GO:0042166

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Name acetylcholine binding
Categary Function
Go Slim No
Go Link GO:0042166
Unique Molecular Interactions 149
Total Molecular Interactions 178
Total Single Events 3367
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for acetylcholine binding. They are ordered first by their pain relevance and then by number of times they were reported for acetylcholine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT54601 Binding of Mtor and Ache 1 0.20 0.8 1.58
2 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
3 INT251704 Ache Regulation of Gene_expression of Acot1 1 0.08 1.68 0.87
4 INT113250 Olr1259 Negative_regulation of Ache 1 0.01 0.38 0.83
5 INT46246 Tpsg1 Regulation of Ache 1 0.15 0.06 0.76
6 INT46247 Tpsg1 Regulation of Binding of Ache 1 0.15 0.06 0.76
7 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
8 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
9 INT18447 Binding of Ache and Chat 2 0.33 0.33 0.73
10 INT43662 Negative_regulation of Binding of Chrna7 and Rac1 1 0.01 0 0.73
11 INT43663 Binding of Chrna7 and Rac2 1 0.01 0 0.72
12 INT43661 Binding of Chrna7 and Rac1 1 0.01 0 0.72
13 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69
14 INT23679 Chrna7 Regulation of Binding of Stx3 1 0.00 0 0.56
15 INT95059 Binding of Oprm1 and Slc18a3 1 0.04 0 0.52
16 INT71839 Chrm3 Positive_regulation of Qrfp 1 0.09 0 0.47
17 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46
18 INT83111 LIAS Negative_regulation of Binding of Chrna7 1 0.02 0 0.45
19 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44
20 INT5531 Binding of Acot1 and Chrna2 1 0.12 0 0.42
21 INT274781 Agrn Positive_regulation of Chrna2 1 0.08 0.18 0.41
22 INT85037 Binding of Cct2 and Chrna3 1 0.00 0.15 0.38
23 INT46788 Chrna7 Positive_regulation of G6pd 1 0.50 0 0.33
24 INT51630 Binding of ACHE and OPRM1 1 0.11 0 0.33
25 INT51628 Binding of ACHE and DRD3 1 0.15 0 0.33
26 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3
27 INT59682 Hps6 Positive_regulation of Binding of Chrna7 1 0.02 0 0.29
28 INT59683 Binding of Chrna7 and Evi2a 1 0.03 0 0.25
29 INT160225 Acot1 Negative_regulation of Ache 1 0.28 2.18 0.25
30 INT23626 Ache Regulation of Mir343 1 0.17 0 0.24
31 INT143972 Chrna7 Negative_regulation of Gene_expression of Trpv1 1 0.01 0.18 0.24
32 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24
33 INT202296 Binding of Slc18a3 and Gopc 1 0.02 0 0.23
34 INT97868 Binding of Chrna2 and Regulation of Acot1 1 0.09 0 0.23
35 INT143974 Chrna7 Positive_regulation of Vti1b 1 0.17 0.16 0.2
36 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19
37 INT326940 Chrm3 Positive_regulation of Nalcn 1 0.06 0.21 0.19
38 INT47426 Chrna7 Positive_regulation of Localization of Ldha 1 0.05 0 0.18
39 INT47427 Chrna7 Positive_regulation of Ldha 1 0.05 0 0.18
40 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17
41 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17
42 INT101725 Binding of ITGA4 and Chrna7 1 0.00 0 0.16
43 INT303744 Binding of Chrm3 and Ins1 1 0.04 1.03 0.15
44 INT303745 Positive_regulation of Binding of Chrm3 and Ins1 1 0.05 1.04 0.15
45 INT70090 TGM1 Positive_regulation of Binding of Ache 1 0.03 0.59 0.15
46 INT340111 Chrna7 Regulation of CYSLTR1 1 0.00 0.25 0.15
47 INT160931 Slc18a3 Positive_regulation of Penk 1 0.30 1.18 0.15
48 INT303747 Binding of Chrm3 and Chrm1 1 0.03 1.02 0.15
49 INT141224 Ache Regulation of Acot1 1 0.09 0.29 0.14
50 INT27393 Tha1 Negative_regulation of Ache 1 0.15 0.24 0.14
51 INT147863 Binding of CHAT and SLC18A3 1 0.34 0.8 0.14
52 INT42772 Penk Negative_regulation of Ache 1 0.06 0 0.14
53 INT210549 Binding of BCHE and Ache 1 0.01 0.82 0.12
54 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
55 INT34497 Binding of Oprl1 and Ache 1 0.40 0 0.1
56 INT207683 Chrnb4 Positive_regulation of Htr3b 1 0.26 0.31 0.1
57 INT139558 Chrna4 Regulation of Neurod1 1 0.17 0 0.1
58 INT207682 Chrnb4 Positive_regulation of Hcn4 1 0.35 0.29 0.1
59 INT207681 Chrnb4 Positive_regulation of Scn2b 1 0.02 0.32 0.1
60 INT139557 Chrna4 Regulation of Gene_expression of Neurod1 1 0.17 0 0.1
61 INT207684 Chrnb4 Positive_regulation of Htr3a 1 0.22 0.3 0.1
62 INT174104 Binding of HSPG2 and Ache 1 0.16 0.98 0.09
63 INT5529 Acot1 Positive_regulation of Chrna2 1 0.17 0 0.09
64 INT262714 ACOT1 Positive_regulation of Negative_regulation of ACHE 1 0.06 1.41 0.08
65 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08
66 INT251712 Fig4 Regulation of Ache 1 0.02 0.23 0.08
67 INT251703 Fig4 Regulation of Localization of Ache 1 0.07 0.23 0.08
68 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08
69 INT5530 Positive_regulation of Binding of Acot1 and Chrna2 1 0.15 0 0.07
70 INT290158 Binding of Ache and Atp6v1e1 1 0.19 0 0.07
71 INT242636 Ret Positive_regulation of Gene_expression of Slc18a3 1 0.20 0 0.06
72 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05
73 INT352062 Binding of SV2A and Chrna7 1 0.00 0.7 0.04
74 INT330875 PLDN Negative_regulation of Gene_expression of Ache 1 0.01 0.85 0.03
75 INT282799 Chrm2 Positive_regulation of Chrm3 1 0.16 0.29 0.03
76 INT46678 H2-Q4 Negative_regulation of Ache 1 0.10 0.12 0
77 INT307602 Binding of ACHE and LRP5 1 0.01 0.17 0
78 INT186689 Binding of ACHE and Edn1 1 0.28 0 0
79 INT190492 Br Regulation of Ache 1 0.30 0.55 0
80 INT84499 Chrm3 Positive_regulation of Ephb1 1 0.40 0 0
81 INT330876 PLDN Negative_regulation of Ache 1 0.01 0.45 0
82 INT262716 Binding of ACHE and BCHE 1 0.09 0.11 0
83 INT84498 Negative_regulation of Chrm3 Positive_regulation of Ephb1 1 0.34 0 0
84 INT202892 Chrm3 Regulation of Negative_regulation of Camk4 1 0.02 0.37 0
85 INT251702 Fig4 Regulation of Positive_regulation of Ache 1 0.07 0.42 0
86 INT242619 Ret Negative_regulation of Transcription of Slc18a3 1 0.18 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for acetylcholine binding. They are ordered first by their pain relevance and then by number of times they were reported in acetylcholine binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4
2 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
3 INT1079 Positive_regulation of Ache 104 0.70 23.52 30.28
4 INT2569 Gene_expression of Ache 120 0.78 26.29 26.89
5 INT276 Regulation of Ache 83 0.62 16.75 25.99
6 INT19071 Localization of Ache 66 0.81 5.1 16.27
7 INT1752 Negative_regulation of Ache 109 0.59 42.05 15.73
8 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
9 INT1252 Binding of Ache 46 0.48 9.94 10.25
10 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
11 INT2597 Negative_regulation of ACHE 82 0.59 46.36 8.62
12 INT88079 Gene_expression of Chrna4 20 0.76 8.52 6.98
13 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
14 INT19072 Regulation of Gene_expression of Ache 14 0.62 2.74 5.29
15 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
16 INT20059 Protein_catabolism of Ache 15 0.98 3.73 4.87
17 INT1753 Gene_expression of Ache 38 0.78 15.31 4.58
18 INT136904 Gene_expression of SLC18A3 4 0.68 3.71 4.4
19 INT119731 Gene_expression of Slc18a3 19 0.41 3.93 4.32
20 INT11946 Transcription of Ache 18 0.69 2.62 4.13
21 INT5527 Binding of Chrna2 11 0.47 1.42 4.01
22 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
23 INT8778 Regulation of Ache 17 0.62 3.7 3.57
24 INT28009 Positive_regulation of Gene_expression of Ache 15 0.70 5.46 3.26
25 INT12273 Regulation of Chrna2 8 0.59 0.4 3.21
26 INT8777 Positive_regulation of Ache 25 0.68 7.77 3.18
27 INT12270 Gene_expression of Chrna2 11 0.67 5.47 3.06
28 INT22069 Positive_regulation of Localization of Ache 9 0.70 0.61 2.9
29 INT88638 Gene_expression of Slc18a3 8 0.57 3.17 2.77
30 INT11892 Gene_expression of ACHE 10 0.68 1.32 2.63
31 INT39367 Negative_regulation of Chrna2 5 0.42 0.53 2.57
32 INT27338 Regulation of ACHE 6 0.62 1.25 2.38
33 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36
34 INT14890 Localization of ACHE 5 0.80 0.47 2.21
35 INT2570 Negative_regulation of Gene_expression of Ache 13 0.43 2.88 2.18
36 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17
37 INT95058 Localization of Slc18a3 2 0.76 0 2.17
38 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
39 INT123253 Localization of Chrna4 4 0.44 1.31 1.99
40 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
41 INT38201 Negative_regulation of Localization of Ache 8 0.59 2.35 1.82
42 INT38574 Binding of Ache 9 0.47 3.64 1.74
43 INT8757 Binding of ACHE 10 0.48 5.84 1.72
44 INT2847 Positive_regulation of Negative_regulation of Ache 8 0.49 1.09 1.65
45 INT14891 Positive_regulation of ACHE 10 0.70 5.37 1.64
46 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63
47 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57
48 INT22426 Positive_regulation of Regulation of Chrna2 2 0.48 0.33 1.31
49 INT74849 Positive_regulation of Chrm3 5 0.64 1.71 1.2
50 INT81768 Negative_regulation of Chrna4 5 0.42 1.97 1.2
51 INT37849 Negative_regulation of Negative_regulation of Ache 3 0.43 0.8 1.19
52 INT29772 Positive_regulation of Positive_regulation of Ache 3 0.50 0.09 1.18
53 INT24197 Regulation of Binding of Chrna7 2 0.11 0 1.14
54 INT27366 Negative_regulation of Negative_regulation of Ache 4 0.43 0.29 1.12
55 INT106960 Gene_expression of Chrm3 15 0.69 6.29 0.96
56 INT104160 Negative_regulation of Slc18a3 1 0.36 0 0.96
57 INT356228 Positive_regulation of Slc18a3 1 0.35 0.9 0.94
58 INT148401 Regulation of Chrm3 3 0.19 1.19 0.91
59 INT73950 Negative_regulation of Chrm3 1 0.41 0 0.88
60 INT112520 Negative_regulation of Regulation of Ache 2 0.28 1.02 0.87
61 INT19070 Regulation of Localization of Ache 5 0.62 0.39 0.84
62 INT12272 Negative_regulation of Gene_expression of Chrna2 3 0.33 2.04 0.82
63 INT270060 Negative_regulation of Gene_expression of SLC18A3 1 0.21 0.51 0.79
64 INT270062 Negative_regulation of SLC18A3 1 0.21 0.51 0.79
65 INT48481 Negative_regulation of Binding of Ache 4 0.36 1.76 0.76
66 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76
67 INT11944 Positive_regulation of Transcription of Ache 3 0.48 1.68 0.75
68 INT46245 Regulation of Binding of Ache 1 0.25 0.06 0.75
69 INT60826 Negative_regulation of Positive_regulation of Ache 3 0.50 0.68 0.73
70 INT135870 Binding of Slc18a3 3 0.32 0 0.67
71 INT85033 Positive_regulation of Chrna3 2 0.06 0.35 0.67
72 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67
73 INT133004 Gene_expression of Chrna3 2 0.58 0.63 0.66
74 INT149689 Binding of Chrm3 3 0.24 1.54 0.65
75 INT99329 Binding of Chrna4 3 0.37 0.45 0.6
76 INT5525 Positive_regulation of Chrna2 3 0.66 0.44 0.59
77 INT135044 Regulation of Gene_expression of Ache 2 0.31 0.85 0.58
78 INT123256 Regulation of Localization of Chrna4 1 0.27 0.28 0.58
79 INT104335 Localization of Chrm3 2 0.62 0.58 0.57
80 INT68027 Localization of Chrna2 1 0.44 0 0.57
81 INT59335 Regulation of Gene_expression of Chrna2 3 0.30 0.81 0.55
82 INT172502 Binding of Chrm3 2 0.08 3.3 0.53
83 INT144394 Protein_catabolism of ACHE 1 0.89 0.24 0.53
84 INT4387 Phosphorylation of Ache 3 0.79 1.15 0.5
85 INT104336 Positive_regulation of Localization of Chrm3 1 0.38 0.14 0.5
86 INT39873 Negative_regulation of Gene_expression of Ache 2 0.59 1.56 0.43
87 INT126807 Regulation of Slc18a3 2 0.11 1.32 0.42
88 INT120690 Regulation of Slc18a3 1 0.22 0 0.42
89 INT80895 Localization of Slc18a3 1 0.04 0 0.42
90 INT86052 Regulation of Transcription of Ache 1 0.12 0 0.41
91 INT281775 Regulation of Positive_regulation of Chrna4 1 0.02 0.98 0.41
92 INT86053 Positive_regulation of Binding of Ache 2 0.43 0 0.4
93 INT94218 Positive_regulation of Regulation of Ache 2 0.40 0 0.38
94 INT169388 Transcription of Chrna7 2 0.69 0.27 0.36
95 INT8776 Negative_regulation of Positive_regulation of Ache 2 0.43 1.17 0.36
96 INT169386 Regulation of Transcription of Chrna7 1 0.45 0.05 0.36
97 INT271775 Positive_regulation of Gene_expression of Ache 3 0.69 5.16 0.34
98 INT201347 Negative_regulation of Gene_expression of Chrm3 4 0.30 2.48 0.31
99 INT255780 Negative_regulation of Negative_regulation of ACHE 2 0.43 1.28 0.24
100 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23
101 INT174101 Protein_catabolism of Ache 3 0.66 2.45 0.22
102 INT73451 Positive_regulation of Positive_regulation of Chrna2 1 0.48 0 0.22
103 INT538 Protein_catabolism of Chrna7 2 0.57 1.01 0.19
104 INT313392 Regulation of Gene_expression of Slc18a3 1 0.10 0.18 0.19
105 INT1255 Regulation of Binding of Ache 1 0.02 0 0.19
106 INT95662 Binding of Chrna3 1 0.00 0.17 0.17
107 INT35620 Positive_regulation of Negative_regulation of ACHE 1 0.48 0 0.17
108 INT147953 Positive_regulation of Positive_regulation of Ache 2 0.46 0.08 0.16
109 INT242578 Negative_regulation of Gene_expression of Slc18a3 1 0.23 0.35 0.15
110 INT147864 Regulation of SLC18A3 1 0.39 0.87 0.14
111 INT261645 Positive_regulation of CHRNA5 1 0.37 0.69 0.14
112 INT251700 Positive_regulation of Protein_catabolism of Ache 1 0.46 0.44 0.14
113 INT147865 Positive_regulation of SLC18A3 1 0.43 0.8 0.14
114 INT261639 Positive_regulation of CHRNA3 1 0.38 0.68 0.14
115 INT7652 Localization of Ache 2 0.80 0 0.13
116 INT242540 Positive_regulation of Gene_expression of Slc18a3 3 0.37 0.38 0.12
117 INT1796 Phosphorylation of Chrna7 1 0.82 0 0.12
118 INT52420 Negative_regulation of Protein_catabolism of Ache 1 0.04 0.44 0.12
119 INT270427 Negative_regulation of Binding of ACHE 2 0.42 1.82 0.11
120 INT43207 Regulation of Positive_regulation of Chrna7 1 0.01 0 0.11
121 INT139554 Positive_regulation of Gene_expression of Chrna4 2 0.25 0 0.1
122 INT139553 Transcription of Chrna4 1 0.27 0 0.1
123 INT139555 Positive_regulation of Positive_regulation of Chrna4 1 0.25 0 0.1
124 INT136073 Regulation of Positive_regulation of Chrna2 1 0.26 0.35 0.1
125 INT303728 Gene_expression of Chrm3 1 0.14 0.98 0.09
126 INT261641 Localization of CHRNA5 1 0.64 0.91 0.09
127 INT261646 Localization of CHRNA3 1 0.65 0.91 0.09
128 INT303727 Positive_regulation of Gene_expression of Chrm3 1 0.10 0.99 0.09
129 INT4388 Negative_regulation of Phosphorylation of Ache 1 0.37 0.07 0.09
130 INT248803 Transcription of Slc18a3 1 0.45 0 0.08
131 INT186574 Negative_regulation of Gene_expression of ACHE 1 0.37 0.51 0.08
132 INT281418 Regulation of Negative_regulation of Ache 2 0.43 1.15 0.07
133 INT271774 Regulation of Positive_regulation of Ache 1 0.27 0 0.06
134 INT242521 Regulation of Gene_expression of Slc18a3 1 0.24 0.18 0.05
135 INT207668 Binding of Chrnb4 1 0.27 0 0.05
136 INT242538 Negative_regulation of Transcription of Slc18a3 1 0.23 0.55 0.05
137 INT210526 Phosphorylation of Ache 1 0.21 0.29 0.05
138 INT201344 Positive_regulation of Gene_expression of Chrm3 1 0.19 0.34 0.04
139 INT246310 Regulation of Negative_regulation of Ache 1 0.27 0 0.04
140 INT264096 Negative_regulation of Binding of Ache 1 0.20 0.78 0.03
141 INT242565 Transcription of Slc18a3 1 0.28 0.28 0.03
142 INT242547 Negative_regulation of Slc18a3 1 0.31 0.23 0.03
143 INT251698 Regulation of Regulation of Ache 1 0.60 0.26 0.03
144 INT220701 Regulation of Negative_regulation of ACHE 2 0.25 1.06 0
145 INT307610 Positive_regulation of Phosphorylation of ACHE 1 0.08 0.2 0
146 INT19017 Negative_regulation of Positive_regulation of ACHE 1 0.42 0.09 0
147 INT190489 Positive_regulation of Binding of Ache 1 0.46 0.2 0
148 INT84493 Positive_regulation of Positive_regulation of Chrm3 1 0.33 0 0
149 INT307614 Phosphorylation of ACHE 1 0.14 0.2 0
150 INT202865 Regulation of Gene_expression of Chrm3 1 0.07 0.37 0
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