GO:0042169

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Name SH2 domain binding
Categary Function
Go Slim No
Go Link GO:0042169
Unique Molecular Interactions 665
Total Molecular Interactions 892
Total Single Events 7538
Pain Genes Associated 48

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for SH2 domain binding. They are ordered first by their pain relevance and then by number of times they were reported for SH2 domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
2 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
3 INT128293 Negative_regulation of Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.34
4 INT128292 Nts Positive_regulation of Insr 1 0.03 0.99 3.34
5 INT128291 Vom1r68 Positive_regulation of Insr 1 0.00 0.99 3.33
6 INT128294 Aldh1a1 Positive_regulation of Insr 1 0.00 0.99 3.33
7 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
8 INT158751 Binding of TRPV1 and Pag1 1 0.03 1.59 3.08
9 INT96462 Pnoc Positive_regulation of Pag1 1 0.01 0.74 2.45
10 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
11 INT37873 Pag1 Regulation of Nrm 2 0.04 1.1 2.41
12 INT158809 Pag1 Regulation of Rvm 1 0.02 1.28 2.33
13 INT211748 Binding of Pag1 and Mors1 2 0.07 0.2 2.26
14 INT14910 Binding of GPR182 and SIT1 1 0.02 1.87 1.73
15 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
16 INT113337 EPO Positive_regulation of JAK2 1 0.76 2.8 1.55
17 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
18 INT125845 Positive_regulation of Pag1 Positive_regulation of Gene_expression of Arrb2 1 0.09 0.46 1.48
19 INT140021 Avp Positive_regulation of Pag1 1 0.03 0.85 1.38
20 INT140018 Avp Positive_regulation of Gene_expression of Pag1 1 0.04 0.85 1.38
21 INT140020 Avp Positive_regulation of Localization of Pag1 1 0.03 0.85 1.38
22 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36
23 INT14827 Binding of Gabrd and Pag1 1 0.07 0.95 1.33
24 INT124925 Negative_regulation of Slc6a1 Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
25 INT124926 Negative_regulation of Prkaca Negative_regulation of Localization of Pag1 1 0.00 0.61 1.3
26 INT211743 Positive_regulation of Binding of Pag1 and Mors1 1 0.09 0.1 1.25
27 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
28 INT121000 Binding of PAG1 and Nrm 1 0.13 0.67 1.25
29 INT151444 Binding of Oprm1 and Pag1 1 0.00 1.5 1.24
30 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
31 INT153215 Htr5b Positive_regulation of Pag1 1 0.01 0.57 1.22
32 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
33 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2
34 INT25660 Binding of Penk and Pag1 1 0.01 0.67 1.19
35 INT140022 Avp Regulation of Localization of Pag1 1 0.01 0.57 1.17
36 INT107029 Cpox Regulation of Pag1 1 0.01 1.24 1.15
37 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
38 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
39 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12
40 INT53847 Pag1 Regulation of Gabrd 1 0.01 1 1.08
41 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
42 INT291966 Pag1 Positive_regulation of Gene_expression of Grin2b 1 0.19 1.91 1.06
43 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
44 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
45 INT53843 Penk Regulation of Pag1 1 0.07 0.9 1.01
46 INT53846 Positive_regulation of Penk Regulation of Pag1 1 0.07 0.9 1.01
47 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
48 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
49 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
50 INT317543 Pag1 Positive_regulation of Oprm1 1 0.12 0.73 0.97
51 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
52 INT264926 Binding of Gnaz and Pag1 1 0.08 0.19 0.94
53 INT264924 Binding of Pag1 and Gopc 1 0.06 0.19 0.94
54 INT116930 OPRK1 Positive_regulation of Binding of PTK2 1 0.28 0.35 0.93
55 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
56 INT264923 D2Mit212 Positive_regulation of Binding of Pag1 1 0.03 0.2 0.93
57 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
58 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92
59 INT54199 Binding of Pag1 and Agp2 1 0.04 0.18 0.91
60 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
61 INT54198 Agp2 Negative_regulation of Pag1 1 0.05 0.18 0.91
62 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
63 INT54200 Gnai1 Negative_regulation of Pag1 1 0.05 0.18 0.9
64 INT54197 Binding of Gnai1 and Pag1 1 0.04 0.18 0.9
65 INT161412 Pag1 Positive_regulation of Gene_expression of Tens1 1 0.11 0.56 0.9
66 INT54194 Binding of Oprd1 and Pag1 1 0.01 0.18 0.89
67 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
68 INT116109 VEGFA Positive_regulation of PTK2 1 0.13 0.3 0.83
69 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82
70 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
71 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
72 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
73 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79
74 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
75 INT144062 Grm8 Regulation of Localization of Pag1 1 0.21 0.63 0.79
76 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
77 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
78 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
79 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
80 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
81 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
82 INT76499 Binding of Insr and Adora2a 1 0.08 0 0.76
83 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
84 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
85 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
86 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
87 INT133675 NPY6R Negative_regulation of SRC 1 0.17 0.75 0.74
88 INT61165 Binding of Pag1 and Pcyt1a 1 0.01 0.33 0.73
89 INT126305 Binding of Rgs10 and Pag1 1 0.16 0.41 0.72
90 INT126306 Binding of Rgs11 and Pag1 1 0.18 0.41 0.72
91 INT290544 Negative_regulation of Crh Positive_regulation of Insr 1 0.01 0.3 0.72
92 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
93 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
94 INT126303 Binding of Rgs7 and Pag1 1 0.15 0.41 0.72
95 INT126304 Binding of Rgs2 and Pag1 1 0.16 0.41 0.72
96 INT37874 Positive_regulation of Pag1 Regulation of Nrm 1 0.04 0.59 0.71
97 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
98 INT166386 Mapk1 Regulation of Gene_expression of Gnb2l1 1 0.46 0.25 0.7
99 INT132696 Binding of Arc and Pag1 1 0.00 0.5 0.67
100 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
101 INT266064 Binding of PAG1 and Creb1 1 0.04 1.52 0.65
102 INT290549 Gopc Positive_regulation of Positive_regulation of Insr 1 0.01 0.06 0.65
103 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65
104 INT290545 Crh Positive_regulation of Positive_regulation of Insr 1 0.02 0.06 0.64
105 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64
106 INT290550 Gopc Positive_regulation of Insr 1 0.01 0.06 0.64
107 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
108 INT290540 Positive_regulation of Crh Positive_regulation of Insr 1 0.02 0.06 0.64
109 INT46892 Positive_regulation of Binding of Pag1 and Nrm 1 0.01 0.61 0.63
110 INT46891 Binding of Pag1 and Nrm 1 0.01 0.61 0.63
111 INT266065 Positive_regulation of Binding of Ceacam3 and PAG1 1 0.03 1.44 0.63
112 INT266062 Binding of Ceacam3 and PAG1 1 0.02 1.44 0.63
113 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
114 INT46493 Binding of Insr and Oxt 1 0.14 0 0.62
115 INT64540 Binding of Pag1 and Rvm 1 0.04 0.61 0.61
116 INT166387 Binding of Gnb2l1 and Mdk 1 0.30 0.24 0.61
117 INT166385 Binding of Araf and Gnb2l1 1 0.23 0.24 0.6
118 INT276217 Pdk1 Positive_regulation of Positive_regulation of Insr 1 0.05 0.1 0.6
119 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59
120 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59
121 INT38131 Pag1 Negative_regulation of Gsr 1 0.01 0.72 0.58
122 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
123 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
124 INT147273 Bdnf Regulation of Syp 1 0.24 0 0.56
125 INT38422 Zbtb7a Positive_regulation of Pag1 1 0.30 0.66 0.54
126 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
127 INT253897 Binding of Htr1d and Pag1 1 0.30 0.29 0.52
128 INT114070 Agtr2 Positive_regulation of Gene_expression of Insr 1 0.13 0.34 0.52
129 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
130 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
131 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
132 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
133 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
134 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
135 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
136 INT253896 Binding of Htr1a and Pag1 1 0.30 0.29 0.49
137 INT116932 PTK2 Negative_regulation of Positive_regulation of MAPK8 1 0.35 0.17 0.48
138 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
139 INT263977 PROC Negative_regulation of JAK2 1 0.00 0.93 0.47
140 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
141 INT116935 Positive_regulation of OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.47
142 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
143 INT151485 Negative_regulation of Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
144 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
145 INT151484 Binding of Ptpn6 and Oprd1 1 0.00 0 0.47
146 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
147 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
148 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
149 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
150 INT116939 OPRK1 Positive_regulation of Phosphorylation of PTK2 1 0.39 0.17 0.46
151 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
152 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
153 INT116934 OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
154 INT116928 PTK2 Positive_regulation of JUN 1 0.20 0.15 0.46
155 INT116933 SRC Positive_regulation of JUN 1 0.33 0.15 0.46
156 INT116937 Positive_regulation of OPRK1 Positive_regulation of Positive_regulation of SRC 1 0.20 0.17 0.46
157 INT117776 Binding of Ptk2 and Regulation of Phosphorylation of Ddr1 1 0.10 0.17 0.46
158 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
159 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
160 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
161 INT291965 Phex Negative_regulation of Pag1 1 0.05 0.82 0.43
162 INT160046 INPPL1 Regulation of Gene_expression of PTEN 1 0.41 0.6 0.42
163 INT160049 PTEN Regulation of Gene_expression of INPPL1 1 0.41 0.6 0.42
164 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
165 INT44312 Binding of Trh and Pag1 1 0.05 0.36 0.41
166 INT82848 Binding of Gal and Pag1 1 0.23 0.71 0.41
167 INT141242 Binding of SYP and DNLZ 1 0.29 1.74 0.41
168 INT313455 Binding of Ppp2ca and Syp 1 0.45 0.68 0.4
169 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
170 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
171 INT167946 Binding of SRC and Stat5b 1 0.28 0 0.38
172 INT2428 Pag1 Regulation of Kitl 1 0.00 0.41 0.38
173 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
174 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
175 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
176 INT303994 Il6 Positive_regulation of JAK2 1 0.03 0.41 0.37
177 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
178 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
179 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
180 INT353390 Binding of DRD4 and SRC 1 0.25 0.62 0.37
181 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
182 INT336573 Ptpn2 Regulation of INSR 1 0.00 1.36 0.36
183 INT231535 Binding of JAK2 and SOAT1 1 0.01 0.3 0.35
184 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
185 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
186 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
187 INT134080 OPA1 Negative_regulation of Phosphorylation of Gnb2l1 1 0.03 0.22 0.34
188 INT181451 Lck Regulation of Mbp 1 0.08 1.43 0.34
189 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
190 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
191 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
192 INT184084 Jak2 Positive_regulation of Stat1 1 0.33 0.3 0.33
193 INT243622 Twist1 Regulation of Jak2 1 0.30 0.2 0.32
194 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
195 INT143688 Binding of Dlc1 and Trpv1 1 0.01 0.45 0.3
196 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
197 INT295360 Ntn1 Positive_regulation of Ptk2 1 0.09 0.51 0.29
198 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
199 INT118853 Negative_regulation of SRC Negative_regulation of Positive_regulation of STAT3 1 0.41 0.08 0.28
200 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for SH2 domain binding. They are ordered first by their pain relevance and then by number of times they were reported in SH2 domain binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87
2 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76
3 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79
4 INT5610 Positive_regulation of Insr 140 0.69 37.26 86.24
5 INT19771 Positive_regulation of PAG1 69 0.61 75.61 76.88
6 INT6926 Regulation of Pag1 72 0.39 55.79 65.09
7 INT9304 Negative_regulation of Pag1 70 0.39 51.97 64.23
8 INT5034 Negative_regulation of Insr 100 0.55 28.08 54.5
9 INT7800 Localization of Pag1 51 0.56 33.06 53.74
10 INT17915 Gene_expression of Insr 141 0.75 47.45 48.59
11 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
12 INT8691 Localization of Insr 85 0.80 9.27 30.32
13 INT5300 Regulation of Insr 54 0.60 11.33 29.26
14 INT254567 Positive_regulation of Gene_expression of PAG1 10 0.39 31.15 24.26
15 INT19580 Binding of Pag1 24 0.30 15.13 20.88
16 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
17 INT99058 Regulation of PAG1 18 0.45 21.62 18.5
18 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
19 INT62564 Gene_expression of Syp 40 0.76 15.56 17
20 INT63553 Binding of PAG1 14 0.48 12.51 14.76
21 INT14768 Negative_regulation of Positive_regulation of Insr 16 0.56 5.51 13.59
22 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
23 INT118905 Positive_regulation of Positive_regulation of PAG1 8 0.40 7.55 12.25
24 INT42459 Positive_regulation of Gene_expression of Pag1 19 0.25 13.49 12.22
25 INT110988 Gene_expression of Insr 58 0.42 42.12 12.18
26 INT21934 Negative_regulation of Negative_regulation of Pag1 11 0.39 7.91 11.37
27 INT106477 Positive_regulation of Syp 21 0.68 8.69 10.3
28 INT28857 Negative_regulation of Positive_regulation of Pag1 11 0.30 8.46 10.19
29 INT254566 Negative_regulation of Gene_expression of PAG1 7 0.33 9.51 9.91
30 INT159116 Gene_expression of Gnb2l1 12 0.77 2.79 9.49
31 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
32 INT7801 Positive_regulation of Localization of Pag1 7 0.32 5.96 8.67
33 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
34 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06
35 INT81419 Localization of PAG1 10 0.64 11.1 8.01
36 INT38130 Negative_regulation of Gene_expression of Pag1 8 0.28 6.16 7.99
37 INT24891 Gene_expression of SYP 55 0.75 45.76 7.53
38 INT30920 Positive_regulation of Gene_expression of Insr 14 0.66 2.91 7.32
39 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32
40 INT82610 Positive_regulation of SRC 53 0.67 26.89 7.27
41 INT36405 Positive_regulation of Insr 26 0.66 24.5 7.24
42 INT166383 Positive_regulation of Gene_expression of Gnb2l1 1 0.69 2.19 7.02
43 INT21967 Positive_regulation of Positive_regulation of Pag1 5 0.31 5.72 6.86
44 INT24622 Positive_regulation of Localization of Insr 15 0.69 0.32 6.85
45 INT101193 Regulation of Gene_expression of Pag1 13 0.22 8.62 6.77
46 INT92716 Negative_regulation of PAG1 6 0.51 5.82 6.32
47 INT115677 Positive_regulation of Gene_expression of Syp 15 0.63 4.69 6.25
48 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
49 INT51320 Regulation of Localization of Pag1 4 0.17 3.34 6.15
50 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
51 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
52 INT32611 Phosphorylation of Insr 13 0.80 4.18 5.77
53 INT254570 Regulation of Gene_expression of PAG1 3 0.35 6.72 5.76
54 INT132682 Phosphorylation of Pag1 7 0.71 5.61 5.75
55 INT83597 Phosphorylation of Ptk2 20 0.82 3.24 5.7
56 INT50975 Localization of Ptpn6 8 0.65 2.64 5.7
57 INT9895 Binding of GHR 18 0.36 4.8 5.65
58 INT159115 Negative_regulation of Gene_expression of Gnb2l1 3 0.42 1.33 5.59
59 INT14769 Positive_regulation of Positive_regulation of Insr 10 0.43 2.66 5.55
60 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47
61 INT100222 Binding of Src 9 0.26 5.41 5.37
62 INT160853 Gene_expression of Syp 87 0.72 20.06 5.31
63 INT21933 Regulation of Negative_regulation of Pag1 5 0.28 5.48 5.29
64 INT114058 Negative_regulation of Gene_expression of Insr 13 0.31 9.23 4.97
65 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
66 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
67 INT10115 Gene_expression of INSR 31 0.75 11.98 4.86
68 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
69 INT51392 Negative_regulation of Insr 18 0.27 14.75 4.84
70 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
71 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
72 INT24620 Negative_regulation of Gene_expression of Insr 14 0.39 6.98 4.61
73 INT159122 Positive_regulation of Gnb2l1 8 0.69 2.2 4.61
74 INT87345 Phosphorylation of PTK2 110 0.82 59.39 4.28
75 INT51084 Binding of Insr 13 0.30 4.25 4.23
76 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
77 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
78 INT83035 Binding of INSR 16 0.47 9.29 4.11
79 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
80 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
81 INT117773 Positive_regulation of Phosphorylation of Ptk2 9 0.69 0.89 3.71
82 INT166814 Transcription of Pag1 5 0.46 3.95 3.71
83 INT122327 Regulation of Src 6 0.59 0.59 3.6
84 INT10116 Localization of INSR 11 0.57 5.43 3.48
85 INT6339 Negative_regulation of Ptpn6 6 0.14 0.71 3.44
86 INT14060 Negative_regulation of Negative_regulation of Insr 6 0.53 3.53 3.44
87 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
88 INT260159 Negative_regulation of Positive_regulation of PAG1 2 0.33 1.86 3.39
89 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
90 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
91 INT134786 Gene_expression of Adam10 17 0.68 7.61 3.29
92 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
93 INT64 Regulation of Ptpn6 12 0.14 2.45 3.17
94 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
95 INT124736 Positive_regulation of Gene_expression of Insr 6 0.31 7.55 3.12
96 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08
97 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
98 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
99 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
100 INT121759 Localization of Syp 8 0.73 1.78 2.84
101 INT99961 Positive_regulation of SYP 13 0.67 15.13 2.79
102 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
103 INT161310 Negative_regulation of LCK 17 0.42 8.75 2.74
104 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73
105 INT166381 Negative_regulation of Gnb2l1 1 0.43 0.73 2.68
106 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
107 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
108 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
109 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
110 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
111 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
112 INT23527 Negative_regulation of Localization of Insr 10 0.39 2.58 2.5
113 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
114 INT113339 Binding of JAK2 6 0.40 5.31 2.4
115 INT22019 Regulation of GHR 9 0.62 2.56 2.39
116 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
117 INT159117 Regulation of Gene_expression of Gnb2l1 3 0.56 0.5 2.36
118 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
119 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
120 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
121 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
122 INT106476 Regulation of Gene_expression of Syp 3 0.60 2.32 2.3
123 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
124 INT264600 Negative_regulation of Gene_expression of Syp 8 0.31 2.88 2.23
125 INT24890 Localization of SYP 5 0.73 2.22 2.23
126 INT211738 Positive_regulation of Phosphorylation of Pag1 2 0.24 1.3 2.23
127 INT24621 Regulation of Gene_expression of Insr 9 0.42 2.68 2.18
128 INT118871 Negative_regulation of JAK2 15 0.57 11.4 2.16
129 INT137629 Binding of Ptpn6 10 0.30 0.42 2.15
130 INT321023 Positive_regulation of Localization of Ptpn6 1 0.07 0.27 2.15
131 INT122671 Positive_regulation of LCK 4 0.13 2.69 2.14
132 INT255708 Transcription of PAG1 2 0.53 0.84 2.08
133 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
134 INT13243 Gene_expression of Sqstm1 4 0.30 2.07 2.06
135 INT31006 Regulation of Localization of Insr 7 0.50 0.2 2.05
136 INT253890 Regulation of Binding of Pag1 1 0.30 1.22 2.02
137 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
138 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
139 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
140 INT110242 Regulation of Syp 4 0.32 1.72 1.96
141 INT166815 Negative_regulation of Localization of Pag1 2 0.10 1.8 1.95
142 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
143 INT245663 Phosphorylation of Syp 2 0.76 7.4 1.88
144 INT114059 Localization of Insr 10 0.46 3.49 1.87
145 INT98464 Positive_regulation of Positive_regulation of SRC 10 0.67 5.71 1.86
146 INT83596 Gene_expression of Ptk2 6 0.76 2.22 1.84
147 INT159120 Protein_catabolism of Gnb2l1 1 0.26 0.37 1.79
148 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
149 INT339313 Negative_regulation of Protein_catabolism of Pag1 1 0.05 0.8 1.76
150 INT100135 Negative_regulation of Syp 6 0.57 2.76 1.74
151 INT218303 Protein_catabolism of INSR 3 0.29 0.67 1.73
152 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
153 INT339312 Protein_catabolism of Pag1 1 0.11 0.74 1.72
154 INT232645 Transcription of INSR 2 0.09 1.19 1.71
155 INT82609 Phosphorylation of SRC 17 0.80 6.45 1.7
156 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
157 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
158 INT116110 Positive_regulation of PTK2 20 0.66 10.53 1.64
159 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
160 INT206471 Positive_regulation of Ptk2 34 0.51 25.75 1.61
161 INT162547 Negative_regulation of Binding of Pag1 1 0.16 0.64 1.61
162 INT113340 Phosphorylation of JAK2 17 0.78 5.69 1.6
163 INT162546 Positive_regulation of Binding of Pag1 1 0.19 0.63 1.6
164 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56
165 INT19342 Regulation of Insr 12 0.24 6.11 1.54
166 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
167 INT111946 Positive_regulation of Phosphorylation of PTK2 8 0.66 11.5 1.53
168 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
169 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
170 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
171 INT8707 Localization of LILRB1 2 0.60 1.5 1.5
172 INT98455 Regulation of Src 4 0.20 1.76 1.48
173 INT29856 Negative_regulation of Positive_regulation of Ptpn6 3 0.38 1.24 1.47
174 INT122672 Regulation of Positive_regulation of LCK 1 0.06 1.15 1.44
175 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
176 INT118358 Regulation of Regulation of Pag1 3 0.32 1.77 1.43
177 INT202035 Gene_expression of LILRB1 5 0.75 4.78 1.41
178 INT260160 Regulation of Positive_regulation of PAG1 1 0.35 1.1 1.4
179 INT42428 Negative_regulation of Regulation of Pag1 2 0.37 1.82 1.38
180 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
181 INT173328 Positive_regulation of DAG1 6 0.31 1.74 1.36
182 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
183 INT131115 Regulation of Phosphorylation of Ptk2 2 0.61 0.3 1.34
184 INT114715 Binding of SRC 8 0.36 4.26 1.32
185 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
186 INT202817 Gene_expression of Dag1 16 0.75 7.82 1.3
187 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
188 INT245670 Positive_regulation of Gene_expression of Syp 37 0.65 7.34 1.25
189 INT266050 Regulation of Binding of PAG1 1 0.06 2.96 1.25
190 INT124738 Negative_regulation of Positive_regulation of Insr 5 0.23 3.73 1.24
191 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
192 INT254569 Regulation of Localization of PAG1 2 0.20 3.08 1.23
193 INT10117 Positive_regulation of INSR 10 0.43 4.71 1.22
194 INT55235 Regulation of Positive_regulation of Pag1 2 0.09 1.34 1.22
195 INT87343 Negative_regulation of Phosphorylation of PTK2 34 0.59 18.38 1.19
196 INT87346 Binding of PTK2 6 0.37 4.03 1.18
197 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15
198 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15
199 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15
200 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
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