GO:0042116

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Name macrophage activation
Categary Process
Go Slim No
Go Link GO:0042116
Unique Molecular Interactions 1090
Total Molecular Interactions 1633
Total Single Events 7521
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for macrophage activation. They are ordered first by their pain relevance and then by number of times they were reported for macrophage activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
2 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
3 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
4 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
5 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
6 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
7 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
8 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61
9 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54
10 INT158282 Binding of Penk and Csf2 1 0.33 0.87 1.44
11 INT294775 IRF6 Positive_regulation of TLR4 6 0.08 2.04 1.32
12 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
13 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
14 INT161508 Tlr4 Positive_regulation of Mapk14 2 0.19 0.46 1.24
15 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
16 INT261410 Slc7a2 Positive_regulation of Ltp 1 0.06 0.08 1.21
17 INT349587 Binding of Aap and Csf2 1 0.04 0.41 1.18
18 INT170655 Binding of Csf2 and Ngf 1 0.36 1.25 1.18
19 INT161509 Tlr4 Positive_regulation of Mapk8 1 0.15 0.3 1.16
20 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
21 INT185321 Tlr4 Positive_regulation of Gene_expression of Il6 5 0.14 1.97 1.15
22 INT89938 Tlr4 Positive_regulation of Gene_expression of TNF 6 0.25 1.3 1.12
23 INT167426 Tlr4 Positive_regulation of Localization of Gpt 1 0.25 1.26 1.1
24 INT130656 Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
25 INT130657 Negative_regulation of Tlr4 Positive_regulation of Cyba 1 0.00 0.05 1.09
26 INT282712 Binding of MUC5AC and Csf2 1 0.01 2.63 1.07
27 INT170653 Ngf Regulation of Csf2 1 0.34 1.11 1.05
28 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03
29 INT145163 Tlr4 Positive_regulation of Localization of Nsfl1c 1 0.02 0.43 0.94
30 INT219154 Binding of HMGB1 and TLR4 2 0.17 4.45 0.93
31 INT336017 Vip Regulation of Tlr4 1 0.22 1.23 0.93
32 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
33 INT306327 Binding of Ly96 and Tlr4 1 0.10 1.83 0.91
34 INT343909 IgG Positive_regulation of Gene_expression of TLR4 1 0.04 3.49 0.91
35 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9
36 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
37 INT120147 Tlr4 Positive_regulation of Tnf 3 0.39 2.14 0.89
38 INT168281 Tlr4 Positive_regulation of Phosphorylation of Mapk4 1 0.06 1.05 0.89
39 INT244323 Csf2 Positive_regulation of Gene_expression of Tlr4 1 0.23 1.93 0.85
40 INT343829 TLR1 Positive_regulation of TBCE 1 0.03 0.96 0.85
41 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
42 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
43 INT131793 Binding of Slco1c1 and Csf2 1 0.02 0 0.81
44 INT131794 Binding of Csf2 and Gpm6a 1 0.17 0 0.81
45 INT223753 Tlr4 Positive_regulation of Gene_expression of Il10 4 0.32 1.93 0.78
46 INT209043 Binding of Fn1 and Slc11a1 3 0.03 1.91 0.78
47 INT152235 Mapk8 Positive_regulation of Localization of Tlr4 1 0.38 0.26 0.78
48 INT339495 Tlr4 Positive_regulation of Eif2ak2 1 0.21 0.58 0.77
49 INT194644 Tlr4 Positive_regulation of TNF 6 0.58 2.42 0.76
50 INT170658 Binding of Ntf3 and Csf2 1 0.33 0.8 0.74
51 INT75937 MLXIPL Regulation of Csf2 1 0.01 0.68 0.74
52 INT284306 Tlr4 Positive_regulation of Adrb3 1 0.00 1.19 0.74
53 INT209037 Il4 Positive_regulation of Csf2 1 0.03 0.38 0.73
54 INT209051 Il2 Positive_regulation of Csf2 1 0.02 0.38 0.73
55 INT209062 Il3 Positive_regulation of Csf2 1 0.02 0.38 0.73
56 INT209057 Il6 Positive_regulation of Csf2 1 0.03 0.38 0.72
57 INT209045 Il10 Positive_regulation of Csf2 1 0.03 0.37 0.72
58 INT209032 Il12b Positive_regulation of Csf2 1 0.08 0.37 0.72
59 INT222432 Binding of Tlr4 and Cd14 1 0.02 0.74 0.71
60 INT89936 Tlr4 Positive_regulation of Il6 3 0.49 0.95 0.7
61 INT215098 Tlr4 Positive_regulation of Localization of Il6 3 0.18 1.18 0.69
62 INT280951 Tlr4 Positive_regulation of Localization of S100a8 1 0.01 1.09 0.69
63 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
64 INT75936 Csf2 Positive_regulation of Oprk1 1 0.25 0.78 0.67
65 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66
66 INT120144 Negative_regulation of Tlr4 Positive_regulation of Tnf 1 0.18 0.91 0.66
67 INT343851 Positive_regulation of Binding of IRF6 and TLR4 1 0.07 1.96 0.66
68 INT209063 Slc11a1 Positive_regulation of Il17a 1 0.11 0.4 0.65
69 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
70 INT244320 Tlr4 Positive_regulation of Aliq1 3 0.04 4.51 0.64
71 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
72 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
73 INT276603 Il10 Positive_regulation of Gene_expression of Tlr4 1 0.12 0.49 0.6
74 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
75 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
76 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59
77 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
78 INT162790 Binding of TLR4 and NOD2 1 0.36 0.51 0.57
79 INT236783 IRF6 Negative_regulation of Gene_expression of TLR4 1 0.01 1.17 0.57
80 INT306330 Cd14 Positive_regulation of Gene_expression of Tlr4 1 0.48 0.54 0.57
81 INT146871 Tlr4 Positive_regulation of Gene_expression of ROS1 2 0.00 1.16 0.56
82 INT184242 Mthfd1 Negative_regulation of Gene_expression of Csf2 1 0.03 0.87 0.56
83 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
84 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56
85 INT175323 Tlr4 Positive_regulation of Gene_expression of TLR2 1 0.02 0.31 0.56
86 INT120143 Tlr4 Negative_regulation of Gene_expression of Tnf 1 0.18 0.76 0.55
87 INT243056 Binding of LBP and Tlr4 1 0.00 1.11 0.55
88 INT310767 Tlr4 Regulation of Gene_expression of S100a8 1 0.02 0.7 0.54
89 INT282711 Binding of Csf2 and Mmp9 1 0.16 1.35 0.54
90 INT210934 Gene_expression of Tlr4 Negative_regulation of Ccl2 1 0.47 0.69 0.54
91 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53
92 INT194915 Csf2 Positive_regulation of Gene_expression of Mmp1a 1 0.01 0.85 0.52
93 INT194918 Csf2 Positive_regulation of Gene_expression of VEGFA 1 0.02 0.85 0.52
94 INT179503 Cd14 Regulation of Positive_regulation of Tlr4 1 0.38 0.58 0.52
95 INT343838 EDA Positive_regulation of TLR4 1 0.11 0.87 0.51
96 INT285911 Binding of TLR4 and Cd14 1 0.05 1.13 0.51
97 INT324523 Tlr4 Regulation of Gene_expression of PGE 1 0.23 1.98 0.51
98 INT143504 IFNG Positive_regulation of Gene_expression of Aif1 1 0.04 1.26 0.51
99 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
100 INT340212 Csf2 Positive_regulation of Pttg1ip 1 0.02 0.46 0.49
101 INT306019 Binding of Tlr4 and LY96 1 0.06 0.91 0.49
102 INT254119 Binding of Bcl2a1a and Tlr4 1 0.01 1.34 0.49
103 INT209046 Slc11a1 Positive_regulation of Regulation of Tlr4 1 0.07 0.09 0.48
104 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
105 INT244319 Csf2 Positive_regulation of Positive_regulation of Tlr4 1 0.23 1.03 0.48
106 INT322264 Binding of MPZ and TLR4 1 0.18 1.68 0.47
107 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
108 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47
109 INT284300 Tlr4 Positive_regulation of Gene_expression of Mir155 1 0.18 0.91 0.47
110 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
111 INT207141 Tlr4 Positive_regulation of Positive_regulation of Pawr 1 0.05 0.79 0.46
112 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46
113 INT310769 Pam Regulation of Tlr4 1 0.01 0.69 0.46
114 INT181444 Ccl5 Positive_regulation of Csf2 1 0.07 1.88 0.45
115 INT181447 Ccl3 Positive_regulation of Csf2 1 0.06 1.89 0.45
116 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45
117 INT170656 Ntf3 Positive_regulation of Csf2 1 0.35 1.46 0.44
118 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
119 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
120 INT230461 Binding of TLR1 and TLR2 3 0.33 2.06 0.43
121 INT80415 Binding of Csf2 and Gnptab 1 0.02 0 0.43
122 INT170657 Ntf3 Regulation of Csf2 1 0.31 0.46 0.43
123 INT212810 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.03 0.74 0.43
124 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
125 INT308696 Binding of Tlr4 and Tlr4 1 0.00 0.34 0.42
126 INT329085 Csf2 Positive_regulation of Apoe 1 0.00 1.23 0.42
127 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41
128 INT348790 Binding of MYD88 and Tlr4 1 0.35 1.84 0.4
129 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
130 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4
131 INT295478 IRF6 Positive_regulation of Positive_regulation of TLR4 2 0.20 0.78 0.39
132 INT181443 Csf2 Positive_regulation of Cxcl10 1 0.02 1.69 0.39
133 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
134 INT152238 Mapk14 Positive_regulation of Localization of Tlr4 1 0.29 0.13 0.39
135 INT152237 Mapk1 Positive_regulation of Localization of Tlr4 1 0.33 0.13 0.39
136 INT81300 Tlr4 Positive_regulation of Gene_expression of Nos2 1 0.02 0.38 0.39
137 INT181441 Csf2 Positive_regulation of Cxcl12 1 0.02 1.69 0.39
138 INT310697 Tlr4 Positive_regulation of Gene_expression of Ptger2 2 0.03 1.34 0.38
139 INT339504 Binding of Irak1 and Tlr4 1 0.08 0.12 0.38
140 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38
141 INT260746 Binding of TLR4 and Ecm1 1 0.02 0.44 0.38
142 INT147969 Binding of Ly86 and Tlr4 1 0.30 0.37 0.38
143 INT181439 Csf2 Positive_regulation of Ccl19 1 0.06 1.68 0.38
144 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
145 INT215275 Tlr4 Positive_regulation of Gene_expression of Ros1 1 0.01 1.37 0.38
146 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
147 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38
148 INT188560 Negative_regulation of Binding of IRF6 and TLR4 1 0.04 0.58 0.38
149 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38
150 INT324821 Tlr4 Positive_regulation of Gene_expression of Maob 1 0.07 0.44 0.37
151 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
152 INT100091 Tlr4 Regulation of Localization of Tnf 1 0.01 0.42 0.37
153 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
154 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
155 INT110135 Tlr4 Regulation of Localization of Gnrh1 1 0.01 0.2 0.36
156 INT209047 Slc11a1 Positive_regulation of Localization of Il10 1 0.10 0.52 0.36
157 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
158 INT337304 PTAFR Positive_regulation of Gene_expression of TLR4 1 0.62 1.99 0.36
159 INT188563 TLR4 Positive_regulation of Gene_expression of PRF1 1 0.03 0.78 0.36
160 INT202810 Pin1 Regulation of Csf2 1 0.03 0.82 0.36
161 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
162 INT19477 Binding of IL1A and Csf2 1 0.00 2.19 0.36
163 INT272412 VSX1 Positive_regulation of Gene_expression of Slc11a1 1 0.00 0.57 0.35
164 INT118743 Tlr4 Positive_regulation of Itgam 1 0.39 0.41 0.35
165 INT110132 Tlr4 Regulation of Localization of LH 1 0.01 0.2 0.35
166 INT244324 Csf2 Positive_regulation of Tlr4 1 0.23 0.95 0.34
167 INT110134 Tlr4 Regulation of Regulation of Gnrh1 1 0.01 0.15 0.33
168 INT244325 Csf2 Regulation of Positive_regulation of Aliq1 1 0.03 1.02 0.33
169 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
170 INT185385 Binding of TLR2 and TLR4 3 0.27 3.63 0.32
171 INT253766 Binding of Apex1 and Tlr4 1 0.03 0.53 0.32
172 INT295198 Tlr4 Positive_regulation of Gene_expression of Ptger2 1 0.01 0.15 0.32
173 INT322016 Binding of IL1B and TLR4 1 0.05 0.18 0.32
174 INT222441 Tlr4 Positive_regulation of Gene_expression of Tac1 1 0.00 0.39 0.32
175 INT215395 Csf2 Positive_regulation of Ppara 1 0.12 1.33 0.32
176 INT303106 CAMK4 Positive_regulation of Csf2 1 0.26 0.17 0.31
177 INT276604 Tlr4 Positive_regulation of Gene_expression of Paf 1 0.22 0.37 0.31
178 INT276605 Tlr4 Positive_regulation of Gene_expression of Mthfd1 1 0.06 0.37 0.31
179 INT288198 Binding of Tlr4 and Mapk14 1 0.01 0.63 0.31
180 INT185319 Il6 Positive_regulation of Gene_expression of Tlr4 1 0.11 0.36 0.31
181 INT185322 TNF Positive_regulation of Gene_expression of Tlr4 1 0.01 0.36 0.31
182 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
183 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
184 INT306323 Tlr4 Positive_regulation of Ticam1 3 0.25 0.55 0.3
185 INT324832 Tlr4 Positive_regulation of IFNA1 1 0.05 0.46 0.3
186 INT229600 Tlr4 Positive_regulation of Il1a 1 0.00 0.41 0.3
187 INT223752 Tlr4 Positive_regulation of Il1 1 0.12 0.64 0.3
188 INT210953 Binding of VEGFA and Csf2 1 0.00 0.47 0.3
189 INT178342 Positive_regulation of Tlr4 Positive_regulation of Il6 1 0.13 0.25 0.3
190 INT306319 Cd14 Positive_regulation of Tlr4 1 0.48 0.29 0.3
191 INT168616 Tlr4 Negative_regulation of Localization of Tnf 1 0.33 0.44 0.3
192 INT181432 Csf2 Positive_regulation of Ccl5 1 0.03 0.81 0.29
193 INT181446 Csf2 Positive_regulation of Ccl3 1 0.05 0.81 0.29
194 INT354368 FGFR1 Positive_regulation of Tlr4 1 0.01 0.16 0.29
195 INT144862 Tlr4 Positive_regulation of PGE 2 0.13 0.35 0.28
196 INT215274 Tlr4 Positive_regulation of Ros1 2 0.02 1.48 0.28
197 INT310696 Tlr4 Positive_regulation of Positive_regulation of Cftr 1 0.16 0.74 0.28
198 INT337293 PTAFR Positive_regulation of Positive_regulation of TLR4 1 0.62 1.43 0.28
199 INT54639 Edn3 Negative_regulation of Edn2 1 0.00 0 0.28
200 INT339494 Eif2ak2 Positive_regulation of Tlr4 1 0.13 0.18 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for macrophage activation. They are ordered first by their pain relevance and then by number of times they were reported in macrophage activation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
2 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
3 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
4 INT25383 Gene_expression of Csf2 222 0.76 152.93 43.32
5 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77
6 INT81289 Positive_regulation of Gene_expression of Tlr4 192 0.69 104.5 33.89
7 INT77310 Gene_expression of Aif1 89 0.78 50.49 33.68
8 INT9694 Positive_regulation of Csf2 102 0.68 70.09 33.07
9 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22
10 INT56809 Binding of Tlr4 184 0.48 106.02 31.18
11 INT118734 Gene_expression of Tlr4 70 0.78 55.7 28.19
12 INT134651 Binding of TLR4 89 0.48 66.96 23.19
13 INT78057 Localization of Tlr4 140 0.77 67.75 21.72
14 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37
15 INT117220 Positive_regulation of TLR4 64 0.69 53.61 17.33
16 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49
17 INT67641 Negative_regulation of Gene_expression of Tlr4 90 0.58 46 14.6
18 INT151120 Negative_regulation of Tlr4 18 0.59 21.09 14.46
19 INT18720 Localization of Csf2 72 0.67 13.65 13.41
20 INT117222 Positive_regulation of Gene_expression of TLR4 80 0.70 51.6 12.9
21 INT3521 Regulation of Csf2 38 0.54 11.09 12.73
22 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22
23 INT118742 Positive_regulation of Tlr4 32 0.69 27.55 11.09
24 INT25381 Localization of Csf2 62 0.76 47.48 9.03
25 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03
26 INT146991 Positive_regulation of Gene_expression of Tlr4 21 0.69 20.76 8.69
27 INT25392 Positive_regulation of Gene_expression of Csf2 41 0.49 34.28 8.36
28 INT75932 Binding of Csf2 45 0.37 33.2 8.01
29 INT75684 Regulation of Aif1 32 0.47 8.03 7.89
30 INT1952 Negative_regulation of Positive_regulation of Tlr4 33 0.51 15.8 7.41
31 INT1950 Positive_regulation of Positive_regulation of Tlr4 38 0.49 20.17 7.14
32 INT68279 Positive_regulation of Gene_expression of Csf2 30 0.67 16.31 6.88
33 INT295467 Negative_regulation of Gene_expression of Tlr4 11 0.58 7.94 6.83
34 INT79770 Regulation of Gene_expression of Aif1 13 0.45 5.28 6.82
35 INT9695 Negative_regulation of Csf2 41 0.57 31.65 6.28
36 INT88245 Gene_expression of Slc11a1 42 0.53 18.86 6.2
37 INT46721 Regulation of Csf2 26 0.45 20.4 6.18
38 INT3520 Binding of Csf2 27 0.43 9.68 6.08
39 INT97797 Localization of TLR4 18 0.77 13.78 6
40 INT103760 Regulation of Gene_expression of Tlr4 35 0.59 16.26 5.95
41 INT25394 Negative_regulation of Gene_expression of Csf2 22 0.52 13.18 5.84
42 INT143158 Negative_regulation of Gene_expression of TLR4 31 0.56 20.62 5.69
43 INT168279 Regulation of Tlr4 17 0.54 8.97 5.5
44 INT145767 Negative_regulation of TLR4 18 0.43 11.03 5.25
45 INT157622 Positive_regulation of Localization of Tlr4 34 0.48 22.63 5.09
46 INT89959 Positive_regulation of Gene_expression of Aif1 14 0.58 7.44 5.05
47 INT40782 Gene_expression of Slc7a2 10 0.57 4.59 5
48 INT79767 Negative_regulation of Aif1 30 0.42 5.14 4.73
49 INT79768 Negative_regulation of Gene_expression of Aif1 8 0.58 5.15 4.52
50 INT209018 Positive_regulation of Slc11a1 11 0.55 7.12 3.83
51 INT186808 Transcription of TLR4 22 0.69 12.77 3.73
52 INT143159 Regulation of Gene_expression of TLR4 28 0.62 15.08 3.54
53 INT57397 Binding of Aif1 15 0.28 4.06 3.49
54 INT151123 Negative_regulation of Gene_expression of Csf2 21 0.53 21.76 3.22
55 INT178711 Protein_catabolism of Tlr4 15 0.84 6.75 3.19
56 INT145768 Regulation of TLR4 19 0.45 8.31 2.96
57 INT185315 Transcription of Tlr4 24 0.69 8.65 2.93
58 INT100086 Negative_regulation of Localization of Tlr4 15 0.37 5.92 2.47
59 INT209019 Localization of Slc11a1 12 0.33 4.33 2.33
60 INT209027 Positive_regulation of Positive_regulation of Slc11a1 3 0.14 2.41 2.18
61 INT181396 Transcription of Csf2 15 0.48 6.38 2.17
62 INT96841 Regulation of Slc11a1 9 0.36 6.83 2.14
63 INT82557 Positive_regulation of Localization of Csf2 6 0.41 1.11 2.07
64 INT222609 Binding of Tlr4 8 0.43 4.03 1.98
65 INT326816 Negative_regulation of Positive_regulation of Tlr4 2 0.59 3.96 1.95
66 INT222903 Gene_expression of TLR1 20 0.60 8.77 1.9
67 INT295469 Localization of Tlr4 3 0.75 2.22 1.88
68 INT151273 Negative_regulation of Localization of Csf2 2 0.18 0 1.79
69 INT301954 Regulation of Negative_regulation of Tlr4 1 0.45 2.46 1.77
70 INT191862 Phosphorylation of Tlr4 17 0.79 6.89 1.74
71 INT96842 Binding of Slc11a1 16 0.34 7.15 1.66
72 INT188584 Positive_regulation of Positive_regulation of TLR4 8 0.65 5.98 1.64
73 INT25384 Positive_regulation of Localization of Csf2 11 0.66 7.81 1.62
74 INT159489 Positive_regulation of Positive_regulation of Csf2 6 0.42 6.02 1.61
75 INT183761 Phosphorylation of Csf2 6 0.80 4.04 1.58
76 INT335495 Regulation of Regulation of Aif1 5 0.21 1.22 1.51
77 INT77311 Localization of Aif1 10 0.75 4.21 1.5
78 INT46722 Regulation of Gene_expression of Csf2 8 0.45 4.84 1.45
79 INT75933 Positive_regulation of Binding of Csf2 4 0.49 2.7 1.42
80 INT194912 Regulation of Binding of Csf2 3 0.10 3.03 1.41
81 INT179497 Positive_regulation of Binding of Tlr4 12 0.50 6.49 1.27
82 INT40783 Localization of Slc7a2 1 0.62 0 1.25
83 INT16427 Negative_regulation of Positive_regulation of Csf2 2 0.43 1.5 1.2
84 INT152225 Regulation of Positive_regulation of Tlr4 8 0.53 2.5 1.12
85 INT272172 Regulation of Positive_regulation of Aif1 3 0.26 0 1.11
86 INT61123 Localization of Edn2 1 0.55 0.27 1.05
87 INT118738 Transcription of Tlr4 4 0.70 1.39 1
88 INT191478 Negative_regulation of Positive_regulation of Aif1 2 0.25 0.31 0.95
89 INT295466 Positive_regulation of Regulation of Tlr4 2 0.44 1.33 0.89
90 INT168278 Positive_regulation of Phosphorylation of Tlr4 1 0.48 1.05 0.88
91 INT168277 Phosphorylation of Tlr4 1 0.78 1.05 0.88
92 INT208243 Positive_regulation of Phosphorylation of Tlr4 5 0.31 3.74 0.86
93 INT217990 Negative_regulation of Slc7a2 1 0.41 2.16 0.85
94 INT33195 Positive_regulation of Slc7a2 2 0.23 0 0.82
95 INT135816 Transcription of Slc7a2 1 0.54 0 0.81
96 INT135819 Positive_regulation of Transcription of Slc7a2 1 0.38 0 0.81
97 INT135821 Negative_regulation of Transcription of Slc7a2 1 0.32 0 0.81
98 INT155052 Regulation of Gene_expression of Csf2 6 0.37 7.75 0.8
99 INT188582 Positive_regulation of Transcription of TLR4 2 0.50 4.07 0.77
100 INT181415 Regulation of Regulation of Csf2 1 0.07 2.42 0.77
101 INT139945 Transcription of Aif1 2 0.65 0.89 0.76
102 INT186681 Gene_expression of Edn2 2 0.09 1.01 0.76
103 INT56703 Negative_regulation of Negative_regulation of Csf2 1 0.38 0 0.76
104 INT295465 Regulation of Positive_regulation of Tlr4 2 0.39 1.28 0.75
105 INT151128 Positive_regulation of Negative_regulation of Tlr4 2 0.46 1 0.75
106 INT232588 Negative_regulation of Binding of Csf2 4 0.38 1.47 0.74
107 INT8614 Negative_regulation of Edn2 3 0.06 0.07 0.73
108 INT140708 Gene_expression of Tlr1 10 0.50 5.24 0.72
109 INT68281 Positive_regulation of Positive_regulation of Csf2 5 0.67 2.17 0.72
110 INT254115 Negative_regulation of Phosphorylation of Tlr4 5 0.27 3.91 0.71
111 INT3522 Positive_regulation of Binding of Csf2 3 0.40 0 0.71
112 INT221108 Negative_regulation of Slc11a1 5 0.33 3.76 0.69
113 INT161529 Regulation of Gene_expression of Tlr4 3 0.45 2.7 0.69
114 INT186800 Positive_regulation of Binding of TLR4 2 0.47 1.31 0.67
115 INT236785 Regulation of Positive_regulation of TLR4 1 0.32 1.28 0.66
116 INT209023 Positive_regulation of Gene_expression of Slc11a1 3 0.22 1.19 0.6
117 INT142780 Negative_regulation of Positive_regulation of Csf2 3 0.35 1.48 0.6
118 INT236786 Positive_regulation of Localization of TLR4 2 0.45 1.89 0.57
119 INT204864 Negative_regulation of Negative_regulation of Tlr4 3 0.30 2.05 0.56
120 INT209015 Positive_regulation of Localization of Slc11a1 1 0.14 0.45 0.54
121 INT8663 Positive_regulation of EDN2 3 0.38 0.65 0.5
122 INT246926 Negative_regulation of Transcription of Tlr4 3 0.41 1.78 0.49
123 INT209020 Negative_regulation of Gene_expression of Slc11a1 3 0.16 0.78 0.49
124 INT242887 Positive_regulation of Gene_expression of TLR1 2 0.28 1.87 0.49
125 INT343888 Regulation of Regulation of TLR4 1 0.25 1.34 0.49
126 INT147606 Positive_regulation of TLR1 5 0.67 4.35 0.47
127 INT202063 Regulation of Binding of TLR4 2 0.44 2.14 0.47
128 INT152229 Positive_regulation of Regulation of Tlr4 2 0.40 0.29 0.46
129 INT202799 Regulation of Transcription of Csf2 3 0.16 0.92 0.45
130 INT183759 Negative_regulation of Localization of Csf2 3 0.42 1.28 0.42
131 INT288184 Binding of Tlr1 8 0.29 4.73 0.4
132 INT185313 Regulation of Transcription of Tlr4 3 0.20 0.49 0.39
133 INT230469 Binding of TLR1 6 0.40 1.81 0.38
134 INT178182 Negative_regulation of Binding of Tlr4 3 0.33 2.13 0.38
135 INT324921 Regulation of Localization of Aif1 1 0.23 0.46 0.38
136 INT354234 Regulation of Binding of Aif1 1 0.30 0.57 0.36
137 INT187778 Gene_expression of Slc11a1 12 0.33 7.37 0.35
138 INT11941 Binding of Slc11a1 3 0.14 2.18 0.35
139 INT118736 Positive_regulation of Transcription of Tlr4 1 0.49 0.42 0.35
140 INT242895 Negative_regulation of Gene_expression of TLR1 3 0.38 0.95 0.34
141 INT226881 Regulation of Positive_regulation of Slc11a1 1 0.09 0.95 0.32
142 INT230494 Regulation of Binding of Tlr4 3 0.45 2.97 0.31
143 INT157768 Negative_regulation of Binding of TLR4 1 0.43 0.29 0.27
144 INT242891 Transcription of TLR1 5 0.56 0.86 0.26
145 INT275828 Positive_regulation of Gene_expression of Tlr1 2 0.24 1.75 0.26
146 INT204866 Regulation of Localization of Tlr4 3 0.37 0.66 0.25
147 INT215080 Positive_regulation of Negative_regulation of Tlr4 1 0.31 0.05 0.23
148 INT301950 Regulation of Regulation of Tlr4 1 0.40 0.32 0.23
149 INT8660 Positive_regulation of Positive_regulation of EDN2 2 0.38 0.23 0.22
150 INT255967 Transcription of Tlr1 2 0.35 2.56 0.21
151 INT348772 Positive_regulation of Positive_regulation of Tlr4 1 0.61 0.72 0.21
152 INT245220 Regulation of TLR1 1 0.36 1.6 0.21
153 INT215822 Regulation of Localization of Csf2 1 0.11 0.48 0.2
154 INT334246 Positive_regulation of Protein_catabolism of Tlr4 1 0.07 0.18 0.18
155 INT191479 Negative_regulation of Negative_regulation of Aif1 1 0.08 0.09 0.17
156 INT26353 Binding of Edn2 1 0.01 0 0.17
157 INT306008 Positive_regulation of Transcription of Tlr4 2 0.50 1.41 0.16
158 INT167360 Negative_regulation of Regulation of Aif1 2 0.38 0.59 0.16
159 INT217991 Regulation of Slc7a2 1 0.19 0.44 0.16
160 INT224838 Positive_regulation of Transcription of Csf2 4 0.42 1.49 0.15
161 INT285435 Protein_catabolism of TLR4 2 0.62 0.9 0.14
162 INT246424 Negative_regulation of Transcription of TLR4 2 0.41 0.52 0.14
163 INT290324 Positive_regulation of Binding of TLR1 1 0.22 0.48 0.14
164 INT290321 Negative_regulation of Positive_regulation of TLR1 1 0.19 0.48 0.14
165 INT285444 Localization of TLR1 2 0.63 0.47 0.13
166 INT323040 Gene_expression of EDN2 1 0.32 0.13 0.13
167 INT285441 Regulation of Localization of TLR4 2 0.38 0.15 0.12
168 INT305199 Regulation of Regulation of Csf2 1 0.09 0.33 0.12
169 INT355270 Positive_regulation of Transcription of Tlr1 1 0.01 1.76 0.12
170 INT185509 Transcription of Csf2 3 0.56 0.85 0.11
171 INT206025 Negative_regulation of Binding of Csf2 2 0.29 1.95 0.1
172 INT323038 Regulation of Positive_regulation of EDN2 1 0.21 0 0.1
173 INT185510 Protein_catabolism of Csf2 2 0.63 0.37 0.09
174 INT255958 Regulation of Transcription of Tlr1 1 0.22 0.89 0.09
175 INT276938 Localization of Tlr1 1 0.38 0.23 0.07
176 INT242893 Negative_regulation of Transcription of TLR1 1 0.17 0.58 0.07
177 INT324681 Positive_regulation of Tlr1 2 0.22 2.02 0.05
178 INT276930 Regulation of Regulation of Tlr4 1 0.17 0.45 0.05
179 INT242899 Negative_regulation of Negative_regulation of TLR4 1 0.20 0.09 0.05
180 INT184726 Negative_regulation of Protein_catabolism of Tlr4 2 0.36 0.21 0.04
181 INT272173 Positive_regulation of Positive_regulation of Aif1 1 0.03 0 0.04
182 INT231780 Regulation of Transcription of TLR4 1 0.19 0.62 0.04
183 INT325426 Negative_regulation of Negative_regulation of Csf2 1 0.34 1.48 0.03
184 INT187781 Positive_regulation of Slc11a1 3 0.24 1.76 0
185 INT187780 Localization of Slc11a1 2 0.28 0.9 0
186 INT275829 Negative_regulation of Gene_expression of Tlr1 1 0.05 0.72 0
187 INT221110 Regulation of Regulation of Slc11a1 1 0.35 0.22 0
188 INT262807 Positive_regulation of Transcription of Slc11a1 1 0.19 0.08 0
189 INT187779 Regulation of Slc11a1 1 0.10 0.75 0
190 INT323037 Negative_regulation of EDN2 1 0.20 0.23 0
191 INT187777 Positive_regulation of Localization of Slc11a1 1 0.19 0.27 0
192 INT230466 Negative_regulation of TLR1 1 0.36 0.39 0
193 INT337311 Negative_regulation of Positive_regulation of TLR4 1 0.35 0 0
194 INT178964 Positive_regulation of Gene_expression of Slc7a2 1 0.10 0.66 0
195 INT262808 Transcription of Slc11a1 1 0.26 0.08 0
196 INT167359 Positive_regulation of Regulation of Aif1 1 0.41 0.06 0
197 INT323036 Regulation of EDN2 1 0.13 0 0
198 INT183762 Regulation of Localization of Csf2 1 0.45 0.39 0
199 INT323041 Binding of EDN2 1 0.18 0.12 0
200 INT323039 Regulation of Binding of EDN2 1 0.21 0.12 0
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