GO:0035985

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Name senescence-associated heterochromatin focus
Categary Component
Go Slim No
Go Link GO:0035985
Unique Molecular Interactions 58
Total Molecular Interactions 91
Total Single Events 799
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for senescence-associated heterochromatin focus. They are ordered first by their pain relevance and then by number of times they were reported for senescence-associated heterochromatin focus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
3 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
4 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
5 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
6 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
7 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
8 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
9 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
10 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
11 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
12 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
13 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
14 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
15 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
16 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
17 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
18 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
19 INT223536 Binding of HAND1 and Hmga1 1 0.26 0.57 0.07
20 INT223531 Binding of Hmga1 and Tcf3 1 0.26 0.57 0.07
21 INT204073 Binding of Cdkn2a and Cdk4 1 0.02 0.78 0.05
22 INT204072 Binding of Cdkn2a and Cdk6 1 0.02 0.78 0.05
23 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
24 INT314677 TP53 Regulation of Positive_regulation of CDKN2A 1 0.27 0.97 0.03
25 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
26 INT225228 Binding of Cdk4 and Cdkn2a 1 0.21 1.24 0
27 INT329680 BMI1 Negative_regulation of Gene_expression of CDKN2A 1 0.15 1.14 0
28 INT329676 CBX7 Regulation of Localization of CDKN2A 1 0.51 2.4 0
29 INT215707 Cdkn2a Negative_regulation of Cdkn1b 1 0.01 0 0
30 INT246914 Binding of CDKN2A and Ifng 1 0.01 0.71 0
31 INT311404 Binding of CDKN2A and Celf1 1 0.32 0.07 0
32 INT185281 Binding of CDK6 and CDKN2A 1 0.29 0.87 0
33 INT204234 Binding of CDKN2A and TP53 1 0.43 1.27 0
34 INT225229 Binding of Cdk6 and Cdkn2a 1 0.19 1.25 0
35 INT353437 Negative_regulation of Trp53 Positive_regulation of Gene_expression of Cdkn2a 1 0.24 0.59 0
36 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
37 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
38 INT184956 ID1 Negative_regulation of CDKN2A 1 0.42 0.21 0
39 INT204078 Binding of CDKN2A and Cdk4 1 0.15 0.72 0
40 INT215699 Cdkn2a Negative_regulation of Cdkn1c 1 0.01 0 0
41 INT215696 Cdkn2a Negative_regulation of Kras 1 0.00 0 0
42 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
43 INT223523 Positive_regulation of Hmga1 Positive_regulation of Erv4 1 0.21 0.95 0
44 INT329677 CDKN2A Regulation of CBX7 1 0.31 2.23 0
45 INT217151 Gene_expression of MIR98 Negative_regulation of HMGA2 1 0.24 1.08 0
46 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
47 INT204077 Binding of CDKN2A and Cdk6 1 0.15 0.72 0
48 INT268600 Mirlet7a-1 Regulation of HMGA2 1 0.01 0.72 0
49 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
50 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
51 INT196951 Hmga2 Positive_regulation of E2f1 1 0.50 0.98 0
52 INT196942 Binding of E2f1 and Hmga2 1 0.39 0.87 0
53 INT314685 TBX2 Negative_regulation of CDKN2A 1 0.32 1.16 0
54 INT217142 MIR98 Regulation of Gene_expression of HMGA2 1 0.40 2.22 0
55 INT329679 CBX7 Regulation of CDKN2A 1 0.31 4.18 0
56 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
57 INT314680 Positive_regulation of TBX2 Negative_regulation of CDKN2A 1 0.34 1.16 0
58 INT311403 CDKN2A Regulation of Celf1 1 0.41 0.14 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for senescence-associated heterochromatin focus. They are ordered first by their pain relevance and then by number of times they were reported in senescence-associated heterochromatin focus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
2 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
3 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
4 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
5 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
6 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
7 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
8 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
9 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
10 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
11 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
12 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
13 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
14 INT168167 Gene_expression of Hmga1 3 0.60 3.48 1.09
15 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
16 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
17 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
18 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
19 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
20 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
21 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
22 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
23 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
24 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
25 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
26 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
27 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
28 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
29 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
30 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
31 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
32 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
33 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
34 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
35 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
36 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
37 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
38 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
39 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
40 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
41 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
42 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
43 INT223502 Binding of Hmga1 1 0.27 0.96 0.13
44 INT223509 Positive_regulation of Gene_expression of Hmga1 1 0.38 0.96 0.13
45 INT112001 Binding of Cdkn2a 1 0.24 0.35 0.1
46 INT273604 Regulation of Negative_regulation of Cdkn2a 1 0.12 0.68 0.09
47 INT170298 Regulation of Gene_expression of Hmga2 1 0.01 0.48 0.08
48 INT88990 Binding of HMGA2 1 0.48 0.95 0.07
49 INT170300 Positive_regulation of Gene_expression of Hmga2 2 0.68 4.51 0.06
50 INT170302 Regulation of Hmga2 2 0.44 0.94 0.06
51 INT315215 Negative_regulation of Binding of Cdkn2a 1 0.35 0.11 0.05
52 INT76371 Protein_catabolism of Hmga2 1 0.02 0.06 0.03
53 INT94773 Negative_regulation of Gene_expression of Cdkn2a 3 0.41 0.65 0
54 INT282090 Regulation of Cdkn2a 2 0.33 2.02 0
55 INT308355 Negative_regulation of Gene_expression of Cdkn2a 2 0.48 1.42 0
56 INT147151 Positive_regulation of Negative_regulation of CDKN2A 2 0.47 1.74 0
57 INT196931 Phosphorylation of Hmga2 1 0.80 0.4 0
58 INT308400 Negative_regulation of Regulation of CDKN2A 1 0.40 0.87 0
59 INT196923 Binding of Hmga2 1 0.47 2.5 0
60 INT172979 Regulation of Negative_regulation of CDKN2A 1 0.44 0.57 0
61 INT281254 Negative_regulation of Negative_regulation of CDKN2A 1 0.08 1.44 0
62 INT300344 Localization of HMGA2 1 0.42 1.75 0
63 INT217195 Negative_regulation of HMGA2 1 0.55 3.54 0
64 INT147147 Positive_regulation of Transcription of CDKN2A 1 0.49 0 0
65 INT185285 Negative_regulation of Transcription of CDKN2A 1 0.43 1.12 0
66 INT196932 Negative_regulation of Binding of Hmga2 1 0.42 0.24 0
67 INT196938 Negative_regulation of Hmga2 1 0.42 0.23 0
68 INT223519 Positive_regulation of Hmga1 1 0.35 0.87 0
69 INT268581 Regulation of HMGA2 1 0.18 0.72 0
70 INT184623 Positive_regulation of Localization of CDKN2A 1 0.04 0.86 0
71 INT247424 Transcription of Cdkn2a 1 0.47 0.82 0
72 INT355162 Regulation of Localization of CDKN2A 1 0.40 1.13 0
73 INT217225 Negative_regulation of Negative_regulation of HMGA2 1 0.55 2.4 0
74 INT247425 Regulation of Transcription of Cdkn2a 1 0.18 0.82 0
75 INT196921 Localization of Hmga2 1 0.74 0.44 0
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