GO:0038028

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Name insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade
Categary Process
Go Slim No
Go Link GO:0038028
Unique Molecular Interactions 44
Total Molecular Interactions 48
Total Single Events 354
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported for insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
2 INT190181 Positive_regulation of PIK3CA Positive_regulation of MMP12 1 0.01 0.54 0.56
3 INT257738 PIK3CA Regulation of Localization of ACTN4 1 0.16 1.03 0.39
4 INT257746 SHC1 Positive_regulation of Positive_regulation of PIK3CA 1 0.26 1.04 0.34
5 INT257743 Binding of PIK3CA and SHC1 1 0.21 1.03 0.31
6 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
7 INT34773 GH1 Regulation of IGF2 1 0.31 0.05 0.22
8 INT92580 IGF2 Positive_regulation of Gene_expression of PTGER2 1 0.07 0.43 0.15
9 INT92583 IGF2 Positive_regulation of Transcription of PTGER2 1 0.07 0.43 0.15
10 INT147726 Phosphorylation of PTK2 Regulation of Positive_regulation of PIK3CA 1 0.09 0.32 0.14
11 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1
12 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09
13 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09
14 INT246846 Binding of PIK3CA and Irs1 1 0.39 0.14 0.08
15 INT246845 Binding of PIK3CA and Ppp1r13b 1 0.13 0.15 0.08
16 INT51274 IGF1 Negative_regulation of IGF2 1 0.28 0.13 0.06
17 INT179951 Binding of PIK3CA and Ins1 1 0.39 0.32 0.03
18 INT179950 Binding of PIK3CA and Irs1 1 0.32 0.31 0.03
19 INT295476 PIK3CA Regulation of Gene_expression of TNF 1 0.00 0.05 0.03
20 INT199365 Igf2 Positive_regulation of Phosphorylation of Macf1 1 0.13 1.84 0
21 INT199359 Igf2 Regulation of Macf1 1 0.11 3.11 0
22 INT199361 Regulation of Igf2 Regulation of Macf1 1 0.11 1.59 0
23 INT199367 DST Regulation of Igf2 1 0.03 1.03 0
24 INT304012 Binding of AKT1 and PIK3CA 1 0.28 1.14 0
25 INT300901 Binding of IGF2 and IGF2BP1 1 0.04 0.71 0
26 INT199368 DST Positive_regulation of Gene_expression of Igf2 1 0.04 1.51 0
27 INT199371 DST Regulation of Transcription of Igf2 1 0.05 1.47 0
28 INT304025 Binding of PIK3CA and TP53 1 0.30 0.67 0
29 INT202431 Binding of IGF2 and INSRR 1 0.01 0.85 0
30 INT198025 PIK3CA Positive_regulation of Gene_expression of MCL1 1 0.28 1.24 0
31 INT304015 Binding of PIK3CA and PIK3CG 1 0.09 0.67 0
32 INT199360 Igf2 Regulation of Gene_expression of Lyve1 1 0.30 1.13 0
33 INT199363 Igf2 Regulation of Gopc 1 0.15 1.61 0
34 INT199370 DST Regulation of Gene_expression of Igf2 1 0.02 1.07 0
35 INT215205 Binding of Igf2 and Igfbp3 1 0.04 0 0
36 INT141959 Binding of IGFBP3 and Igf2 1 0.01 0.09 0
37 INT300899 IGF2BP3 Positive_regulation of IGF2 1 0.37 1.06 0
38 INT198001 Negative_regulation of PIK3CA Negative_regulation of Gene_expression of MCL1 1 0.26 0.89 0
39 INT141950 Binding of Igf2 and Mb 1 0.00 0.1 0
40 INT202430 Binding of IGF2 and INS 1 0.16 0.85 0
41 INT198020 PIK3CA Regulation of Gene_expression of MCL1 1 0.16 2.25 0
42 INT300898 IGF2BP3 Regulation of Gene_expression of IGF2 1 0.21 0.38 0
43 INT225904 Binding of GAB1 and PIK3CA 1 0.07 0.06 0
44 INT199362 Igf2 Positive_regulation of Macf1 1 0.11 1.67 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade. They are ordered first by their pain relevance and then by number of times they were reported in insulin receptor signaling pathway via phosphatidylinositol 3-kinase cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
2 INT89397 Positive_regulation of PIK3CA 33 0.67 16.98 2.78
3 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
4 INT9327 Localization of Igf2 8 0.80 5.07 2.36
5 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
6 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
7 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
8 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
9 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
10 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07
11 INT34779 Regulation of IGF2 7 0.38 4.34 0.9
12 INT58245 Regulation of Localization of Igf2 1 0.62 1.27 0.78
13 INT34778 Localization of IGF2 5 0.62 4.78 0.59
14 INT277644 Negative_regulation of Localization of Igf2 1 0.02 0.69 0.56
15 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44
16 INT9328 Regulation of Gene_expression of Igf2 1 0.39 0.91 0.42
17 INT199340 Localization of Igf2 4 0.75 4.47 0.39
18 INT48617 Negative_regulation of IGF2 4 0.25 0.22 0.36
19 INT89403 Negative_regulation of PIK3CA 19 0.57 11.74 0.35
20 INT57131 Negative_regulation of Positive_regulation of Igf2 1 0.36 0.67 0.35
21 INT257764 Positive_regulation of Positive_regulation of PIK3CA 5 0.44 2.72 0.31
22 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3
23 INT202435 Transcription of IGF2 3 0.58 2.44 0.29
24 INT9329 Transcription of Igf2 2 0.58 1.28 0.29
25 INT215027 Regulation of Localization of Igf2 1 0.07 1.71 0.24
26 INT89399 Negative_regulation of Positive_regulation of PIK3CA 3 0.57 1 0.22
27 INT147732 Binding of PIK3CA 3 0.36 1.13 0.2
28 INT246833 Positive_regulation of Binding of PIK3CA 1 0.49 0.29 0.16
29 INT199349 Regulation of Gene_expression of Igf2 4 0.50 4.56 0.15
30 INT147731 Phosphorylation of PIK3CA 3 0.44 1.93 0.14
31 INT118235 Positive_regulation of Igf2 9 0.70 10.05 0.12
32 INT76311 Binding of Igf2 2 0.44 1.91 0.12
33 INT199357 Negative_regulation of Igf2 1 0.38 1.91 0.09
34 INT199337 Binding of Igf2 1 0.37 1.55 0.09
35 INT175512 Positive_regulation of Gene_expression of Igf2 16 0.70 22.75 0.08
36 INT147733 Regulation of Binding of PIK3CA 1 0.10 0.23 0.08
37 INT185028 Binding of IGF2 4 0.46 1.72 0.07
38 INT51277 Negative_regulation of Gene_expression of IGF2 1 0.25 0.07 0.06
39 INT92591 Negative_regulation of Positive_regulation of IGF2 1 0.28 0.45 0.06
40 INT300903 Negative_regulation of Localization of IGF2 1 0.40 1.45 0.05
41 INT300907 Negative_regulation of Transcription of IGF2 1 0.29 1.44 0.05
42 INT176154 Gene_expression of PIK3CA 6 0.55 10.43 0.03
43 INT176150 Localization of PIK3CA 2 0.73 0.22 0.03
44 INT176160 Positive_regulation of Localization of PIK3CA 1 0.13 0.22 0.03
45 INT198037 Regulation of PIK3CA 2 0.28 2.63 0
46 INT291365 Positive_regulation of Gene_expression of PIK3CA 2 0.41 5.76 0
47 INT315886 Regulation of Positive_regulation of PIK3CA 1 0.10 0.53 0
48 INT199347 Transcription of Igf2 1 0.72 1.41 0
49 INT353186 Positive_regulation of Gene_expression of Igf2 1 0.37 0.08 0
50 INT202433 Positive_regulation of Transcription of IGF2 1 0.42 0.55 0
51 INT199353 Positive_regulation of Positive_regulation of Igf2 1 0.50 1.35 0
52 INT198035 Regulation of Negative_regulation of PIK3CA 1 0.15 0.95 0
53 INT198030 Regulation of Regulation of PIK3CA 1 0.24 1.08 0
54 INT199355 Negative_regulation of Positive_regulation of Igf2 1 0.43 0.86 0
55 INT300911 Regulation of Gene_expression of IGF2 1 0.31 0.38 0
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