GO:0035589

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Name G-protein coupled purinergic nucleotide receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0035589
Unique Molecular Interactions 86
Total Molecular Interactions 99
Total Single Events 1060
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled purinergic nucleotide receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for G-protein coupled purinergic nucleotide receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106850 P2ry2 Positive_regulation of Phosphorylation of Creb1 2 0.49 0.73 1.36
2 INT61637 Binding of P2ry2 and Gtpbp4 1 0.02 0.1 0.99
3 INT216654 Binding of P2ry2 and DRGX 1 0.01 1.59 0.71
4 INT153289 Binding of Lpar1 and Gpr87 2 0.29 1.19 0.67
5 INT216644 Binding of P2ry1 and P2ry2 1 0.24 0.55 0.64
6 INT345180 Binding of Lpar4 and Gpr87 1 0.06 0.69 0.59
7 INT345192 Binding of Gpr87 and Lpar5 1 0.07 0.69 0.59
8 INT308891 Adp Positive_regulation of P2ry13 1 0.15 0.11 0.55
9 INT308895 Adp Positive_regulation of P2ry12 1 0.14 0.11 0.55
10 INT308894 Adp Regulation of P2ry1 1 0.05 0.49 0.53
11 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
12 INT308892 Adp Positive_regulation of P2ry1 1 0.11 0.44 0.47
13 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
14 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
15 INT191489 Positive_regulation of P2ry2 Negative_regulation of Positive_regulation of Trpv1 1 0.03 0.08 0.44
16 INT215564 Hmmr Negative_regulation of P2ry2 1 0.00 0 0.44
17 INT308970 Abn-CBD Regulation of Gpr18 1 0.03 0.14 0.41
18 INT153288 Binding of Lpar1 and Lpar6 2 0.31 0.78 0.36
19 INT308890 Binding of Idh1 and P2ry13 1 0.06 0 0.35
20 INT217023 Lpar4 Regulation of Gene_expression of Ik 1 0.00 0.27 0.33
21 INT243151 P2ry4 Positive_regulation of P2rx6 1 0.00 0 0.3
22 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
23 INT215683 P2ry2 Positive_regulation of Gene_expression of Il6 1 0.02 0.76 0.29
24 INT258856 P2ry2 Positive_regulation of P9Ehs1 1 0.01 0.76 0.26
25 INT308893 P2ry1 Positive_regulation of Adp 1 0.12 0 0.25
26 INT242245 Binding of P2ry1 and Adp 1 0.00 0.31 0.21
27 INT167113 Binding of P2ry1 and Trpv1 1 0.40 0 0.21
28 INT242250 Binding of P2ry1 and P2ry12 1 0.01 0.3 0.21
29 INT242244 Binding of P2ry12 and Adp 1 0.00 0.31 0.21
30 INT249892 Cysltr1 Positive_regulation of Gpr17 1 0.09 0.92 0.2
31 INT249893 Ltc4s Positive_regulation of Gpr17 1 0.04 0.92 0.2
32 INT249897 Cysltr1 Positive_regulation of P2ry4 1 0.01 0.7 0.17
33 INT249895 Ltc4s Positive_regulation of P2ry4 1 0.00 0.71 0.17
34 INT352290 Binding of Agtr1a and P2ry1 1 0.00 0 0.16
35 INT233511 Tlr4 Negative_regulation of Transcription of Lpar6 1 0.05 0.1 0.15
36 INT108598 Positive_regulation of Oprl1 Positive_regulation of Phosphorylation of P2ry2 1 0.10 0 0.13
37 INT345191 Lpar4 Negative_regulation of Dmbx1 1 0.04 1.25 0.13
38 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09
39 INT308968 Binding of Cnr2 and Gpr18 1 0.15 0 0.08
40 INT249890 Binding of Mbp and Gpr17 1 0.11 0.09 0.08
41 INT308969 Binding of Cnr1 and Gpr18 1 0.11 0 0.08
42 INT215767 Binding of P2ry1 and Ca2 1 0.02 0.2 0.08
43 INT345160 S1pr1 Positive_regulation of P2ry10 1 0.11 0.09 0.07
44 INT345164 Binding of Lpar1 and P2ry10 1 0.14 0.09 0.07
45 INT308967 Gpr18 Positive_regulation of Mapk14 1 0.06 0.08 0.06
46 INT246206 Binding of P2ry2 and P2ry4 1 0.12 0 0.05
47 INT345181 Gpr87 Regulation of Trp53 1 0.01 0.42 0.05
48 INT351915 P2ry1 Regulation of Gfm1 1 0.01 0.86 0.03
49 INT351914 P2ry1 Regulation of Gene_expression of Gfm1 1 0.01 0.86 0.03
50 INT215691 Binding of P2ry2 and P2rx3 1 0.08 0.46 0.03
51 INT215765 Binding of P2ry1 and P2ry2 1 0.07 0.46 0.03
52 INT215684 Binding of P2ry2 and P2rx4 1 0.06 0.46 0.03
53 INT216788 Svs4 Positive_regulation of Gene_expression of P2ry12 1 0.04 0 0.03
54 INT301409 Binding of Lpar6 and Gpr87 2 0.09 0 0
55 INT233504 Tlr4 Regulation of P2ry2 1 0.04 0.07 0
56 INT345174 Spib Regulation of P2ry10 1 0.05 0.26 0
57 INT233516 Tlr4 Regulation of Gpr18 1 0.04 0.07 0
58 INT233500 Tlr4 Negative_regulation of P2ry1 1 0.06 0.18 0
59 INT233523 Tlr4 Regulation of P2ry12 1 0.04 0.07 0
60 INT216785 Svs4 Regulation of Positive_regulation of P2ry12 1 0.03 0.05 0
61 INT301407 Binding of Lpar6 and Dmbx1 1 0.13 0 0
62 INT345185 Gtf3a Regulation of P2ry10 1 0.00 0.26 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for G-protein coupled purinergic nucleotide receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in G-protein coupled purinergic nucleotide receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8
2 INT61635 Positive_regulation of P2ry2 35 0.56 12.08 14.68
3 INT69166 Positive_regulation of P2ry1 35 0.67 8.41 13.63
4 INT148301 Gene_expression of P2ry12 23 0.75 14.24 13.63
5 INT93122 Gene_expression of P2ry1 32 0.75 11.82 11.42
6 INT111680 Gene_expression of P2ry2 20 0.58 9.23 7.39
7 INT95466 Regulation of P2ry2 23 0.56 3.66 6.86
8 INT148308 Regulation of P2ry12 8 0.44 6.2 6.23
9 INT95170 Localization of P2ry1 10 0.78 5.08 5.63
10 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59
11 INT139238 Positive_regulation of P2ry1 19 0.60 9.22 5.15
12 INT65509 Regulation of P2ry1 13 0.60 2.38 4.96
13 INT130203 Gene_expression of P2ry4 14 0.50 8.79 4.82
14 INT112038 Positive_regulation of P2ry2 8 0.45 2.41 4.4
15 INT150464 Positive_regulation of P2ry12 5 0.67 4.39 4.3
16 INT165182 Gene_expression of P2ry12 4 0.65 4.29 4.08
17 INT102347 Localization of P2ry2 4 0.56 1.23 3.31
18 INT183249 Binding of P2ry12 12 0.47 7.4 3.3
19 INT148306 Transcription of P2ry12 4 0.69 2.45 3.14
20 INT130202 Negative_regulation of Gene_expression of P2ry4 3 0.15 3.89 3.14
21 INT215521 Negative_regulation of P2ry1 10 0.56 2.68 2.72
22 INT91284 Negative_regulation of P2ry2 8 0.25 2.66 2.71
23 INT249873 Positive_regulation of Gpr17 1 0.53 7.33 2.71
24 INT107846 Transcription of P2ry2 6 0.46 2.06 2.52
25 INT150465 Positive_regulation of Gene_expression of P2ry2 3 0.56 3.48 2.33
26 INT115401 Negative_regulation of P2ry1 6 0.42 1.27 2.25
27 INT151816 Negative_regulation of P2ry2 3 0.02 3.1 2.23
28 INT99844 Localization of P2ry1 7 0.74 4.05 2.19
29 INT354232 Regulation of Gene_expression of P2ry12 1 0.26 2.47 2.19
30 INT233458 Gene_expression of Gpr18 2 0.66 1.75 2.11
31 INT249861 Gene_expression of Gpr17 1 0.60 5.64 2.07
32 INT308877 Gene_expression of P2ry13 1 0.68 1.89 1.98
33 INT103236 Positive_regulation of Positive_regulation of P2ry1 5 0.54 2.39 1.92
34 INT95467 Transcription of P2ry2 7 0.49 1.43 1.87
35 INT102288 Localization of P2ry2 4 0.55 1.02 1.83
36 INT102348 Regulation of P2ry2 6 0.40 2.18 1.79
37 INT130204 Positive_regulation of Gene_expression of P2ry4 2 0.00 2.73 1.79
38 INT111682 Transcription of P2ry1 4 0.52 1.26 1.71
39 INT216977 Gene_expression of Lpar4 7 0.35 3.93 1.66
40 INT164544 Positive_regulation of Gene_expression of P2ry12 4 0.67 2.41 1.64
41 INT107376 Negative_regulation of P2ry12 12 0.43 4.39 1.5
42 INT150466 Regulation of Positive_regulation of P2ry2 1 0.37 1.26 1.42
43 INT61636 Positive_regulation of Positive_regulation of P2ry2 4 0.34 0.13 1.4
44 INT169232 Negative_regulation of Gene_expression of P2ry2 3 0.31 2.29 1.32
45 INT117966 Binding of P2ry2 5 0.36 0.44 1.31
46 INT91555 Positive_regulation of Gpr18 3 0.40 0.63 1.14
47 INT111681 Regulation of P2ry1 8 0.45 2.64 1.11
48 INT117967 Binding of P2ry4 4 0.36 0.24 1.1
49 INT108241 Negative_regulation of P2ry4 3 0.27 1.78 1.1
50 INT196863 Positive_regulation of P2ry4 4 0.27 1.87 1.07
51 INT308875 Positive_regulation of P2ry12 1 0.43 0.9 1.02
52 INT129577 Negative_regulation of Positive_regulation of P2ry2 4 0.29 0.45 1
53 INT216611 Regulation of Gene_expression of P2ry2 1 0.30 0.29 0.99
54 INT103235 Regulation of Localization of P2ry1 2 0.44 0.09 0.97
55 INT249860 Regulation of Gpr17 1 0.47 5.8 0.94
56 INT233482 Positive_regulation of Gene_expression of P2ry2 4 0.43 0.76 0.92
57 INT252417 Negative_regulation of P2ry12 2 0.37 1.59 0.89
58 INT108242 Regulation of P2ry4 3 0.32 0.81 0.88
59 INT95468 Transcription of P2ry1 4 0.60 0 0.86
60 INT151817 Positive_regulation of Transcription of P2ry2 2 0.21 1.19 0.82
61 INT148310 Regulation of Regulation of P2ry12 1 0.43 0.09 0.74
62 INT148302 Regulation of Regulation of P2ry1 1 0.44 0.09 0.74
63 INT183250 Negative_regulation of Binding of P2ry12 2 0.16 0.98 0.73
64 INT138580 Positive_regulation of P2ry13 2 0.44 0.23 0.72
65 INT148303 Localization of P2ry12 1 0.67 0.09 0.72
66 INT111406 Binding of P2ry1 2 0.36 0.31 0.7
67 INT308884 Regulation of P2ry13 1 0.24 0.55 0.7
68 INT354233 Positive_regulation of Regulation of P2ry12 1 0.45 0.33 0.68
69 INT249870 Localization of Gpr17 1 0.62 2.18 0.66
70 INT216662 Regulation of Gene_expression of P2ry1 1 0.24 0.2 0.63
71 INT308952 Regulation of Gpr18 1 0.23 0.75 0.63
72 INT153277 Gene_expression of Lpar6 2 0.49 1.76 0.61
73 INT249865 Positive_regulation of Positive_regulation of Gpr17 1 0.39 0.43 0.59
74 INT215572 Negative_regulation of Localization of P2ry1 1 0.15 0.08 0.55
75 INT243133 Positive_regulation of Positive_regulation of P2ry2 2 0.24 0.31 0.54
76 INT259774 Negative_regulation of Positive_regulation of P2ry1 1 0.33 1.11 0.54
77 INT233484 Positive_regulation of Gene_expression of P2ry1 4 0.43 0.95 0.5
78 INT308880 Positive_regulation of Negative_regulation of P2ry1 1 0.48 0.13 0.49
79 INT249866 Negative_regulation of Gpr17 1 0.33 1.32 0.45
80 INT308953 Binding of Gpr18 1 0.41 0.67 0.41
81 INT345109 Gene_expression of Gpr87 1 0.26 0.78 0.4
82 INT99845 Localization of P2ry4 1 0.73 0 0.39
83 INT323020 Positive_regulation of Binding of P2ry12 1 0.06 0.49 0.37
84 INT106849 Phosphorylation of P2ry2 2 0.37 0.1 0.35
85 INT102287 Binding of P2ry2 2 0.25 0 0.34
86 INT308886 Binding of P2ry13 1 0.33 0 0.33
87 INT141814 Regulation of Positive_regulation of P2ry1 1 0.44 0.15 0.33
88 INT216983 Positive_regulation of Lpar4 2 0.31 1.11 0.32
89 INT345094 Binding of Gpr87 1 0.13 0.4 0.31
90 INT95464 Regulation of Transcription of P2ry1 1 0.25 0 0.28
91 INT233461 Transcription of Lpar6 1 0.48 0.37 0.26
92 INT308883 Negative_regulation of Positive_regulation of P2ry1 1 0.41 0.05 0.2
93 INT351912 Binding of P2ry1 1 0.09 2.15 0.19
94 INT249872 Positive_regulation of Gene_expression of Gpr17 1 0.53 0.78 0.19
95 INT308882 Transcription of P2ry12 1 0.46 0.61 0.19
96 INT308881 Transcription of P2ry13 1 0.47 0.62 0.19
97 INT249877 Negative_regulation of Binding of Gpr17 1 0.33 1.89 0.18
98 INT308948 Localization of Gpr18 1 0.56 0 0.16
99 INT308942 Negative_regulation of Localization of Gpr18 1 0.32 0 0.16
100 INT308944 Negative_regulation of Gpr18 1 0.32 0 0.16
101 INT308954 Positive_regulation of Localization of Gpr18 1 0.37 0 0.16
102 INT249868 Positive_regulation of Localization of Gpr17 1 0.39 0.76 0.15
103 INT282054 Negative_regulation of Gene_expression of P2ry2 1 0.18 0.54 0.15
104 INT308956 Positive_regulation of Gene_expression of Gpr18 1 0.59 0.05 0.15
105 INT249864 Regulation of Localization of Gpr17 1 0.35 0.74 0.15
106 INT108597 Positive_regulation of Phosphorylation of P2ry2 1 0.21 0 0.13
107 INT249875 Negative_regulation of Gene_expression of Gpr17 1 0.33 0 0.13
108 INT249878 Binding of Gpr17 1 0.29 1.08 0.13
109 INT233465 Regulation of Positive_regulation of Lpar6 1 0.30 0.07 0.11
110 INT233486 Negative_regulation of Lpar6 1 0.29 0.07 0.11
111 INT233491 Positive_regulation of Lpar6 1 0.34 0.07 0.11
112 INT233495 Regulation of Lpar6 1 0.30 0.07 0.11
113 INT216520 Regulation of Gene_expression of P2ry1 2 0.45 0.43 0.09
114 INT345133 Transcription of Lpar4 1 0.32 0 0.09
115 INT345092 Binding of Lpar4 1 0.17 0 0.09
116 INT291034 Regulation of Transcription of P2ry2 1 0.28 0.78 0.09
117 INT345104 Transcription of Gpr87 1 0.24 0.15 0.08
118 INT216522 Negative_regulation of Localization of P2ry1 1 0.42 0.13 0.07
119 INT291037 Regulation of Gene_expression of P2ry2 1 0.12 0.64 0.05
120 INT308945 Positive_regulation of Positive_regulation of Gpr18 1 0.37 0.07 0.05
121 INT249871 Positive_regulation of Binding of Gpr17 1 0.39 0.14 0.05
122 INT345083 Regulation of Gpr87 1 0.15 0.42 0.05
123 INT308940 Regulation of Gene_expression of Gpr18 1 0.39 0 0.04
124 INT345127 Gene_expression of P2ry10 1 0.34 0.53 0.04
125 INT345096 Positive_regulation of Gene_expression of P2ry10 1 0.20 0.08 0.04
126 INT345124 Positive_regulation of P2ry10 1 0.20 0.08 0.04
127 INT345077 Localization of Lpar4 1 0.33 0.59 0.03
128 INT138581 Localization of P2ry13 1 0.00 0 0.03
129 INT308959 Transcription of Gpr18 1 0.26 0 0.03
130 INT345103 Localization of P2ry10 1 0.32 0.32 0.03
131 INT243134 Positive_regulation of Positive_regulation of P2ry4 1 0.20 0 0.03
132 INT138579 Positive_regulation of Positive_regulation of P2ry13 1 0.00 0 0.03
133 INT243132 Negative_regulation of Regulation of P2ry2 1 0.16 0 0.03
134 INT351911 Positive_regulation of Positive_regulation of P2ry1 1 0.13 1.47 0.03
135 INT216615 Positive_regulation of Gene_expression of P2ry1 1 0.25 0.22 0
136 INT345099 Positive_regulation of Gene_expression of Lpar4 1 0.21 0.25 0
137 INT307251 Regulation of Gene_expression of Lpar4 1 0.04 0.22 0
138 INT183251 Negative_regulation of Regulation of P2ry12 1 0.16 0 0
139 INT249863 Regulation of Positive_regulation of Gpr17 1 0.35 0.41 0
140 INT233454 Negative_regulation of Transcription of Lpar6 1 0.39 0.1 0
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