GO:0042163

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Name interleukin-12 beta subunit binding
Categary Function
Go Slim No
Go Link GO:0042163
Unique Molecular Interactions 136
Total Molecular Interactions 175
Total Single Events 1354
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for interleukin-12 beta subunit binding. They are ordered first by their pain relevance and then by number of times they were reported for interleukin-12 beta subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69030 IL18 Positive_regulation of IL12A 3 0.31 5.57 2.72
2 INT350148 Binding of IL12A and ERAL1 1 0.21 8.23 2.26
3 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56
4 INT69031 IL12A Positive_regulation of IFNA1 9 0.13 4.23 1.52
5 INT87026 ZAK Positive_regulation of Gene_expression of IL12A 3 0.12 2.55 1.26
6 INT70046 IL12A Regulation of IL10 1 0.07 1.42 1.21
7 INT70045 IL12A Regulation of Negative_regulation of PRF1 1 0.04 1.42 1.21
8 INT70044 IL12A Regulation of PRF1 1 0.04 1.42 1.21
9 INT70034 IL12A Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
10 INT156545 Il13 Positive_regulation of Gene_expression of Il12a 1 0.27 1.56 1.13
11 INT128700 BBS9 Negative_regulation of Il12a 1 0.47 0.76 1.03
12 INT110033 Adrb1 Positive_regulation of Gene_expression of Il12a 1 0.05 0 0.99
13 INT85879 Il12a Positive_regulation of Gene_expression of Ifng 1 0.20 0.89 0.92
14 INT133176 Regulation of Mastl Negative_regulation of Il12a 1 0.01 0.24 0.86
15 INT133177 Mastl Negative_regulation of Il12a 1 0.01 0.24 0.86
16 INT249656 tm Positive_regulation of Il12a 1 0.07 1.17 0.84
17 INT113240 Il12a Regulation of Transcription of Tacr1 1 0.21 0.79 0.82
18 INT113238 Il12a Positive_regulation of Transcription of Tacr1 1 0.38 0.78 0.79
19 INT184125 Il12a Positive_regulation of Stat4 2 0.11 1.04 0.7
20 INT176365 IL12A Positive_regulation of Gene_expression of IFNA1 1 0.13 1.35 0.6
21 INT250326 Binding of Il12a and Rpsa 1 0.09 0.93 0.59
22 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57
23 INT110032 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il12a 1 0.36 0 0.57
24 INT176371 LBR Positive_regulation of IL12A 1 0.04 1.22 0.55
25 INT217037 Binding of IRF6 and Il12a 1 0.01 0.08 0.5
26 INT240537 Binding of Il12a and Ebi3 1 0.08 1.23 0.49
27 INT184117 Il12a Positive_regulation of Stat6 1 0.07 0.28 0.48
28 INT176364 IL12A Regulation of Positive_regulation of IFNA1 1 0.12 0.59 0.46
29 INT95564 Positive_regulation of HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
30 INT95562 HRAS Positive_regulation of IL12A 1 0.03 0.7 0.45
31 INT222924 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il12a 1 0.01 0.59 0.45
32 INT329794 TLR2 Positive_regulation of Positive_regulation of IL12A 1 0.01 1.05 0.44
33 INT209049 Slc11a1 Positive_regulation of Localization of Il12a 1 0.04 0.09 0.44
34 INT292887 IL4 Regulation of IL12A 1 0.01 0.25 0.39
35 INT292889 IL2 Regulation of IL12A 1 0.01 0.25 0.39
36 INT292888 TNF Regulation of IL12A 1 0.02 0.25 0.39
37 INT267595 IL12A Positive_regulation of IFN1@ 1 0.03 0.69 0.36
38 INT320692 C5 Regulation of Gene_expression of Il12a 1 0.03 2.15 0.34
39 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34
40 INT346915 Il12a Positive_regulation of Positive_regulation of IFN1@ 1 0.20 1.26 0.34
41 INT73494 PTGER2 Positive_regulation of Gene_expression of IL12A 1 0.05 0.51 0.33
42 INT73493 PTGER2 Negative_regulation of Gene_expression of IL12A 1 0.04 0.51 0.33
43 INT221417 IL12A Positive_regulation of Binding of IFN1@ 1 0.14 0.98 0.33
44 INT313915 Binding of Il12a and Il23a 2 0.16 0.44 0.31
45 INT93989 Rab8a Positive_regulation of Gene_expression of Il12a 1 0.10 0.48 0.3
46 INT243630 Il12a Positive_regulation of Gene_expression of Twist1 1 0.18 0.69 0.3
47 INT164433 Il12a Positive_regulation of Il6 1 0.01 1.71 0.29
48 INT164434 Il12a Positive_regulation of Tnf 1 0.00 1.7 0.29
49 INT213808 Il12a Regulation of Gene_expression of Insrr 1 0.00 0.76 0.28
50 INT329369 Jun Regulation of Gene_expression of Il12a 1 0.00 1.48 0.27
51 INT120855 PRL Positive_regulation of Localization of IL12A 1 0.43 0.5 0.26
52 INT254598 Il12a Positive_regulation of Gene_expression of IFNA1 1 0.11 0.4 0.25
53 INT304582 IL12A Positive_regulation of Gene_expression of TH1L 1 0.21 0.83 0.25
54 INT304580 IL12A Regulation of Gene_expression of TH1L 1 0.19 0.82 0.25
55 INT225652 Gene_expression of IL4 Positive_regulation of Positive_regulation of IL12A 1 0.06 1.2 0.25
56 INT289406 C3ar1 Positive_regulation of Gene_expression of Il12a 1 0.01 1.04 0.25
57 INT189142 MTNR1B Positive_regulation of Gene_expression of IL12A 1 0.01 0.29 0.24
58 INT186368 Il10 Negative_regulation of Gene_expression of Il12a 1 0.06 0.17 0.24
59 INT343914 Hmgb1 Positive_regulation of Gene_expression of IL12A 1 0.01 0.41 0.24
60 INT343911 Mthfd1 Positive_regulation of Gene_expression of IL12A 1 0.00 0.41 0.23
61 INT186374 Il13 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
62 INT186371 Il4 Negative_regulation of Positive_regulation of Il12a 1 0.06 0.3 0.23
63 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23
64 INT350146 Binding of IL12A and RS1 1 0.01 0.97 0.23
65 INT240539 Il12a Positive_regulation of Stat3 1 0.11 0.75 0.22
66 INT325314 Binding of IL12A and STAT3 1 0.19 0.6 0.22
67 INT240538 Il12a Positive_regulation of Phosphorylation of Stat4 1 0.11 0.76 0.22
68 INT325317 Binding of IL12A and TH1L 1 0.18 0.59 0.22
69 INT104833 IGKV2OR2-1 Negative_regulation of Gene_expression of IL12A 1 0.00 0 0.22
70 INT260437 Positive_regulation of Tlr7 Positive_regulation of Positive_regulation of Il12a 1 0.03 0.27 0.21
71 INT240535 Il12a Positive_regulation of Tyk2 1 0.10 0.75 0.21
72 INT240536 Il12a Positive_regulation of Jak2 1 0.10 0.74 0.21
73 INT306746 Il12a Positive_regulation of TNF 1 0.24 0.5 0.21
74 INT306744 IL23A Positive_regulation of Il12a 1 0.13 0.59 0.2
75 INT186353 Binding of Il12a and Il1 1 0.21 0.38 0.2
76 INT252821 Binding of CD4 and IL12A 1 0.02 1.36 0.19
77 INT237777 Il23a Regulation of Localization of Il12a 1 0.19 0.93 0.19
78 INT252817 Binding of CD8A and IL12A 1 0.02 1.36 0.19
79 INT252788 Binding of IL12A and IL18 1 0.01 1.33 0.19
80 INT323134 Binding of IL10 and IL12A 1 0.06 0.55 0.18
81 INT266616 Il4 Positive_regulation of Il12a 1 0.01 0.4 0.17
82 INT104827 IRF6 Positive_regulation of IL12A 2 0.07 0.13 0.16
83 INT329305 Spp1 Positive_regulation of Gene_expression of Il12a 1 0.12 0.88 0.16
84 INT243632 Il12a Positive_regulation of Nfatc1 1 0.03 0.44 0.16
85 INT273251 Binding of IL6 and IL12A 1 0.00 1.15 0.16
86 INT224797 IL12A Regulation of Gene_expression of TNF 1 0.26 1.59 0.15
87 INT233386 Binding of Il12a and Il12b 1 0.01 0.48 0.15
88 INT316535 Il23a Regulation of Il12a 1 0.07 1.15 0.15
89 INT274474 IL12A Regulation of Gene_expression of VEGFA 1 0.04 0.36 0.14
90 INT274472 IL12A Negative_regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
91 INT330467 IL12A Positive_regulation of Localization of TH1L 1 0.16 0.3 0.14
92 INT274473 IL12A Regulation of Gene_expression of FGF2 1 0.02 0.36 0.14
93 INT313914 Binding of Il12a and Il23r 1 0.14 0.44 0.13
94 INT247157 Tas2r129 Positive_regulation of Gene_expression of Il12a 1 0.00 1.23 0.13
95 INT329303 Spp1 Positive_regulation of Localization of Il12a 1 0.12 0.92 0.12
96 INT186379 Il12a Positive_regulation of Binding of IFNA1 1 0.03 0.07 0.12
97 INT292628 IL12A Positive_regulation of Gene_expression of IL9 1 0.07 0.15 0.12
98 INT338434 Binding of Il12a and TBX21 1 0.07 0.58 0.11
99 INT303989 Lep Positive_regulation of IL12A 1 0.05 0.39 0.11
100 INT233384 Il10 Negative_regulation of Il12a 1 0.01 0.54 0.11
101 INT259852 Binding of Il12a and Retnlb 1 0.01 0.59 0.11
102 INT274471 IL12A Negative_regulation of Gene_expression of IL10 1 0.02 0.99 0.1
103 INT233510 Wnt5a Positive_regulation of Gene_expression of Il12a 1 0.03 0.33 0.1
104 INT274470 Binding of IL12A and GOPC 1 0.02 0.6 0.09
105 INT243652 Gk Negative_regulation of Gene_expression of Il12a 1 0.01 0 0.09
106 INT194828 IL12A Positive_regulation of Phosphorylation of Stat4 1 0.03 0.08 0.09
107 INT349331 Tlr4 Positive_regulation of Positive_regulation of Il12a 1 0.01 0.19 0.08
108 INT294679 GPI Positive_regulation of Gene_expression of Il12a 1 0.00 0.69 0.08
109 INT286298 Binding of Hand2 and Negative_regulation of Gene_expression of Il12a 1 0.07 0.3 0.07
110 INT247156 Tas2r129 Positive_regulation of Il12a 1 0.00 0.8 0.07
111 INT233502 Fzd5 Positive_regulation of Gene_expression of Il12a 1 0.04 0.33 0.07
112 INT292629 IL21 Positive_regulation of IL12A 1 0.06 0.05 0.06
113 INT243637 Il12a Positive_regulation of Transcription of Twist1 1 0.18 0.12 0.06
114 INT292624 IL21 Positive_regulation of Binding of IL12A 1 0.06 0.05 0.06
115 INT274469 IL12A Positive_regulation of Gene_expression of IL6 1 0.04 1.39 0.06
116 INT110751 IL12A Negative_regulation of KRR1 1 0.64 0.57 0.05
117 INT194665 IL12A Positive_regulation of MAPK1 1 0.06 0 0.05
118 INT294771 IL6 Positive_regulation of IL12A 1 0.05 0.15 0.04
119 INT285863 Positive_regulation of IL12A Regulation of TH1L 1 0.01 0.25 0.04
120 INT303996 Lep Positive_regulation of Gene_expression of IL12A 1 0.08 0.29 0.04
121 INT194679 IL12A Positive_regulation of GADD45A 1 0.04 0 0.04
122 INT285864 IL12A Regulation of TH1L 1 0.00 0.25 0.04
123 INT186382 TNF Regulation of Il12a 1 0.06 0.72 0.03
124 INT225648 IL4 Positive_regulation of Gene_expression of IL12A 1 0.06 0.89 0.03
125 INT186386 Il12a Regulation of Gene_expression of TNF 1 0.06 0.66 0.03
126 INT186378 IFNA1 Positive_regulation of Il12a 1 0.03 0.76 0
127 INT300079 IL12A Positive_regulation of Positive_regulation of IFNA1 1 0.05 2.14 0
128 INT191059 Bcl2 Positive_regulation of Localization of Il12a 1 0.16 0.77 0
129 INT243623 Il12a Positive_regulation of Twist1 1 0.17 0 0
130 INT274475 IL12A Regulation of Gene_expression of IL6 1 0.04 0.68 0
131 INT317857 Tlr4 Positive_regulation of Il12a 1 0.11 1.11 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for interleukin-12 beta subunit binding. They are ordered first by their pain relevance and then by number of times they were reported in interleukin-12 beta subunit binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96
2 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97
3 INT60690 Positive_regulation of Gene_expression of Il12a 69 0.63 41.41 20.85
4 INT88949 Positive_regulation of Il12a 79 0.60 47.68 19.98
5 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87
6 INT103757 Negative_regulation of Il12a 37 0.55 21.62 16.38
7 INT61624 Positive_regulation of Gene_expression of IL12A 50 0.56 33.07 13.07
8 INT87239 Localization of Il12a 51 0.75 31.95 12.05
9 INT67401 Gene_expression of Il12a 25 0.55 20.04 11.12
10 INT95565 Positive_regulation of IL12A 47 0.56 33.96 10.16
11 INT91667 Localization of IL12A 39 0.74 25.51 7.36
12 INT77945 Regulation of Gene_expression of Il12a 19 0.58 6.55 6.4
13 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69
14 INT106189 Regulation of Il12a 18 0.44 12.4 5.3
15 INT98251 Binding of IL12A 20 0.37 16.03 4.51
16 INT71374 Positive_regulation of Gene_expression of Il12a 5 0.22 7.49 3.8
17 INT174160 Binding of Il12a 19 0.24 12.61 3.4
18 INT70051 Transcription of IL12A 7 0.25 5.61 3.39
19 INT79553 Localization of Il12a 9 0.31 5.85 3.16
20 INT78467 Negative_regulation of IL12A 18 0.38 11.29 2.98
21 INT114181 Negative_regulation of Positive_regulation of Il12a 7 0.34 3.65 2.82
22 INT85878 Negative_regulation of Il12a 4 0.58 2.88 2.21
23 INT105378 Regulation of IL12A 6 0.26 8.82 2.15
24 INT85877 Positive_regulation of Il12a 6 0.43 4.87 2.11
25 INT91663 Positive_regulation of Localization of IL12A 9 0.27 5.91 1.95
26 INT258781 Regulation of Regulation of Il12a 1 0.17 1.54 1.87
27 INT140906 Negative_regulation of Gene_expression of Il12a 4 0.38 5.28 1.86
28 INT91659 Negative_regulation of Localization of IL12A 8 0.14 3.9 1.75
29 INT110950 Positive_regulation of Negative_regulation of Il12a 2 0.44 1.75 1.73
30 INT128699 Regulation of Il12a 3 0.45 3.36 1.59
31 INT87241 Positive_regulation of Localization of Il12a 8 0.50 1.3 1.58
32 INT110028 Transcription of Il12a 6 0.49 1.48 1.51
33 INT67398 Transcription of Il12a 3 0.26 3.16 1.49
34 INT95566 Positive_regulation of Positive_regulation of IL12A 10 0.41 7.47 1.43
35 INT79554 Negative_regulation of Localization of Il12a 2 0.09 1.14 1.24
36 INT67399 Negative_regulation of Transcription of Il12a 2 0.03 2.63 1.05
37 INT110949 Negative_regulation of Negative_regulation of Il12a 1 0.41 0 0.98
38 INT77947 Regulation of Gene_expression of IL12A 6 0.24 5.23 0.94
39 INT110027 Regulation of Localization of Il12a 3 0.41 0.6 0.85
40 INT240523 Phosphorylation of Il12a 2 0.29 1.32 0.7
41 INT95567 Negative_regulation of Positive_regulation of IL12A 2 0.34 1.83 0.59
42 INT226482 Phosphorylation of IL12A 3 0.10 1.47 0.57
43 INT237764 Regulation of Binding of Il12a 1 0.29 0.82 0.52
44 INT252282 Positive_regulation of Phosphorylation of Il12a 1 0.08 0.59 0.49
45 INT174157 Negative_regulation of Localization of Il12a 4 0.09 1.54 0.48
46 INT290393 Regulation of Localization of IL12A 1 0.16 1.02 0.48
47 INT110022 Positive_regulation of Transcription of Il12a 2 0.43 0.13 0.45
48 INT301687 Negative_regulation of Phosphorylation of IL12A 1 0.05 0.94 0.37
49 INT186272 Positive_regulation of Positive_regulation of Il12a 7 0.26 4.45 0.36
50 INT237901 Protein_catabolism of Il12a 2 1.00 0.79 0.36
51 INT77946 Positive_regulation of Transcription of IL12A 1 0.24 0 0.24
52 INT216975 Regulation of Negative_regulation of Il12a 1 0.16 0 0.14
53 INT323145 Regulation of Positive_regulation of IL12A 1 0.12 0.42 0.11
54 INT306724 Negative_regulation of Transcription of Il12a 1 0.18 0.3 0.1
55 INT274483 Positive_regulation of Binding of IL12A 1 0.16 1.08 0.05
56 INT350811 Regulation of Transcription of Il12a 1 0.11 0.2 0.04
57 INT186281 Positive_regulation of Binding of Il12a 2 0.26 2.09 0
58 INT274486 Protein_catabolism of IL12A 1 0.28 0.98 0
59 INT300093 Positive_regulation of Negative_regulation of IL12A 1 0.26 1.28 0
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