GO:0035690

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Name cellular response to drug
Categary Process
Go Slim No
Go Link GO:0035690
Unique Molecular Interactions 1038
Total Molecular Interactions 1454
Total Single Events 11466
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to drug. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to drug. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
4 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
5 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
6 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
7 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
8 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
9 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
10 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
11 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
12 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
13 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
14 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
15 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
16 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
17 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
18 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
19 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
20 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
21 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
22 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
23 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
24 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
25 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
26 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
27 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
28 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
29 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
30 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
31 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
32 INT40887 Penk Regulation of Th 1 0.04 0 1.53
33 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
34 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
35 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
36 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
37 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
38 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
39 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
40 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
41 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
42 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
43 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
44 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
45 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
46 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
47 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
48 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
49 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
50 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
51 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
52 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
53 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
54 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
55 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
56 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
57 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
58 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
59 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
60 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
61 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
62 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
63 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
64 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
65 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
66 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
67 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
68 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
69 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
70 INT229913 Positive_regulation of Ntsr1 Positive_regulation of Gene_expression of Egr1 1 0.12 1.33 1.11
71 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
72 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
73 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
74 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
75 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
76 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
77 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
78 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
79 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
80 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
81 INT31547 Binding of Th and Vip 1 0.31 0 1.08
82 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
83 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
84 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
85 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
86 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
87 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
88 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
89 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
90 INT229914 Egr1 Positive_regulation of Phosphorylation of Mapk3 1 0.46 1.03 1.02
91 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
92 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
93 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
94 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
95 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
96 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
97 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
98 INT61860 Akr1d1 Regulation of Egr1 1 0.01 0 0.96
99 INT73461 PTPLA Positive_regulation of Transcription of TP53 1 0.06 0.99 0.96
100 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
101 INT61861 Akr1d1 Regulation of Positive_regulation of Egr1 1 0.01 0 0.96
102 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
103 INT60827 Ddc Positive_regulation of Localization of Abat 1 0.12 0.34 0.94
104 INT330629 TP53 Negative_regulation of Gene_expression of Fos 1 0.30 1.76 0.94
105 INT73467 PTPLA Positive_regulation of Transcription of Myc 1 0.29 0.97 0.94
106 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
107 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
108 INT60828 Ddc Positive_regulation of Abat 1 0.13 0.34 0.93
109 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
110 INT61859 Akr1d1 Positive_regulation of Egr1 1 0.01 0 0.92
111 INT61862 Slc3a1 Positive_regulation of Egr1 1 0.05 0 0.92
112 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
113 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
114 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
115 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
116 INT116269 Binding of Myc and Mycbp2 1 0.19 0.5 0.87
117 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
118 INT14626 Binding of Dpep1 and Pax3 1 0.01 0 0.87
119 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
120 INT330630 Binding of TP53 and Car1 1 0.23 1.56 0.86
121 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
122 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
123 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
124 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
125 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
126 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
127 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
128 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
129 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
130 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
131 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
132 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
133 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
134 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
135 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
136 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
137 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
138 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
139 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
140 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
141 INT255324 Negative_regulation of Binding of Dpep1 and 2E 1 0.02 0 0.73
142 INT255325 Binding of Dpep1 and 2E 1 0.02 0 0.73
143 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
144 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
145 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
146 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
147 INT123494 Binding of Egr1 and Ccr5 1 0.04 0.94 0.71
148 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
149 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
150 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
151 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
152 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
153 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
154 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
155 INT99937 Ddc Regulation of Transcription of Qrfp 1 0.02 0 0.69
156 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
157 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
158 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
159 INT92025 Egr1 Positive_regulation of Jun 1 0.15 0.61 0.67
160 INT92026 Egr1 Positive_regulation of Fos 1 0.50 0.61 0.67
161 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
162 INT101986 TP53 Positive_regulation of Gene_expression of GDF15 1 0.52 2.45 0.67
163 INT314560 RYBP Positive_regulation of Gene_expression of MYC 1 0.02 0.06 0.67
164 INT326586 SLC18A2 Negative_regulation of DDC 1 0.28 0.91 0.66
165 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
166 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
167 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
168 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
169 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
170 INT50634 Ddc Regulation of Gene_expression of Glul 1 0.02 0 0.65
171 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
172 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
173 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
174 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
175 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
176 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
177 INT127057 Ddc Positive_regulation of Gene_expression of Slc1a2 1 0.01 0.06 0.63
178 INT113146 Ddc Positive_regulation of Gene_expression of Nr4a1 1 0.06 0.1 0.63
179 INT127056 Ddc Positive_regulation of Transcription of Drd3 1 0.10 0.06 0.63
180 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
181 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
182 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
183 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
184 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
185 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
186 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
187 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
188 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
189 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
190 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
191 INT255319 Binding of Dpep1 and Kcnq2 1 0.01 0 0.6
192 INT255320 Binding of Dpep1 and Kcnq3 1 0.01 0 0.6
193 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
194 INT255326 Binding of Dpep1 and AIS 1 0.00 0 0.6
195 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
196 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
197 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
198 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
199 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
200 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to drug. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to drug. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
3 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
4 INT7327 Regulation of Th 164 0.62 29.67 110.14
5 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
6 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
7 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
8 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
9 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
10 INT6849 Localization of IL1B 229 0.81 112.56 69.63
11 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
12 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
13 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
14 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
15 INT350 Localization of Th 79 0.80 10.26 41.17
16 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
17 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
18 INT7326 Transcription of Th 83 0.72 13.5 35.33
19 INT6484 Binding of IL1B 122 0.47 75.84 35.07
20 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
21 INT9347 Localization of Il1b 58 0.81 26.13 31.53
22 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
23 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
24 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96
25 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
26 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
27 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
28 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93
29 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
30 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
31 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
32 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
33 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
34 INT48081 Localization of Il1b 46 0.80 21.59 22.4
35 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
36 INT6230 Localization of Ddc 40 0.79 13.11 20.88
37 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
38 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
39 INT65856 Positive_regulation of TP53 138 0.67 112.65 16.71
40 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
41 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
42 INT13716 Positive_regulation of TH 33 0.68 19.11 16
43 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
44 INT20420 Gene_expression of MYC 99 0.75 49.32 14.36
45 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
46 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
47 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
48 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
49 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
50 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
51 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
52 INT141 Binding of Th 21 0.48 3.53 11.04
53 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
54 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19
55 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
56 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
57 INT53062 Gene_expression of Ddc 31 0.77 11.59 9.63
58 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
59 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
60 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
61 INT6055 Transcription of Egr1 47 0.69 3.61 7.68
62 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
63 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
64 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6
65 INT57748 Positive_regulation of Gene_expression of TP53 85 0.69 79.55 7.49
66 INT4284 Regulation of Ddc 17 0.43 8.17 7.31
67 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
68 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
69 INT6057 Negative_regulation of Gene_expression of Egr1 17 0.57 4.17 7.17
70 INT47707 Negative_regulation of Egr1 9 0.41 0.17 7.03
71 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
72 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
73 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
74 INT3506 Localization of TH 12 0.81 0.78 6.66
75 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
76 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
77 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
78 INT11048 Gene_expression of CD69 59 0.67 42.85 6.4
79 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38
80 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
81 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
82 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
83 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
84 INT80750 Binding of Il1b 11 0.47 7.97 5.95
85 INT112545 Phosphorylation of TP53 28 0.80 14.13 5.93
86 INT17892 Gene_expression of Myc 57 0.75 36.37 5.82
87 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
88 INT10705 Binding of Il1b 9 0.36 2.8 5.53
89 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
90 INT30317 Regulation of TH 14 0.43 7.27 5.38
91 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
92 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31
93 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
94 INT60585 Regulation of TP53 59 0.59 54.55 5.21
95 INT47704 Regulation of Egr1 17 0.60 2.43 5.18
96 INT80038 Positive_regulation of Gene_expression of MYC 24 0.67 13.93 5.17
97 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
98 INT47706 Negative_regulation of Positive_regulation of Egr1 9 0.41 6.11 5.1
99 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
100 INT51944 Positive_regulation of Transcription of Egr1 12 0.49 1.96 4.72
101 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
102 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
103 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62
104 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62
105 INT57749 Negative_regulation of Gene_expression of TP53 39 0.56 36.79 4.45
106 INT137178 Gene_expression of TLR3 46 0.72 24.97 4.33
107 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
108 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
109 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
110 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
111 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
112 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
113 INT123502 Binding of Egr1 11 0.35 6.7 3.77
114 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
115 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
116 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
117 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
118 INT14625 Binding of Dpep1 2 0.02 0 3.36
119 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
120 INT20419 Negative_regulation of Gene_expression of MYC 19 0.57 9.7 3.29
121 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
122 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
123 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
124 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
125 INT8103 Binding of TP53 46 0.44 40.2 2.96
126 INT73263 Negative_regulation of MYC 20 0.57 12.86 2.95
127 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
128 INT199255 Binding of Rest 14 0.41 1.43 2.94
129 INT36886 Transcription of Myc 6 0.69 3.16 2.86
130 INT47812 Negative_regulation of Localization of Ddc 5 0.51 1.99 2.8
131 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
132 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
133 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
134 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
135 INT111368 Transcription of Mt2A 1 0.69 0.94 2.66
136 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
137 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
138 INT73460 Positive_regulation of Gene_expression of Myc 26 0.67 20.44 2.61
139 INT16406 Positive_regulation of Negative_regulation of Ddc 6 0.67 0.53 2.6
140 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
141 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
142 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
143 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
144 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
145 INT11052 Positive_regulation of Gene_expression of CD69 23 0.43 16.66 2.54
146 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
147 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
148 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
149 INT55952 Transcription of TP53 16 0.61 12.14 2.36
150 INT82798 Regulation of MYC 19 0.60 12.06 2.31
151 INT107685 Phosphorylation of MYC 3 0.80 2.52 2.28
152 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
153 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
154 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
155 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
156 INT73476 Transcription of MYC 18 0.69 12.14 2.13
157 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
158 INT80599 Regulation of Positive_regulation of Egr1 3 0.28 0.46 2.09
159 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
160 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
161 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02
162 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
163 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
164 INT157095 Binding of Ddc 5 0.27 4.6 2
165 INT243846 Localization of DDC 3 0.63 0.66 1.99
166 INT125080 Positive_regulation of Positive_regulation of TP53 21 0.58 16.16 1.98
167 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
168 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
169 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
170 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
171 INT20421 Positive_regulation of MYC 19 0.67 10.43 1.9
172 INT65855 Localization of TP53 18 0.76 17.08 1.89
173 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
174 INT37649 Gene_expression of Fbp1 4 0.49 3.16 1.84
175 INT155110 Negative_regulation of Phosphorylation of MYC 1 0.57 1.61 1.83
176 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
177 INT113345 Positive_regulation of Phosphorylation of TP53 8 0.66 6.11 1.8
178 INT3505 Binding of TH 5 0.39 2.6 1.8
179 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
180 INT94534 Gene_expression of MT2A 8 0.75 11.28 1.76
181 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
182 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
183 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
184 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
185 INT73475 Positive_regulation of Transcription of MYC 7 0.67 5.46 1.66
186 INT145545 Transcription of TH 3 0.67 1.48 1.64
187 INT64529 Localization of Pde2a 1 0.59 0 1.63
188 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
189 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
190 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
191 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
192 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
193 INT111367 Regulation of Transcription of Mt2A 1 0.44 0.65 1.5
194 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
195 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
196 INT53003 Positive_regulation of Positive_regulation of Egr1 6 0.64 2.36 1.44
197 INT15800 Positive_regulation of CD69 14 0.43 9.28 1.43
198 INT82676 Negative_regulation of Gene_expression of Ddc 4 0.55 0.55 1.43
199 INT101990 Negative_regulation of Positive_regulation of TP53 5 0.33 3.69 1.42
200 INT162469 Positive_regulation of Protein_catabolism of TP53 5 0.52 5.48 1.42
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