GO:0035729

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Name cellular response to hepatocyte growth factor stimulus
Categary Process
Go Slim No
Go Link GO:0035729
Unique Molecular Interactions 119
Total Molecular Interactions 199
Total Single Events 948
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cellular response to hepatocyte growth factor stimulus. They are ordered first by their pain relevance and then by number of times they were reported for cellular response to hepatocyte growth factor stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
2 INT182159 Binding of HGF and DCPS 1 0.01 2.5 1.17
3 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
4 INT335401 Hgf Positive_regulation of Ngf 1 0.30 1.13 1.04
5 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94
6 INT260832 Binding of NRP2 and Nrp1 1 0.00 2.32 0.7
7 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
8 INT182156 Binding of HGF and IL3RA 1 0.03 1.31 0.62
9 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48
10 INT173475 Bcar1 Regulation of Isl1 1 0.01 0 0.47
11 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47
12 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47
13 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47
14 INT323702 HGF Regulation of Gene_expression of CRP 1 0.01 0.81 0.43
15 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
16 INT23882 Npy Positive_regulation of Bcar1 1 0.34 0.67 0.34
17 INT294117 HGF Positive_regulation of PTGER2 1 0.02 0.36 0.31
18 INT74940 HGF Positive_regulation of CPOX 1 0.13 0.25 0.3
19 INT93580 Hgf Positive_regulation of Cpox 1 0.19 2.2 0.29
20 INT74942 HGF Positive_regulation of PTGS1 1 0.11 0.25 0.29
21 INT355038 NRP1 Negative_regulation of CKAP4 1 0.02 1.23 0.29
22 INT294905 Binding of Hgf and Pax3 1 0.01 1.54 0.25
23 INT334522 Ngf Positive_regulation of Nrp1 1 0.19 0.93 0.22
24 INT80704 CAMP Positive_regulation of Gene_expression of HGF 1 0.50 0.46 0.22
25 INT80706 IL4I1 Positive_regulation of Gene_expression of HGF 1 0.06 0.43 0.22
26 INT334525 Ngf Positive_regulation of Gene_expression of Nrp1 1 0.19 0.93 0.22
27 INT80705 IL4I1 Positive_regulation of HGF 1 0.03 0.43 0.22
28 INT118434 HGF Positive_regulation of TRPV1 1 0.54 0.13 0.2
29 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
30 INT192902 HGF Regulation of Kdm5d 1 0.00 0.36 0.19
31 INT57612 Binding of ALB and HGF 1 0.20 0.52 0.18
32 INT175596 Binding of ACAT1 and HGF 1 0.01 1.58 0.18
33 INT172232 CALCRL Positive_regulation of Gene_expression of NRP1 1 0.02 0.07 0.17
34 INT172237 TAS2R14 Positive_regulation of Gene_expression of NRP1 1 0.01 0.07 0.17
35 INT316123 Binding of HLA-DRA and BCAR1 1 0.02 0.48 0.16
36 INT156833 Binding of MED1 and TRPV6 1 0.32 0 0.15
37 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
38 INT334531 Nrp1 Negative_regulation of Gene_expression of Il4 1 0.08 0.48 0.14
39 INT93579 Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 1.1 0.14
40 INT334534 Nrp1 Negative_regulation of Gene_expression of Sema3a 1 0.17 0.48 0.14
41 INT334528 Nrp1 Negative_regulation of Sema3a 1 0.17 0.47 0.13
42 INT272389 Bcar1 Negative_regulation of Gene_expression of Trpv6 1 0.01 0 0.1
43 INT180200 Binding of BCAR1 and MMVP1 1 0.11 8.57 0.08
44 INT213419 Negative_regulation of FOXF1 Negative_regulation of Gene_expression of HGF 1 0.25 0.15 0.08
45 INT179872 Binding of HGF and MET 7 0.09 4.69 0.07
46 INT231440 PDGFA Positive_regulation of Gene_expression of HGF 1 0.16 0.83 0.07
47 INT98715 HGF Positive_regulation of Gene_expression of PTGS2 1 0.02 1.03 0.07
48 INT333243 Gene_expression of Cxcl12 Negative_regulation of Bcar1 1 0.15 1 0.07
49 INT231442 FN1 Positive_regulation of Gene_expression of HGF 1 0.05 0.83 0.07
50 INT278243 HGF Positive_regulation of Gene_expression of Hsdr1 1 0.00 0.4 0.06
51 INT291355 CXCL12 Positive_regulation of Gene_expression of HGF 1 0.06 1.53 0.06
52 INT225490 Med1 Positive_regulation of Ppara 1 0.12 0.26 0.06
53 INT339871 PCS Positive_regulation of Gene_expression of HGF 1 0.07 0.12 0.06
54 INT173477 Bcar1 Regulation of Localization of Ins1 1 0.16 0.07 0.05
55 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04
56 INT212442 HGF Positive_regulation of MET 2 0.21 1.25 0.04
57 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04
58 INT265771 NRP1 Positive_regulation of VEGFA 1 0.46 0 0.04
59 INT265764 NRP1 Positive_regulation of FLT1 1 0.45 0 0.04
60 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04
61 INT207699 HGF Regulation of MSMB 1 0.21 0.69 0.04
62 INT261393 Binding of Nsdhl and Med1 1 0.02 1 0.04
63 INT265772 Binding of KDR and NRP1 1 0.29 0 0.04
64 INT311926 Binding of NRP1 and SEMA3A 1 0.26 0.48 0.04
65 INT265749 Binding of FLT1 and NRP1 1 0.43 0 0.04
66 INT238210 Binding of STAT3 and Bcar1 1 0.04 0 0.03
67 INT238217 Positive_regulation of Binding of STAT3 and Bcar1 1 0.04 0 0.03
68 INT310040 Hgf Positive_regulation of Met 1 0.06 0.15 0.03
69 INT225585 Regulation of Binding of Med1 and Tpr 1 0.00 0.07 0
70 INT265744 VEGFA Regulation of Localization of NRP1 1 0.25 0 0
71 INT310044 Binding of Hgf and Slc30a4 1 0.08 0.38 0
72 INT211333 Binding of HGF and MKI67 1 0.04 1.6 0
73 INT353540 Egf Positive_regulation of Hgf 1 0.23 0.08 0
74 INT225887 HGF Positive_regulation of ATF2 1 0.01 0 0
75 INT214892 Positive_regulation of HGF Positive_regulation of CDKN1A 1 0.17 0.31 0
76 INT177262 Binding of MED1 and SV2A 1 0.23 0 0
77 INT265767 Positive_regulation of Binding of VEGFA and NRP1 1 0.46 0 0
78 INT332409 Egr1 Regulation of Hgf 1 0.26 0.14 0
79 INT265604 Egf Positive_regulation of Gene_expression of Hgf 1 0.14 0.46 0
80 INT332408 Binding of Egr1 and Hgf 1 0.35 0.14 0
81 INT211334 Binding of HGF and VEGFA 1 0.23 4.89 0
82 INT235787 Binding of NR5A1 and HGF 1 0.02 0 0
83 INT173054 NRP1 Positive_regulation of KDR 1 0.08 0.34 0
84 INT305316 Binding of Hgf and Serpina5 1 0.21 1 0
85 INT337628 Binding of HGF and PLG 1 0.17 0.69 0
86 INT311948 Binding of NRP1 and Plxna3 1 0.05 0.26 0
87 INT225896 HGF Positive_regulation of STAT3 1 0.01 0 0
88 INT265752 NRP1 Negative_regulation of Gene_expression of FLT1 1 0.33 0 0
89 INT305317 Binding of HGF and Serpina5 1 0.04 0.28 0
90 INT214891 HGF Positive_regulation of CDKN1A 1 0.25 1.15 0
91 INT265605 Egf Positive_regulation of Hgf 1 0.14 0.46 0
92 INT225481 Binding of Med1 and Acp5 1 0.16 0 0
93 INT339676 CSF2 Positive_regulation of HGF 1 0.08 0.46 0
94 INT177286 Binding of CXADR and MED1 1 0.27 0 0
95 INT265765 Binding of NRP1 and GOPC 1 0.13 0 0
96 INT210493 Binding of HGF and TEP1 1 0.01 0.19 0
97 INT351678 Nrp1 Regulation of Binding of Ecm1 1 0.00 1.55 0
98 INT265737 Binding of AR and NRP1 1 0.10 0 0
99 INT265751 NRP1 Negative_regulation of Localization of FLT1 1 0.33 0 0
100 INT339869 Binding of HGF and TSPAN12 1 0.05 0 0
101 INT339872 HGF Positive_regulation of MCS 1 0.10 0 0
102 INT225541 Binding of Med1 and Tpr 1 0.00 0.07 0
103 INT265756 Positive_regulation of Binding of AR and NRP1 1 0.10 0 0
104 INT339870 Binding of HGF and PCS 1 0.05 0.07 0
105 INT192903 Kdm5d Regulation of HGF 1 0.00 0.33 0
106 INT196185 Binding of SEMA3A and Nrp1 1 0.01 0.05 0
107 INT339874 Binding of HGF and MCS 1 0.06 0.07 0
108 INT177280 Binding of MED1 and FAUP1 1 0.01 0 0
109 INT265757 Regulation of Binding of VEGFA and NRP1 1 0.41 0 0
110 INT353543 Hgf Regulation of Gene_expression of ONECUT1 1 0.00 0.08 0
111 INT337631 Binding of HGF and CLEC3B 1 0.42 0.35 0
112 INT221638 Binding of Nrp1 and Sema3a 1 0.05 0.38 0
113 INT265738 NRP1 Positive_regulation of KLKB1 1 0.03 0 0
114 INT265741 Negative_regulation of Binding of FLT1 and NRP1 1 0.38 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cellular response to hepatocyte growth factor stimulus. They are ordered first by their pain relevance and then by number of times they were reported in cellular response to hepatocyte growth factor stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62710 Gene_expression of HGF 160 0.78 88.27 26.14
2 INT61946 Positive_regulation of HGF 57 0.69 38.93 11.99
3 INT74944 Positive_regulation of Gene_expression of HGF 31 0.70 17.69 6.68
4 INT86805 Localization of HGF 49 0.71 28.48 6.35
5 INT38595 Localization of BCAR1 8 0.73 2.9 6.25
6 INT1807 Negative_regulation of Bcar1 9 0.38 4.04 4.59
7 INT7725 Positive_regulation of Hgf 9 0.67 3.62 4.25
8 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02
9 INT38033 Regulation of HGF 26 0.45 14.96 3.81
10 INT74946 Negative_regulation of Gene_expression of HGF 14 0.58 6.29 3.39
11 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23
12 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07
13 INT87340 Negative_regulation of BCAR1 8 0.38 6.96 2.63
14 INT67318 Positive_regulation of Hgf 13 0.69 5.47 2.6
15 INT61378 Positive_regulation of Bcar1 13 0.45 2.84 2.45
16 INT67317 Gene_expression of Hgf 9 0.00 3.24 2.25
17 INT240113 Gene_expression of Nrp1 11 0.30 10.88 2.24
18 INT62711 Binding of HGF 27 0.31 15.23 2.08
19 INT76813 Gene_expression of Hgf 20 0.75 10.96 2.08
20 INT204139 Positive_regulation of Gene_expression of BCAR1 1 0.23 0.9 1.96
21 INT49146 Negative_regulation of Hgf 6 0.57 2.46 1.95
22 INT99416 Negative_regulation of Bcar1 1 0.34 0.64 1.84
23 INT113676 Gene_expression of NRP1 22 0.72 10.81 1.71
24 INT23881 Gene_expression of Bcar1 8 0.52 2.48 1.69
25 INT62712 Negative_regulation of HGF 19 0.58 7.21 1.67
26 INT112506 Transcription of HGF 14 0.64 16.71 1.64
27 INT3404 Binding of BCAR1 10 0.33 7.97 1.33
28 INT86804 Protein_catabolism of HGF 3 0.14 1.53 1.3
29 INT74945 Regulation of Gene_expression of HGF 3 0.62 1.21 1.07
30 INT183820 Regulation of BCAR1 4 0.39 3.27 1.06
31 INT93578 Localization of Hgf 6 0.77 2.97 1.03
32 INT126672 Binding of Bcar1 7 0.20 2.67 0.98
33 INT204136 Regulation of Gene_expression of BCAR1 2 0.21 0.62 0.93
34 INT49324 Binding of Hgf 9 0.36 5.5 0.88
35 INT149291 Negative_regulation of NRP1 5 0.40 2.64 0.84
36 INT149298 Protein_catabolism of NRP1 2 0.82 1.52 0.77
37 INT99090 Regulation of Hgf 3 0.55 1.33 0.76
38 INT139205 Binding of NRP1 27 0.45 4.34 0.71
39 INT3536 Positive_regulation of Nrp1 2 0.19 0.93 0.7
40 INT265800 Localization of NRP1 14 0.75 3.66 0.69
41 INT196155 Binding of Nrp1 5 0.16 2.38 0.69
42 INT7723 Localization of Hgf 10 0.46 6.28 0.68
43 INT260823 Positive_regulation of Gene_expression of Nrp1 3 0.19 2.14 0.65
44 INT7724 Positive_regulation of Localization of Hgf 1 0.24 1.58 0.65
45 INT74647 Regulation of Hgf 3 0.45 3.67 0.55
46 INT102562 Positive_regulation of Positive_regulation of HGF 3 0.36 0.92 0.53
47 INT204137 Negative_regulation of Gene_expression of BCAR1 1 0.20 0.24 0.49
48 INT61947 Positive_regulation of Regulation of HGF 2 0.46 1.35 0.48
49 INT173474 Localization of Bcar1 2 0.35 0 0.47
50 INT79935 Negative_regulation of Nrp1 3 0.17 1.36 0.46
51 INT149293 Negative_regulation of Protein_catabolism of NRP1 1 0.05 0.93 0.44
52 INT145045 Gene_expression of Med1 29 0.65 5.37 0.39
53 INT233917 Gene_expression of MED1 2 0.20 0.17 0.38
54 INT265574 Positive_regulation of Gene_expression of Hgf 5 0.62 3.6 0.31
55 INT143442 Positive_regulation of NRP1 11 0.57 2.62 0.3
56 INT106734 Phosphorylation of MED1 4 0.74 1.65 0.28
57 INT74648 Phosphorylation of Hgf 1 0.63 1.81 0.28
58 INT187017 Positive_regulation of Bcar1 2 0.44 2.02 0.27
59 INT87337 Phosphorylation of BCAR1 2 0.62 2.28 0.27
60 INT87339 Negative_regulation of Phosphorylation of BCAR1 1 0.32 0.87 0.27
61 INT264305 Negative_regulation of Gene_expression of NRP1 3 0.40 1.4 0.25
62 INT312589 Positive_regulation of Gene_expression of Bcar1 1 0.23 0 0.23
63 INT88128 Positive_regulation of Localization of HGF 7 0.45 2.74 0.17
64 INT134823 Positive_regulation of Positive_regulation of Bcar1 2 0.27 0.38 0.17
65 INT106730 Regulation of Phosphorylation of MED1 2 0.24 0.7 0.16
66 INT288628 Negative_regulation of Gene_expression of Hgf 1 0.14 0.58 0.14
67 INT174294 Regulation of Transcription of HGF 1 0.02 1.55 0.14
68 INT265792 Regulation of Localization of NRP1 1 0.22 0.21 0.13
69 INT265797 Regulation of Protein_catabolism of NRP1 1 0.51 0.21 0.13
70 INT111684 Binding of Hgf 2 0.34 0.42 0.12
71 INT106731 Negative_regulation of Phosphorylation of MED1 1 0.02 0.96 0.12
72 INT143446 Positive_regulation of Gene_expression of NRP1 1 0.45 1.02 0.12
73 INT212451 Positive_regulation of Transcription of HGF 1 0.56 7.89 0.11
74 INT88125 Regulation of Positive_regulation of HGF 1 0.36 0.48 0.1
75 INT88126 Negative_regulation of Localization of HGF 4 0.49 1.17 0.09
76 INT212448 Negative_regulation of Transcription of HGF 2 0.38 1.42 0.09
77 INT245405 Gene_expression of Bcar1 4 0.19 2.07 0.07
78 INT156864 Positive_regulation of Phosphorylation of MED1 1 0.45 0 0.07
79 INT333208 Phosphorylation of Bcar1 1 0.20 0.95 0.06
80 INT183819 Negative_regulation of Positive_regulation of BCAR1 1 0.38 2.04 0.05
81 INT306489 Regulation of Bcar1 1 0.01 0.8 0.05
82 INT332388 Positive_regulation of Phosphorylation of Hgf 1 0.42 0.05 0.04
83 INT337347 Regulation of Gene_expression of Hgf 1 0.39 0.06 0.04
84 INT332377 Phosphorylation of Hgf 1 0.56 0.05 0.04
85 INT332397 Negative_regulation of Phosphorylation of Hgf 1 0.39 0.05 0.04
86 INT307189 Localization of Med1 3 0.53 0.32 0
87 INT225400 Positive_regulation of Gene_expression of Med1 2 0.35 0.82 0
88 INT235629 Phosphorylation of NRP1 2 0.76 0.81 0
89 INT88127 Negative_regulation of Positive_regulation of HGF 2 0.42 0.19 0
90 INT225358 Negative_regulation of Gene_expression of Med1 2 0.30 1.16 0
91 INT192901 Phosphorylation of HGF 1 0.08 0 0
92 INT177336 Positive_regulation of Binding of MED1 1 0.24 0 0
93 INT307197 Negative_regulation of Med1 1 0.30 0.7 0
94 INT225844 Regulation of Localization of HGF 1 0.08 0 0
95 INT113675 Regulation of Gene_expression of NRP1 1 0.00 1.62 0
96 INT307188 Transcription of Med1 1 0.48 0.7 0
97 INT283892 Positive_regulation of Binding of BCAR1 1 0.27 0.42 0
98 INT315923 Negative_regulation of Positive_regulation of NRP1 1 0.40 0.19 0
99 INT225389 Regulation of Binding of Med1 1 0.17 0.07 0
100 INT177320 Binding of MED1 1 0.25 0 0
101 INT225457 Binding of Med1 1 0.35 0.28 0
102 INT107128 Positive_regulation of Positive_regulation of Hgf 1 0.45 0 0
103 INT265576 Regulation of Localization of Hgf 1 0.22 0.79 0
104 INT187016 Binding of Bcar1 1 0.31 1.36 0
105 INT172956 Transcription of Hgf 1 0.12 0.67 0
106 INT302041 Negative_regulation of Gene_expression of Nrp1 1 0.07 0.14 0
107 INT270756 Regulation of Bcar1 1 0.13 0.13 0
108 INT341851 Positive_regulation of MED1 1 0.01 0.5 0
109 INT349312 Regulation of Gene_expression of Bcar1 1 0.07 0.58 0
110 INT112505 Negative_regulation of Negative_regulation of HGF 1 0.42 0 0
111 INT334482 Regulation of Gene_expression of Med1 1 0.17 0.1 0
112 INT265577 Negative_regulation of Localization of Hgf 1 0.21 0.79 0
113 INT265785 Positive_regulation of Localization of NRP1 1 0.41 0 0
114 INT265793 Regulation of NRP1 1 0.22 0 0
115 INT265798 Positive_regulation of Binding of NRP1 1 0.41 0 0
116 INT99707 Positive_regulation of Gene_expression of Hgf 1 0.57 0.14 0
117 INT334481 Negative_regulation of Localization of Med1 1 0.16 0.09 0
118 INT283884 Positive_regulation of Phosphorylation of BCAR1 1 0.27 1.2 0
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