GO:0040037

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Name negative regulation of fibroblast growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0040037
Unique Molecular Interactions 132
Total Molecular Interactions 208
Total Single Events 1282
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73539 Binding of Ngf and Ngfr 5 0.45 3.99 4
2 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48
3 INT280480 Binding of Bdnf and Ngfr 5 0.25 3.14 1.27
4 INT256041 Binding of Ngfr and Ntrk1 3 0.14 0.9 1.13
5 INT150794 ZNF398 Positive_regulation of Localization of THBS1 1 0.09 1.02 1.07
6 INT150789 THBS3 Negative_regulation of THBS1 1 0.18 1.01 1.06
7 INT82024 Binding of Ngfr and Ngf 2 0.33 1.48 1.05
8 INT76001 Ngf Positive_regulation of Ngfr 1 0.16 0.93 1.05
9 INT242642 Binding of BDNF and Ngfr 2 0.21 1.38 1.01
10 INT127672 Binding of NGFR and NTRK1 1 0.17 2.28 0.97
11 INT73538 Ngf Positive_regulation of Ngfr 2 0.41 1.05 0.85
12 INT213726 Binding of Ngfr and Ntrk1 1 0.14 0.96 0.72
13 INT289333 Binding of Ngfr and Rtn4r 1 0.03 2.35 0.72
14 INT289332 Binding of Ngfr and Lingo1 1 0.04 2.36 0.72
15 INT82021 Negative_regulation of Binding of Ngfr and Ngf 1 0.29 0.32 0.69
16 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
17 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
18 INT134528 Grin1 Regulation of Ngfr 1 0.03 0 0.57
19 INT134531 Gria1 Regulation of Ngfr 1 0.01 0 0.57
20 INT129270 Binding of Wnt4 and Efs 1 0.00 0 0.55
21 INT76002 Ngf Positive_regulation of Ngfr 1 0.05 0.48 0.53
22 INT245558 Runx3 Regulation of Ngfr 1 0.06 1 0.53
23 INT150791 THBS1 Negative_regulation of TIMP2 1 0.17 0.5 0.52
24 INT150796 ZNF398 Positive_regulation of THBS1 1 0.06 0.5 0.52
25 INT150785 THBS1 Negative_regulation of MMP2 1 0.10 0.5 0.52
26 INT127677 NGF Regulation of Gene_expression of NGFR 1 0.20 1.11 0.5
27 INT161227 Binding of Ngfr and Tnf 1 0.06 0.41 0.49
28 INT120295 Ngf Positive_regulation of Positive_regulation of Ngfr 1 0.47 0.22 0.43
29 INT73537 Ntf3 Positive_regulation of Ngfr 1 0.21 0.1 0.38
30 INT130930 Egr1 Negative_regulation of Positive_regulation of Thbs1 1 0.58 0.64 0.38
31 INT73536 Ngf Regulation of Ngfr 1 0.22 0.08 0.37
32 INT354886 Thbs1 Regulation of Positive_regulation of Tgfb1 1 0.17 2.18 0.34
33 INT112283 Bdnf Regulation of Gene_expression of Ngfr 1 0.14 0.28 0.34
34 INT162599 Wnt5a Regulation of Gene_expression of IL4I1 1 0.00 0.1 0.28
35 INT203733 Thbs1 Positive_regulation of Negative_regulation of Ppara 1 0.36 1.55 0.26
36 INT252356 Binding of THBS1 and Cd47 1 0.00 0.44 0.24
37 INT252357 Binding of THBS1 and Cd36 2 0.01 2.4 0.21
38 INT241451 Mag Positive_regulation of Ngfr 1 0.09 0.1 0.21
39 INT308654 Binding of Ngfr and Nts 1 0.06 0.39 0.21
40 INT337260 ELL Positive_regulation of Gene_expression of THBS1 1 0.11 0.82 0.18
41 INT337263 ELL Regulation of Gene_expression of THBS1 1 0.10 0.82 0.18
42 INT280486 Binding of Ngfr and Ntrk2 2 0.18 1.21 0.17
43 INT160539 Binding of NGF and NGFR 1 0.06 0.46 0.17
44 INT160542 Binding of BDNF and NGFR 1 0.08 0.46 0.17
45 INT231677 Binding of CD47 and THBS1 1 0.18 0 0.16
46 INT241462 Binding of OMG and Ngfr 1 0.11 0.15 0.15
47 INT252352 Binding of THBS1 and Sirpa 1 0.00 0.26 0.15
48 INT241457 Binding of Mag and Ngfr 1 0.09 0.15 0.15
49 INT241453 Binding of Ngfr and Rtn4r 1 0.03 0.15 0.15
50 INT287884 WNT5A Positive_regulation of THEMIS 1 0.00 0.08 0.13
51 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11
52 INT280493 Ngfr Regulation of Protein_catabolism of BDNF 1 0.09 0.14 0.1
53 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
54 INT294439 KLK4 Negative_regulation of THBS1 1 0.01 0 0.1
55 INT211960 Wnt5a Positive_regulation of Car2 1 0.13 0.38 0.08
56 INT348167 Thbs1 Positive_regulation of RAC1 1 0.04 0.71 0.08
57 INT164675 Binding of NGF and Ngfr 1 0.00 0.5 0.08
58 INT287879 Binding of WNT5A and FZD5 1 0.06 1.16 0.08
59 INT164676 Negative_regulation of Binding of NGF and Ngfr 1 0.00 0.5 0.08
60 INT348168 Thbs1 Positive_regulation of PIK3CD 1 0.00 0.65 0.07
61 INT203732 Thbs1 Regulation of Gene_expression of Ppara 1 0.33 0.94 0.05
62 INT341535 F2RL1 Positive_regulation of Gene_expression of THBS1 1 0.28 0.75 0.04
63 INT201766 Binding of RIPK2 and Ngfr 1 0.02 0.41 0.04
64 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 0.09 0 0.03
65 INT272528 THBS1 Positive_regulation of TGFB2 1 0.09 0.64 0.03
66 INT201732 Ngfr Positive_regulation of Nfkb1 1 0.01 0.43 0.03
67 INT200063 Binding of MAGED1 and Ngfr 1 0.44 0.45 0
68 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0
69 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0
70 INT337270 E2F1 Positive_regulation of Transcription of THBS1 1 0.67 0.19 0
71 INT183090 Gene_expression of SULF1 Positive_regulation of Phosphorylation of FGF2 1 0.19 0.42 0
72 INT337268 E2F1 Regulation of Transcription of THBS1 1 0.44 0 0
73 INT337274 E2F1 Regulation of THBS1 1 0.44 0 0
74 INT99770 Thbs1 Regulation of PGR 1 0.01 0 0
75 INT337269 Binding of E2F1 and Positive_regulation of Gene_expression of THBS1 1 0.45 0.21 0
76 INT335884 Akt1 Regulation of Positive_regulation of Wnt5a 1 0.03 0.15 0
77 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0
78 INT308352 Binding of Ctnnd2 and Tcf7l2 1 0.15 0.74 0
79 INT337262 PRB1 Negative_regulation of THBS1 1 0.18 0.61 0
80 INT338013 Binding of Ngfrap1 and Ngfr 1 0.06 1.3 0
81 INT200062 Binding of Ngfr and Bbs4 1 0.30 0.3 0
82 INT262750 GLYR1 Positive_regulation of THBS1 1 0.01 0.99 0
83 INT99769 Thbs1 Regulation of THBS1 1 0.00 0 0
84 INT277490 Binding of F2 and Thbs1 1 0.09 0 0
85 INT200053 Binding of Nuc and Ngfr 1 0.10 0.3 0
86 INT183093 SULF1 Negative_regulation of Binding of FGF2 1 0.17 0.41 0
87 INT200057 Binding of Ndn and Ngfr 1 0.43 1.96 0
88 INT337264 Binding of E2F1 and THBS1 1 0.47 0.78 0
89 INT268524 MYC Regulation of THBS1 1 0.02 1.85 0
90 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
91 INT337273 E2F1 Regulation of Gene_expression of THBS1 1 0.60 0 0
92 INT320346 Binding of Ngfr and Np4 1 0.01 0 0
93 INT349543 Tnfsf10 Positive_regulation of NGFR 1 0.01 0.43 0
94 INT337266 E2F1 Positive_regulation of Gene_expression of THBS1 1 0.67 0.21 0
95 INT99772 Pgr Regulation of THBS1 1 0.00 0 0
96 INT335883 Binding of Lrp6 and Wnt5a 1 0.27 0.08 0
97 INT201742 Binding of Ngfr and Gtf3a 1 0.00 0.77 0
98 INT253020 Pttg1 Negative_regulation of THBS1 1 0.03 0.16 0
99 INT277489 Binding of Thbs1 and Gopc 1 0.14 0 0
100 INT200061 Binding of Ngfr and Fez1 1 0.31 0.3 0
101 INT337265 Negative_regulation of E2F1 Positive_regulation of THBS1 1 0.42 0 0
102 INT337272 E2F1 Positive_regulation of THBS1 1 0.49 1.27 0
103 INT337267 THBS1 Positive_regulation of E2F1 1 0.49 0.05 0
104 INT99771 Oxtr Regulation of THBS1 1 0.01 0 0
105 INT290372 Binding of Ngfr and Scarb1 1 0.01 0.48 0
106 INT201741 Binding of Rhoa and Ngfr 1 0.01 1 0
107 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0
108 INT200055 Binding of Ngfr and Mageh1 1 0.33 0.45 0
109 INT183134 Binding of SULF1 and Panc1 1 0.03 0.42 0
110 INT268511 MIR19B1 Regulation of THBS1 1 0.20 0.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of fibroblast growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of fibroblast growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT55908 Gene_expression of Ngfr 74 0.78 34.46 28.8
2 INT46016 Gene_expression of Ngfr 69 0.77 41.22 19.8
3 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75
4 INT75921 Negative_regulation of Ngfr 13 0.59 8.58 8.35
5 INT48310 Binding of Ngfr 25 0.48 9.72 8.16
6 INT61542 Positive_regulation of Ngfr 15 0.70 6.35 7.34
7 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73
8 INT117142 Gene_expression of Thbs1 58 0.72 45.02 6.51
9 INT183119 Gene_expression of SULF1 1 0.75 46.71 5.44
10 INT96492 Gene_expression of NGFR 24 0.00 12.3 4.59
11 INT64711 Regulation of Ngfr 10 0.45 3.12 4.33
12 INT121170 Positive_regulation of Gene_expression of Ngfr 10 0.64 9.32 3.94
13 INT121171 Negative_regulation of Gene_expression of Ngfr 6 0.58 3.46 3.89
14 INT55907 Binding of Ngfr 13 0.47 5.79 3.75
15 INT12385 Localization of NGFR 6 0.81 3.05 3.47
16 INT61540 Negative_regulation of Gene_expression of Ngfr 11 0.59 6.36 3.43
17 INT61541 Positive_regulation of Gene_expression of Ngfr 7 0.53 2.87 2.75
18 INT137135 Gene_expression of THBS1 28 0.75 11.55 2.45
19 INT75225 Transcription of Ngfr 4 0.60 1.95 2.44
20 INT130364 Positive_regulation of Thbs1 7 0.62 7.73 1.97
21 INT64712 Localization of Ngfr 4 0.78 1.19 1.91
22 INT60337 Positive_regulation of THBS1 8 0.46 4.69 1.83
23 INT140247 Negative_regulation of Negative_regulation of Ngfr 3 0.33 3.15 1.59
24 INT163594 Regulation of Ngfr 5 0.43 2.55 1.53
25 INT127679 Positive_regulation of Gene_expression of NGFR 7 0.67 4.98 1.43
26 INT64713 Regulation of Gene_expression of Ngfr 4 0.50 2.04 1.36
27 INT138939 Positive_regulation of Transcription of Ngfr 3 0.43 0.89 1.31
28 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28
29 INT56127 Positive_regulation of NGFR 8 0.49 5.3 1.27
30 INT288546 Regulation of Positive_regulation of THBS1 1 0.36 2.65 1.27
31 INT150805 Localization of THBS1 4 0.46 2.88 1.23
32 INT164372 Positive_regulation of Positive_regulation of Ngfr 6 0.62 4.1 1.22
33 INT12386 Binding of NGFR 6 0.48 2.15 1.22
34 INT110392 Transcription of Ngfr 3 0.52 2.48 1.19
35 INT150074 Gene_expression of WNT5A 8 0.75 6.3 1.17
36 INT183127 Localization of SULF1 1 0.77 3.45 1.13
37 INT203729 Binding of Thbs1 1 0.27 3.83 1.1
38 INT130928 Positive_regulation of Gene_expression of Thbs1 7 0.62 5.62 1.08
39 INT163595 Positive_regulation of Regulation of Ngfr 1 0.46 0.57 1.04
40 INT99767 Regulation of THBS1 18 0.42 11.51 1.03
41 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86
42 INT130363 Localization of Thbs1 9 0.75 4.99 0.76
43 INT143427 Regulation of NGFR 1 0.26 1.65 0.73
44 INT317733 Positive_regulation of Binding of Ngfr 1 0.18 0.51 0.71
45 INT133018 Regulation of Gene_expression of Ngfr 2 0.43 1.47 0.7
46 INT252993 Negative_regulation of THBS1 8 0.55 6.93 0.59
47 INT150075 Positive_regulation of Gene_expression of WNT5A 2 0.67 2.53 0.59
48 INT183133 Negative_regulation of Localization of SULF1 1 0.41 1.34 0.59
49 INT117145 Negative_regulation of Gene_expression of Thbs1 11 0.43 5.67 0.57
50 INT139929 Phosphorylation of Ngfr 3 0.58 1.67 0.57
51 INT118729 Regulation of Transcription of Ngfr 1 0.36 0.45 0.57
52 INT110393 Positive_regulation of Transcription of Ngfr 1 0.46 1 0.54
53 INT150808 Negative_regulation of Localization of THBS1 1 0.25 0.5 0.53
54 INT268576 Positive_regulation of Gene_expression of THBS1 2 0.64 2.26 0.47
55 INT203728 Regulation of Binding of Thbs1 1 0.33 2.76 0.42
56 INT203726 Regulation of Thbs1 2 0.33 1.41 0.41
57 INT117096 Gene_expression of Wnt4 2 0.67 4.68 0.38
58 INT165518 Positive_regulation of Regulation of Ngfr 2 0.47 0.47 0.37
59 INT183114 Positive_regulation of Gene_expression of SULF1 1 0.48 7.61 0.37
60 INT130927 Negative_regulation of Thbs1 19 0.59 3.72 0.36
61 INT183116 Positive_regulation of SULF1 1 0.67 3.22 0.34
62 INT127678 Transcription of NGFR 1 0.29 0.9 0.33
63 INT130368 Transcription of Thbs1 2 0.69 1.39 0.23
64 INT130360 Positive_regulation of Transcription of Thbs1 1 0.46 1.41 0.23
65 INT297460 Regulation of Regulation of Ngfr 1 0.33 0.32 0.21
66 INT222635 Gene_expression of Thbs1 4 0.39 15.2 0.2
67 INT114371 Negative_regulation of Tcf7l2 1 0.05 0.7 0.2
68 INT178504 Positive_regulation of Localization of THBS1 2 0.05 1.9 0.19
69 INT231474 Binding of THBS1 4 0.34 2.04 0.16
70 INT348150 Binding of Thbs1 1 0.24 2.06 0.15
71 INT183125 Negative_regulation of SULF1 2 0.42 2.26 0.13
72 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13
73 INT162574 Gene_expression of Wnt5a 7 0.47 0.92 0.1
74 INT282594 Localization of WNT5A 2 0.18 0.89 0.1
75 INT348149 Regulation of Gene_expression of Thbs1 1 0.31 1.94 0.1
76 INT348145 Localization of Thbs1 1 0.41 6.72 0.1
77 INT233483 Regulation of Gene_expression of Wnt5a 1 0.19 0.33 0.1
78 INT297459 Protein_catabolism of Ngfr 1 0.21 0.5 0.1
79 INT183124 Regulation of Gene_expression of SULF1 1 0.59 1.92 0.1
80 INT162576 Positive_regulation of Wnt5a 3 0.48 0.71 0.08
81 INT222588 Negative_regulation of Gene_expression of Thbs1 2 0.30 7.93 0.07
82 INT290078 Regulation of WNT5A 1 0.07 2.3 0.07
83 INT183129 Negative_regulation of Gene_expression of SULF1 1 0.56 5.19 0.07
84 INT183122 Regulation of SULF1 1 0.59 1.53 0.06
85 INT311643 Negative_regulation of Spry1 1 0.40 0.95 0.05
86 INT285151 Regulation of Localization of NGFR 1 0.02 0.24 0.05
87 INT222624 Negative_regulation of Thbs1 2 0.30 8.42 0.04
88 INT99763 Regulation of Thbs1 2 0.23 2.08 0.04
89 INT311641 Regulation of Gene_expression of Spry1 1 0.57 0.5 0.04
90 INT348152 Positive_regulation of Localization of Thbs1 1 0.24 0.85 0.04
91 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04
92 INT348157 Regulation of Transcription of Thbs1 1 0.14 0.96 0.04
93 INT348147 Transcription of Thbs1 1 0.27 0.96 0.04
94 INT294469 Transcription of THBS1 2 0.66 0.46 0.03
95 INT241405 Localization of Ngfr 2 0.56 0.4 0.03
96 INT231690 Negative_regulation of Binding of THBS1 1 0.16 0.37 0.03
97 INT241402 Protein_catabolism of Ngfr 1 0.39 0 0.03
98 INT210256 Positive_regulation of Tcf7l2 2 0.28 1.25 0
99 INT337281 Regulation of Gene_expression of THBS1 1 0.57 0.48 0
100 INT143428 Negative_regulation of Gene_expression of NGFR 1 0.57 0 0
101 INT277482 Negative_regulation of Transcription of Thbs1 1 0.43 0 0
102 INT311653 Binding of Spry1 1 0.34 0.98 0
103 INT252974 Positive_regulation of Negative_regulation of THBS1 1 0.03 0.09 0
104 INT348156 Positive_regulation of Gene_expression of Thbs1 1 0.24 0.9 0
105 INT335880 Regulation of Wnt5a 1 0.32 0.07 0
106 INT311645 Gene_expression of Spry2 1 0.70 1.81 0
107 INT311639 Positive_regulation of Spry1 1 0.64 0.19 0
108 INT311640 Regulation of Binding of Spry1 1 0.42 0.77 0
109 INT228789 Positive_regulation of Negative_regulation of Thbs1 1 0.26 0.07 0
110 INT193880 Regulation of Phosphorylation of Ngfr 1 0.02 0.25 0
111 INT201629 Negative_regulation of Positive_regulation of Ngfr 1 0.07 0.37 0
112 INT260764 Negative_regulation of Spry2 1 0.28 0.1 0
113 INT348146 Positive_regulation of Thbs1 1 0.25 2.41 0
114 INT277481 Negative_regulation of Negative_regulation of Thbs1 1 0.59 0 0
115 INT252970 Negative_regulation of Positive_regulation of THBS1 1 0.04 0.2 0
116 INT348158 Negative_regulation of Positive_regulation of Thbs1 1 0.22 0.65 0
117 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0
118 INT311633 Localization of Spry2 1 0.68 0.26 0
119 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0
120 INT205585 Regulation of Wnt4 1 0.45 0.7 0
121 INT207312 Phosphorylation of THBS1 1 0.43 0.28 0
122 INT277486 Negative_regulation of Positive_regulation of Thbs1 1 0.43 0 0
123 INT337279 Positive_regulation of Binding of THBS1 1 0.46 0 0
124 INT205578 Negative_regulation of Wnt4 1 0.43 1.69 0
125 INT320827 Negative_regulation of Gene_expression of THBS1 1 0.03 1.52 0
126 INT311654 Regulation of Spry2 1 0.21 0.75 0
127 INT162572 Positive_regulation of Gene_expression of Wnt5a 1 0.02 0.3 0
128 INT205581 Regulation of Negative_regulation of Wnt4 1 0.27 0.7 0
129 INT183128 Transcription of SULF1 1 0.66 0.17 0
130 INT337283 Positive_regulation of Regulation of THBS1 1 0.46 0 0
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