GO:0042136

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Name neurotransmitter biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042136
Unique Molecular Interactions 262
Total Molecular Interactions 371
Total Single Events 6239
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for neurotransmitter biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for neurotransmitter biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
2 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
3 INT326585 Binding of GYPA and SLC6A3 1 0.13 0.86 2.64
4 INT12140 Ngf Regulation of Chat 1 0.44 1.67 2.18
5 INT283050 Binding of Gad2 and Trpm8 1 0.23 2.02 1.93
6 INT145940 Binding of Gad1 and Abat 2 0.14 1.44 1.78
7 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76
8 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
9 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
10 INT40887 Penk Regulation of Th 1 0.04 0 1.53
11 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
12 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
13 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
14 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
15 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
16 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
17 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
18 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
19 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
20 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
21 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15
22 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
23 INT1619 Binding of Gad1 and Oprl1 1 0.14 0 1.13
24 INT1620 Negative_regulation of Binding of Gad1 and Oprl1 1 0.16 0 1.13
25 INT270053 HOXD12 Positive_regulation of Gene_expression of GAD1 1 0.03 0.68 1.12
26 INT270052 GAD1 Positive_regulation of Gene_expression of SFTPA1 1 0.03 0.68 1.11
27 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
28 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
29 INT31547 Binding of Th and Vip 1 0.31 0 1.08
30 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
31 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
32 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
33 INT12138 Ins1 Negative_regulation of Chat 1 0.27 0.71 1.01
34 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
35 INT56742 LIF Positive_regulation of Chat 1 0.02 0.2 0.98
36 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
37 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
38 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
39 INT184916 Binding of da and Th 1 0.09 1.22 0.87
40 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
41 INT251706 Chat Regulation of Gene_expression of Acot1 1 0.06 1.64 0.85
42 INT251708 Chat Regulation of Acot1 1 0.03 1.64 0.84
43 INT12142 Ins1 Regulation of Chat 1 0.24 0.69 0.84
44 INT12137 Ngf Regulation of Gad1 1 0.27 0.67 0.83
45 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
46 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
47 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
48 INT102932 Nos3 Positive_regulation of NOS1 1 0.03 1.63 0.82
49 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
50 INT235087 NOS1 Positive_regulation of Localization of ABAT 1 0.02 0.61 0.81
51 INT317705 Gad2 Regulation of Gene_expression of Gabrg1 1 0.28 0.53 0.8
52 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
53 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77
54 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
55 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
56 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
57 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
58 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
59 INT68211 Binding of Calca and Chat 1 0.37 0 0.71
60 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
61 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
62 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
63 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
64 INT98386 GAD1 Positive_regulation of Gene_expression of Abat 1 0.30 1.67 0.62
65 INT148257 NR4A2 Regulation of Gene_expression of SLC6A3 1 0.60 0.4 0.59
66 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58
67 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
68 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
69 INT106346 Mtpn Regulation of Chat 1 0.06 0 0.52
70 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
71 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
72 INT121081 Negative_regulation of NOS1 Negative_regulation of Slep1 1 0.00 0 0.52
73 INT12143 Ngf Positive_regulation of Chat 1 0.45 0.29 0.49
74 INT103535 Obfc1 Negative_regulation of Positive_regulation of Gad1 1 0.03 0.07 0.49
75 INT90131 NOS1 Regulation of Fos 1 0.00 0.25 0.49
76 INT56736 Cntf Positive_regulation of Chat 1 0.00 0.1 0.49
77 INT235090 Positive_regulation of GRIN1 Positive_regulation of NOS1 1 0.42 0.81 0.49
78 INT56745 CNTF Positive_regulation of Chat 1 0.02 0.1 0.49
79 INT186713 IK Positive_regulation of Gene_expression of NOS1 1 0.00 0.55 0.49
80 INT189859 Binding of SLC6A3 and ADHD1 2 0.32 0.68 0.48
81 INT72928 Magel2 Negative_regulation of Positive_regulation of NOS1 1 0.01 0 0.47
82 INT338447 GAD1 Negative_regulation of Slc32a1 1 0.04 0.59 0.47
83 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
84 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
85 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
86 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
87 INT12139 Ins1 Regulation of Gad1 1 0.15 0.33 0.42
88 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
89 INT205567 Regulation of Binding of Fgf1 and Chat 1 0.29 0.28 0.41
90 INT205566 Binding of Fgf1 and Chat 1 0.24 0.28 0.41
91 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
92 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
93 INT148514 Binding of Gad2 and Penk 1 0.25 0 0.4
94 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
95 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
96 INT68066 Binding of MAOA and NRL 1 0.34 0 0.39
97 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
98 INT79504 Binding of Gad1 and Chat 1 0.35 0 0.38
99 INT109683 NOS1 Positive_regulation of Positive_regulation of ISYNA1 1 0.01 0.11 0.38
100 INT79507 Binding of Pvalb and Chat 1 0.06 0 0.38
101 INT235091 CALM1 Positive_regulation of NOS1 1 0.02 0.63 0.37
102 INT261597 Binding of PAH and COPD 1 0.00 1.08 0.34
103 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
104 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
105 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
106 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
107 INT230855 KNG1 Regulation of NOS1 2 0.03 0.94 0.33
108 INT51630 Binding of ACHE and OPRM1 1 0.11 0 0.33
109 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33
110 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
111 INT55087 Binding of Gad1 and Penk 1 0.08 0 0.32
112 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
113 INT344036 Binding of NOS1 and SPTB 1 0.01 0.31 0.32
114 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
115 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
116 INT313740 Negative_regulation of NOS1 Positive_regulation of Gene_expression of Ccl2 1 0.02 0.38 0.3
117 INT42253 Bbx Regulation of Gad1 1 0.15 0 0.3
118 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
119 INT55404 Binding of ENG and Th 1 0.02 0 0.3
120 INT98385 Abat Negative_regulation of GAD1 1 0.24 1.28 0.3
121 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
122 INT156440 Cpox Positive_regulation of NOS1 1 0.01 0.52 0.28
123 INT261609 Binding of PAH and Hypt 1 0.00 1.26 0.28
124 INT78484 Binding of DBH and TH 1 0.09 0 0.28
125 INT22722 Binding of Chat and Hc3 1 0.39 0 0.28
126 INT177491 Binding of Gad2 and Slc32a1 1 0.06 0.06 0.25
127 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
128 INT272618 Positive_regulation of Binding of GAD1 and CEBPZ 1 0.14 0.91 0.25
129 INT177502 Binding of Gabrg1 and Gad2 1 0.14 0.07 0.25
130 INT272619 Binding of GAD1 and CEBPZ 1 0.10 0.91 0.25
131 INT181900 TP53 Negative_regulation of Gene_expression of NOS1 1 0.03 0.94 0.24
132 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
133 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
134 INT235088 NOS1 Regulation of ISYNA1 1 0.07 0.75 0.23
135 INT356231 Binding of Gabrb3 and Gad1 1 0.32 1.25 0.23
136 INT344746 GAD1 Regulation of Gene_expression of ABAT 1 0.19 0.75 0.23
137 INT180247 Binding of Gad1 and Tbca 1 0.02 0.22 0.22
138 INT180248 Binding of Gad1 and Plp1 1 0.08 0.22 0.21
139 INT266103 Binding of COMT and SNRNP70 1 0.04 0.78 0.21
140 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
141 INT284142 ERAS Regulation of PAH 1 0.10 0.55 0.2
142 INT192109 PAH Positive_regulation of Binding of COL7A1 1 0.04 1.45 0.2
143 INT132054 NBN Positive_regulation of NOS1 1 0.00 0.08 0.2
144 INT284138 ERAS Regulation of Positive_regulation of PAH 1 0.10 0.55 0.2
145 INT61987 Th Regulation of Penk 1 0.46 0 0.2
146 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
147 INT222543 Il1a Regulation of Chat 1 0.01 0.64 0.19
148 INT159720 Slc5a7 Regulation of Gene_expression of Acot1 1 0.12 0 0.19
149 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
150 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
151 INT79511 Negative_regulation of NOS1 Regulation of Negative_regulation of Nqo1 1 0.05 0.08 0.19
152 INT159722 Slc5a7 Positive_regulation of Gene_expression of Acot1 1 0.12 0 0.19
153 INT269322 TMPO Positive_regulation of Positive_regulation of NOS1 1 0.03 0 0.18
154 INT338443 Binding of Gad1 and Slc32a1 1 0.31 0.64 0.18
155 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
156 INT313453 Siglec1 Regulation of Th 1 0.02 0.61 0.17
157 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
158 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17
159 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
160 INT350363 Gatm Negative_regulation of NOS1 1 0.00 0.31 0.17
161 INT147954 Slc5a7 Negative_regulation of Hacu 1 0.06 0 0.16
162 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
163 INT160929 Chat Positive_regulation of Penk 1 0.35 1.18 0.15
164 INT235085 NOS1 Positive_regulation of CA2 1 0.07 0.18 0.15
165 INT180252 Negative_regulation of Gad1 Positive_regulation of CP 1 0.03 0.75 0.14
166 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
167 INT271553 Binding of Gad2 and Gfap 1 0.24 0 0.13
168 INT313441 Th Regulation of Siglec1 1 0.02 0.22 0.13
169 INT347868 Ntf3 Negative_regulation of Negative_regulation of Chat 1 0.03 0.22 0.13
170 INT313439 Syp Negative_regulation of Th 1 0.30 0.14 0.13
171 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12
172 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
173 INT349274 Binding of CGF1 and NOS1 1 0.00 2.97 0.12
174 INT209922 IL1B Positive_regulation of Gene_expression of NOS1 1 0.06 0.41 0.12
175 INT353318 NOS1 Positive_regulation of Localization of Tbxa2r 1 0.04 0.71 0.12
176 INT119158 Binding of NOS1 and Agtr2 1 0.01 0 0.11
177 INT177490 Binding of Gad1 and Gad2 1 0.10 0.19 0.11
178 INT71310 Il1a Positive_regulation of NOS1 1 0.07 0.09 0.11
179 INT71311 Il1a Positive_regulation of Positive_regulation of NOS1 1 0.07 0.09 0.11
180 INT200213 PAH Positive_regulation of SDHD 1 0.21 2.43 0.1
181 INT313454 Negative_regulation of Syp Negative_regulation of Th 1 0.30 0.14 0.1
182 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
183 INT284140 Binding of EDNRB and PAH 1 0.08 0.1 0.1
184 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
185 INT201721 Ngf Regulation of Chat 1 0.02 0.4 0.1
186 INT114367 Binding of GAD2 and SEPHS1 1 0.11 0.55 0.1
187 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09
188 INT313741 Negative_regulation of NOS1 Positive_regulation of Sdcbp 1 0.00 0.78 0.09
189 INT341776 ESR1 Positive_regulation of Gene_expression of SLC6A3 1 0.06 0.08 0.09
190 INT284141 Binding of EDNRA and PAH 1 0.05 0.1 0.09
191 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09
192 INT313442 Th Regulation of Phosphorylation of Syp 1 0.32 0 0.08
193 INT322969 Binding of Gad1 and Fos 1 0.23 0.23 0.08
194 INT181583 Binding of Edn1 and Positive_regulation of NOS1 1 0.02 0.86 0.08
195 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
196 INT313459 Gene_expression of Syp Negative_regulation of Th 1 0.30 0.49 0.08
197 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
198 INT313437 Th Regulation of Phosphorylation of Siglec1 1 0.04 0 0.08
199 INT251710 Fig4 Regulation of Chat 1 0.03 0.23 0.08
200 INT189550 Binding of BMPR2 and PAH 1 0.06 2.68 0.08

Single Events

The table below shows the top 100 pain related interactions that have been reported for neurotransmitter biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in neurotransmitter biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
4 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
5 INT7327 Regulation of Th 164 0.62 29.67 110.14
6 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
7 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
8 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11
9 INT26788 Gene_expression of Gad1 93 0.78 27.05 42.71
10 INT350 Localization of Th 79 0.80 10.26 41.17
11 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
12 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
13 INT2416 Negative_regulation of MAOA 92 0.59 42.24 36.5
14 INT7326 Transcription of Th 83 0.72 13.5 35.33
15 INT10453 Positive_regulation of Gad1 65 0.70 10.75 31.9
16 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
17 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
18 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
19 INT1616 Regulation of Gad1 46 0.61 10.2 28.64
20 INT48766 Regulation of NOS1 73 0.61 37.01 24.59
21 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
22 INT82461 Gene_expression of Gad2 40 0.78 19.12 22.79
23 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
24 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72
25 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
26 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
27 INT16326 Transcription of Gad1 58 0.71 15.78 20.45
28 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
29 INT135629 Binding of COMT 33 0.48 16.68 19.37
30 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
31 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
32 INT13716 Positive_regulation of TH 33 0.68 19.11 16
33 INT6381 Negative_regulation of Chat 51 0.59 19.68 15.86
34 INT22143 Gene_expression of Gad1 35 0.76 14.4 15.4
35 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23
36 INT4851 Positive_regulation of Chat 53 0.70 9.21 15.11
37 INT11945 Regulation of Chat 38 0.62 7.75 14.97
38 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
39 INT4736 Gene_expression of Chat 67 0.77 17.15 14.24
40 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
41 INT90909 Negative_regulation of Gene_expression of NOS1 44 0.55 23.83 12.47
42 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41
43 INT17619 Regulation of COMT 12 0.45 8.46 12.22
44 INT2415 Binding of MAOA 26 0.47 13.26 11.86
45 INT141 Binding of Th 21 0.48 3.53 11.04
46 INT48912 Localization of NOS1 52 0.77 24.14 10.92
47 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
48 INT71633 Negative_regulation of SLC6A3 25 0.59 10.5 10.69
49 INT86361 Positive_regulation of Positive_regulation of NOS1 39 0.53 18.93 10.42
50 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
51 INT130280 Positive_regulation of Gene_expression of Gad2 7 0.69 8.13 9.55
52 INT96637 Gene_expression of Gad2 21 0.76 8.15 9.53
53 INT336 Negative_regulation of Gad1 19 0.58 7.71 9.51
54 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
55 INT26789 Positive_regulation of Gene_expression of Gad1 22 0.70 7.39 9.02
56 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
57 INT63739 Regulation of Gad2 15 0.58 3.44 8.86
58 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62
59 INT15308 Localization of Chat 29 0.81 2.35 8.47
60 INT48908 Transcription of NOS1 27 0.55 13.46 8.39
61 INT46112 Regulation of GAD1 15 0.52 11.09 8.37
62 INT109265 Transcription of Th 18 0.68 4.5 8.21
63 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
64 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
65 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
66 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
67 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
68 INT270 Regulation of MAOA 17 0.60 2.58 6.84
69 INT66987 Regulation of Th 23 0.61 7.86 6.8
70 INT3506 Localization of TH 12 0.81 0.78 6.66
71 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54
72 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
73 INT49011 Regulation of Gene_expression of Gad1 10 0.62 0.55 6.07
74 INT84965 Gene_expression of MAOA 15 0.75 6.9 6.06
75 INT157121 Gene_expression of GAD2 15 0.67 7.21 5.91
76 INT48911 Binding of NOS1 24 0.40 11.21 5.89
77 INT75978 Transcription of Gad2 11 0.69 2.28 5.68
78 INT49209 Positive_regulation of GAD1 17 0.70 15.39 5.59
79 INT30317 Regulation of TH 14 0.43 7.27 5.38
80 INT74394 Negative_regulation of Gad2 6 0.42 1.96 5.26
81 INT86717 Negative_regulation of Positive_regulation of NOS1 18 0.30 8.88 5.2
82 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
83 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
84 INT37151 Localization of Th 13 0.57 3.11 4.82
85 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
86 INT66388 Positive_regulation of Transcription of Gad1 14 0.67 2.45 4.67
87 INT106971 Positive_regulation of Gene_expression of GAD1 19 0.58 10.89 4.59
88 INT76581 Regulation of Negative_regulation of NOS1 14 0.45 7.49 4.4
89 INT119785 Localization of GAD1 7 0.63 5.99 4.34
90 INT63740 Positive_regulation of Gad2 11 0.66 0.78 4.32
91 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
92 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4
93 INT19158 Gene_expression of PAH 35 0.65 35.81 3.88
94 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
95 INT141125 Regulation of Gene_expression of GAD1 5 0.52 8.81 3.63
96 INT42251 Regulation of Gad1 10 0.44 5.25 3.45
97 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
98 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
99 INT9110 Binding of PAH 32 0.41 42.1 3.1
100 INT122577 Regulation of SLC6A3 9 0.53 1.47 3.09
101 INT82462 Positive_regulation of Transcription of Gad2 5 0.49 1.03 3.01
102 INT67952 Regulation of Transcription of Gad1 6 0.51 1.23 2.98
103 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
104 INT54170 Positive_regulation of Positive_regulation of Gad1 5 0.69 0 2.89
105 INT165514 Regulation of Gad2 7 0.45 3.15 2.76
106 INT143663 Negative_regulation of Gene_expression of Gad2 2 0.43 2.32 2.75
107 INT194289 Transcription of COMT 3 0.72 3.56 2.72
108 INT202257 Localization of COMT 7 0.75 2.13 2.65
109 INT11892 Gene_expression of ACHE 10 0.68 1.32 2.63
110 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
111 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
112 INT97523 Phosphorylation of NOS1 3 0.46 0.59 2.58
113 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
114 INT42255 Negative_regulation of Gad1 7 0.56 4.83 2.54
115 INT127458 Positive_regulation of PAH 24 0.58 27.25 2.53
116 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
117 INT244283 Negative_regulation of Gene_expression of MAOA 2 0.27 1.7 2.5
118 INT229111 Localization of SLC6A3 5 0.68 1.12 2.48
119 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
120 INT200217 Localization of PAH 10 0.36 15.51 2.46
121 INT90566 Positive_regulation of Gene_expression of Gad1 5 0.48 1.46 2.42
122 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
123 INT31231 Protein_catabolism of MAOA 7 0.96 2.44 2.4
124 INT27338 Regulation of ACHE 6 0.62 1.25 2.38
125 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
126 INT11943 Transcription of Chat 10 0.70 1.55 2.36
127 INT14890 Localization of ACHE 5 0.80 0.47 2.21
128 INT132669 Positive_regulation of Transcription of NOS1 7 0.44 4.43 2.19
129 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
130 INT104263 Regulation of Positive_regulation of NOS1 5 0.28 3.15 2.15
131 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
132 INT67951 Negative_regulation of Gene_expression of Gad1 4 0.43 1.08 2.13
133 INT42256 Positive_regulation of Gad1 4 0.66 1.1 2.09
134 INT49210 Transcription of GAD1 8 0.60 3.48 2.06
135 INT207830 Localization of GAD2 10 0.65 0.49 1.97
136 INT44109 Localization of Gad1 7 0.74 1.06 1.97
137 INT246089 Negative_regulation of Negative_regulation of MAOA 2 0.41 2.42 1.92
138 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
139 INT79983 Negative_regulation of Gene_expression of GAD1 7 0.41 4.02 1.9
140 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
141 INT55587 Negative_regulation of Positive_regulation of Gad1 6 0.49 1.1 1.82
142 INT3505 Binding of TH 5 0.39 2.6 1.8
143 INT8757 Binding of ACHE 10 0.48 5.84 1.72
144 INT40857 Positive_regulation of MAOA 6 0.49 2.51 1.71
145 INT158339 Gene_expression of ALDH2 18 0.78 4.48 1.65
146 INT158340 Negative_regulation of ALDH2 13 0.58 2.76 1.64
147 INT14891 Positive_regulation of ACHE 10 0.70 5.37 1.64
148 INT145545 Transcription of TH 3 0.67 1.48 1.64
149 INT96642 Transcription of Gad2 4 0.59 0.88 1.59
150 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57
151 INT87316 Negative_regulation of Gad2 6 0.58 1.61 1.56
152 INT36148 Binding of GAD1 10 0.41 7.91 1.47
153 INT96047 Positive_regulation of Localization of NOS1 6 0.38 4.24 1.47
154 INT114808 Positive_regulation of Binding of SLC6A3 4 0.50 0.63 1.45
155 INT32900 Negative_regulation of Positive_regulation of Chat 3 0.43 1.91 1.45
156 INT103531 Regulation of Positive_regulation of Gad1 3 0.61 0.31 1.43
157 INT147754 Binding of ALDH2 7 0.35 3.31 1.41
158 INT90567 Negative_regulation of Gene_expression of Gad1 4 0.41 2.88 1.36
159 INT96641 Transcription of Gad1 3 0.60 0.84 1.36
160 INT58452 Positive_regulation of Negative_regulation of Chat 4 0.50 1.99 1.35
161 INT99930 Positive_regulation of Gene_expression of SLC6A3 4 0.43 0.08 1.34
162 INT53548 Negative_regulation of Transcription of Gad1 3 0.43 0.46 1.32
163 INT83833 Localization of Gad2 2 0.72 0.57 1.31
164 INT229116 Negative_regulation of Localization of SLC6A3 1 0.22 0.17 1.31
165 INT1618 Binding of Gad1 6 0.37 2.01 1.3
166 INT148262 Negative_regulation of Gene_expression of SLC6A3 2 0.38 1.66 1.29
167 INT61395 Negative_regulation of Negative_regulation of NOS1 5 0.30 1.83 1.25
168 INT97869 Negative_regulation of Positive_regulation of Th 3 0.25 0.79 1.23
169 INT227150 Localization of Gad1 4 0.49 0.15 1.22
170 INT96643 Positive_regulation of Gene_expression of Gad2 3 0.49 0.15 1.18
171 INT44621 Binding of Chat 5 0.45 0.87 1.15
172 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
173 INT57188 Regulation of Gene_expression of Chat 4 0.45 1.89 1.12
174 INT50267 Negative_regulation of Negative_regulation of Th 3 0.42 1.57 1.12
175 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
176 INT165513 Negative_regulation of Regulation of Gad1 1 0.41 1.59 1.11
177 INT57189 Negative_regulation of Gene_expression of Chat 5 0.56 1.35 1.07
178 INT127459 Negative_regulation of PAH 18 0.56 15.15 1.05
179 INT161968 Positive_regulation of Gene_expression of GAD2 2 0.40 0.91 1.04
180 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1
181 INT148863 Positive_regulation of Localization of GAD1 1 0.38 1.41 1
182 INT89288 Positive_regulation of Negative_regulation of NOS1 5 0.40 4.84 0.96
183 INT132667 Regulation of Transcription of NOS1 1 0.30 2.58 0.95
184 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
185 INT198953 Regulation of Regulation of Th 1 0.01 0.1 0.93
186 INT24242 Negative_regulation of Phosphorylation of Th 3 0.38 1.44 0.9
187 INT90568 Regulation of Gene_expression of Gad1 3 0.27 0.46 0.89
188 INT110298 Regulation of Positive_regulation of GAD1 2 0.38 0.99 0.89
189 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
190 INT56200 Negative_regulation of Negative_regulation of Chat 3 0.25 1.38 0.88
191 INT50266 Regulation of Negative_regulation of Th 1 0.42 0.94 0.88
192 INT132668 Negative_regulation of Transcription of NOS1 3 0.18 1.72 0.87
193 INT180240 Binding of Gad1 7 0.47 2.99 0.86
194 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
195 INT78003 Regulation of Transcription of Gad2 2 0.26 0.62 0.81
196 INT78001 Negative_regulation of Regulation of Gad2 1 0.29 0.15 0.81
197 INT78000 Negative_regulation of Transcription of Gad2 1 0.29 0.15 0.81
198 INT78002 Regulation of Negative_regulation of Gad2 1 0.18 0.15 0.81
199 INT148263 Transcription of SLC6A3 1 0.62 0.49 0.81
200 INT147138 Positive_regulation of Phosphorylation of NOS1 1 0.12 0.45 0.8
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