GO:0042089

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Name cytokine biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042089
Unique Molecular Interactions 32
Total Molecular Interactions 66
Total Single Events 228
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cytokine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for cytokine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
2 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
3 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
4 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
5 INT174509 Binding of CD4 and CD28 1 0.26 1.68 0.84
6 INT188567 IRF6 Positive_regulation of Gene_expression of CD28 1 0.05 1.28 0.82
7 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5
8 INT188565 IRF6 Regulation of Gene_expression of CD28 1 0.03 0.7 0.43
9 INT188572 CD14 Regulation of Gene_expression of CD28 1 0.11 0.6 0.4
10 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34
11 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32
12 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32
13 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
14 INT289959 Negative_regulation of Binding of CD28 and CD80 1 0.07 0.24 0.23
15 INT288006 Binding of CD28 and LRRC23 1 0.02 0.54 0.19
16 INT188568 Negative_regulation of IRF6 Positive_regulation of CD28 1 0.05 0.19 0.19
17 INT171127 Binding of CD28 and IFN1@ 1 0.39 0.36 0.19
18 INT188571 IRF6 Positive_regulation of CD28 1 0.06 0.19 0.19
19 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18
20 INT194700 CD28 Positive_regulation of MAPK1 1 0.10 0.55 0.16
21 INT194817 CD28 Positive_regulation of Il4 1 0.15 0.41 0.13
22 INT194717 CD28 Positive_regulation of IL13 1 0.03 0.41 0.13
23 INT351031 Binding of CD28 and CD96 1 0.02 0.36 0.09
24 INT338433 Il17f Positive_regulation of Gene_expression of IL8 1 0.01 1.62 0.09
25 INT194674 CD28 Negative_regulation of Gene_expression of IL13 1 0.02 0.06 0.08
26 INT270201 Binding of CD28 and Cd86 1 0.10 0.58 0.08
27 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
28 INT270202 Binding of CD28 and Cd80 1 0.09 0.58 0.08
29 INT194831 CD28 Positive_regulation of Gene_expression of Il4 1 0.15 0 0.06
30 INT288007 Binding of CD28 and CD40 1 0.05 0.51 0.03
31 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 0.15 0.15 0.03
32 INT277811 Binding of CD28 and DCPS 1 0.04 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cytokine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in cytokine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171134 Gene_expression of CD28 67 0.65 32.55 13.61
2 INT73504 Binding of CD28 35 0.45 15.99 10.04
3 INT254269 Gene_expression of Il17f 12 0.48 13.29 6.02
4 INT116902 Positive_regulation of CD28 17 0.47 13.56 4.27
5 INT174527 Negative_regulation of CD28 13 0.35 5.06 2.65
6 INT144652 Negative_regulation of Binding of CD28 6 0.55 3.09 2.28
7 INT350632 Positive_regulation of Il17f 2 0.29 6.22 1.96
8 INT174511 Positive_regulation of Gene_expression of CD28 7 0.41 4.31 1.83
9 INT171133 Localization of CD28 8 0.71 3.42 1.48
10 INT300541 Negative_regulation of Gene_expression of Il17f 3 0.26 2.6 1.27
11 INT254179 Localization of Il17f 3 0.49 3.29 1.25
12 INT338411 Positive_regulation of Gene_expression of Il17f 5 0.29 4.58 1.21
13 INT300538 Negative_regulation of Il17f 2 0.26 1.98 1.07
14 INT53660 Positive_regulation of Pcsk5 2 0.49 0.29 0.85
15 INT279357 Regulation of Binding of CD28 1 0.18 0.3 0.72
16 INT188586 Negative_regulation of Gene_expression of CD28 6 0.34 1.9 0.69
17 INT300542 Binding of Il17f 2 0.05 1.68 0.5
18 INT353934 Positive_regulation of Negative_regulation of Il17f 1 0.31 0.9 0.44
19 INT308493 Positive_regulation of Positive_regulation of Pcsk5 1 0.27 0 0.44
20 INT270195 Positive_regulation of Positive_regulation of CD28 1 0.25 2.49 0.41
21 INT174476 Regulation of CD28 3 0.34 0.67 0.37
22 INT188577 Transcription of CD28 1 0.43 0.54 0.32
23 INT188583 Regulation of Transcription of CD28 1 0.22 0.54 0.32
24 INT171131 Protein_catabolism of CD28 1 0.73 0.47 0.27
25 INT278163 Negative_regulation of Localization of CD28 1 0.08 0.87 0.26
26 INT338405 Regulation of Il17f 1 0.04 0.58 0.16
27 INT70641 Gene_expression of Pcsk5 1 0.21 0.18 0.09
28 INT264194 Positive_regulation of Binding of CD28 1 0.23 0.22 0
29 INT338412 Positive_regulation of Localization of Il17f 1 0.07 0.69 0
30 INT270194 Regulation of Gene_expression of CD28 1 0.22 1.1 0
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