GO:0042026

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Name protein refolding
Categary Process
Go Slim No
Go Link GO:0042026
Unique Molecular Interactions 71
Total Molecular Interactions 90
Total Single Events 698
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for protein refolding. They are ordered first by their pain relevance and then by number of times they were reported for protein refolding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
2 INT210789 Bst2 Positive_regulation of B2m 1 0.32 0.54 0.89
3 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
4 INT27871 Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
5 INT27872 Positive_regulation of Binding of FCGR1B and HSPD1 1 0.01 1.93 0.56
6 INT324816 Hspd1 Positive_regulation of Gene_expression of Ik 1 0.00 1.59 0.5
7 INT324830 Hspd1 Positive_regulation of IFNA1 1 0.04 0.46 0.3
8 INT111909 Binding of HSPD1 and CCT4 1 0.29 0.48 0.25
9 INT111908 Binding of HSPD1 and AP4B1 1 0.03 0.48 0.25
10 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
11 INT324835 Hspd1 Positive_regulation of Gene_expression of IFNA1 1 0.15 0.31 0.23
12 INT324822 Binding of Cd24a and Hsp90aa1 1 0.10 0.71 0.19
13 INT231763 Binding of HSPD1 and TLR2 1 0.12 2 0.19
14 INT251492 Binding of HSPD1 and SOD1 1 0.02 1.45 0.18
15 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
16 INT231765 Binding of HSPD1 and TLR4 1 0.13 1.94 0.16
17 INT324804 Binding of Hspd1 and Tlr4 1 0.14 0.36 0.13
18 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
19 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
20 INT192358 CRP Regulation of Positive_regulation of HSPD1 1 0.15 2.46 0.1
21 INT192352 CRP Regulation of HSPD1 1 0.15 2.46 0.1
22 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09
23 INT132266 Binding of HLA-B and B2m 1 0.02 0.14 0.09
24 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09
25 INT293494 Sfpi1 Regulation of Negative_regulation of Hsp90aa1 1 0.04 0.23 0.05
26 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
27 INT276951 Hspd1 Positive_regulation of Il10 1 0.05 0.75 0.04
28 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
29 INT276949 Hspd1 Positive_regulation of Gene_expression of Socs3 1 0.15 0.71 0.04
30 INT276977 Hspd1 Positive_regulation of Gene_expression of Il13 1 0.07 0.75 0.04
31 INT276956 Hspd1 Positive_regulation of Il13 1 0.07 0.75 0.04
32 INT350434 Negative_regulation of HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 2.44 0.04
33 INT276954 Hspd1 Positive_regulation of Stat3 1 0.31 0.65 0.04
34 INT276967 Hspd1 Regulation of Gene_expression of Socs3 1 0.14 0.71 0.04
35 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
36 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
37 INT234195 HSP90AA1 Regulation of AKT1 1 0.14 0.65 0.03
38 INT276970 Hspd1 Positive_regulation of Gene_expression of Il10 1 0.10 0.69 0.03
39 INT350792 Binding of Hspd1 and Lsr1 1 0.00 0.25 0
40 INT192354 Binding of CRP and HSPD1 1 0.12 1.28 0
41 INT350432 HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 1.27 0
42 INT292679 GOPC Positive_regulation of HSP90AA1 1 0.01 0.1 0
43 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
44 INT172118 Binding of HSPA1B and C4b 1 0.39 0.92 0
45 INT293492 Hsp90aa1 Regulation of Gene_expression of Sfpi1 1 0.04 0.1 0
46 INT340914 Binding of Hsp90aa1 and Fkbp6 1 0.12 0.26 0
47 INT350430 Negative_regulation of HSP90AA1 Positive_regulation of ATF3 1 0.32 3.11 0
48 INT293493 Hsp90aa1 Regulation of Gene_expression of Erbb2 1 0.38 0.1 0
49 INT320632 Ptger2 Regulation of Gene_expression of Hspd1 1 0.00 0.41 0
50 INT234214 Binding of HSP90AA1 and Tpt1 1 0.04 0.42 0
51 INT146131 Binding of Gnrh1 and Hspd1 1 0.02 0.88 0
52 INT265233 Binding of APC and FKBP1A 1 0.08 0.41 0
53 INT256701 Binding of Hsp90aa1 and Hsp90b1 1 0.12 0.34 0
54 INT282743 Hsp90aa1 Positive_regulation of Kit 1 0.22 0.54 0
55 INT340913 Fkbp6 Negative_regulation of Binding of Hsp90aa1 1 0.14 0.26 0
56 INT317307 Binding of Hsp90aa1 and Pink1 1 0.12 0.56 0
57 INT350503 Binding of HSP90AA1 and JAK2 1 0.06 1.39 0
58 INT340915 Binding of Hsp90aa1 and Ptplad1 1 0.12 0.17 0
59 INT265383 Hsp90aa1 Negative_regulation of HDAC9 1 0.06 0.7 0
60 INT265234 Binding of FKBP1A and SGCG 1 0.03 0.35 0
61 INT265232 Regulation of Binding of APC and FKBP1A 1 0.08 0.41 0
62 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
63 INT311064 HSP90AA1 Positive_regulation of Positive_regulation of HSF1 1 0.20 0.17 0
64 INT350431 HSP90AA1 Positive_regulation of ATF3 1 0.47 1.55 0
65 INT311061 HSP90AA1 Positive_regulation of HSF1 1 0.20 0.17 0
66 INT350796 Binding of CEBPB and Hspd1 1 0.00 0.25 0
67 INT350505 Negative_regulation of Binding of HSP90AA1 and JAK2 1 0.07 1.5 0
68 INT351095 Binding of FKBP1A and RPS6KB1 1 0.24 0.36 0
69 INT351101 Negative_regulation of Binding of FKBP1A and RPS6KB1 1 0.27 0.36 0
70 INT351096 Binding of FKBP1A and MTOR 1 0.28 1.35 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for protein refolding. They are ordered first by their pain relevance and then by number of times they were reported in protein refolding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111335 Gene_expression of HSPD1 57 0.75 55.51 10.38
2 INT71494 Positive_regulation of Hspa1b 14 0.67 8.5 9.19
3 INT670 Gene_expression of B2m 31 0.66 27.32 8.49
4 INT73179 Gene_expression of Hspa1b 10 0.73 6.24 6.04
5 INT673 Positive_regulation of B2m 24 0.68 24.24 4.82
6 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72
7 INT21678 Negative_regulation of B2m 20 0.55 10.11 3.12
8 INT73175 Positive_regulation of Gene_expression of Hspa1b 3 0.48 2.53 2.72
9 INT27880 Positive_regulation of HSPD1 17 0.65 18.16 2.23
10 INT152436 Positive_regulation of Gene_expression of HSPD1 12 0.67 10.06 2.16
11 INT81924 Positive_regulation of HSPA1B 1 0.03 1.47 1.82
12 INT27881 Binding of HSPD1 10 0.31 9.2 1.78
13 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42
14 INT53775 Gene_expression of Hspd1 21 0.78 31.25 1.38
15 INT53776 Positive_regulation of Hspd1 17 0.70 10.64 1.23
16 INT73176 Positive_regulation of Hspd1 5 0.35 3.96 1.22
17 INT112891 Regulation of Gene_expression of HSPD1 2 0.43 3.98 1.17
18 INT76305 Negative_regulation of Positive_regulation of Hspa1b 1 0.09 0.49 1.17
19 INT131475 Regulation of Hspa1b 1 0.31 2.01 1.14
20 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12
21 INT131474 Regulation of Gene_expression of Hspa1b 1 0.31 1.51 1
22 INT215363 Regulation of HSPD1 4 0.51 2.74 0.99
23 INT672 Positive_regulation of Gene_expression of B2m 2 0.44 1.95 0.96
24 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
25 INT81925 Positive_regulation of Positive_regulation of HSPA1B 1 0.02 0.74 0.91
26 INT233603 Transcription of Hspa1b 1 0.68 0.98 0.73
27 INT233621 Positive_regulation of Transcription of Hspa1b 1 0.47 0.98 0.73
28 INT188347 Localization of Hspd1 2 0.41 4.53 0.71
29 INT116838 Regulation of Gene_expression of Hspd1 1 0.18 0.19 0.62
30 INT131476 Negative_regulation of Hspa1b 1 0.30 1.07 0.61
31 INT53774 Positive_regulation of Gene_expression of Hspd1 7 0.70 6.99 0.6
32 INT192235 Binding of Hsp90aa1 6 0.19 1.46 0.6
33 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58
34 INT71497 Binding of Hspa1b 3 0.08 1.43 0.58
35 INT127480 Negative_regulation of Hsp90aa1 20 0.57 10.67 0.56
36 INT27710 Binding of B2m 5 0.36 3.54 0.53
37 INT53778 Regulation of Gene_expression of Hspd1 2 0.58 3.61 0.52
38 INT207614 Binding of Hspd1 4 0.18 1.16 0.5
39 INT71495 Localization of Hspa1b 1 0.16 0.22 0.49
40 INT19023 Localization of B2m 6 0.75 5.15 0.46
41 INT73976 Gene_expression of Hsp90aa1 18 0.75 7.92 0.45
42 INT100082 Negative_regulation of Hspd1 3 0.54 1.91 0.42
43 INT75971 Regulation of B2m 7 0.45 3.96 0.37
44 INT306291 Localization of HSPD1 1 0.31 0.81 0.36
45 INT130187 Negative_regulation of Gene_expression of B2m 2 0.35 1.61 0.33
46 INT293480 Protein_catabolism of Hsp90aa1 2 0.65 0.82 0.32
47 INT324772 Positive_regulation of Gene_expression of Hspd1 1 0.49 0.41 0.29
48 INT321170 Positive_regulation of Protein_catabolism of Hsp90aa1 1 0.29 0.2 0.25
49 INT669 Phosphorylation of B2m 1 0.77 0.76 0.24
50 INT304603 Positive_regulation of HSP90AA1 1 0.26 7.01 0.24
51 INT166356 Negative_regulation of HSPD1 4 0.55 3 0.23
52 INT73178 Positive_regulation of Hsp90aa1 4 0.45 0.7 0.21
53 INT164519 Gene_expression of FKBP1A 2 0.39 0.22 0.19
54 INT36149 Positive_regulation of Positive_regulation of B2m 1 0.49 0.78 0.19
55 INT235538 Positive_regulation of Binding of HSPD1 1 0.08 1.15 0.19
56 INT207611 Regulation of Hspd1 1 0.20 0.19 0.17
57 INT293345 Negative_regulation of Binding of FKBP1A 1 0.02 0.19 0.13
58 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12
59 INT53777 Negative_regulation of Positive_regulation of Hspd1 1 0.59 0.58 0.12
60 INT192360 Positive_regulation of Positive_regulation of HSPD1 1 0.29 0.77 0.11
61 INT109025 Negative_regulation of Hspd1 2 0.55 1.48 0.1
62 INT36150 Negative_regulation of Positive_regulation of B2m 1 0.37 0.38 0.1
63 INT109020 Positive_regulation of Negative_regulation of Hspd1 1 0.39 0.76 0.1
64 INT117158 Positive_regulation of Localization of B2m 1 0.41 0.94 0.09
65 INT215368 Regulation of Positive_regulation of HSPD1 1 0.38 0.51 0.09
66 INT299319 Localization of FKBP1A 1 0.44 0 0.09
67 INT192236 Positive_regulation of Binding of Hsp90aa1 2 0.24 0.59 0.08
68 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06
69 INT234211 Regulation of Negative_regulation of HSP90AA1 2 0.27 1.13 0.06
70 INT221986 Localization of Hspd1 1 0.52 1.8 0.06
71 INT234207 Negative_regulation of Binding of HSP90AA1 2 0.26 0.84 0.05
72 INT73177 Positive_regulation of Positive_regulation of Hspa1b 1 0.06 0.31 0.05
73 INT299313 Positive_regulation of Gene_expression of FKBP1A 1 0.29 0 0.05
74 INT258395 Positive_regulation of Positive_regulation of Hspd1 5 0.25 2.79 0.04
75 INT269823 Transcription of Hspd1 1 0.30 1.66 0.04
76 INT302546 Regulation of Gene_expression of Hsp90aa1 1 0.21 0.88 0.04
77 INT223372 Gene_expression of HSPA1B 2 0.58 1.03 0.03
78 INT328544 Localization of Hsp90aa1 1 0.10 0.17 0.03
79 INT234208 Negative_regulation of Localization of HSP90AA1 1 0.26 0.59 0.03
80 INT222086 Positive_regulation of Gene_expression of Hsp90aa1 1 0.24 0 0.03
81 INT234209 Protein_catabolism of HSP90AA1 5 0.54 2.67 0
82 INT234212 Positive_regulation of Gene_expression of HSP90AA1 3 0.41 1.36 0
83 INT73983 Transcription of Hsp90aa1 2 0.43 0.08 0
84 INT230477 Binding of Hspd1 2 0.34 1.09 0
85 INT234213 Regulation of Binding of HSP90AA1 1 0.27 0.21 0
86 INT350514 Positive_regulation of Phosphorylation of HSP90AA1 1 0.10 0.74 0
87 INT222091 Regulation of Transcription of Hsp90aa1 1 0.09 0 0
88 INT311072 Positive_regulation of Localization of HSP90AA1 1 0.22 0.53 0
89 INT147003 Binding of HSPA1B 1 0.35 0.14 0
90 INT293485 Regulation of Hsp90aa1 1 0.33 0.37 0
91 INT320629 Regulation of Hspd1 1 0.58 0.68 0
92 INT350518 Phosphorylation of HSP90AA1 1 0.16 0.72 0
93 INT276945 Negative_regulation of Positive_regulation of Hspd1 1 0.22 0.9 0
94 INT293483 Positive_regulation of Regulation of Hsp90aa1 1 0.37 0.37 0
95 INT320630 Negative_regulation of Gene_expression of Hspd1 1 0.55 1.3 0
96 INT293488 Positive_regulation of Negative_regulation of Hsp90aa1 1 0.37 0.21 0
97 INT234205 Negative_regulation of Negative_regulation of HSP90AA1 1 0.26 0.28 0
98 INT293486 Negative_regulation of Protein_catabolism of Hsp90aa1 1 0.31 0.41 0
99 INT350445 Positive_regulation of Negative_regulation of HSP90AA1 1 0.30 3.25 0
100 INT293490 Negative_regulation of Gene_expression of Hsp90aa1 1 0.31 0.15 0
101 INT222079 Positive_regulation of Transcription of Hsp90aa1 1 0.16 0 0
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