Positive_regulation of Mapk3 34 0.67 12.82 10.38
164 INT91948 Positive_regulation of Prkce 16 0.64 11.36 10.32
165 INT28857 Negative_regulation of Positive_regulation of Pag1 11 0.30 8.46 10.19
166 INT12620 Negative_regulation of Negative_regulation of ADCY1 16 0.44 2.98 10.1
167 INT13606 Negative_regulation of Negative_regulation of Npr1 13 0.40 1.21 10.01
168 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
169 INT10480 Positive_regulation of Ppp1r1b 15 0.70 2.82 9.97
170 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
171 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91
172 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
173 INT4737 Gene_expression of Ppp1r1b 29 0.67 5.73 9.83
174 INT79248 Regulation of Negative_regulation of Prkcg 13 0.44 3.44 9.78
175 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
176 INT3366 Localization of PLEK 44 0.78 15.83 9.55
177 INT82005 Positive_regulation of Phosphorylation of Ppp1r1b 10 0.69 0 9.51
178 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49
179 INT72148 Positive_regulation of Prkce 17 0.68 5.06 9.44
180 INT47845 Regulation of Localization of Prkcg 16 0.62 3.1 9.42
181 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
182 INT71565 Negative_regulation of Prkcc 11 0.54 4.16 9.31
183 INT135372 Positive_regulation of Gsk3b 72 0.70 50.03 9.28
184 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
185 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
186 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
187 INT111133 Negative_regulation of Mapk3 31 0.57 10.89 8.9
188 INT111258 Regulation of Rgs9 11 0.54 1.81 8.9
189 INT26487 Positive_regulation of Npr1 17 0.70 10.01 8.78
190 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
191 INT7801 Positive_regulation of Localization of Pag1 7 0.32 5.96 8.67
192 INT82082 Localization of Lep 63 0.81 26.41 8.56
193 INT91772 Gene_expression of PSEN1 115 0.75 38.12 8.48
194 INT12861 Gene_expression of Cish 40 0.57 23.01 8.48
195 INT75907 Binding of LEP 53 0.46 46.65 8.44
196 INT106719 Gene_expression of Adcy1 18 0.77 12.18 8.42
197 INT10969 Positive_regulation of PLEK 33 0.67 16.96 8.35
198 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
199 INT12975 Regulation of PLEK 21 0.60 13.62 8.28
200 INT195203 Binding of Tenc1 14 0.32 13.97 8.28
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