GO:0042094

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Name interleukin-2 biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042094
Unique Molecular Interactions 65
Total Molecular Interactions 110
Total Single Events 391
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-2 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-2 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69032 IL18 Positive_regulation of IFNA1 12 0.23 7.87 3.83
2 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
3 INT176368 IL18 Positive_regulation of Gene_expression of IFNA1 1 0.16 2.53 1.35
4 INT160585 IL18 Positive_regulation of Gene_expression of OPRM1 1 0.09 0.54 1.35
5 INT203178 IL18 Positive_regulation of Gene_expression of Lts1 1 0.01 1.98 1.02
6 INT226371 IL18 Positive_regulation of IL4 4 0.05 2.49 0.79
7 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7
8 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
9 INT176370 IL18BP Negative_regulation of IL18 1 0.15 0.76 0.56
10 INT226360 IL18 Positive_regulation of Gene_expression of IL4 1 0.05 2.66 0.54
11 INT226348 IL18 Positive_regulation of Gene_expression of IL13 1 0.03 2.66 0.54
12 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
13 INT354395 TNFSF12 Regulation of Gene_expression of IL18 1 0.47 0.79 0.45
14 INT114599 Positive_regulation of Il1rap Positive_regulation of Trib3 1 0.03 0.07 0.43
15 INT172136 IL18 Positive_regulation of Gene_expression of IFN1@ 1 0.09 0.63 0.42
16 INT114600 Positive_regulation of Il1b Positive_regulation of Il1rap 1 0.19 0.09 0.4
17 INT114592 Il1b Positive_regulation of Il1rap 1 0.27 0.09 0.4
18 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
19 INT176361 Positive_regulation of LBR Positive_regulation of Gene_expression of IL18 1 0.10 0.84 0.39
20 INT176373 IL18 Regulation of FASLG 1 0.41 0.4 0.35
21 INT300729 IL18 Positive_regulation of IL13 1 0.00 0 0.33
22 INT174265 IL18 Regulation of Gene_expression of F3 1 0.00 3.21 0.33
23 INT176362 Binding of IL18 and IL18BP 1 0.12 0.49 0.32
24 INT219151 IL18 Positive_regulation of CASP1 1 0.01 1.05 0.3
25 INT176372 Positive_regulation of IL18 Positive_regulation of IFNA1 1 0.16 0.36 0.28
26 INT176369 IL18 Regulation of TH1L 1 0.27 0.33 0.26
27 INT113419 IL10 Negative_regulation of Gene_expression of IL18 1 0.31 0.86 0.24
28 INT303606 Binding of IL18 and SOAT1 1 0.05 0.52 0.22
29 INT91653 Negative_regulation of CASP1 Negative_regulation of IL18 1 0.39 0.15 0.2
30 INT252788 Binding of IL12A and IL18 1 0.01 1.33 0.19
31 INT316748 IL18 Positive_regulation of Regulation of Hand2 1 0.14 1.11 0.18
32 INT159596 Binding of IL18 and IL18R1 1 0.08 0.17 0.17
33 INT354400 IL18 Regulation of Gene_expression of TNFSF12 1 0.35 0.55 0.17
34 INT207144 F2r Positive_regulation of Pawr 1 0.14 0.51 0.16
35 INT354403 IL18 Regulation of TNFSF12 1 0.35 0.11 0.13
36 INT354401 TNFSF12 Regulation of IL18 1 0.47 0 0.1
37 INT294431 IL18 Positive_regulation of Gene_expression of SELE 1 0.06 0.98 0.1
38 INT339498 Binding of Il1rap and Positive_regulation of Irak1 1 0.01 0 0.1
39 INT294430 IL18 Positive_regulation of Gene_expression of VCAM1 1 0.10 0.91 0.09
40 INT276814 IL18 Positive_regulation of Gene_expression of Hgs 1 0.05 0.09 0.09
41 INT239839 IL18 Positive_regulation of TNF 1 0.11 1.08 0.09
42 INT354402 IL18 Positive_regulation of Gene_expression of TNFSF12 1 0.39 0.55 0.08
43 INT325264 Il1rap Positive_regulation of Mapk1 1 0.08 0 0.07
44 INT325262 Il1rap Positive_regulation of Mapk8 1 0.09 0 0.07
45 INT325258 Il1rap Positive_regulation of Mapk14 1 0.08 0 0.07
46 INT354391 Binding of IL18 and UNK 1 0.23 0.66 0.06
47 INT354397 Positive_regulation of IL18 Regulation of Gene_expression of TNFSF12 1 0.18 0 0.05
48 INT178430 Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
49 INT178447 Negative_regulation of Pawr Positive_regulation of Phosphorylation of Mapk14 1 0.05 0.29 0.05
50 INT194735 IL18 Positive_regulation of Positive_regulation of MAPK1 1 0.05 0 0.04
51 INT194741 IL18 Positive_regulation of Gene_expression of GADD45A 1 0.05 0 0.04
52 INT194704 IL18 Positive_regulation of GADD45A 1 0.08 0 0.04
53 INT220634 Binding of Bace1 and Pawr 2 0.06 0.2 0
54 INT165187 Positive_regulation of Binding of CST3 and IL18 1 0.03 0.28 0
55 INT165197 Positive_regulation of Binding of IL18 and Havcr1 1 0.00 0.28 0
56 INT165195 Binding of IL18 and Havcr1 1 0.00 0.28 0
57 INT165198 Positive_regulation of Binding of IL18 and Fabp1 1 0.01 0.55 0
58 INT165190 Binding of IL18 and LCN2 1 0.00 0.28 0
59 INT139563 Tlr4 Positive_regulation of Localization of IL18 1 0.01 0 0
60 INT354404 Binding of IL18 and NCR1 1 0.22 0 0
61 INT165196 Binding of IL18 and Fabp1 1 0.01 0.55 0
62 INT189992 Binding of Ptger2 and Pawr 1 0.00 2.89 0
63 INT165189 Binding of CST3 and IL18 1 0.02 0.28 0
64 INT165188 Positive_regulation of Binding of IL18 and LCN2 1 0.00 0.28 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-2 biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-2 biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69036 Gene_expression of IL18 99 0.77 77.92 25.95
2 INT87863 Positive_regulation of IL18 40 0.69 34.08 9.53
3 INT91721 Binding of IL18 21 0.48 21.17 6.56
4 INT91657 Negative_regulation of IL18 20 0.48 15.97 6.12
5 INT113420 Positive_regulation of Gene_expression of IL18 22 0.69 19.96 5.53
6 INT35175 Localization of IL18 18 0.80 12.96 3.83
7 INT76680 Positive_regulation of Il1rap 5 0.24 4.5 3.21
8 INT176383 Negative_regulation of Binding of IL18 1 0.35 5.91 2.91
9 INT139562 Transcription of IL18 10 0.68 6.14 2.73
10 INT258581 Gene_expression of Il1rap 3 0.14 2.59 2.43
11 INT133567 Regulation of IL18 11 0.50 9.54 2.31
12 INT76681 Transcription of Il1rap 3 0.25 4.46 2.18
13 INT118305 Negative_regulation of Gene_expression of IL18 7 0.39 6.52 2.05
14 INT159598 Positive_regulation of Transcription of IL18 3 0.48 1.84 1.32
15 INT126396 Negative_regulation of Transcription of Il1rap 1 0.15 1.35 1.32
16 INT69037 Regulation of Gene_expression of IL18 4 0.43 3.29 1.31
17 INT176379 Regulation of Binding of IL18 1 0.37 2.37 1.17
18 INT207091 Positive_regulation of Pawr 2 0.36 1.95 1.1
19 INT35174 Positive_regulation of Localization of IL18 7 0.69 5.22 1.08
20 INT114586 Positive_regulation of Positive_regulation of Il1rap 1 0.17 0.07 0.88
21 INT76682 Positive_regulation of Transcription of Il1rap 1 0.17 3.15 0.87
22 INT207103 Positive_regulation of Positive_regulation of Pawr 2 0.36 1.45 0.85
23 INT207108 Gene_expression of Pawr 5 0.40 1.61 0.77
24 INT228470 Phosphorylation of Il1rap 1 0.11 1.34 0.7
25 INT174248 Negative_regulation of Positive_regulation of Il1rap 1 0.00 0.95 0.61
26 INT174249 Positive_regulation of Il1rap 1 0.01 0.95 0.61
27 INT104910 Binding of Il1rap 1 0.25 0.6 0.58
28 INT176384 Positive_regulation of Binding of IL18 1 0.41 0.98 0.51
29 INT207074 Binding of Pawr 2 0.18 0.87 0.48
30 INT114588 Phosphorylation of Il1rap 1 0.22 0 0.46
31 INT91668 Positive_regulation of Negative_regulation of IL18 1 0.38 0.24 0.38
32 INT91660 Positive_regulation of Positive_regulation of IL18 1 0.41 0.25 0.31
33 INT113421 Negative_regulation of Localization of IL18 2 0.58 0.87 0.27
34 INT306736 Negative_regulation of Transcription of IL18 2 0.38 0.31 0.11
35 INT339482 Binding of Il1rap 1 0.01 0 0.1
36 INT239842 Negative_regulation of Positive_regulation of IL18 1 0.20 1.1 0.08
37 INT159600 Regulation of Transcription of IL18 2 0.43 0.07 0.06
38 INT189988 Regulation of Pawr 3 0.13 3.26 0.05
39 INT178410 Negative_regulation of Pawr 1 0.12 0.29 0.05
40 INT316745 Phosphorylation of IL18 1 0.70 0.79 0
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