GO:0036092

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Name phosphatidylinositol-3-phosphate biosynthetic process
Categary Process
Go Slim No
Go Link GO:0036092
Unique Molecular Interactions 123
Total Molecular Interactions 138
Total Single Events 653
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3-phosphate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for phosphatidylinositol-3-phosphate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT190178 PIK3CG Regulation of MMP12 1 0.09 0 0.65
2 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
3 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
4 INT117707 Oprm1 Positive_regulation of PIK3CG 1 0.00 0.08 0.6
5 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
6 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
7 INT337326 PIK3CD Positive_regulation of Localization of ITPR3 1 0.02 0 0.43
8 INT337325 PIK3CD Positive_regulation of Phosphorylation of IL2RG 1 0.00 0 0.43
9 INT337324 PIK3CD Positive_regulation of Gene_expression of ITPR3 1 0.02 0 0.43
10 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
11 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
12 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
13 INT257744 Binding of PIK3R2 and SHC1 1 0.08 0.96 0.28
14 INT303948 LEPR Positive_regulation of PIK3CG 1 0.02 0.22 0.28
15 INT121581 Negative_regulation of PIK3CG Positive_regulation of GDF15 1 0.36 0.59 0.24
16 INT68510 Binding of ATM and PRLR 1 0.01 0 0.19
17 INT179158 ATM Regulation of Gene_expression of GOPC 1 0.01 0 0.18
18 INT179163 ATM Regulation of Gene_expression of IL13 1 0.01 0 0.18
19 INT179161 ATM Regulation of Gene_expression of IL6 1 0.02 0 0.18
20 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
21 INT121580 PIK3CG Regulation of Gene_expression of GDF15 1 0.48 0.4 0.18
22 INT179162 ATM Regulation of Gene_expression of IL8 1 0.01 0 0.18
23 INT265892 IGF1 Positive_regulation of PIK3CG 1 0.18 1.96 0.16
24 INT203591 Positive_regulation of PIK3CG Positive_regulation of Protein_catabolism of LAMB2 1 0.00 0.46 0.14
25 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
26 INT335460 FPR1 Positive_regulation of PIK3CD 1 0.17 0 0.13
27 INT129091 Binding of PIK3CG and Lyn 1 0.00 0.47 0.12
28 INT3751 Binding of GOT1 and PIK3C2A 1 0.08 0.68 0.12
29 INT129073 Binding of GRP and PIK3CG 1 0.00 0.49 0.12
30 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11
31 INT343855 Binding of MYD88 and PIK3CG 1 0.03 0.26 0.1
32 INT224021 PIK3CG Negative_regulation of EPHB2 1 0.03 0.5 0.09
33 INT328435 PIK3CD Positive_regulation of Gene_expression of VEGFA 1 0.23 0.64 0.09
34 INT205204 LPA Positive_regulation of Positive_regulation of Pik3c3 1 0.02 0.22 0.09
35 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
36 INT246845 Binding of PIK3CA and Ppp1r13b 1 0.13 0.15 0.08
37 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
38 INT92584 Negative_regulation of PIK3C3 Negative_regulation of Gene_expression of PTGER2 1 0.01 0.46 0.07
39 INT302164 PTEN Regulation of PIK3CD 1 0.16 1.13 0.06
40 INT328438 PRB4 Negative_regulation of PIK3CD 1 0.06 0.29 0.05
41 INT341021 Positive_regulation of Cp Positive_regulation of Positive_regulation of PIK3CB 1 0.00 0.15 0.04
42 INT341016 Reln Positive_regulation of Positive_regulation of PIK3CB 1 0.01 0.15 0.04
43 INT332286 PIK3CD Positive_regulation of MTOR 1 0.14 0.73 0.03
44 INT179951 Binding of PIK3CA and Ins1 1 0.39 0.32 0.03
45 INT328436 PRB4 Negative_regulation of Gene_expression of PIK3CD 1 0.07 0.24 0.03
46 INT328430 PRB4 Regulation of Positive_regulation of PIK3CD 1 0.06 0.4 0.03
47 INT332284 IRS1 Regulation of PIK3CD 1 0.15 0.72 0.03
48 INT321402 Binding of NPHS1 and PIK3CD 1 0.02 0.73 0.03
49 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
50 INT265880 IGF1 Regulation of PIK3CG 1 0.10 1.23 0.03
51 INT295476 PIK3CA Regulation of Gene_expression of TNF 1 0.00 0.05 0.03
52 INT332288 Positive_regulation of IRS1 Regulation of PIK3CD 1 0.07 0.73 0.03
53 INT176131 Binding of AKT1 and PIK3CG 2 0.15 1.08 0
54 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
55 INT201767 Igf1 Positive_regulation of PIK3CG 1 0.00 0.84 0
56 INT322849 Binding of PIK3CD and PDCD10 1 0.16 0 0
57 INT325770 Binding of EPOR and PIK3R2 1 0.01 0.18 0
58 INT250659 Negative_regulation of PTEN Positive_regulation of Positive_regulation of PIK3CB 1 0.02 1.18 0
59 INT246799 Pik3c3 Positive_regulation of Negative_regulation of Ogg1 1 0.04 0 0
60 INT336033 PIK3CG Regulation of AKT1 1 0.03 0.43 0
61 INT333456 ATM Positive_regulation of CHEK2 1 0.20 0 0
62 INT328431 PIK3CD Negative_regulation of Gene_expression of VEGFA 1 0.22 0.29 0
63 INT304022 Binding of PIK3CG and TP53 1 0.10 0.72 0
64 INT340927 Negative_regulation of PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
65 INT176137 Negative_regulation of Binding of AKT1 and PIK3CG 1 0.17 0.25 0
66 INT341025 PIK3CB Positive_regulation of Regulation of Vim 1 0.01 0 0
67 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
68 INT354122 MIR126 Regulation of PIK3CG 1 0.03 2.01 0
69 INT333455 ATM Positive_regulation of TP53 1 0.18 0 0
70 INT322844 Binding of KDR and PIK3CD 1 0.04 0 0
71 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0
72 INT320712 Binding of NRAS and PIK3CD 1 0.21 1.66 0
73 INT271101 PIK3CB Regulation of Akt1 1 0.01 0.72 0
74 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
75 INT304018 Regulation of Binding of PIK3CG and TP53 1 0.12 0.73 0
76 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
77 INT262759 PIK3CG Positive_regulation of MTOR 1 0.38 0.54 0
78 INT340929 VLDLR Positive_regulation of PIK3CB 1 0.01 0.06 0
79 INT225903 Binding of GAB1 and PIK3CG 1 0.01 0.13 0
80 INT201773 Binding of BCL2L1 and Positive_regulation of Negative_regulation of PIK3CG 1 0.01 0.3 0
81 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
82 INT250666 ERBB2 Positive_regulation of PIK3CB 1 0.15 0.69 0
83 INT225876 PIK3CG Positive_regulation of Ilk 1 0.00 0 0
84 INT341020 PIK3CB Regulation of Gene_expression of Fabp7 1 0.02 0 0
85 INT333450 ATM Positive_regulation of Negative_regulation of MDM2 1 0.18 0 0
86 INT333460 ATM Positive_regulation of Negative_regulation of CHEK2 1 0.14 0 0
87 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0
88 INT250718 PIK3CB Regulation of Gene_expression of Birc5 1 0.23 0.91 0
89 INT293806 AR Positive_regulation of PIK3CG 1 0.06 0.12 0
90 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
91 INT287269 Binding of ERBB3 and PIK3CG 1 0.11 0.74 0
92 INT340924 PIK3CB Negative_regulation of Positive_regulation of AKT1 1 0.00 0 0
93 INT293802 PTEN Regulation of PIK3CG 1 0.03 0.07 0
94 INT294828 DPYD Positive_regulation of PIK3CB 1 0.00 0.51 0
95 INT328427 PIK3CD Negative_regulation of Phosphorylation of AKT1 1 0.09 0.29 0
96 INT341023 PIK3CB Positive_regulation of Nrg1 1 0.03 0.06 0
97 INT322848 VEGFA Positive_regulation of PIK3CD 1 0.09 0 0
98 INT322843 Positive_regulation of PIK3CD Positive_regulation of Positive_regulation of RHOA 1 0.03 0 0
99 INT347290 Positive_regulation of CCL16 Positive_regulation of PIK3CB 1 0.03 0.57 0
100 INT320715 NRAS Positive_regulation of PIK3CD 1 0.27 1.66 0
101 INT304026 Binding of PIK3CG and PTEN 1 0.11 0.62 0
102 INT223579 PTEN Negative_regulation of PIK3CG 1 0.18 0.56 0
103 INT246802 Pik3c3 Positive_regulation of Positive_regulation of Akt1 1 0.04 0 0
104 INT333458 ATM Positive_regulation of MDM2 1 0.25 0 0
105 INT78634 ATM Positive_regulation of AGT 1 0.17 0.16 0
106 INT198001 Negative_regulation of PIK3CA Negative_regulation of Gene_expression of MCL1 1 0.26 0.89 0
107 INT293816 Binding of AR and PIK3CG 1 0.03 0.27 0
108 INT250664 PIK3CB Positive_regulation of AKT1 1 0.09 0.62 0
109 INT225894 Binding of MET and PIK3CG 1 0.00 0.13 0
110 INT201759 Ngf Positive_regulation of PIK3CG 1 0.01 0.84 0
111 INT250660 PIK3CB Negative_regulation of AKT1 1 0.09 0.83 0
112 INT262753 Binding of MTOR and PIK3CG 1 0.20 0.82 0
113 INT223578 INS Positive_regulation of PIK3CG 1 0.05 0.87 0
114 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0
115 INT223576 PIK3CG Regulation of MTOR 1 0.15 0.37 0
116 INT333452 ATM Positive_regulation of Negative_regulation of TP53 1 0.18 0 0
117 INT252549 ATM Positive_regulation of Positive_regulation of CHEK2 1 0.02 0 0
118 INT223580 Positive_regulation of PIK3CG Regulation of MTOR 1 0.25 0.42 0
119 INT225904 Binding of GAB1 and PIK3CA 1 0.07 0.06 0
120 INT341022 PIK3CB Regulation of Gene_expression of Erbb3 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for phosphatidylinositol-3-phosphate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in phosphatidylinositol-3-phosphate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18
2 INT108202 Positive_regulation of PIK3CG 47 0.67 25.83 8.25
3 INT120401 Positive_regulation of PIK3CD 33 0.45 14.89 7.37
4 INT118274 Positive_regulation of Positive_regulation of PIK3CG 8 0.64 4.81 4.62
5 INT26404 Positive_regulation of ATM 15 0.49 10.94 4.39
6 INT110343 Negative_regulation of PIK3CD 22 0.40 5.84 4.2
7 INT86919 Negative_regulation of PIK3CG 40 0.57 21.16 3.97
8 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
9 INT4435 Gene_expression of PIK3C2A 20 0.77 14.43 2.48
10 INT264967 Positive_regulation of Positive_regulation of PIK3CD 4 0.18 1.97 2.13
11 INT243799 Gene_expression of PIK3CD 15 0.45 6.63 1.5
12 INT94572 Negative_regulation of Pik3c3 5 0.13 1.37 1.41
13 INT250707 Gene_expression of PIK3CB 15 0.31 5.4 1.34
14 INT152255 Gene_expression of ATM 14 0.71 12.53 1.26
15 INT148027 Localization of Pik3c3 1 0.24 0.34 1.17
16 INT264969 Localization of PIK3CD 5 0.50 0.64 1.13
17 INT155696 Gene_expression of PIK3CG 16 0.65 8.54 1.02
18 INT1940 Localization of PIK3C2A 8 0.78 7.28 1.01
19 INT2991 Regulation of PIK3C2A 6 0.60 4.46 0.99
20 INT250708 Negative_regulation of PIK3CB 17 0.30 3.09 0.94
21 INT150942 Regulation of Pik3c3 2 0.18 0.96 0.94
22 INT108204 Regulation of PIK3CG 9 0.12 4.16 0.75
23 INT11709 Positive_regulation of Gene_expression of PIK3C2A 2 0.49 1.88 0.74
24 INT190187 Regulation of Gene_expression of PIK3CG 1 0.13 0 0.65
25 INT264964 Positive_regulation of Localization of PIK3CD 1 0.13 0.05 0.62
26 INT48212 Binding of ATM 5 0.47 3.89 0.57
27 INT160778 Transcription of ATM 1 0.40 1.03 0.57
28 INT132781 Phosphorylation of PIK3CG 8 0.52 4.83 0.53
29 INT160776 Positive_regulation of Positive_regulation of ATM 2 0.43 0.94 0.53
30 INT205200 Positive_regulation of Pik3c3 7 0.08 2.76 0.51
31 INT154565 Regulation of Positive_regulation of PIK3CD 2 0.09 1.59 0.45
32 INT240033 Phosphorylation of PIK3R2 1 0.02 1.82 0.45
33 INT337345 Regulation of Gene_expression of PIK3CD 1 0.20 0 0.43
34 INT337344 Negative_regulation of Negative_regulation of PIK3CD 1 0.19 0 0.4
35 INT315892 Negative_regulation of Binding of ATM 1 0.07 1.41 0.4
36 INT132780 Positive_regulation of Phosphorylation of PIK3CG 1 0.01 0.37 0.4
37 INT154768 Negative_regulation of ATM 10 0.57 7.05 0.39
38 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
39 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
40 INT78025 Negative_regulation of PIK3C2A 2 0.22 1.14 0.28
41 INT167438 Localization of ATM 3 0.55 1.61 0.27
42 INT3979 Positive_regulation of Positive_regulation of PIK3C2A 2 0.45 1.49 0.27
43 INT250712 Regulation of PIK3CB 2 0.15 0.88 0.25
44 INT254654 Positive_regulation of Localization of PIK3C2A 1 0.49 0.84 0.25
45 INT89399 Negative_regulation of Positive_regulation of PIK3CA 3 0.57 1 0.22
46 INT176145 Positive_regulation of Gene_expression of PIK3CG 3 0.20 1.36 0.22
47 INT222130 Gene_expression of Pik3c3 3 0.12 0.62 0.21
48 INT276186 Negative_regulation of Gene_expression of Pik3c3 1 0.07 0.3 0.21
49 INT147732 Binding of PIK3CA 3 0.36 1.13 0.2
50 INT178118 Positive_regulation of PIK3CB 12 0.32 5.06 0.19
51 INT92586 Negative_regulation of PIK3C3 2 0.03 0.73 0.18
52 INT246833 Positive_regulation of Binding of PIK3CA 1 0.49 0.29 0.16
53 INT302261 Regulation of PIK3CD 7 0.29 5.34 0.15
54 INT147731 Phosphorylation of PIK3CA 3 0.44 1.93 0.14
55 INT296668 Negative_regulation of Positive_regulation of PIK3C2A 1 0.41 0.54 0.14
56 INT243793 Phosphorylation of PIK3CD 5 0.42 1.74 0.13
57 INT278288 Regulation of Localization of ATM 1 0.09 0.95 0.13
58 INT167440 Regulation of ATM 2 0.20 0.68 0.12
59 INT351430 Binding of PIK3C3 1 0.01 0 0.11
60 INT284321 Gene_expression of PIK3R2 1 0.20 0.97 0.09
61 INT262775 Negative_regulation of Phosphorylation of PIK3CG 1 0.28 1.1 0.09
62 INT147733 Regulation of Binding of PIK3CA 1 0.10 0.23 0.08
63 INT328448 Negative_regulation of Gene_expression of PIK3CD 1 0.21 0.84 0.08
64 INT230866 Negative_regulation of Gene_expression of PIK3CG 2 0.28 1.37 0.07
65 INT284333 Positive_regulation of PIK3R2 1 0.12 0.42 0.05
66 INT341853 Negative_regulation of Negative_regulation of PIK3CG 1 0.14 0.85 0.04
67 INT201693 Negative_regulation of Positive_regulation of PIK3CG 1 0.05 1.04 0.04
68 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03
69 INT176162 Binding of PIK3CG 5 0.15 1.3 0.03
70 INT250703 Negative_regulation of Negative_regulation of PIK3CB 2 0.20 1.16 0.03
71 INT176150 Localization of PIK3CA 2 0.73 0.22 0.03
72 INT176160 Positive_regulation of Localization of PIK3CA 1 0.13 0.22 0.03
73 INT320732 Binding of PIK3CD 3 0.20 1.66 0
74 INT250702 Positive_regulation of Gene_expression of PIK3CB 3 0.23 1.79 0
75 INT347315 Binding of PIK3CB 2 0.19 1.57 0
76 INT176151 Regulation of Negative_regulation of PIK3CG 2 0.28 0.92 0
77 INT198037 Regulation of PIK3CA 2 0.28 2.63 0
78 INT340980 Negative_regulation of Positive_regulation of PIK3CB 2 0.12 0.59 0
79 INT322525 Phosphorylation of PIK3CB 2 0.42 1.09 0
80 INT157290 Regulation of Gene_expression of ATM 2 0.44 0.86 0
81 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0
82 INT246778 Positive_regulation of Positive_regulation of Pik3c3 1 0.06 0 0
83 INT315886 Regulation of Positive_regulation of PIK3CA 1 0.10 0.53 0
84 INT246766 Positive_regulation of Gene_expression of Pik3c3 1 0.04 0.32 0
85 INT354742 Phosphorylation of ATM 1 0.50 1.74 0
86 INT208050 Localization of PIK3C3 1 0.01 0.13 0
87 INT340989 Localization of PIK3CB 1 0.06 0 0
88 INT311855 Regulation of Negative_regulation of PIK3CD 1 0.04 0.28 0
89 INT208038 Regulation of PIK3C3 1 0.00 0.64 0
90 INT193985 Regulation of Phosphorylation of PIK3CG 1 0.03 0.32 0
91 INT271099 Regulation of Gene_expression of PIK3CB 1 0.08 0.62 0
92 INT176159 Regulation of Positive_regulation of PIK3CG 1 0.18 0.21 0
93 INT322533 Negative_regulation of Gene_expression of PIK3CB 1 0.11 0.57 0
94 INT198035 Regulation of Negative_regulation of PIK3CA 1 0.15 0.95 0
95 INT340998 Positive_regulation of Positive_regulation of PIK3CB 1 0.04 0.14 0
96 INT198030 Regulation of Regulation of PIK3CA 1 0.24 1.08 0
97 INT322530 Negative_regulation of Phosphorylation of PIK3CB 1 0.15 0.24 0
98 INT322527 Regulation of Negative_regulation of PIK3CB 1 0.07 0 0
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