GO:0035625

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Name epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0035625
Unique Molecular Interactions 88
Total Molecular Interactions 117
Total Single Events 1032
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
4 INT18520 Adra2c Positive_regulation of Localization of Ins1 3 0.41 0.63 1.66
5 INT70270 Binding of ADRA2B and Pnoc 2 0.02 0.15 1.08
6 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
7 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
8 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
9 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
10 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
11 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
12 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
13 INT56459 ADRA2C Positive_regulation of Localization of AHSP 1 0.23 0 0.78
14 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
15 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
16 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
17 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
18 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
19 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
20 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
21 INT81832 Binding of ADRA2C and CRYGS 1 0.06 0 0.66
22 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
23 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
24 INT31418 Positive_regulation of Adra2c Positive_regulation of Gcg 1 0.22 0 0.65
25 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
26 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
27 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57
28 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
29 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
30 INT135799 Binding of Adra1d and Adra2b 1 0.02 0 0.48
31 INT110031 Positive_regulation of Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
32 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
33 INT110030 Adra2c Positive_regulation of Mapk14 1 0.25 0 0.48
34 INT110034 Negative_regulation of Adra2c Positive_regulation of Mapk14 1 0.23 0 0.48
35 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
36 INT132580 Binding of ADRA2C and Htr1a 1 0.41 0.27 0.45
37 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
38 INT29254 Positive_regulation of ADRA2C Positive_regulation of Localization of GH1 1 0.13 0.06 0.44
39 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
40 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
41 INT145576 Binding of Adra2c and Hcn4 1 0.21 0.19 0.4
42 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
43 INT145575 Binding of Adra2c and Hcn2 1 0.21 0.19 0.4
44 INT145577 Regulation of Binding of Adra2c and Hcn2 1 0.25 0.19 0.4
45 INT145574 Regulation of Binding of Adra2c and Hcn4 1 0.26 0.19 0.4
46 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
47 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
48 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
49 INT31713 Adra2c Regulation of Localization of Ins1 1 0.22 0.31 0.35
50 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
51 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
52 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
53 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
54 INT26942 Adra2c Positive_regulation of Localization of Ins1 1 0.13 0 0.28
55 INT7850 Adra2c Regulation of Localization of Gcg 1 0.08 0 0.27
56 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
57 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
58 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
59 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
60 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
61 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
62 INT81833 Negative_regulation of Binding of ADRA2C and CRYGS 1 0.06 0 0.19
63 INT148397 Adra2c Regulation of Gnb3 1 0.12 0.08 0.19
64 INT71547 ADRA2C Positive_regulation of Localization of GCG 1 0.01 0.14 0.17
65 INT71548 ADRA2C Negative_regulation of Localization of INS 1 0.04 0.13 0.16
66 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
67 INT81831 Positive_regulation of Binding of ADRA2C and CRYGS 1 0.07 0 0.14
68 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
69 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
70 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
71 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
72 INT72302 Regulation of ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
73 INT72304 ADRA2C Regulation of ADCY1 1 0.02 0.14 0.09
74 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
75 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
76 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
77 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
78 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
79 INT264780 Binding of ADRA2B and Regulation of MRGPRX1 1 0.00 0 0.05
80 INT285396 Binding of Adam17 and R3hcc1 1 0.15 0.93 0
81 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
6 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
7 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
8 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
9 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
10 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
11 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
12 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
13 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
14 INT5678 Gene_expression of ADRA2C 17 0.74 2.62 6.24
15 INT18443 Positive_regulation of ADRA2C 12 0.69 2.61 5.48
16 INT26940 Positive_regulation of Adra2c 9 0.49 2.21 5.27
17 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
18 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
19 INT5675 Gene_expression of Adra2c 7 0.75 1.25 4.58
20 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
21 INT30160 Positive_regulation of ADRA2B 14 0.29 1.92 4.37
22 INT13134 Binding of ADRA2C 11 0.46 0.73 3.86
23 INT8711 Binding of Adra2b 6 0.42 0.08 3.78
24 INT30181 Gene_expression of Adra2b 10 0.62 1.89 3.48
25 INT277 Negative_regulation of Adra2c 8 0.43 1.89 3.42
26 INT18459 Regulation of Adra2c 6 0.45 0.42 3.4
27 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
28 INT38760 Positive_regulation of Adra2c 3 0.39 1.82 3.04
29 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
30 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
31 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
32 INT15265 Gene_expression of Adra2c 5 0.54 1.8 2.83
33 INT30870 Negative_regulation of Adra2b 8 0.44 4.5 2.8
34 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
35 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
36 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
37 INT7848 Regulation of Adra2c 3 0.33 1.74 2.37
38 INT53540 Gene_expression of ADRA2B 10 0.46 1.78 2.33
39 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
40 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
41 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
42 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
43 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
44 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
45 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
46 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
47 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
48 INT40907 Localization of Adra2c 3 0.71 0 1.46
49 INT40906 Negative_regulation of Localization of Adra2c 1 0.43 0 1.46
50 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
51 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
52 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
53 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
54 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
55 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
56 INT55318 Localization of ADRA2C 3 0.73 1.39 1.3
57 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
58 INT30161 Negative_regulation of Positive_regulation of ADRA2B 2 0.05 0.25 1.24
59 INT231592 Binding of ADRA2B 5 0.18 0.13 1.23
60 INT82729 Transcription of Adra2b 1 0.02 1.05 1.23
61 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
62 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
63 INT6519 Positive_regulation of Gene_expression of ADRA2C 3 0.44 0.71 1.1
64 INT76497 Transcription of Adra2c 2 0.21 0.08 1.07
65 INT41043 Regulation of Adra2b 3 0.39 0.47 1.03
66 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
67 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
68 INT26012 Binding of Adra2c 2 0.48 0 1.01
69 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
70 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
71 INT33665 Positive_regulation of Gene_expression of Adra2c 1 0.50 0.43 0.89
72 INT65230 Negative_regulation of Adra2c 3 0.42 0.44 0.88
73 INT124538 Positive_regulation of Gene_expression of Adra2c 1 0.27 0.75 0.87
74 INT40928 Regulation of Binding of ADRA2C 1 0.43 0 0.82
75 INT14130 Regulation of ADRA2C 4 0.45 1.57 0.79
76 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
77 INT110117 Negative_regulation of Positive_regulation of Adra2c 1 0.12 0.33 0.77
78 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
79 INT28057 Binding of Adra2c 4 0.36 0.25 0.75
80 INT55317 Transcription of ADRA2C 6 0.63 0.36 0.74
81 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
82 INT95816 Regulation of Positive_regulation of Adra2c 2 0.28 0.66 0.68
83 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
84 INT29256 Positive_regulation of Positive_regulation of ADRA2C 2 0.46 0.06 0.59
85 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
86 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
87 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
88 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
89 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
90 INT18442 Negative_regulation of ADRA2C 2 0.49 0.61 0.51
91 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
92 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
93 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
94 INT68529 Negative_regulation of ADRA2B 3 0.14 0.79 0.47
95 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
96 INT61414 Positive_regulation of Gene_expression of ADRA2B 2 0.18 0.13 0.44
97 INT278 Positive_regulation of Negative_regulation of Adra2c 1 0.47 0.27 0.42
98 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
99 INT251556 Localization of Adam17 2 0.38 2 0.39
100 INT6492 Regulation of ADRA2B 2 0.06 0.31 0.38
101 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
102 INT97767 Positive_regulation of Adra2b 3 0.45 1.75 0.34
103 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
104 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
105 INT26941 Localization of Adra2c 2 0.23 0 0.3
106 INT26939 Positive_regulation of Positive_regulation of Adra2c 1 0.16 0 0.3
107 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
108 INT26858 Regulation of Positive_regulation of ADRA2C 3 0.32 0.63 0.29
109 INT261826 Phosphorylation of ADRA2B 1 0.03 0.38 0.29
110 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
111 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
112 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
113 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
114 INT78865 Localization of Adam17 1 0.43 0.34 0.23
115 INT255069 Positive_regulation of Binding of ADRA2B 1 0.18 0.13 0.23
116 INT25814 Negative_regulation of Binding of ADRA2C 1 0.31 0.08 0.23
117 INT18444 Positive_regulation of Negative_regulation of ADRA2C 1 0.42 0.61 0.19
118 INT306554 Regulation of Localization of ADRA2C 1 0.26 0.98 0.17
119 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
120 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
121 INT356473 Transcription of ADRA2B 1 0.20 0.08 0.14
122 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
123 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
124 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
125 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
126 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
127 INT72309 Positive_regulation of Positive_regulation of ADRA2B 1 0.01 0.17 0.09
128 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
129 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
130 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
131 INT38754 Regulation of Negative_regulation of Adra2b 1 0.34 0.44 0.08
132 INT180094 Binding of Adam17 1 0.06 0 0.05
133 INT210662 Transcription of Adra2a 1 0.01 0.09 0
134 INT87516 Negative_regulation of Gene_expression of ADRA2C 1 0.41 0.1 0
135 INT157839 Positive_regulation of Gene_expression of Adra2b 1 0.03 0 0
136 INT285394 Binding of Adam17 1 0.31 0.93 0
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