GO:0035814

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Name negative regulation of renal sodium excretion
Categary Process
Go Slim No
Go Link GO:0035814
Unique Molecular Interactions 86
Total Molecular Interactions 107
Total Single Events 928
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of renal sodium excretion. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of renal sodium excretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28
2 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
3 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
4 INT130627 Gnas Regulation of Prkaca 1 0.00 0 1.13
5 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
6 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
7 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
8 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
9 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
10 INT245572 Binding of AVPR2 and SPECC1 1 0.10 0.75 0.75
11 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
12 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
13 INT120206 Binding of UTS2R and Il1 1 0.17 1.28 0.59
14 INT120207 Binding of UTS2R and Il1f5 1 0.09 1.28 0.59
15 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
16 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
17 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
18 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
19 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
20 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 0.02 0.25 0.43
21 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
22 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
23 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
24 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
25 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
26 INT81252 Uts2r Regulation of Gene_expression of Oprm1 1 0.01 0.07 0.24
27 INT6641 Negative_regulation of Binding of Avpr2 and Oxtr 1 0.04 0.06 0.23
28 INT6642 Binding of Avpr2 and Oxtr 1 0.03 0.06 0.23
29 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
30 INT148995 Uts2 Positive_regulation of CDNF 1 0.00 0.41 0.2
31 INT104702 KNG1 Negative_regulation of Anpep 1 0.11 0.47 0.19
32 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15
33 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
34 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
35 INT276767 NR3C1 Regulation of Gene_expression of UTS2R 1 0.00 1.09 0.13
36 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12
37 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
38 INT327704 Uts2r Positive_regulation of 4930579C15Rik 1 0.03 0.48 0.1
39 INT350694 Uts2r Negative_regulation of Negative_regulation of Rc3h1 1 0.05 0.79 0.1
40 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
41 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
42 INT255289 Snap25 Regulation of Gene_expression of Gnas 1 0.00 0 0.09
43 INT284303 Mir155 Negative_regulation of Gnas 1 0.00 0.49 0.08
44 INT234802 Binding of AQP2 and AVPR2 2 0.15 0.84 0.07
45 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05
46 INT270568 Binding of UTS2R and STAT6 1 0.04 2 0.05
47 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
48 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05
49 INT327710 Binding of Gopc and Uts2r 1 0.03 0.41 0.04
50 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
51 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
52 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04
53 INT221962 UTS2R Regulation of Gene_expression of CDK5R1 1 0.09 0.43 0.03
54 INT221961 Binding of ELAVL1 and UTS2R 1 0.00 0.26 0.03
55 INT280828 Binding of Avp and Avpr2 2 0.15 0.28 0
56 INT340176 Binding of Avpr2 and Rtcd1 1 0.00 0.13 0
57 INT117419 Binding of AVPR2 and TSKU 1 0.39 0.21 0
58 INT337404 Binding of UTS2R and WG 1 0.01 0.2 0
59 INT343701 Binding of UTS2R and LOC100364739 1 0.00 0 0
60 INT284304 Binding of Adrb3 and Gnas 1 0.00 0.23 0
61 INT354076 Binding of Avpr2 and Oxt 1 0.07 0.09 0
62 INT344880 Binding of ANPEP and Mapt 1 0.08 0.15 0
63 INT350710 Uts2r Negative_regulation of Gene_expression of MIR21 1 0.01 0 0
64 INT284302 Mir155 Regulation of Gnas 1 0.00 0.64 0
65 INT205393 MME Regulation of Gene_expression of ANPEP 1 0.26 1.49 0
66 INT262706 Uts2r Positive_regulation of Bace1 1 0.10 0.39 0
67 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
68 INT292135 Binding of Anpep and Rtn4r 1 0.01 0.91 0
69 INT221442 Binding of UTS2R and CREG1 1 0.01 0.92 0
70 INT70122 NAGLU Positive_regulation of Localization of Anpep 1 0.10 0 0
71 INT327705 Binding of Sugt1 and Uts2r 1 0.00 0.19 0
72 INT221957 Binding of UTS2R and GOPC 1 0.02 0.08 0
73 INT205389 Binding of ANPEP and DCLK1 1 0.09 1.42 0
74 INT354080 Avpr2 Positive_regulation of Localization of Aqp2 1 0.02 0.07 0
75 INT205392 Binding of ANPEP and PCSK1 1 0.06 1.4 0
76 INT237461 Binding of UTS2R and TTPA 1 0.01 0.63 0
77 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0
78 INT231169 Gnas Positive_regulation of Gene_expression of Dmd 1 0.00 0.19 0
79 INT283201 Gm4658 Regulation of Gnas 1 0.00 0.56 0
80 INT262700 Uts2r Regulation of Gene_expression of Bace1 1 0.12 0.21 0
81 INT205391 MME Regulation of ANPEP 1 0.26 1.36 0
82 INT234791 Binding of AVP and AVPR2 1 0.14 0.55 0
83 INT354079 Binding of Avpr2 and Oxtr 1 0.12 0.09 0
84 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
85 INT325836 Binding of Dnm2 and Gnas 1 0.00 0.22 0
86 INT325839 Binding of Dnm1 and Gnas 1 0.00 0.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of renal sodium excretion. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of renal sodium excretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
2 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
3 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28
4 INT19155 Binding of Adora1 25 0.47 6.41 10.72
5 INT62919 Regulation of Gnas 22 0.43 5.61 9.55
6 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
7 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
8 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
9 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51
10 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
11 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
12 INT9167 Binding of Adora1 6 0.40 0.53 6.9
13 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
14 INT11258 Gene_expression of Gnas 58 0.58 21.6 6.33
15 INT67635 Negative_regulation of Gnas 29 0.04 11.4 6.32
16 INT24504 Localization of Anpep 19 0.80 3.44 6.23
17 INT3768 Negative_regulation of ANPEP 16 0.59 4.96 5.52
18 INT98357 Binding of Gnas 11 0.41 1.87 4.35
19 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26
20 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18
21 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
22 INT215604 Localization of Adora1 10 0.78 1.47 3.49
23 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38
24 INT18477 Protein_catabolism of ANPEP 7 0.79 0.41 3.26
25 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
26 INT30228 Protein_catabolism of Anpep 3 0.42 0.82 2.87
27 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
28 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
29 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
30 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
31 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
32 INT24997 Protein_catabolism of Anpep 6 0.96 0 2.34
33 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
34 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13
35 INT51570 Regulation of Anpep 6 0.43 1.7 2
36 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
37 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
38 INT48357 Positive_regulation of Anpep 7 0.39 2.04 1.75
39 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
40 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
41 INT54366 Gene_expression of Anpep 6 0.77 1.38 1.52
42 INT9953 Positive_regulation of Gnas 10 0.34 3.21 1.51
43 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
44 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
45 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31
46 INT47514 Localization of Avpr2 7 0.61 4.43 1.24
47 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
48 INT130814 Binding of ANPEP 8 0.48 4.83 1.05
49 INT84325 Regulation of Gene_expression of Anpep 2 0.62 0.06 1.02
50 INT79862 Negative_regulation of Gene_expression of ANPEP 3 0.38 1.67 0.98
51 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
52 INT51744 Regulation of Uts2 8 0.56 0.23 0.86
53 INT79861 Localization of ANPEP 4 0.62 0.54 0.86
54 INT184678 Regulation of Uts2r 7 0.14 2.57 0.85
55 INT244897 Binding of Uts2r 7 0.11 1.8 0.84
56 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
57 INT213960 Localization of Anpep 1 0.09 0.28 0.83
58 INT31046 Negative_regulation of Uts2 6 0.42 0.44 0.76
59 INT215783 Localization of Gnas 1 0.12 1.64 0.76
60 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
61 INT18479 Negative_regulation of Protein_catabolism of ANPEP 1 0.34 0 0.69
62 INT6640 Negative_regulation of Avpr2 3 0.37 1.21 0.65
63 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
64 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
65 INT147323 Transcription of Anpep 1 0.42 0.19 0.56
66 INT147321 Negative_regulation of Transcription of Anpep 1 0.34 0.2 0.56
67 INT52780 Positive_regulation of Protein_catabolism of Anpep 1 0.17 0 0.55
68 INT47513 Negative_regulation of Localization of Avpr2 1 0.22 0.62 0.53
69 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
70 INT65215 Negative_regulation of Protein_catabolism of Anpep 1 0.36 0 0.53
71 INT317151 Transcription of Uts2r 4 0.24 1.16 0.51
72 INT124614 Transcription of ANPEP 3 0.52 1.1 0.51
73 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
74 INT28507 Regulation of ANPEP 4 0.26 1.84 0.5
75 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
76 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
77 INT81357 Regulation of Negative_regulation of Gnas 1 0.02 0.1 0.47
78 INT61867 Positive_regulation of Regulation of Anpep 1 0.36 0.33 0.44
79 INT48356 Binding of Anpep 1 0.32 0 0.4
80 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
81 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
82 INT130815 Regulation of Gene_expression of ANPEP 3 0.62 1.88 0.37
83 INT48355 Transcription of Anpep 1 0.40 0 0.37
84 INT48358 Positive_regulation of Transcription of Anpep 1 0.35 0 0.37
85 INT6637 Positive_regulation of Avpr2 2 0.10 1.02 0.34
86 INT51743 Gene_expression of Uts2 5 0.76 0.3 0.33
87 INT92881 Transcription of ADORA1 1 0.69 0 0.31
88 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
89 INT53854 Regulation of Negative_regulation of Uts2 3 0.44 0 0.29
90 INT240681 Positive_regulation of AVPR2 3 0.41 0.87 0.29
91 INT31740 Positive_regulation of Localization of Anpep 1 0.16 0 0.27
92 INT310382 Positive_regulation of Binding of Uts2r 1 0.03 0.19 0.27
93 INT31741 Positive_regulation of Positive_regulation of Anpep 1 0.15 0 0.27
94 INT62618 Positive_regulation of Negative_regulation of Anpep 1 0.14 0 0.27
95 INT106639 Negative_regulation of Negative_regulation of AVPR2 1 0.29 1.58 0.25
96 INT317149 Localization of Uts2r 1 0.07 0 0.25
97 INT6639 Binding of Avpr2 1 0.08 0.06 0.24
98 INT147324 Positive_regulation of Gene_expression of Anpep 1 0.40 0.09 0.24
99 INT6636 Positive_regulation of Binding of Avpr2 1 0.11 0.06 0.24
100 INT186700 Localization of Adora1 1 0.23 0 0.23
101 INT327694 Positive_regulation of Transcription of Uts2r 1 0.17 0.26 0.21
102 INT177664 Gene_expression of Avpr2 3 0.35 0.49 0.2
103 INT106638 Negative_regulation of AVPR2 2 0.39 2.05 0.2
104 INT320068 Gene_expression of AVPR2 1 0.65 0.91 0.19
105 INT208539 Positive_regulation of Gene_expression of Gnas 4 0.08 2.76 0.18
106 INT320070 Localization of AVPR2 1 0.72 1.07 0.15
107 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
108 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
109 INT208039 Gene_expression of UTS2R 14 0.43 4.95 0.13
110 INT31309 Binding of Anpep 1 0.36 0 0.13
111 INT183206 Regulation of UTS2R 5 0.13 3.17 0.12
112 INT53855 Positive_regulation of Gene_expression of Uts2 1 0.49 0 0.11
113 INT51742 Binding of Uts2 1 0.34 0 0.08
114 INT107569 Transcription of Gnas 1 0.01 0 0.08
115 INT208046 Positive_regulation of UTS2R 3 0.45 0.7 0.07
116 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
117 INT311337 Positive_regulation of Uts2r 3 0.12 1.34 0.05
118 INT183205 Binding of UTS2R 3 0.11 1.33 0.05
119 INT222268 Transcription of UTS2R 2 0.44 0.21 0.05
120 INT222265 Regulation of Transcription of UTS2R 1 0.29 0 0.05
121 INT277277 Regulation of Gene_expression of Gnas 2 0.00 0.33 0.04
122 INT327271 Negative_regulation of Uts2r 2 0.13 0.42 0.04
123 INT341318 Positive_regulation of Gene_expression of ANPEP 1 0.45 1.97 0.04
124 INT341317 Positive_regulation of Binding of ANPEP 1 0.45 0.98 0.04
125 INT263258 Protein_catabolism of Uts2r 1 0.05 0.47 0.04
126 INT174354 Gene_expression of Avpr2 8 0.35 0.87 0
127 INT174351 Binding of Avpr2 3 0.09 0 0
128 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0
129 INT146789 Regulation of Anpep 2 0.20 0 0
130 INT208049 Regulation of Gene_expression of UTS2R 2 0.16 0.24 0
131 INT177667 Positive_regulation of Gene_expression of Avpr2 1 0.31 0.27 0
132 INT265296 Negative_regulation of Gene_expression of UTS2R 1 0.04 0.16 0
133 INT234812 Binding of AVPR2 1 0.17 0.55 0
134 INT263261 Regulation of Gene_expression of Uts2r 1 0.04 0 0
135 INT202870 Negative_regulation of Negative_regulation of Gnas 1 0.01 0.53 0
136 INT234829 Phosphorylation of AVPR2 1 0.29 0.24 0
137 INT208042 Localization of UTS2R 1 0.06 0.45 0
138 INT202861 Positive_regulation of Negative_regulation of Gnas 1 0.01 0.39 0
139 INT174350 Positive_regulation of Gene_expression of Avpr2 1 0.15 0.27 0
140 INT177668 Regulation of Gene_expression of Avpr2 1 0.20 0.39 0
141 INT208041 Positive_regulation of Localization of UTS2R 1 0.04 0.45 0
142 INT141560 Positive_regulation of Uts2 1 0.50 0 0
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