GO:0042168

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Name heme metabolic process
Categary Process
Go Slim No
Go Link GO:0042168
Unique Molecular Interactions 62
Total Molecular Interactions 81
Total Single Events 1124
Pain Genes Associated 3

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heme metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for heme metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT75806 Cyp2a5 Negative_regulation of Cyp2g1 1 0.48 0.08 1.09
2 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9
3 INT81299 Ifng Positive_regulation of Gene_expression of Hmox1 1 0.52 0.75 0.76
4 INT99743 Olr1742 Regulation of Gene_expression of Hmox1 1 0.00 0 0.68
5 INT86519 Binding of Hmox1 and Hmox2 1 0.08 0.1 0.66
6 INT103868 IFNG Positive_regulation of Hmox1 1 0.09 0.83 0.65
7 INT99744 Calca Positive_regulation of Positive_regulation of Hmox1 1 0.48 0 0.64
8 INT103870 IRF6 Positive_regulation of Hmox1 1 0.14 0.83 0.64
9 INT81303 Tlr4 Positive_regulation of Gene_expression of Hmox1 1 0.03 0.55 0.56
10 INT270044 Il10 Positive_regulation of Positive_regulation of Hmox1 1 0.20 1.59 0.53
11 INT350076 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 1.29 0.5
12 INT148466 Ccl4 Positive_regulation of Hmox1 1 0.28 0.06 0.47
13 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
14 INT103871 Negative_regulation of IRF6 Positive_regulation of Hmox1 1 0.12 0.61 0.45
15 INT216881 Binding of Apoc4 and Hmox1 1 0.01 1.78 0.4
16 INT147473 Nfe2l2 Positive_regulation of Gene_expression of Hmox1 1 0.74 0.49 0.39
17 INT147472 co Positive_regulation of Gene_expression of Hmox1 1 0.01 0.57 0.36
18 INT91751 Binding of PTGS2 and Hmox1 1 0.00 0.21 0.27
19 INT270046 Ido1 Positive_regulation of Positive_regulation of Hmox1 1 0.15 0.8 0.27
20 INT216880 Apoc4 Positive_regulation of Hmox1 1 0.03 1.06 0.25
21 INT349652 Positive_regulation of Hmox1 Negative_regulation of Positive_regulation of Itk 1 0.01 0.85 0.25
22 INT350099 Gene_expression of Hmox1 Positive_regulation of Gene_expression of MRXS5 1 0.01 0.51 0.24
23 INT328228 Binding of Cpox and Hmox1 1 0.03 0.83 0.23
24 INT350065 Gene_expression of Hmox1 Negative_regulation of Gene_expression of Tlr4 1 0.18 0.35 0.22
25 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
26 INT103867 SFTPA1 Positive_regulation of Hmox1 1 0.00 0.35 0.22
27 INT64340 Zc3h15 Negative_regulation of Hmox1 1 0.12 0.47 0.22
28 INT350078 Hmox1 Negative_regulation of Gene_expression of Ptger2 1 0.02 0.35 0.22
29 INT103869 Binding of IRF6 and Positive_regulation of Hmox1 1 0.10 0.27 0.21
30 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
31 INT350096 Hmox1 Negative_regulation of Gene_expression of MRXS5 1 0.01 0.32 0.2
32 INT266646 HMOX2 Regulation of Gene_expression of Hmox1 1 0.00 0.87 0.2
33 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
34 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
35 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19
36 INT81296 Positive_regulation of Pparg Regulation of Gene_expression of Hmox1 1 0.25 0.17 0.17
37 INT350072 Ptger2 Positive_regulation of Hmox1 1 0.02 0.2 0.15
38 INT216882 Tlr4 Positive_regulation of Hmox1 1 0.17 0.19 0.15
39 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15
40 INT350069 Prkaca Positive_regulation of Hmox1 1 0.05 0.2 0.15
41 INT199195 Gnat3 Regulation of Transcription of Hmox1 1 0.24 0.12 0.14
42 INT295267 Binding of Hmox1 and Gtf3a 1 0.01 0.49 0.13
43 INT295261 Binding of Hmox1 and Nfe2l2 1 0.17 0.49 0.13
44 INT295264 Positive_regulation of Binding of Hmox1 and Nfe2l2 1 0.25 0.5 0.13
45 INT201456 Hmox1 Positive_regulation of Gene_expression of Bcl2 1 0.06 0.74 0.08
46 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
47 INT244290 Il6 Positive_regulation of Hmox1 1 0.38 0.09 0.07
48 INT244291 Nos2 Positive_regulation of Positive_regulation of Hmox1 1 0.34 0.07 0.07
49 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05
50 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04
51 INT227333 Il2 Positive_regulation of Hmox1 1 0.05 0.93 0.04
52 INT350071 Hmox1 Regulation of Tlr4 1 0.22 0.33 0.03
53 INT229818 Fos Positive_regulation of Hmox1 1 0.43 0.37 0
54 INT350098 Gene_expression of PSEN2 Positive_regulation of Gene_expression of Hmox1 1 0.39 0 0
55 INT307160 Regulation of Binding of Cyp2a5 and Ppig 1 0.05 1.22 0
56 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
57 INT307159 Cyp2a5 Regulation of Ppig 1 0.03 0.91 0
58 INT259670 CSE Positive_regulation of Hmox1 1 0.06 0.97 0
59 INT260398 Dclk2 Regulation of Gene_expression of Hmox1 1 0.01 1.02 0
60 INT307158 Binding of Cyp2a5 and Ppig 1 0.04 1.22 0
61 INT260393 Hmox1 Regulation of Positive_regulation of Bcl2 1 0.22 0.86 0
62 INT350068 Positive_regulation of Hmox1 Negative_regulation of Gene_expression of Ptgs2 1 0.03 0.16 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heme metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in heme metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
2 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
3 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64
4 INT76406 Gene_expression of Hmox1 140 0.78 85.86 17.15
5 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01
6 INT82450 Negative_regulation of Hmox1 33 0.55 19.07 8.12
7 INT81293 Positive_regulation of Gene_expression of Hmox1 53 0.70 41.54 7.25
8 INT75800 Gene_expression of Cyp2a5 12 0.77 5.15 5.37
9 INT64338 Negative_regulation of Hmox1 16 0.56 12.72 4.2
10 INT97096 Regulation of Hmox1 18 0.61 6.42 3.9
11 INT80224 Regulation of Hmox1 19 0.32 10.53 3.52
12 INT102634 Transcription of Hmox1 22 0.62 4.5 3.3
13 INT127904 Negative_regulation of Gene_expression of Hmox1 11 0.42 9.54 2.8
14 INT81291 Regulation of Gene_expression of Hmox1 11 0.60 8.78 2.46
15 INT14081 Regulation of Cyp2a5 11 0.50 7.91 2.18
16 INT77072 Positive_regulation of Cyp2a5 18 0.56 15.47 1.92
17 INT99742 Negative_regulation of Gene_expression of Hmox1 12 0.58 9.94 1.77
18 INT114381 Negative_regulation of Gene_expression of Cyp2a5 1 0.55 2.25 1.66
19 INT80227 Regulation of Gene_expression of Hmox1 12 0.44 11.04 1.61
20 INT91232 Regulation of Positive_regulation of Hmox1 5 0.45 2.43 1.55
21 INT103305 Positive_regulation of Positive_regulation of Hmox1 8 0.49 4.81 1.49
22 INT91320 Localization of Hmox1 8 0.81 4.06 1.28
23 INT115831 Transcription of Hmox1 16 0.66 5.31 1.14
24 INT199187 Localization of Hmox1 2 0.78 3.36 1.11
25 INT75803 Negative_regulation of Cyp2a5 2 0.43 0.13 1.08
26 INT201454 Positive_regulation of Positive_regulation of Hmox1 6 0.35 5.2 0.94
27 INT148461 Positive_regulation of Transcription of Hmox1 6 0.33 1.83 0.93
28 INT82568 Protein_catabolism of Hmox1 5 0.86 1.03 0.79
29 INT287003 Negative_regulation of Positive_regulation of Hmox1 2 0.34 3.1 0.63
30 INT270030 Negative_regulation of Positive_regulation of Hmox1 3 0.30 2.49 0.47
31 INT216879 Binding of Hmox1 4 0.36 2.82 0.31
32 INT114383 Regulation of Gene_expression of Cyp2a5 2 0.58 0.9 0.3
33 INT328227 Positive_regulation of Localization of Hmox1 1 0.45 0.67 0.28
34 INT91231 Binding of Hmox1 4 0.36 0.29 0.27
35 INT201453 Protein_catabolism of Hmox1 3 0.95 4.25 0.23
36 INT350048 Negative_regulation of Regulation of Hmox1 1 0.30 0.37 0.23
37 INT115829 Regulation of Transcription of Hmox1 1 0.35 1.03 0.17
38 INT316626 Negative_regulation of Localization of Cyp2a5 1 0.23 0 0.15
39 INT316623 Localization of Cyp2a5 1 0.31 0 0.15
40 INT115824 Positive_regulation of Transcription of Hmox1 3 0.45 0.43 0.06
41 INT232833 Positive_regulation of Gene_expression of Cyp2a5 2 0.38 0.79 0.04
42 INT350052 Positive_regulation of Negative_regulation of Hmox1 1 0.35 0.34 0.04
43 INT307149 Positive_regulation of Positive_regulation of Cyp2a5 1 0.38 0.75 0.03
44 INT337766 Phosphorylation of Hmox1 1 0.79 0.08 0
45 INT307150 Regulation of Positive_regulation of Cyp2a5 1 0.37 1.04 0
46 INT337767 Positive_regulation of Phosphorylation of Hmox1 1 0.49 0.08 0
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