GO:0038048

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Name dynorphin receptor activity
Categary Function
Go Slim No
Go Link GO:0038048
Unique Molecular Interactions 85
Total Molecular Interactions 112
Total Single Events 949
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for dynorphin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for dynorphin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8
2 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52
3 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1
4 INT150596 Binding of Oprd1 and Oprk1 1 0.08 0.14 2.59
5 INT154226 Positive_regulation of Oprk1 Negative_regulation of Negative_regulation of Oprm1 1 0.28 0.07 2.32
6 INT133946 Binding of DNM2 and OPRK1 1 0.11 0 2.1
7 INT6931 Binding of Oprk1 and Pdyn 2 0.24 0.92 1.92
8 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75
9 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69
10 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64
11 INT155497 Oprk1 Negative_regulation of Tenc1 1 0.08 0.34 1.48
12 INT83416 Binding of OPRK1 and Ntrk1 1 0.02 0 1.45
13 INT133937 Binding of OPRK1 and ARFGEF1 1 0.01 0 1.39
14 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36
15 INT126831 Binding of Oprk1 and Rbm39 1 0.05 0.88 1.33
16 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25
17 INT150595 Binding of Oprk1 and Insrr 1 0.01 0.07 1.23
18 INT240095 Binding of PDYN and Oprk1 1 0.52 1.3 1.22
19 INT200455 OPRK1 Positive_regulation of Gene_expression of CCL2 1 0.19 0.07 1.21
20 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12
21 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05
22 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04
23 INT108413 Binding of OPRK1 and Oprd1 1 0.00 0.08 1.04
24 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03
25 INT6930 Binding of Oprk1 and Pomc 1 0.08 0.16 1.01
26 INT81329 Binding of ARRB1 and OPRK1 1 0.05 0.1 0.93
27 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
28 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92
29 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91
30 INT150350 Oprk1 Regulation of Pat 1 0.22 0.38 0.81
31 INT133941 ARFGEF1 Positive_regulation of OPRK1 1 0.02 0 0.76
32 INT133935 DNM2 Positive_regulation of OPRK1 1 0.11 0 0.76
33 INT290553 Positive_regulation of Oprk1 Positive_regulation of Crh 1 0.33 0.39 0.72
34 INT126598 Binding of BSG and OPRK1 1 0.01 0.05 0.72
35 INT33889 pcp Regulation of Oprk1 1 0.41 0.77 0.71
36 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7
37 INT290541 Gpr3 Positive_regulation of Phosphorylation of Oprk1 1 0.18 0.45 0.69
38 INT75936 Csf2 Positive_regulation of Oprk1 1 0.25 0.78 0.67
39 INT96496 Binding of Oprk1 and Cq1 1 0.01 0.27 0.64
40 INT165317 Oprd1 Positive_regulation of Gene_expression of Oprk1 1 0.30 0.24 0.6
41 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
42 INT295411 Grb7 Positive_regulation of Oprk1 1 0.02 1.03 0.57
43 INT21568 Oprk1 Regulation of Localization of Pomc 1 0.18 0 0.55
44 INT21567 Oprk1 Regulation of Pomc 1 0.18 0 0.55
45 INT290546 Oprk1 Regulation of Positive_regulation of Anxty 1 0.02 0.42 0.52
46 INT86264 OPRK1 Negative_regulation of Gene_expression of HIVEP1 1 0.33 1.76 0.51
47 INT135378 Binding of Cfb and Oprk1 1 0.01 0.31 0.49
48 INT81331 ADRBK1 Regulation of OPRK1 1 0.03 0.09 0.48
49 INT112843 Binding of OPRK1 and Nfatc4 1 0.00 0 0.48
50 INT81330 ARRB1 Regulation of OPRK1 1 0.04 0.09 0.47
51 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
52 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47
53 INT81333 Binding of OPRK1 and SNORD50A 1 0.07 0.09 0.46
54 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
55 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
56 INT81335 Negative_regulation of Binding of OPRK1 and SNORD50A 1 0.08 0.1 0.46
57 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
58 INT116929 OPRK1 Positive_regulation of JUN 1 0.28 0.15 0.46
59 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
60 INT105188 Binding of Oprk1 and Nol3 1 0.34 0.07 0.43
61 INT105189 Negative_regulation of Binding of Oprk1 and Nol3 1 0.41 0.07 0.43
62 INT116931 OPRK1 Regulation of MAPK8 1 0.31 0.07 0.43
63 INT66196 OPRK1 Negative_regulation of Oprd1 1 0.00 0 0.43
64 INT65361 Binding of Oprk1 and Ceacam1 1 0.00 0 0.42
65 INT53802 SNORD50A Positive_regulation of Oprk1 1 0.12 0.16 0.37
66 INT70836 Positive_regulation of OPRK1 Positive_regulation of Binding of CRYGS 1 0.03 0.09 0.36
67 INT295407 Egf Positive_regulation of Localization of Oprk1 1 0.02 0.67 0.36
68 INT54344 Oprk1 Regulation of Prl 1 0.22 0 0.33
69 INT51629 Binding of DRD3 and OPRK1 1 0.15 0 0.33
70 INT102953 OPRK1 Positive_regulation of Localization of ADRBK2 1 0.13 0 0.3
71 INT102955 OPRK1 Positive_regulation of Localization of ADRBK1 1 0.13 0 0.3
72 INT83569 Grk5 Regulation of Oprk1 1 0.02 0 0.29
73 INT83568 Adrbk2 Regulation of Oprk1 1 0.02 0 0.29
74 INT102954 Binding of ADRBK1 and OPRK1 1 0.11 0 0.14
75 INT62775 Regulation of Binding of NT5E and OPRK1 1 0.03 0 0.1
76 INT62776 Binding of NT5E and OPRK1 1 0.02 0 0.1
77 INT295405 Binding of Oprk1 and Grb7 1 0.02 0.09 0.05
78 INT295412 Egf Regulation of Transcription of Oprk1 1 0.01 0 0
79 INT295408 Binding of Oprk1 and Xpo1 1 0.00 0 0
80 INT295409 Ptk2 Positive_regulation of Phosphorylation of Oprk1 1 0.01 0 0
81 INT295404 Binding of Oprk1 and Hua 1 0.01 0 0
82 INT295410 Positive_regulation of Binding of Oprk1 and Xpo1 1 0.00 0 0
83 INT295403 Egf Positive_regulation of Oprk1 1 0.02 0 0
84 INT295402 Ptk2 Positive_regulation of Localization of Oprk1 1 0.01 0 0
85 INT169484 Dbi Regulation of Oprk1 1 0.01 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for dynorphin receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in dynorphin receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97
2 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7
3 INT20964 Gene_expression of OPRK1 96 0.78 23.54 58.18
4 INT10304 Binding of OPRK1 89 0.48 9.28 49.42
5 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69
6 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49
7 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61
8 INT6179 Binding of Oprk1 37 0.48 9.24 24.83
9 INT48006 Negative_regulation of Oprk1 27 0.58 10.14 19.11
10 INT20881 Negative_regulation of OPRK1 20 0.43 3.73 13.37
11 INT99587 Positive_regulation of Gene_expression of Oprk1 15 0.57 5.26 12.39
12 INT76138 Transcription of Oprk1 21 0.72 5.79 11.25
13 INT90903 Positive_regulation of Positive_regulation of Oprk1 13 0.47 3.49 11.18
14 INT6870 Positive_regulation of Oprk1 14 0.70 4 10.91
15 INT69528 Regulation of Gene_expression of Oprk1 10 0.45 4.27 8.84
16 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63
17 INT53798 Gene_expression of Oprk1 14 0.73 1.82 8.24
18 INT50191 Positive_regulation of Gene_expression of OPRK1 9 0.67 3.44 7.91
19 INT105185 Negative_regulation of Gene_expression of Oprk1 9 0.42 3.53 7.53
20 INT12699 Transcription of OPRK1 11 0.52 0.08 6.66
21 INT290523 Phosphorylation of Oprk1 3 0.81 3.1 6.34
22 INT76741 Localization of OPRK1 7 0.68 0.22 5.9
23 INT104226 Localization of Oprk1 12 0.75 3.22 5.41
24 INT74182 Positive_regulation of Binding of OPRK1 8 0.49 1.39 5.25
25 INT29354 Regulation of Binding of OPRK1 7 0.60 1.72 5.04
26 INT34132 Binding of Oprk1 6 0.48 2.15 4.78
27 INT102363 Negative_regulation of Positive_regulation of OPRK1 7 0.43 0.99 4.25
28 INT66782 Negative_regulation of Gene_expression of OPRK1 4 0.28 1.42 3.41
29 INT59301 Negative_regulation of Positive_regulation of Oprk1 4 0.58 1.33 3.24
30 INT80521 Negative_regulation of Binding of OPRK1 4 0.43 0.8 2.93
31 INT63725 Transcription of Oprk1 4 0.66 0 2.87
32 INT52166 Positive_regulation of Positive_regulation of OPRK1 2 0.57 0.48 2.74
33 INT85597 Positive_regulation of Localization of OPRK1 2 0.45 0 2.65
34 INT297507 Positive_regulation of Phosphorylation of Oprk1 1 0.50 0.63 2.26
35 INT80921 Positive_regulation of Transcription of Oprk1 2 0.43 0 1.95
36 INT80918 Regulation of Transcription of Oprk1 1 0.62 1.2 1.89
37 INT54242 Negative_regulation of Oprk1 4 0.59 1.29 1.7
38 INT90703 Positive_regulation of Transcription of Oprk1 2 0.45 0.73 1.42
39 INT75931 Positive_regulation of Binding of Oprk1 2 0.50 0.83 1.33
40 INT118924 Positive_regulation of Regulation of OPRK1 2 0.68 0 1
41 INT76139 Negative_regulation of Transcription of Oprk1 2 0.57 0.22 0.95
42 INT121687 Positive_regulation of Negative_regulation of OPRK1 1 0.49 0 0.79
43 INT90904 Regulation of Positive_regulation of Oprk1 2 0.40 0 0.76
44 INT110346 Regulation of Binding of Oprk1 1 0.31 0 0.72
45 INT80920 Regulation of Transcription of Oprk1 1 0.41 0 0.7
46 INT95855 Positive_regulation of Regulation of Oprk1 1 0.37 0.19 0.65
47 INT121950 Regulation of Gene_expression of Oprk1 1 0.45 0.18 0.6
48 INT118923 Protein_catabolism of OPRK1 1 0.00 0 0.59
49 INT71672 Phosphorylation of OPRK1 2 0.12 0 0.56
50 INT53941 Positive_regulation of Gene_expression of Oprk1 1 0.18 0 0.54
51 INT70840 Regulation of Positive_regulation of OPRK1 1 0.09 0.09 0.5
52 INT105186 Negative_regulation of Binding of Oprk1 1 0.42 0.06 0.44
53 INT54243 Regulation of Negative_regulation of Oprk1 1 0.26 0 0.37
54 INT76137 Regulation of Regulation of Oprk1 1 0.02 0.07 0.36
55 INT146074 Regulation of Transcription of OPRK1 1 0.26 0 0.34
56 INT34133 Regulation of Binding of Oprk1 1 0.12 0 0.22
57 INT181237 Negative_regulation of Negative_regulation of OPRK1 1 0.07 0 0.14
58 INT295335 Positive_regulation of Localization of Oprk1 1 0.02 0 0
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