GO:0042059

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Name negative regulation of epidermal growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0042059
Unique Molecular Interactions 277
Total Molecular Interactions 409
Total Single Events 2823
Pain Genes Associated 21

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of epidermal growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of epidermal growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
2 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
3 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
4 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24
5 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23
6 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
7 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
8 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
9 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
10 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
11 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
12 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
13 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
14 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
15 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
16 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
17 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
18 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
19 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
20 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
21 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
22 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
23 INT207540 Tfap2a Regulation of Oprm1 1 0.13 0.06 0.7
24 INT135207 Gmeb1 Regulation of Gene_expression of Tfap2a 1 0.07 0.48 0.69
25 INT135206 Ighen Regulation of Gene_expression of Tfap2a 1 0.06 0.48 0.69
26 INT135202 Tfap2a Regulation of Gene_expression of Ighen 1 0.06 0.48 0.69
27 INT135213 Tfap2a Regulation of Gene_expression of Nfkb1 1 0.02 0.48 0.69
28 INT135211 Nfkb1 Regulation of Gene_expression of Tfap2a 1 0.02 0.48 0.69
29 INT135204 Tfap2a Regulation of Gene_expression of Gmeb1 1 0.10 0.48 0.69
30 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
31 INT207543 Tfap2a Regulation of Qsox1 1 0.04 0.06 0.67
32 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
33 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
34 INT74729 Binding of Mpz and Ptprj 1 0.06 0.15 0.66
35 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
36 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
37 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
38 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
39 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
40 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
41 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
42 INT97949 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of CDC42 1 0.06 0.72 0.51
43 INT97953 ST3GAL3 Positive_regulation of CDC42 1 0.09 0.7 0.5
44 INT244028 Positive_regulation of Binding of Cacnb3 and Tfap2a 1 0.01 0.24 0.49
45 INT244037 Positive_regulation of Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
46 INT220741 Binding of EGFR and SOAT1 1 0.02 0.37 0.49
47 INT244000 Positive_regulation of Binding of Tfap2a and Dnm1 1 0.04 0.24 0.49
48 INT244035 Binding of Prkaca and Tfap2a 1 0.01 0.24 0.49
49 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
50 INT243997 Binding of Tfap2a and Dnm1 1 0.03 0.24 0.49
51 INT244060 Binding of Cacnb3 and Tfap2a 1 0.00 0.24 0.49
52 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
53 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
54 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
55 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
56 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
57 INT351237 HRAS Regulation of CBL 1 0.00 0.48 0.4
58 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
59 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
60 INT353391 Binding of DRD4 and GRB2 1 0.37 0.62 0.37
61 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
62 INT301054 Tfap2a Regulation of Gene_expression of Faslg 1 0.00 1.23 0.34
63 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
64 INT311997 Regulation of STAM Regulation of BGLAP 1 0.00 0.61 0.32
65 INT220740 EGF Positive_regulation of Regulation of NAV1 1 0.31 0.61 0.32
66 INT220749 EGF Positive_regulation of Positive_regulation of KRT20 1 0.01 0.61 0.32
67 INT318323 Binding of GRB2 and HSPA5 1 0.34 0.28 0.31
68 INT311991 STAM Regulation of BGLAP 1 0.00 0.61 0.31
69 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
70 INT166093 Negative_regulation of ROS1 Negative_regulation of Positive_regulation of EGFR 1 0.12 0.33 0.28
71 INT166094 Negative_regulation of CSK Negative_regulation of Positive_regulation of EGFR 1 0.02 0.33 0.28
72 INT193027 EGF Positive_regulation of Positive_regulation of MRGPRX1 1 0.02 0 0.27
73 INT285243 EGF Positive_regulation of Egf 1 0.00 1.55 0.27
74 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
75 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
76 INT258521 EGFR Positive_regulation of MMP2 1 0.39 0.91 0.24
77 INT292565 MAP3K5 Positive_regulation of Positive_regulation of CDC42 1 0.02 0 0.23
78 INT220750 EGF Positive_regulation of PCa 1 0.05 0.45 0.23
79 INT258565 EGFR Positive_regulation of Meta 1 0.39 0.89 0.23
80 INT173294 LPA Positive_regulation of EGF 1 0.01 0.07 0.23
81 INT272753 Positive_regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.23
82 INT173292 F2 Positive_regulation of EGF 1 0.00 0.07 0.23
83 INT193033 Binding of CHRM1 and EGF 1 0.01 1.96 0.22
84 INT193035 Positive_regulation of PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
85 INT188203 EGF Positive_regulation of Protein_catabolism of OSM 1 0.30 0.17 0.21
86 INT193025 PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
87 INT193036 EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
88 INT193032 Positive_regulation of EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
89 INT352355 Binding of CNR1 and EGFR 1 0.19 0.76 0.2
90 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
91 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
92 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
93 INT298196 EGFR Positive_regulation of PIK3CD 1 0.04 0.65 0.18
94 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
95 INT352354 EGFR Regulation of Gene_expression of CNR1 1 0.23 1.16 0.17
96 INT24668 Binding of COL7A1 and EGF 1 0.14 0.25 0.16
97 INT238329 EGF Regulation of Negative_regulation of ADAMTS5 1 0.03 0 0.14
98 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14
99 INT153154 OPN1MW Regulation of PTPRF 1 0.03 0.51 0.14
100 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14
101 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14
102 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13
103 INT73924 EGF Positive_regulation of Localization of COL7A1 1 0.31 0.33 0.13
104 INT258016 AGTR1 Positive_regulation of EGFR 1 0.15 1.24 0.13
105 INT108330 EGF Negative_regulation of EPHB2 1 0.41 1.15 0.13
106 INT182493 HGS Positive_regulation of OLR1 1 0.00 2.51 0.13
107 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
108 INT341828 Binding of BTC and EGFR 1 0.22 0.95 0.12
109 INT315829 Binding of EGFR and TKT 1 0.03 1.14 0.12
110 INT272750 Prkaca Positive_regulation of EGFR 1 0.02 0 0.11
111 INT272752 Regulation of Prkaca Positive_regulation of EGFR 1 0.01 0 0.11
112 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
113 INT191184 Binding of EGFR and GRB2 7 0.35 1.06 0.1
114 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1
115 INT291353 IL8 Positive_regulation of Binding of EGFR 1 0.32 0.52 0.1
116 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
117 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1
118 INT220743 Binding of AR and EGFR 1 0.01 0.46 0.1
119 INT291351 Binding of EGFR and SHC1 1 0.05 0.57 0.1
120 INT286963 EGF Positive_regulation of Gene_expression of STAT3 1 0.03 0.57 0.1
121 INT291350 IL8 Positive_regulation of Phosphorylation of EGFR 1 0.32 0.52 0.1
122 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
123 INT145153 JUN Positive_regulation of EGFR 1 0.24 0.94 0.09
124 INT311990 FCGR3B Regulation of STAM 1 0.01 0.27 0.09
125 INT145154 Positive_regulation of JUN Positive_regulation of EGFR 1 0.24 0.95 0.09
126 INT302167 PTGER2 Positive_regulation of EGFR 1 0.10 3.08 0.09
127 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
128 INT280007 Binding of CLTC and PAEP 1 0.06 0.8 0.08
129 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08
130 INT249332 GPNMB Positive_regulation of EGFR 1 0.17 2.63 0.08
131 INT188210 EGF Positive_regulation of OSM 1 0.28 0 0.07
132 INT188208 EGF Regulation of STAT3 1 0.46 0 0.07
133 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
134 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07
135 INT182491 OLR1 Positive_regulation of HGS 1 0.00 1.22 0.07
136 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07
137 INT24666 Binding of EGF and FGF2 1 0.35 0 0.06
138 INT221368 EGFR Regulation of Gene_expression of MUC1 1 0.05 3.82 0.06
139 INT210146 Binding of EGFR and TXN 1 0.15 0.09 0.06
140 INT339105 ERBB2 Positive_regulation of EGFR 1 0.37 0.68 0.06
141 INT251774 Negative_regulation of TXK Negative_regulation of EGFR 1 0.07 1.06 0.06
142 INT279290 EGFR Regulation of CDCP1 1 0.01 0.98 0.05
143 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
144 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
145 INT302165 PTGER2 Positive_regulation of Localization of EGFR 1 0.06 1.73 0.05
146 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
147 INT73194 GRB2 Positive_regulation of Positive_regulation of PLCG2 1 0.19 0.81 0.05
148 INT355583 Binding of EGFR and ANGPTL4 1 0.12 2.14 0.05
149 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
150 INT355589 Binding of EGFR and LTBP1 1 0.11 2.15 0.05
151 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
152 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05
153 INT213903 Binding of EGFR and ERBB2 10 0.37 5.03 0.04
154 INT188737 Egfr Positive_regulation of EGFR 1 0.21 0.6 0.04
155 INT213901 EGFR Positive_regulation of ERBB2 1 0.52 0.41 0.04
156 INT302166 Positive_regulation of PTGER2 Positive_regulation of EGFR 1 0.07 1.49 0.04
157 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
158 INT352356 Gene_expression of CNR1 Positive_regulation of Gene_expression of EGFR 1 0.24 0.95 0.04
159 INT302291 Positive_regulation of EGFR Positive_regulation of Myc 1 0.18 1.3 0.04
160 INT188735 EGFR Positive_regulation of Egfr 1 0.21 0.6 0.04
161 INT188732 EGFR Positive_regulation of Gene_expression of Egfr 1 0.21 0.6 0.04
162 INT213906 EGFR Positive_regulation of Gene_expression of ERBB2 1 0.52 0.42 0.04
163 INT188731 Egfr Regulation of EGFR 1 0.46 0.59 0.03
164 INT213902 ESR1 Positive_regulation of EGFR 1 0.48 0.31 0.03
165 INT181079 Binding of Akt1 and Errfi1 1 0.00 0.8 0.03
166 INT187640 Binding of EGFR and KLF1 3 0.01 2.54 0
167 INT351090 Phosphorylation of TXK Positive_regulation of EGFR 1 0.04 0.33 0
168 INT250665 EGFR Positive_regulation of PIK3CB 1 0.21 1.39 0
169 INT145150 Positive_regulation of Binding of EGFR and JUN 1 0.24 0.11 0
170 INT285071 EGF Positive_regulation of CCL16 1 0.03 0.77 0
171 INT266925 Regulation of Binding of EGFR and ERBB2 1 0.26 0.5 0
172 INT225909 Binding of GRB2 and SOS1 1 0.01 0.11 0
173 INT318081 Binding of RPL5 and UBC 1 0.02 0.52 0
174 INT250630 CLTC Negative_regulation of Gene_expression of Fbxo23 1 0.00 0 0
175 INT278014 Ptprf Regulation of Localization of Gh 1 0.61 0.31 0
176 INT223577 TXK Negative_regulation of EGFR 1 0.08 0.18 0
177 INT206058 EGFR Negative_regulation of Gene_expression of IL6 1 0.07 0.62 0
178 INT311992 Binding of FCGR3B and STAM 1 0.02 0 0
179 INT356237 Binding of CLTC and GPSM2 1 0.00 0 0
180 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0
181 INT341631 EGFR Positive_regulation of TXK 1 0.05 0.42 0
182 INT298197 EGFR Regulation of CDKN1A 1 0.04 1.14 0
183 INT225905 Binding of GRB2 and SHC1 1 0.00 0 0
184 INT293801 EGF Positive_regulation of EPHB2 1 0.11 0 0
185 INT186096 EGF Regulation of Positive_regulation of CASP3 1 0.01 0.28 0
186 INT297000 Binding of AP2A1 and AP1B1 1 0.00 0.21 0
187 INT334320 EGFR Positive_regulation of RASGRP1 1 0.05 0.76 0
188 INT327101 Binding of AREG and EGF 1 0.05 0.35 0
189 INT356252 Binding of CLTC and Dlg3 1 0.00 0 0
190 INT213583 Binding of EGFR and NRG2 1 0.16 0.13 0
191 INT227670 EGF Positive_regulation of Gene_expression of ISYNA1 1 0.01 2.92 0
192 INT267255 Bcl2 Positive_regulation of Gene_expression of Ptprj 1 0.04 0.63 0
193 INT145148 Positive_regulation of Binding of EGFR and FOS 1 0.50 0.05 0
194 INT351604 TXK Positive_regulation of EGFR 1 0.02 1.78 0
195 INT339117 Binding of EGFR and GRB7 1 0.28 1.18 0
196 INT191183 Binding of GRB2 and RECQL5 1 0.37 0.17 0
197 INT234996 Ctnnd1 Positive_regulation of CDC42 1 0.01 0.07 0
198 INT225906 Binding of GAB1 and GRB2 1 0.01 0.27 0
199 INT277664 Negative_regulation of Binding of EGF and EGFR 1 0.18 0.5 0
200 INT245820 Binding of Sp1 and Tfap2a 1 0.03 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of epidermal growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of epidermal growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
2 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
3 INT11157 Binding of EGF 88 0.48 53.73 21.25
4 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
5 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
6 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
7 INT2036 Localization of EGF 42 0.77 21.5 9.74
8 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
9 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
10 INT11154 Binding of EGFR 149 0.48 96.23 6.29
11 INT37227 Regulation of EGF 19 0.45 11.16 5.17
12 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
13 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
14 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
15 INT192450 Gene_expression of CLTC 26 0.55 18.82 3.26
16 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
17 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
18 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
19 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
20 INT65545 Localization of EGFR 35 0.79 20.8 1.88
21 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
22 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
23 INT207521 Gene_expression of Tfap2a 7 0.48 1.89 1.45
24 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
25 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
26 INT12806 Positive_regulation of AP2M1 2 0.67 0.19 1.35
27 INT127725 Negative_regulation of Positive_regulation of EGFR 6 0.57 2.69 1.3
28 INT97955 Positive_regulation of CDC42 8 0.49 2.47 1.19
29 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
30 INT118293 Regulation of Phosphorylation of EGFR 2 0.61 1.01 1.1
31 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08
32 INT247970 Regulation of CLTC 8 0.28 5.37 1.06
33 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
34 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
35 INT84511 Positive_regulation of Tfap2a 3 0.27 0.72 1.04
36 INT86384 Negative_regulation of Localization of EGFR 4 0.43 2.5 0.97
37 INT11160 Regulation of Gene_expression of EGFR 27 0.62 22.05 0.96
38 INT243974 Binding of Tfap2a 7 0.18 1.36 0.93
39 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
40 INT278709 Gene_expression of CBL 4 0.14 3.91 0.85
41 INT117347 Positive_regulation of Positive_regulation of EGFR 15 0.69 11.17 0.84
42 INT221796 Positive_regulation of Gene_expression of Tfap2a 2 0.10 1.19 0.83
43 INT138955 Transcription of EGFR 18 0.71 11.39 0.78
44 INT186119 Protein_catabolism of EGFR 6 0.98 3.68 0.76
45 INT207535 Transcription of Tfap2a 3 0.31 0.98 0.74
46 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71
47 INT114246 Positive_regulation of Negative_regulation of EGFR 13 0.49 8.67 0.7
48 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7
49 INT59696 Gene_expression of AP2M1 1 0.65 0.23 0.7
50 INT135197 Gene_expression of Tfap2a 1 0.45 0.48 0.69
51 INT186117 Negative_regulation of Protein_catabolism of EGFR 1 0.42 0.67 0.68
52 INT186118 Positive_regulation of Protein_catabolism of EGFR 1 0.68 0.66 0.68
53 INT136927 Gene_expression of HGS 18 0.70 14.42 0.6
54 INT207529 Localization of Tfap2a 2 0.34 0.13 0.6
55 INT260422 Positive_regulation of Localization of EGF 3 0.10 1.58 0.56
56 INT243970 Phosphorylation of Tfap2a 2 0.25 0.56 0.56
57 INT97956 Negative_regulation of CDC42 3 0.27 1.58 0.55
58 INT175219 Binding of NUP62 31 0.27 4.51 0.53
59 INT74724 Regulation of Ptprj 2 0.05 0.35 0.51
60 INT74725 Localization of Ptprj 1 0.14 0.15 0.5
61 INT113532 Binding of AP2M1 1 0.47 0.19 0.47
62 INT217452 Binding of Nup62 1 0.38 2.7 0.44
63 INT102181 Negative_regulation of CLTC 5 0.37 1.37 0.42
64 INT297020 Positive_regulation of CLTC 5 0.36 3.38 0.41
65 INT114740 Binding of GRB2 8 0.36 2.24 0.37
66 INT168101 Positive_regulation of PTPRF 2 0.45 1.04 0.37
67 INT344613 Negative_regulation of Gene_expression of CLTC 2 0.31 1.19 0.37
68 INT138954 Regulation of Transcription of EGFR 2 0.27 0.82 0.35
69 INT303286 Localization of Nup62 1 0.08 0 0.35
70 INT145155 Regulation of Positive_regulation of EGFR 6 0.38 4.54 0.33
71 INT186115 Negative_regulation of Negative_regulation of EGFR 5 0.57 3.42 0.33
72 INT192448 Positive_regulation of Gene_expression of CLTC 5 0.32 3.01 0.33
73 INT191211 Gene_expression of GRB2 5 0.62 0.96 0.32
74 INT192447 Localization of CLTC 6 0.44 2.32 0.29
75 INT212615 Localization of PTPRF 2 0.68 0.34 0.28
76 INT85329 Regulation of Errfi1 1 0.01 0.39 0.28
77 INT5397 Negative_regulation of AP2B1 1 0.08 0.4 0.28
78 INT13818 Negative_regulation of Protein_catabolism of EGF 1 0.59 0.37 0.27
79 INT184995 Binding of HGS 4 0.26 3.1 0.25
80 INT240034 Phosphorylation of GRB2 3 0.79 1.79 0.25
81 INT217446 Negative_regulation of Binding of Nup62 1 0.33 1.54 0.25
82 INT223597 Negative_regulation of Binding of EGFR 12 0.43 7.97 0.23
83 INT183881 Localization of CDC42 3 0.49 1.92 0.23
84 INT136929 Transcription of HGS 1 0.48 3.75 0.23
85 INT183876 Regulation of CDC42 3 0.30 1.94 0.19
86 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17
87 INT111291 Transcription of EGF 2 0.52 0.35 0.17
88 INT162939 Binding of Tfap2a 1 0.26 0.34 0.17
89 INT162940 Negative_regulation of Tfap2a 1 0.32 0.34 0.17
90 INT162941 Negative_regulation of Binding of Tfap2a 1 0.32 0.34 0.17
91 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15
92 INT275446 Gene_expression of STAM 1 0.01 0.27 0.15
93 INT175416 Regulation of Negative_regulation of EGFR 4 0.60 3.94 0.14
94 INT96224 Positive_regulation of Ptprf 1 0.11 0.36 0.14
95 INT184977 Negative_regulation of HGS 3 0.28 1.38 0.13
96 INT312008 Binding of STAM 1 0.02 0.34 0.13
97 INT206133 Binding of CDC42 3 0.25 0.8 0.12
98 INT111294 Negative_regulation of Transcription of EGF 1 0.32 0.09 0.12
99 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11
100 INT187313 Regulation of PTPRF 1 0.01 0 0.11
101 INT187312 Regulation of Positive_regulation of PTPRF 1 0.03 0 0.11
102 INT192449 Binding of CLTC 5 0.23 3.57 0.09
103 INT119719 Positive_regulation of CBL 3 0.49 1.67 0.09
104 INT201016 Positive_regulation of AP2B1 2 0.36 1.01 0.09
105 INT70651 Positive_regulation of Binding of EGF 1 0.50 0.98 0.09
106 INT127433 Negative_regulation of Gene_expression of Nup62 2 0.53 2.36 0.08
107 INT280016 Positive_regulation of Regulation of CLTC 1 0.12 1.23 0.08
108 INT326522 Positive_regulation of Gene_expression of HGS 1 0.07 2.62 0.08
109 INT326523 Negative_regulation of Gene_expression of HGS 1 0.06 2.64 0.08
110 INT229184 Regulation of Protein_catabolism of EGFR 1 0.25 1.11 0.08
111 INT266934 Regulation of Binding of EGFR 3 0.45 1.16 0.07
112 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07
113 INT217461 Negative_regulation of Positive_regulation of Nup62 1 0.33 0.41 0.07
114 INT275447 Phosphorylation of STAM 1 0.02 0.05 0.07
115 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
116 INT206169 Gene_expression of CDC42 2 0.26 1.05 0.05
117 INT217443 Regulation of Nup62 1 0.48 1.47 0.05
118 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
119 INT267251 Gene_expression of Ptprj 1 0.12 2.02 0.05
120 INT206167 Positive_regulation of Gene_expression of CDC42 1 0.08 0.05 0.05
121 INT183275 Positive_regulation of Regulation of EGFR 1 0.36 0.21 0.05
122 INT185008 Localization of HGS 2 0.52 0.43 0.04
123 INT318095 Gene_expression of UBC 1 0.16 1.24 0.04
124 INT223370 Regulation of CBL 1 0.01 0.91 0.04
125 INT185015 Positive_regulation of HGS 8 0.40 4.65 0.03
126 INT297034 Gene_expression of EPS15 1 0.54 1.03 0.03
127 INT145156 Regulation of Regulation of EGFR 1 0.24 1.31 0.03
128 INT267249 Positive_regulation of Gene_expression of Ptprj 1 0.08 0.39 0.03
129 INT266931 Positive_regulation of Binding of EGFR 6 0.50 5.44 0
130 INT118289 Negative_regulation of Phosphorylation of EGF 3 0.40 0.47 0
131 INT114742 Positive_regulation of GRB2 3 0.49 1.59 0
132 INT315831 Positive_regulation of Localization of EGFR 2 0.49 0.6 0
133 INT297019 Regulation of Gene_expression of CLTC 2 0.37 0.8 0
134 INT319331 Regulation of Localization of EGFR 2 0.32 1.85 0
135 INT217457 Negative_regulation of Nup62 2 0.33 0.94 0
136 INT297043 Regulation of AP2B1 1 0.19 1.22 0
137 INT356250 Positive_regulation of Transcription of CLTC 1 0.03 0.1 0
138 INT223596 Positive_regulation of Gene_expression of GRB2 1 0.03 0.51 0
139 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
140 INT209724 Binding of CBL 1 0.00 0 0
141 INT297044 Positive_regulation of EPS15 1 0.35 0.2 0
142 INT175213 Negative_regulation of Binding of UBC 1 0.02 0.13 0
143 INT356251 Positive_regulation of Localization of CLTC 1 0.04 0.07 0
144 INT156902 Positive_regulation of UBC 1 0.49 0 0
145 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
146 INT344614 Protein_catabolism of CLTC 1 0.56 0.77 0
147 INT287281 Positive_regulation of Positive_regulation of CDC42 1 0.26 0 0
148 INT297036 Regulation of Gene_expression of AP2B1 1 0.32 0.54 0
149 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
150 INT278004 Localization of Ptprf 1 0.68 0.31 0
151 INT267250 Positive_regulation of Ptprj 1 0.08 1.31 0
152 INT200396 Negative_regulation of Binding of HGS 1 0.29 0.84 0
153 INT217459 Regulation of Gene_expression of Nup62 1 0.35 0.35 0
154 INT175222 Binding of UBC 1 0.02 0.54 0
155 INT297027 Binding of EPS15 1 0.26 0.37 0
156 INT244929 Transcription of GRB2 1 0.47 0 0
157 INT119720 Negative_regulation of CBL 1 0.42 0.15 0
158 INT184982 Regulation of HGS 1 0.18 1.25 0
159 INT356244 Positive_regulation of Binding of CLTC 1 0.04 0 0
160 INT311630 Negative_regulation of Tfap2a 1 0.34 0.23 0
161 INT356249 Transcription of CLTC 1 0.05 0.1 0
162 INT297032 Gene_expression of AP2B1 1 0.48 0.54 0
163 INT319128 Positive_regulation of Binding of Tfap2a 1 0.23 0.5 0
164 INT311626 Negative_regulation of Gene_expression of Tfap2a 1 0.34 0.29 0
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