GO:0038003

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Name opioid receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0038003
Unique Molecular Interactions 310
Total Molecular Interactions 432
Total Single Events 3286
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for opioid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for opioid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22
3 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29
4 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
5 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85
6 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
7 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
8 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45
9 INT137918 Oprm1 Positive_regulation of Pdgfrb 1 0.41 0 3.31
10 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
11 INT317563 Binding of Hint1 and Oprm1 1 0.20 0.25 3.03
12 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01
13 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
14 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68
15 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67
16 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
17 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
18 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
19 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
20 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
21 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
22 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
23 INT317540 Camk2a Negative_regulation of Oprm1 1 0.19 0 1.98
24 INT146099 Binding of Oprm1 and Rgs9 1 0.48 0 1.95
25 INT65025 Binding of Oprm1 and Hps4 1 0.01 0 1.93
26 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
27 INT169498 Binding of Oprm1 and Mirlet7a-1 1 0.32 0 1.9
28 INT153582 Binding of Oprm1 and Hint1 1 0.01 0 1.87
29 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86
30 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84
31 INT169502 Mirlet7a-1 Regulation of Oprm1 1 0.53 0 1.81
32 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
33 INT168925 Binding of Oprm1 and Imraq2 1 0.04 0.13 1.78
34 INT168924 Positive_regulation of Binding of Oprm1 and Imraq2 1 0.06 0.13 1.78
35 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78
36 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
37 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
38 INT6407 Binding of Lama5 and Oprm1 1 0.02 0.08 1.72
39 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
40 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
41 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68
42 INT149680 Binding of Parp1 and Oprm1 1 0.53 0 1.66
43 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64
44 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
45 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64
46 INT90046 Oprm1 Positive_regulation of P9Ehs1 2 0.16 0.92 1.63
47 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63
48 INT140341 Ngf Positive_regulation of Gene_expression of Oprm1 1 0.02 0.33 1.59
49 INT317558 Binding of Oprm1 and Rgs17 1 0.18 0 1.59
50 INT114926 Creb1 Negative_regulation of Positive_regulation of Oprm1 1 0.13 0.23 1.56
51 INT148821 Binding of Oprm1 and Grin1 1 0.05 0.24 1.55
52 INT148820 Binding of Oprm1 and Naa15 1 0.02 0.24 1.55
53 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53
54 INT117008 Sfpi1 Regulation of Oprm1 1 0.56 0.56 1.49
55 INT8735 Oprm1 Positive_regulation of Scn4a 1 0.00 0 1.49
56 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
57 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46
58 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
59 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43
60 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43
61 INT43814 Binding of Cpe and Oprm1 1 0.08 0 1.41
62 INT142852 Oprm1 Positive_regulation of Oprd1 1 0.41 0.06 1.41
63 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
64 INT106839 Arrb2 Regulation of Oprm1 2 0.21 0.44 1.33
65 INT126831 Binding of Oprk1 and Rbm39 1 0.05 0.88 1.33
66 INT38624 Binding of Oprm1 and Insrr 2 0.01 0.24 1.31
67 INT317519 Grin1 Positive_regulation of Negative_regulation of Oprm1 1 0.14 0 1.31
68 INT130786 Positive_regulation of Oprm1 Positive_regulation of Arc 1 0.27 0.9 1.31
69 INT168229 Oprm1 Regulation of Cea 1 0.10 0.26 1.3
70 INT128310 Oprm1 Positive_regulation of Oprm1 1 0.00 0.1 1.29
71 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
72 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
73 INT124767 Creb1 Regulation of Oprm1 1 0.45 0 1.26
74 INT207548 U Negative_regulation of Gene_expression of Oprm1 1 0.01 0.46 1.26
75 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26
76 INT87375 Binding of Gabrg1 and Oprm1 1 0.00 0.83 1.25
77 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
78 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24
79 INT125857 Insrr Negative_regulation of Oprm1 1 0.01 0.27 1.24
80 INT92800 Arrb2 Negative_regulation of Oprm1 1 0.37 0.33 1.24
81 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
82 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
83 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
84 INT75229 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.44 0 1.22
85 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
86 INT124157 Oprm1 Negative_regulation of Gnb5 1 0.25 0.4 1.19
87 INT153589 Binding of PRKCI and Oprm1 1 0.06 0 1.17
88 INT153588 Binding of HINT1 and Oprm1 1 0.06 0 1.17
89 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
90 INT76256 Binding of Slc6a3 and Sigmar1 1 0.20 0 1.16
91 INT88778 Binding of Oprm1 and Pomc 3 0.21 0.56 1.14
92 INT317549 Negative_regulation of Camk2a Negative_regulation of Phosphorylation of Oprm1 1 0.19 0 1.14
93 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
94 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
95 INT69338 Binding of Oprd1 and Oprm1 1 0.24 0.26 1.11
96 INT133497 Binding of Oprm1 and Cckbr 1 0.03 0 1.1
97 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
98 INT142413 Oprm1 Positive_regulation of Gdnf 1 0.19 0.29 1.09
99 INT114007 Binding of Crygs and Oprm1 1 0.03 0 1.09
100 INT317561 Binding of Grin1 and Oprm1 1 0.14 0.09 1.08
101 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04
102 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02
103 INT98555 Oprm1 Positive_regulation of Casp8 1 0.51 0.36 1.02
104 INT106956 Oprm1 Positive_regulation of Positive_regulation of P9Ehs1 1 0.08 0.54 1.02
105 INT116751 Positive_regulation of Oprm1 Positive_regulation of Pik3cd 1 0.28 0.38 1.01
106 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
107 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
108 INT98002 Positive_regulation of Oprm1 Positive_regulation of P9Ehs1 1 0.10 0 1
109 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
110 INT317532 Grin1 Regulation of Negative_regulation of Oprm1 1 0.18 0.07 1
111 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
112 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
113 INT317544 Camk2a Regulation of Negative_regulation of Oprm1 1 0.20 0.07 1
114 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
115 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
116 INT169500 Negative_regulation of Mirlet7a-1 Regulation of Oprm1 1 0.37 0 0.99
117 INT200323 Binding of Oprm1 and Sp3 1 0.39 0 0.99
118 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
119 INT317543 Pag1 Positive_regulation of Oprm1 1 0.12 0.73 0.97
120 INT137919 Binding of Oprm1 and Stat3 1 0.30 0 0.97
121 INT137922 VEGFA Positive_regulation of Oprm1 1 0.06 0 0.94
122 INT117005 Sfpi1 Positive_regulation of Oprm1 1 0.52 0.56 0.94
123 INT146096 Positive_regulation of Binding of Oprm1 and Rgs9 1 0.44 0 0.94
124 INT65024 Binding of Oprm1 and Penk 1 0.03 0 0.93
125 INT107335 Pdpk1 Positive_regulation of Regulation of Sigmar1 1 0.02 0 0.93
126 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92
127 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91
128 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
129 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
130 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
131 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
132 INT52195 Sigmar1 Positive_regulation of Positive_regulation of Grin1 1 0.15 0 0.87
133 INT63859 Oprm1 Negative_regulation of Oprm1 1 0.10 0.08 0.86
134 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86
135 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
136 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
137 INT167947 Binding of STAT1 and Oprm1 1 0.00 0 0.86
138 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85
139 INT167944 Binding of Oprm1 and Stat5a 1 0.00 0 0.85
140 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
141 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
142 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
143 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
144 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81
145 INT150350 Oprk1 Regulation of Pat 1 0.22 0.38 0.81
146 INT6409 Binding of NFKBIL1 and Oprm1 1 0.00 0 0.8
147 INT106838 Lyar Regulation of Oprm1 1 0.04 0.28 0.8
148 INT114924 Creb1 Regulation of Positive_regulation of Oprm1 1 0.09 0.13 0.79
149 INT108811 Esr2 Positive_regulation of Binding of Oprm1 1 0.46 0.44 0.79
150 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
151 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78
152 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
153 INT302119 Positive_regulation of Binding of Oprm1 and Ppp1r9b 1 0.02 0 0.77
154 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
155 INT140312 Oprm1 Regulation of Gene_expression of Penk 1 0.07 0.26 0.77
156 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
157 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76
158 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
159 INT98771 Binding of Dll1 and Oprm1 1 0.29 0 0.74
160 INT93710 Oprm1 Positive_regulation of Gene_expression of Calm3 1 0.25 0 0.73
161 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73
162 INT76069 Binding of Oprl1 and Oprm1 1 0.07 0 0.73
163 INT290553 Positive_regulation of Oprk1 Positive_regulation of Crh 1 0.33 0.39 0.72
164 INT145121 Msh3 Positive_regulation of Oprm1 1 0.06 0.15 0.72
165 INT145120 Msh3 Negative_regulation of Positive_regulation of Oprm1 1 0.05 0.15 0.72
166 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
167 INT107933 Oprm1 Positive_regulation of Gene_expression of Mastl 1 0.33 0.61 0.71
168 INT33889 pcp Regulation of Oprk1 1 0.41 0.77 0.71
169 INT104110 Negative_regulation of Adrbk2 Negative_regulation of Oprm1 1 0.00 0 0.71
170 INT207542 Sp1 Regulation of Oprm1 1 0.15 0.06 0.7
171 INT65426 Sigmar1 Regulation of Gpi1 1 0.21 0 0.7
172 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
173 INT207544 Qsox1 Regulation of Oprm1 1 0.08 0.06 0.7
174 INT290541 Gpr3 Positive_regulation of Phosphorylation of Oprk1 1 0.18 0.45 0.69
175 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69
176 INT199489 Stat6 Positive_regulation of Oprm1 1 0.02 0.85 0.68
177 INT75936 Csf2 Positive_regulation of Oprk1 1 0.25 0.78 0.67
178 INT149684 Negative_regulation of Parp1 Positive_regulation of Oprm1 1 0.51 0 0.65
179 INT96496 Binding of Oprk1 and Cq1 1 0.01 0.27 0.64
180 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
181 INT145122 Oprm1 Negative_regulation of Msh3 1 0.06 0.15 0.63
182 INT117007 Binding of Oprm1 and Sfpi1 1 0.50 0.07 0.63
183 INT149681 Parp1 Regulation of Transcription of Oprm1 1 0.67 0 0.63
184 INT123416 Gene_expression of Sp1 Positive_regulation of Oprm1 1 0.60 0 0.63
185 INT124158 Binding of Oprm1 and Rgs7 1 0.30 0.18 0.62
186 INT112032 Positive_regulation of Oprm1 Positive_regulation of Pdia3 1 0.44 0.13 0.62
187 INT124159 Binding of Oprm1 and Rgs11 1 0.31 0.18 0.62
188 INT200334 Binding of Oprm1 and Nenf 1 0.01 0 0.61
189 INT149682 Parp1 Negative_regulation of Oprm1 1 0.47 0 0.6
190 INT165317 Oprd1 Positive_regulation of Gene_expression of Oprk1 1 0.30 0.24 0.6
191 INT55919 Binding of Sigmar1 and Ap2s1 1 0.02 0.84 0.6
192 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
193 INT149683 Parp1 Negative_regulation of Transcription of Oprm1 1 0.47 0 0.58
194 INT295411 Grb7 Positive_regulation of Oprk1 1 0.02 1.03 0.57
195 INT98245 Binding of Oprm1 and Rbm39 1 0.01 0 0.57
196 INT95895 Sigmar1 Regulation of Positive_regulation of Npy 1 0.18 0 0.55
197 INT200348 Sp3 Negative_regulation of Gene_expression of Oprm1 1 0.48 0.4 0.55
198 INT114928 Positive_regulation of Creb1 Positive_regulation of Positive_regulation of Oprm1 1 0.16 0.05 0.54
199 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
200 INT21372 Binding of pcp and Sigmar1 1 0.01 0 0.53

Single Events

The table below shows the top 100 pain related interactions that have been reported for opioid receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in opioid receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29
2 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71
3 INT6406 Binding of Oprm1 280 0.48 40.54 226.26
4 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85
5 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1
6 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
7 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
8 INT8733 Localization of Oprm1 61 0.75 7.55 64.61
9 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83
10 INT68813 Transcription of Oprm1 93 0.71 20.11 57.65
11 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45
12 INT88081 Negative_regulation of Gene_expression of Oprm1 45 0.59 16.56 37.5
13 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95
14 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66
15 INT72677 Regulation of Gene_expression of Oprm1 45 0.62 13.95 26.75
16 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
17 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
18 INT57253 Negative_regulation of Binding of Oprm1 24 0.43 5.27 22.67
19 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11
20 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11
21 INT33915 Regulation of Positive_regulation of Oprm1 22 0.60 2.44 16.43
22 INT68811 Regulation of Transcription of Oprm1 19 0.61 3.67 15.15
23 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95
24 INT20715 Binding of Sigmar1 45 0.48 4.03 13.17
25 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51
26 INT99587 Positive_regulation of Gene_expression of Oprk1 15 0.57 5.26 12.39
27 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35
28 INT76138 Transcription of Oprk1 21 0.72 5.79 11.25
29 INT90903 Positive_regulation of Positive_regulation of Oprk1 13 0.47 3.49 11.18
30 INT20835 Negative_regulation of Negative_regulation of Oprm1 10 0.43 0.56 8.96
31 INT69528 Regulation of Gene_expression of Oprk1 10 0.45 4.27 8.84
32 INT98835 Positive_regulation of Transcription of Oprm1 15 0.65 2.47 8.67
33 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85
34 INT60148 Regulation of Sigmar1 20 0.43 7.23 7.76
35 INT62372 Positive_regulation of Localization of Oprm1 8 0.50 0.46 7.71
36 INT105185 Negative_regulation of Gene_expression of Oprk1 9 0.42 3.53 7.53
37 INT62524 Negative_regulation of Phosphorylation of Oprm1 7 0.59 0.08 6.92
38 INT75228 Positive_regulation of Negative_regulation of Oprm1 8 0.49 0.95 6.9
39 INT21294 Gene_expression of OGFR 32 0.78 5.75 6.41
40 INT290523 Phosphorylation of Oprk1 3 0.81 3.1 6.34
41 INT49883 Gene_expression of NPBWR1 9 0.77 3.66 6.32
42 INT25242 Positive_regulation of Sigmar1 17 0.66 3.93 5.65
43 INT112927 Negative_regulation of Localization of Oprm1 4 0.39 0.31 5.59
44 INT55917 Binding of Sigmar1 26 0.45 12.65 5.58
45 INT104226 Localization of Oprk1 12 0.75 3.22 5.41
46 INT140142 Positive_regulation of Sigmar1 17 0.63 3.78 5.26
47 INT91401 Binding of OGFR 12 0.41 4.1 4.47
48 INT105998 Protein_catabolism of Oprm1 5 0.95 0.88 4.08
49 INT72290 Localization of Sigmar1 21 0.74 4.35 3.54
50 INT114571 Gene_expression of Sigmar1 39 0.77 36.78 3.4
51 INT8731 Regulation of Localization of Oprm1 3 0.43 0.25 3.4
52 INT68812 Regulation of Regulation of Oprm1 5 0.40 0.16 3.28
53 INT59301 Negative_regulation of Positive_regulation of Oprk1 4 0.58 1.33 3.24
54 INT120601 Positive_regulation of Gene_expression of OGFR 9 0.70 2.73 3
55 INT29064 Gene_expression of Sigmar1 9 0.77 2.48 2.65
56 INT91402 Negative_regulation of OGFR 12 0.59 2.77 2.6
57 INT297507 Positive_regulation of Phosphorylation of Oprk1 1 0.50 0.63 2.26
58 INT123851 Positive_regulation of Gene_expression of NPBWR1 1 0.69 1.52 2.25
59 INT62522 Regulation of Phosphorylation of Oprm1 3 0.13 0 1.96
60 INT80918 Regulation of Transcription of Oprk1 1 0.62 1.2 1.89
61 INT107332 Negative_regulation of Regulation of Sigmar1 1 0.19 0 1.86
62 INT49882 Positive_regulation of NPBWR1 5 0.67 0.89 1.56
63 INT25241 Negative_regulation of Sigmar1 10 0.56 2.97 1.5
64 INT91404 Negative_regulation of Binding of OGFR 3 0.38 1.54 1.46
65 INT105997 Positive_regulation of Protein_catabolism of Oprm1 2 0.66 0.41 1.45
66 INT65248 Positive_regulation of OGFR 6 0.49 2.05 1.43
67 INT90703 Positive_regulation of Transcription of Oprk1 2 0.45 0.73 1.42
68 INT49881 Gene_expression of NPBWR2 5 0.76 0.22 1.35
69 INT75931 Positive_regulation of Binding of Oprk1 2 0.50 0.83 1.33
70 INT26153 Localization of Sigmar1 4 0.80 0.1 1.26
71 INT169618 Localization of OGFR 2 0.72 0.38 1.22
72 INT129374 Negative_regulation of Regulation of Oprm1 3 0.43 0.58 1.18
73 INT51897 Binding of OPCML 8 0.43 5.59 1.11
74 INT70604 Positive_regulation of Positive_regulation of Sigmar1 2 0.50 0 0.98
75 INT172294 Binding of NPBWR1 1 0.41 0.27 0.96
76 INT76139 Negative_regulation of Transcription of Oprk1 2 0.57 0.22 0.95
77 INT120164 Gene_expression of OPCML 47 0.77 36.89 0.94
78 INT26326 Regulation of Binding of Sigmar1 4 0.27 0.66 0.9
79 INT107333 Regulation of Regulation of Sigmar1 1 0.27 0 0.9
80 INT167761 Phosphorylation of Sigmar1 1 0.46 0.22 0.88
81 INT167762 Positive_regulation of Phosphorylation of Sigmar1 1 0.34 0.22 0.88
82 INT123412 Negative_regulation of Transcription of Oprm1 2 0.56 0.06 0.79
83 INT90904 Regulation of Positive_regulation of Oprk1 2 0.40 0 0.76
84 INT49880 Positive_regulation of NPBWR2 3 0.49 0.14 0.74
85 INT110346 Regulation of Binding of Oprk1 1 0.31 0 0.72
86 INT167760 Positive_regulation of Positive_regulation of Sigmar1 2 0.32 0.42 0.68
87 INT95855 Positive_regulation of Regulation of Oprk1 1 0.37 0.19 0.65
88 INT82856 Binding of NPBWR2 2 0.35 0.27 0.64
89 INT123850 Negative_regulation of NPBWR1 1 0.43 0.46 0.6
90 INT51895 Localization of OPCML 6 0.68 3.43 0.54
91 INT63458 Negative_regulation of Binding of Sigmar1 2 0.36 0.39 0.52
92 INT110278 Negative_regulation of Sigmar1 3 0.32 0.35 0.47
93 INT105186 Negative_regulation of Binding of Oprk1 1 0.42 0.06 0.44
94 INT149198 Positive_regulation of Regulation of Oprm1 2 0.47 0.23 0.42
95 INT109457 Negative_regulation of Gene_expression of OGFR 4 0.43 0.4 0.41
96 INT90553 Positive_regulation of Regulation of Sigmar1 1 0.39 0 0.41
97 INT214974 Positive_regulation of Gene_expression of Sigmar1 2 0.52 1.92 0.38
98 INT76137 Regulation of Regulation of Oprk1 1 0.02 0.07 0.36
99 INT132515 Negative_regulation of OPCML 3 0.51 10.15 0.35
100 INT214965 Positive_regulation of Localization of Sigmar1 1 0.44 0.42 0.31
101 INT136823 Transcription of OGFR 1 0.53 0.71 0.28
102 INT132513 Positive_regulation of OPCML 4 0.50 7.24 0.27
103 INT132519 Regulation of OPCML 4 0.54 5.18 0.25
104 INT63457 Positive_regulation of Gene_expression of Sigmar1 1 0.36 0.09 0.23
105 INT82855 Negative_regulation of NPBWR2 1 0.42 0 0.22
106 INT110279 Regulation of Localization of Sigmar1 1 0.01 0 0.21
107 INT74607 Negative_regulation of Positive_regulation of NPBWR1 1 0.09 0.26 0.19
108 INT214971 Protein_catabolism of Sigmar1 1 0.56 0.45 0.16
109 INT132520 Negative_regulation of Gene_expression of OPCML 3 0.51 3.99 0.14
110 INT59959 Positive_regulation of Binding of Sigmar1 1 0.47 0.16 0.14
111 INT211344 Regulation of Binding of Sigmar1 2 0.41 0.65 0.1
112 INT266951 Negative_regulation of Binding of Sigmar1 1 0.32 0.48 0.1
113 INT109458 Regulation of OGFR 6 0.53 0.46 0.07
114 INT132517 Regulation of Regulation of OPCML 1 0.45 0.38 0.07
115 INT132514 Positive_regulation of Gene_expression of OPCML 2 0.69 4.81 0.06
116 INT132518 Regulation of Binding of OPCML 1 0.39 0.32 0.05
117 INT219967 Phosphorylation of OPCML 2 0.71 1.32 0
118 INT241297 Transcription of OPCML 1 0.62 1.79 0
119 INT241291 Regulation of Gene_expression of OPCML 1 0.39 0.67 0
120 INT241294 Positive_regulation of Negative_regulation of OPCML 1 0.44 0.64 0
121 INT241296 Negative_regulation of Positive_regulation of OPCML 1 0.37 1.21 0
122 INT295335 Positive_regulation of Localization of Oprk1 1 0.02 0 0
123 INT241288 Negative_regulation of Phosphorylation of OPCML 1 0.37 0.7 0
124 INT77301 Positive_regulation of Regulation of Sigmar1 1 0.43 0 0
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