GO:0035630

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Name bone mineralization involved in bone maturation
Categary Process
Go Slim No
Go Link GO:0035630
Unique Molecular Interactions 437
Total Molecular Interactions 644
Total Single Events 5135
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bone mineralization involved in bone maturation. They are ordered first by their pain relevance and then by number of times they were reported for bone mineralization involved in bone maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
2 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
3 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
4 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
5 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
6 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
7 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
8 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 0.44 3.31 1.31
9 INT131184 PTGER2 Positive_regulation of Gene_expression of IGF1 1 0.63 2.47 1.29
10 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
11 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
12 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
13 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
14 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 0.32 0.63 0.98
15 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 0.26 0.63 0.98
16 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
17 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
18 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
19 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
20 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
21 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
22 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
23 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
24 INT28947 GH1 Positive_regulation of Gene_expression of IGF1 4 0.22 3.78 0.69
25 INT34772 GH1 Regulation of IGF1 2 0.32 0.95 0.69
26 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
27 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
28 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
29 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
30 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66
31 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
32 INT45369 IGF1 Regulation of GH1 1 0.04 1.12 0.65
33 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
34 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
35 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
36 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
37 INT192291 OR5A1 Positive_regulation of Gene_expression of IGF1 1 0.02 0.93 0.57
38 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
39 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
40 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
41 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
42 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
43 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
44 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
45 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
46 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
47 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
48 INT142882 IGF1 Positive_regulation of Gene_expression of TRPV1 1 0.06 0.57 0.52
49 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
50 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
51 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
52 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
53 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
54 INT264295 Binding of DMD and IGF1 1 0.07 1.38 0.44
55 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
56 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
57 INT303655 Positive_regulation of Binding of IGF1 and SSTR1 1 0.16 2.19 0.41
58 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
59 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
60 INT303650 Binding of IGF1 and SSTR1 1 0.12 2.17 0.4
61 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
62 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
63 INT182492 IL1B Regulation of Gene_expression of IGF1 1 0.01 0.83 0.38
64 INT78444 Binding of GH1 and IGF1 4 0.16 2.82 0.37
65 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
66 INT316545 Binding of IGF1 and SST 1 0.06 0.45 0.37
67 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
68 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
69 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
70 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
71 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
72 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
73 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
74 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
75 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
76 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
77 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
78 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
79 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
80 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
81 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
82 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
83 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
84 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
85 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
86 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
87 INT173947 Il6 Positive_regulation of Gene_expression of IGF1 1 0.05 1.02 0.31
88 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
89 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
90 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
91 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
92 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
93 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
94 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
95 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
96 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
97 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
98 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
99 INT142885 Positive_regulation of IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.29
100 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
101 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
102 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
103 INT177478 Gnrhr Positive_regulation of Localization of IGF1 1 0.04 1.01 0.28
104 INT173949 Binding of IGF1 and Atp6v1e1 1 0.01 0.89 0.28
105 INT142884 IGF1 Positive_regulation of TRPV1 1 0.04 0.24 0.28
106 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
107 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
108 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
109 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
110 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
111 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
112 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
113 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
114 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
115 INT7869 Gh Negative_regulation of IGF1 1 0.39 0.47 0.23
116 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
117 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
118 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
119 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
120 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
121 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
122 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
123 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
124 INT173945 Hrt1 Positive_regulation of Positive_regulation of IGF1 1 0.01 0.32 0.21
125 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
126 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
127 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
128 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
129 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
130 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
131 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
132 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
133 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
134 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
135 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
136 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
137 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
138 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19
139 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
140 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
141 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
142 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
143 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19
144 INT173943 Binding of IGF1 and Il6 1 0.04 0.11 0.19
145 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18
146 INT303981 Lep Positive_regulation of Localization of CXCL1 1 0.02 0.34 0.18
147 INT231033 Igf1 Positive_regulation of Sec22b 1 0.06 0 0.17
148 INT226988 Lias Positive_regulation of Localization of Lep 1 0.08 0.3 0.17
149 INT175991 Binding of VEGFA and Igf1 1 0.04 0.57 0.17
150 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17
151 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
152 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
153 INT59952 Gh Positive_regulation of IGF1 1 0.46 0.84 0.16
154 INT269758 Negative_regulation of IGF1 Negative_regulation of Positive_regulation of IGFBP2 1 0.10 2.15 0.16
155 INT303980 Lep Positive_regulation of Transcription of IL2 1 0.10 0.24 0.16
156 INT73076 IGF1 Positive_regulation of GH1 4 0.45 0.99 0.15
157 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
158 INT185515 Binding of Igf1 and Csf2 1 0.29 0.4 0.15
159 INT50302 Igf1 Regulation of Gh1 1 0.22 0 0.14
160 INT217667 LEP Negative_regulation of Localization of INS 1 0.15 1.18 0.14
161 INT225778 Igf1 Negative_regulation of Positive_regulation of Ppi-rs 1 0.01 0.82 0.14
162 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14
163 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14
164 INT217664 LEP Negative_regulation of INS 1 0.15 1.18 0.14
165 INT65272 Igf1 Positive_regulation of Binding of Col7a1 1 0.42 0 0.14
166 INT45371 IGF1 Regulation of Smc1b 1 0.08 0 0.14
167 INT323877 LEP Positive_regulation of SOAT1 1 0.20 1.26 0.14
168 INT303600 IGF1 Regulation of Gene_expression of GH1 1 0.39 0.83 0.14
169 INT65269 Igf1 Positive_regulation of Gene_expression of Lox 1 0.15 0 0.14
170 INT298715 Igf1 Positive_regulation of Gene_expression of PDGFA 1 0.00 0.22 0.14
171 INT45370 IGF1 Regulation of Gh1 1 0.13 0 0.14
172 INT68753 IGF1 Regulation of Gene_expression of Gh 2 0.02 0.68 0.13
173 INT253009 Igf1 Regulation of PTTG1 1 0.03 0.44 0.13
174 INT215034 Gh Regulation of Igf1 1 0.13 0.27 0.13
175 INT139975 Binding of LEP and Prl 1 0.02 0.49 0.13
176 INT220147 IGFBP3 Positive_regulation of IGF1 1 0.10 0.53 0.13
177 INT65267 Igf1 Regulation of Gene_expression of Plod3 1 0.07 0 0.13
178 INT65271 Igf1 Positive_regulation of Gene_expression of Plod3 1 0.12 0 0.13
179 INT328060 LEP Positive_regulation of FAAH 1 0.06 0.7 0.13
180 INT346714 LEP Regulation of GALP 1 0.06 0.08 0.13
181 INT228453 Igf1 Positive_regulation of Prkca 2 0.12 1.17 0.12
182 INT81179 LEP Regulation of Localization of GH1 1 0.11 0.91 0.12
183 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12
184 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
185 INT228456 Igf1 Positive_regulation of Trpv1 1 0.24 0.97 0.12
186 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
187 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
188 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 0.22 1.18 0.11
189 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
190 INT308651 Binding of Igf1 and Ins1 1 0.02 0.22 0.11
191 INT175985 Igf1 Positive_regulation of Gene_expression of Serpina1c 1 0.14 0.55 0.11
192 INT323871 LEP Regulation of Gene_expression of IGF1 1 0.14 1.19 0.11
193 INT50301 Igf1 Positive_regulation of Regulation of Gh1 1 0.24 0 0.11
194 INT270746 INS Regulation of LEP 1 0.07 0.72 0.11
195 INT222507 Igf1 Positive_regulation of Localization of Edn3 1 0.05 0 0.11
196 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
197 INT163817 Lep Positive_regulation of Phosphorylation of Akt1 1 0.33 0.31 0.11
198 INT175987 Igf1 Positive_regulation of Serpina1c 1 0.13 0.54 0.11
199 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
200 INT222472 Lep Positive_regulation of Localization of Cartpt 1 0.05 0 0.11

Single Events

The table below shows the top 100 pain related interactions that have been reported for bone mineralization involved in bone maturation. They are ordered first by their pain relevance and then by number of times they were reported in bone mineralization involved in bone maturation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
2 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
3 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
4 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
5 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36
6 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
7 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
8 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
9 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
10 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9
11 INT28950 Positive_regulation of Gene_expression of IGF1 99 0.69 46.9 16.47
12 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
13 INT75908 Regulation of LEP 77 0.60 60.16 15.19
14 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
15 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
16 INT73641 Regulation of Lep 45 0.62 26.2 12.59
17 INT28952 Negative_regulation of Gene_expression of IGF1 75 0.58 41.11 12.32
18 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
19 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
20 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
21 INT11729 Regulation of IGF1 71 0.61 44.58 9.71
22 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
23 INT34777 Localization of IGF1 82 0.80 42.68 8.62
24 INT82082 Localization of Lep 63 0.81 26.41 8.56
25 INT75907 Binding of LEP 53 0.46 46.65 8.44
26 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
27 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
28 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
29 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
30 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
31 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
32 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
33 INT151032 Localization of Igf1 49 0.76 26.32 5.71
34 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
35 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
36 INT65356 Localization of LEP 46 0.79 41.17 5.43
37 INT91338 Binding of Lep 31 0.48 26.86 5.39
38 INT102935 Regulation of Lep 31 0.60 18.47 5.24
39 INT97391 Binding of Lep 18 0.48 8.97 4.47
40 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
41 INT49360 Localization of Igf1 22 0.76 6.96 4.26
42 INT163581 Localization of Lep 27 0.79 18.99 4.08
43 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
44 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
45 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
46 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
47 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
48 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
49 INT131187 Regulation of Gene_expression of IGF1 18 0.62 11.18 3.05
50 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
51 INT16130 Binding of IGF1 67 0.48 27.43 2.95
52 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
53 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
54 INT66544 Binding of Igf1 23 0.46 8.33 2.44
55 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
56 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
57 INT83392 Transcription of Lep 6 0.54 5.07 2.04
58 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
59 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
60 INT132971 Negative_regulation of Localization of IGF1 5 0.42 3.98 1.94
61 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
62 INT66709 Transcription of IGF1 13 0.71 5.65 1.64
63 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
64 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
65 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
66 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
67 INT90491 Binding of Igf1 25 0.44 9.75 1.36
68 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
69 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
70 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
71 INT213465 Transcription of Lep 4 0.68 2.11 1.15
72 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
73 INT28949 Negative_regulation of Positive_regulation of IGF1 11 0.42 5.03 1.11
74 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
75 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
76 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
77 INT72129 Positive_regulation of Positive_regulation of IGF1 11 0.50 4.61 1.05
78 INT169407 Phosphorylation of IGF1 4 0.63 0.83 1.01
79 INT114664 Binding of BMP2 12 0.37 6.54 0.91
80 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
81 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
82 INT202241 Positive_regulation of Negative_regulation of IGF1 5 0.48 1.56 0.82
83 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
84 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
85 INT156533 Transcription of LEP 9 0.69 4.35 0.74
86 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
87 INT124211 Protein_catabolism of IGF1 2 1.00 1.29 0.63
88 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
89 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
90 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
91 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
92 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
93 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
94 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
95 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53
96 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
97 INT85808 Localization of BMP2 7 0.77 1.94 0.51
98 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
99 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
100 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
101 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
102 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
103 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
104 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
105 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
106 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
107 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
108 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
109 INT200198 Regulation of Localization of Igf1 6 0.58 4.51 0.34
110 INT49672 Regulation of Negative_regulation of IGF1 1 0.21 1.07 0.33
111 INT105968 Positive_regulation of Binding of Igf1 2 0.20 0.56 0.32
112 INT169405 Negative_regulation of Phosphorylation of IGF1 1 0.07 0.15 0.32
113 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
114 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
115 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
116 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
117 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
118 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
119 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
120 INT200200 Positive_regulation of Negative_regulation of Igf1 3 0.47 2.33 0.22
121 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
122 INT265899 Regulation of Binding of IGF1 2 0.22 0.94 0.22
123 INT173753 Positive_regulation of Negative_regulation of Igf1 1 0.34 0.47 0.19
124 INT172368 Negative_regulation of Binding of IGF1 3 0.42 1.57 0.18
125 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
126 INT148064 Localization of Bmp2 2 0.29 0.14 0.17
127 INT231055 Regulation of Localization of Igf1 1 0.15 0 0.17
128 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
129 INT198357 Negative_regulation of Localization of Igf1 1 0.03 0.51 0.17
130 INT286068 Positive_regulation of Positive_regulation of Igf1 2 0.40 1.03 0.16
131 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
132 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
133 INT204088 Regulation of Negative_regulation of LEP 1 0.59 1.16 0.16
134 INT106010 Positive_regulation of Bmp2 2 0.26 0.91 0.15
135 INT300489 Negative_regulation of Binding of LEP 1 0.41 1.12 0.15
136 INT278979 Negative_regulation of Positive_regulation of LEP 2 0.40 0.81 0.14
137 INT185511 Regulation of Phosphorylation of Igf1 1 0.37 0 0.14
138 INT187723 Regulation of Positive_regulation of LEP 3 0.42 2.29 0.13
139 INT175970 Negative_regulation of Phosphorylation of Igf1 2 0.39 2.1 0.13
140 INT323898 Regulation of Phosphorylation of LEP 1 0.42 1.25 0.13
141 INT323895 Phosphorylation of LEP 1 0.76 1.23 0.13
142 INT285632 Regulation of Binding of Igf1 1 0.37 0.55 0.13
143 INT157241 Negative_regulation of Localization of LEP 5 0.56 2.1 0.12
144 INT212553 Negative_regulation of Transcription of IGF1 1 0.39 0.3 0.12
145 INT163815 Negative_regulation of Negative_regulation of Lep 1 0.43 0.32 0.12
146 INT48615 Positive_regulation of Binding of IGF1 5 0.50 0.54 0.11
147 INT254992 Negative_regulation of Gene_expression of BMP2 3 0.34 0.56 0.11
148 INT238044 Positive_regulation of Transcription of BMP2 2 0.43 0.83 0.11
149 INT226984 Regulation of Transcription of Lep 1 0.27 0.3 0.11
150 INT175968 Phosphorylation of Igf1 6 0.74 2.54 0.1
151 INT326976 Regulation of Localization of BMP2 1 0.59 0.08 0.1
152 INT196035 Localization of Bmp2 3 0.63 0.23 0.09
153 INT278036 Negative_regulation of BMP2 2 0.34 0.64 0.09
154 INT114663 Regulation of Binding of BMP2 1 0.38 0.19 0.09
155 INT163072 Regulation of Binding of Bmp2 1 0.30 0.52 0.08
156 INT187729 Positive_regulation of Binding of LEP 1 0.18 0.3 0.08
157 INT213475 Negative_regulation of Positive_regulation of Lep 2 0.40 1.79 0.07
158 INT318819 Positive_regulation of Transcription of IGF1 1 0.33 1.94 0.07
159 INT175972 Regulation of Phosphorylation of Igf1 1 0.41 0.95 0.07
160 INT213466 Negative_regulation of Regulation of Lep 1 0.41 0 0.06
161 INT202238 Regulation of Transcription of IGF1 1 0.38 0 0.06
162 INT196025 Negative_regulation of Bmp2 2 0.34 0.14 0.05
163 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05
164 INT229753 Positive_regulation of Gene_expression of Bmp2 2 0.11 1.22 0.04
165 INT287236 Positive_regulation of Positive_regulation of BMP2 1 0.29 0.08 0.04
166 INT176243 Positive_regulation of Binding of Igf1 3 0.07 1.36 0
167 INT294924 Regulation of Localization of IGF1 3 0.39 1.07 0
168 INT185508 Protein_catabolism of Igf1 2 0.84 0 0
169 INT189593 Regulation of Gene_expression of BMP2 2 0.33 0.8 0
170 INT202239 Negative_regulation of Negative_regulation of IGF1 2 0.39 0.53 0
171 INT253406 Negative_regulation of Positive_regulation of Lep 2 0.41 0.74 0
172 INT145300 Positive_regulation of Positive_regulation of Bmp2 2 0.34 1.03 0
173 INT142343 Negative_regulation of Regulation of Igf1 2 0.41 0.35 0
174 INT196031 Binding of Bmp2 1 0.16 0 0
175 INT150408 Regulation of Regulation of Lep 1 0.27 0 0
176 INT305226 Negative_regulation of Phosphorylation of Lep 1 0.42 1.89 0
177 INT305239 Positive_regulation of Phosphorylation of Lep 1 0.43 1.09 0
178 INT278735 Negative_regulation of Gene_expression of Bmp2 1 0.43 0.06 0
179 INT216450 Regulation of Transcription of Igf1 1 0.26 0 0
180 INT112084 Negative_regulation of Positive_regulation of Igf1 1 0.31 0.11 0
181 INT332954 Regulation of Transcription of Lep 1 0.11 1.4 0
182 INT157243 Negative_regulation of Transcription of LEP 1 0.02 0.09 0
183 INT278737 Positive_regulation of Transcription of Bmp2 1 0.47 1.4 0
184 INT120087 Negative_regulation of Gene_expression of Bmp2 1 0.11 0.14 0
185 INT174279 Positive_regulation of Negative_regulation of Lep 1 0.46 0.16 0
186 INT295565 Positive_regulation of Phosphorylation of Igf1 1 0.19 0.17 0
187 INT274266 Regulation of Positive_regulation of IGF1 1 0.35 0.17 0
188 INT264308 Negative_regulation of Regulation of IGF1 1 0.39 0.23 0
189 INT309421 Positive_regulation of Regulation of Lep 1 0.41 0.61 0
190 INT269768 Negative_regulation of Negative_regulation of Igf1 1 0.08 0.96 0
191 INT288213 Positive_regulation of Negative_regulation of Lep 1 0.47 0.06 0
192 INT278040 Negative_regulation of Localization of BMP2 1 0.32 0.32 0
193 INT112083 Negative_regulation of Negative_regulation of Igf1 1 0.31 0.22 0
194 INT246771 Negative_regulation of Phosphorylation of Igf1 1 0.09 0.37 0
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