GO:0042177

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Name negative regulation of protein catabolic process
Categary Process
Go Slim No
Go Link GO:0042177
Unique Molecular Interactions 1124
Total Molecular Interactions 1557
Total Single Events 19435
Pain Genes Associated 31

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89
2 INT221180 Binding of OPRM1 and Flna 1 0.09 0.22 12.65
3 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85
4 INT259209 Binding of Glul and Flna 1 0.03 0 4.2
5 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15
6 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
7 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
8 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
9 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
10 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
11 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
12 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
13 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
14 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
15 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
16 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
17 INT221181 Binding of GOPC and Flna 1 0.03 0.06 2.08
18 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
19 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
20 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
21 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
22 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
23 INT169468 Binding of Egfr and Spink3 1 0.37 3.73 1.83
24 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
25 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
26 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
27 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
28 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
29 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
30 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
31 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
32 INT221182 Negative_regulation of Binding of OPRM1 and Flna 1 0.07 0 1.57
33 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
34 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
35 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
36 INT121747 Prkcg Negative_regulation of Positive_regulation of Creb1 1 0.16 0.2 1.5
37 INT161870 OPRM1 Positive_regulation of Prkcg 1 0.01 0.12 1.47
38 INT161865 Mors1 Positive_regulation of Prkcg 1 0.00 0.12 1.47
39 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44
40 INT78974 Binding of Prkcg and Prkaca 2 0.31 0.35 1.4
41 INT138099 Binding of Grin2a and Insrr 1 0.01 0.36 1.39
42 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39
43 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33
44 INT131888 gr Positive_regulation of Gene_expression of Prkcg 1 0.00 0 1.32
45 INT120929 Prkcg Regulation of Gene_expression of Fos 2 0.50 0.34 1.31
46 INT131886 Creb1 Positive_regulation of Gene_expression of Prkcg 1 0.03 0 1.31
47 INT169297 TRPV1 Positive_regulation of EGFR 1 0.64 0.37 1.3
48 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
49 INT169289 CNR1 Positive_regulation of EGFR 1 0.62 0.36 1.28
50 INT251142 Binding of Dlg4 and Grin2a 3 0.30 0.5 1.24
51 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23
52 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
53 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19
54 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
55 INT107579 Kitl Negative_regulation of Grin2a 1 0.10 1.02 1.18
56 INT85780 Prkaca Regulation of Prkcg 1 0.29 0.47 1.17
57 INT131887 Nr3c1 Regulation of Gene_expression of Prkcg 1 0.01 0 1.17
58 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
59 INT122267 Prkcg Positive_regulation of Grin2b 1 0.26 0.61 1.14
60 INT130471 Prkcg Regulation of Regulation of Fos 1 0.45 0.27 1.12
61 INT132683 Bdnf Positive_regulation of Phosphorylation of Grin2a 1 0.00 0.93 1.11
62 INT193328 Grid1 Regulation of Positive_regulation of Prkcg 1 0.00 0.1 1.1
63 INT269189 Binding of Grin2a and Grin3a 2 0.25 1.05 1.09
64 INT269193 Prkcg Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
65 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
66 INT269198 Prkaca Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
67 INT88875 Ifng Positive_regulation of Transcription of Nos2 1 0.02 0.27 1.03
68 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
69 INT88887 IRF6 Positive_regulation of Transcription of Nos2 1 0.21 0.27 1.02
70 INT88874 Ifng Regulation of Nos2 1 0.01 0.26 1.01
71 INT240453 Prkcg Positive_regulation of Positive_regulation of Prkaca 1 0.23 0.63 1.01
72 INT88884 IRF6 Regulation of Nos2 1 0.12 0.26 1
73 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
74 INT88886 IRF6 Positive_regulation of Nos2 1 0.22 0.26 1
75 INT88888 Regulation of IRF6 Positive_regulation of Nos2 1 0.20 0.26 1
76 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
77 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
78 INT256357 Phosphorylation of Rela Positive_regulation of Localization of Ik 1 0.00 0.05 0.96
79 INT146579 Hba Negative_regulation of Gene_expression of Nos2 1 0.44 1.01 0.95
80 INT78976 Prkcg Regulation of Ina 1 0.13 0.16 0.93
81 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
82 INT251153 Dlg2 Positive_regulation of Gene_expression of Grin2a 1 0.40 0.6 0.92
83 INT161455 Mmp7 Positive_regulation of Egfr 1 0.03 0.19 0.92
84 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
85 INT165280 Tnf Positive_regulation of Gene_expression of Nos2 1 0.24 1.02 0.91
86 INT159995 Prkcg Regulation of Gene_expression of Bace1 1 0.39 0.32 0.91
87 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
88 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
89 INT113946 Binding of FLNA and OPRM1 1 0.10 0.37 0.9
90 INT85783 PRKG1 Regulation of Prkcg 1 0.09 0.38 0.9
91 INT108647 Binding of Grin2a and Camk1d 1 0.33 0.78 0.9
92 INT12766 Ins1 Positive_regulation of Prkcg 3 0.53 0.07 0.89
93 INT113383 Negative_regulation of Sert1 Positive_regulation of Prkcg 1 0.31 0 0.89
94 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
95 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
96 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
97 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
98 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
99 INT152835 Prkcg Regulation of Phosphorylation of Nfasc 1 0.10 0.21 0.87
100 INT152853 Prkcg Regulation of PRS 1 0.01 0.21 0.87
101 INT160412 Tat Positive_regulation of Transcription of Nos2 1 0.37 0.98 0.86
102 INT80792 Prkcg Regulation of Oprd1 1 0.19 0.2 0.86
103 INT80793 Prkcg Regulation of Pkm2 1 0.29 0.2 0.83
104 INT102931 Nos3 Positive_regulation of Nos2 1 0.43 1.63 0.83
105 INT152236 Tlr4 Regulation of Gene_expression of Nos2 3 0.19 0.64 0.82
106 INT212290 Binding of Grin2a and Grin2b 2 0.20 1.36 0.82
107 INT185937 NOS2 Regulation of Prkaca 1 0.03 1.08 0.82
108 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
109 INT186428 Trib3 Regulation of Prkcg 1 0.02 0.09 0.81
110 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81
111 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81
112 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
113 INT322397 Egfr Positive_regulation of Adarb1 1 0.00 0.08 0.8
114 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
115 INT96501 Il11 Regulation of Gene_expression of NOS2 1 0.00 1.04 0.8
116 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
117 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
118 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
119 INT168456 Arr3 Positive_regulation of Nos2 1 0.21 1.98 0.79
120 INT132889 Nfkb1 Regulation of Gene_expression of Nos2 1 0.16 0.21 0.79
121 INT107739 Prkcg Negative_regulation of Positive_regulation of Pld2 1 0.46 0 0.79
122 INT132894 CHUK Regulation of Gene_expression of Nos2 1 0.00 0.21 0.79
123 INT152833 Nefl Regulation of Prkcg 1 0.12 0.19 0.77
124 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
125 INT152831 Nefh Regulation of Prkcg 1 0.05 0.19 0.77
126 INT152836 Nefm Regulation of Prkcg 1 0.15 0.19 0.77
127 INT94816 Prkcg Positive_regulation of TACR1 1 0.06 0.1 0.76
128 INT152854 PRS Regulation of Prkcg 1 0.01 0.19 0.76
129 INT128815 Mapk14 Regulation of Gene_expression of Nos2 1 0.21 0.46 0.74
130 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
131 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74
132 INT128813 Mapk8 Regulation of Gene_expression of Nos2 1 0.23 0.46 0.74
133 INT219914 Prkcg Regulation of Phosphorylation of Trpv1 1 0.11 1 0.74
134 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
135 INT124353 Prkcg Positive_regulation of Positive_regulation of Gorasp2 1 0.02 1.19 0.73
136 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
137 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
138 INT228494 Binding of Ncoa5 and Rela 1 0.00 1.58 0.72
139 INT296292 Binding of Car1 and Grin2a 1 0.14 0.32 0.72
140 INT296289 Grin2a Regulation of Negative_regulation of Kcnip3 1 0.30 0.3 0.72
141 INT351351 Prkcg Regulation of Lpar1 1 0.12 0.58 0.72
142 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
143 INT296288 Grin2a Regulation of Negative_regulation of Hmmr 1 0.03 0.29 0.71
144 INT263236 DAG1 Positive_regulation of Prkcg 2 0.01 0.31 0.7
145 INT186162 Phosphorylation of Prkaca Positive_regulation of Phosphorylation of Prkcg 1 0.04 0.22 0.7
146 INT187522 ATIC Negative_regulation of Gene_expression of Nos2 1 0.02 1.46 0.7
147 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69
148 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
149 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
150 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67
151 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
152 INT171825 Binding of Prkcg and Ncs1 1 0.00 0.07 0.66
153 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
154 INT330046 Mapk8 Negative_regulation of Prkcg 1 0.13 0.4 0.66
155 INT135829 Cat2 Regulation of Nos2 1 0.47 0 0.65
156 INT266489 Dcps Positive_regulation of Gene_expression of Nos2 1 0.06 3.43 0.63
157 INT265144 Olah Positive_regulation of Prkcg 1 0.02 0 0.62
158 INT265140 Olah Regulation of Prkcg 1 0.01 0 0.62
159 INT128812 Mapk8 Negative_regulation of Gene_expression of Nos2 1 0.19 0.37 0.61
160 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
161 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
162 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
163 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
164 INT339072 Eae1 Positive_regulation of Gene_expression of Nos2 1 0.02 3.76 0.59
165 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
166 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
167 INT131072 Cc2d1b Negative_regulation of Prkcg 1 0.01 0 0.58
168 INT270943 Binding of Prkcg and Cpe 1 0.05 0 0.58
169 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
170 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
171 INT143426 Positive_regulation of B4GALNT1 Negative_regulation of Gene_expression of Nos2 1 0.00 0.83 0.58
172 INT212813 Tlr4 Positive_regulation of Nos2 3 0.34 0.89 0.57
173 INT151459 Olr1745 Negative_regulation of Gene_expression of Nos2 1 0.04 0.82 0.57
174 INT169286 CNR1 Positive_regulation of Phosphorylation of EGFR 1 0.45 0.18 0.57
175 INT112107 Negative_regulation of Dlg2 Negative_regulation of Gene_expression of Grin2a 1 0.40 0.49 0.57
176 INT134532 Grin2a Regulation of Ngfr 1 0.02 0 0.57
177 INT78588 Positive_regulation of Binding of Nfkb1 and Nos2 1 0.01 0.33 0.56
178 INT263230 Prkcg Regulation of Trpv1 1 0.05 0.95 0.56
179 INT81546 TNF Positive_regulation of Gene_expression of Nos2 1 0.04 0.54 0.56
180 INT112106 Negative_regulation of Dlg2 Negative_regulation of Grin2a 1 0.40 0.48 0.56
181 INT78973 Prkcg Positive_regulation of Positive_regulation of Ina 1 0.10 0.07 0.55
182 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55
183 INT78587 Binding of Nfkb1 and Nos2 1 0.01 0.33 0.55
184 INT263231 Positive_regulation of Trpv1 Positive_regulation of Prkcg 1 0.08 0.57 0.55
185 INT333991 Binding of FLNA and SELL 1 0.00 1.69 0.55
186 INT251151 Binding of Grin2a and Dlg3 1 0.24 0.32 0.54
187 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
188 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
189 INT222691 Negative_regulation of Binding of FLNA and TNF 1 0.14 1.92 0.54
190 INT263229 Trpv1 Positive_regulation of Prkcg 1 0.08 0.57 0.54
191 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
192 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
193 INT222692 Binding of FLNA and TNF 1 0.12 1.92 0.53
194 INT330544 Bcl2l11 Negative_regulation of Prkcg 1 0.03 0.38 0.52
195 INT330541 Bcl2l11 Negative_regulation of Negative_regulation of Prkcg 1 0.03 0.38 0.52
196 INT144130 Binding of Gja1 and Prkcg 1 0.48 0.5 0.52
197 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
198 INT191947 NFKB2 Positive_regulation of Gene_expression of NOS2 1 0.08 1.51 0.52
199 INT208121 Binding of Grin2a and Grin2b 3 0.35 0.06 0.51
200 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of protein catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of protein catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
2 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08
3 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
4 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
5 INT812 Localization of INS 1026 0.81 515.6 145.31
6 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87
7 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
8 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
9 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
10 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
11 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53
12 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
13 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
14 INT251 Regulation of INS 398 0.62 232.47 55.04
15 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15
16 INT49017 Negative_regulation of Gene_expression of Nos2 169 0.59 80.64 52.67
17 INT221172 Binding of Flna 32 0.42 1.37 51.59
18 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
19 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
20 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
21 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
22 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
23 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
24 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
25 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
26 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
27 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
28 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
29 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
30 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
31 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
32 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
33 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
34 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69
35 INT61953 Transcription of Nos2 101 0.72 46.64 25.49
36 INT89854 Regulation of Nos2 49 0.61 42.58 24.1
37 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01
38 INT79061 Positive_regulation of NOS2 92 0.65 58.89 23.96
39 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78
40 INT66281 Transcription of Nos2 81 0.71 39.49 20.37
41 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
42 INT90612 Positive_regulation of Grin2a 33 0.65 15.11 18.84
43 INT65211 Binding of Prkcg 38 0.48 14.75 16.92
44 INT61949 Regulation of Nos2 74 0.58 34.08 16.7
45 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33
46 INT74545 Negative_regulation of Gene_expression of Prkcg 22 0.42 7.77 16.26
47 INT9525 Regulation of Positive_regulation of Prkcg 20 0.62 7.82 16.18
48 INT93482 Localization of Rela 56 0.78 24.52 14.82
49 INT14647 Positive_regulation of Grin2a 26 0.67 4.69 14.8
50 INT79887 Gene_expression of Prkcc 20 0.78 12.59 14.73
51 INT63854 Regulation of Gene_expression of Prkcg 27 0.56 9.41 14.15
52 INT14572 Binding of INS 205 0.48 175.43 13.38
53 INT86383 Negative_regulation of EGFR 258 0.59 173.94 13.32
54 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
55 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
56 INT103997 Phosphorylation of Grin2a 17 0.64 10.75 12.67
57 INT47847 Negative_regulation of Localization of Prkcg 11 0.58 4.02 12.36
58 INT100799 Negative_regulation of Grin2a 27 0.57 7.33 12.2
59 INT221167 Gene_expression of Flna 11 0.60 0.69 11.81
60 INT97381 Negative_regulation of Positive_regulation of Nos2 34 0.59 16.66 11.6
61 INT51625 Regulation of Gene_expression of Grin2a 12 0.60 3.28 11.6
62 INT19795 Positive_regulation of EGFR 161 0.70 103.69 11.55
63 INT95369 Positive_regulation of Gene_expression of NOS2 36 0.55 25.09 11.37
64 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15
65 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
66 INT51626 Transcription of Grin2a 16 0.68 1.65 10.5
67 INT93036 Negative_regulation of Grin2a 23 0.50 7.1 10.32
68 INT64193 Regulation of Grin2a 19 0.54 2.98 10.31
69 INT79248 Regulation of Negative_regulation of Prkcg 13 0.44 3.44 9.78
70 INT70850 Positive_regulation of Transcription of Nos2 30 0.70 18.95 9.68
71 INT68373 Negative_regulation of FLNA 59 0.57 60.46 9.55
72 INT47845 Regulation of Localization of Prkcg 16 0.62 3.1 9.42
73 INT71565 Negative_regulation of Prkcc 11 0.54 4.16 9.31
74 INT78769 Regulation of Grin2a 16 0.58 5.22 9.28
75 INT66213 Localization of RELA 63 0.78 14.71 8.77
76 INT221173 Negative_regulation of Binding of Flna 4 0.33 0.13 8.25
77 INT116605 Binding of Nos2 28 0.37 16.88 8.18
78 INT72337 Positive_regulation of Positive_regulation of Nos2 37 0.65 17.02 8.11
79 INT112191 Positive_regulation of Transcription of Nos2 22 0.66 12.4 7.74
80 INT85751 Positive_regulation of Positive_regulation of Nos2 40 0.60 23.53 7.72
81 INT113705 Gene_expression of Egfr 228 0.78 149.05 7.59
82 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
83 INT96994 Phosphorylation of EGFR 99 0.82 52.75 7.33
84 INT79247 Negative_regulation of Negative_regulation of Prkcg 11 0.42 1.78 7.13
85 INT256345 Phosphorylation of Rela 21 0.75 9.51 6.56
86 INT89131 Negative_regulation of NOS2 20 0.58 9.68 6.56
87 INT100926 Positive_regulation of Gene_expression of Grin2a 11 0.63 3.24 6.41
88 INT11154 Binding of EGFR 149 0.48 96.23 6.29
89 INT115849 Localization of Prkcc 5 0.77 0.65 6.26
90 INT127237 Phosphorylation of Prkcc 7 0.81 0 5.96
91 INT67693 Binding of Grin2a 9 0.38 1.74 5.68
92 INT94428 Negative_regulation of Gene_expression of NOS2 20 0.47 11.61 5.62
93 INT112124 Positive_regulation of Egfr 71 0.70 47.82 5.61
94 INT59879 Transcription of Prkcg 9 0.69 2.29 5.3
95 INT208108 Localization of Grin2a 19 0.70 1.5 5.22
96 INT19549 Binding of Grin2a 12 0.45 1.24 5.09
97 INT112190 Regulation of Negative_regulation of Nos2 8 0.62 5.83 5.09
98 INT73608 Localization of Nos2 21 0.75 9.58 5.05
99 INT89132 Regulation of NOS2 9 0.61 7.34 4.95
100 INT11158 Positive_regulation of Gene_expression of EGFR 165 0.70 131.26 4.93
101 INT135474 Negative_regulation of Gene_expression of Grin2a 7 0.39 6.94 4.89
102 INT61950 Regulation of Positive_regulation of Nos2 17 0.43 9.01 4.87
103 INT111947 Positive_regulation of Gene_expression of Grin2a 7 0.68 1.75 4.84
104 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81
105 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
106 INT103914 Phosphorylation of Egfr 35 0.82 16.98 4.31
107 INT94427 Positive_regulation of Positive_regulation of NOS2 14 0.47 11.15 4.3
108 INT39948 Binding of FLNA 45 0.42 58.05 4.27
109 INT89784 Regulation of Transcription of Nos2 14 0.42 8.39 4.24
110 INT93483 Negative_regulation of Localization of Rela 11 0.57 5.1 4.19
111 INT158377 Positive_regulation of Positive_regulation of Rela 6 0.49 3.08 4.11
112 INT221168 Localization of Flna 1 0.58 0.05 4.05
113 INT148168 Positive_regulation of Localization of Prkcc 4 0.48 0.15 4.03
114 INT63880 Positive_regulation of FLNA 29 0.59 13.88 3.97
115 INT103999 Positive_regulation of Phosphorylation of Grin2a 5 0.38 3.12 3.94
116 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
117 INT229912 Phosphorylation of Fyn 5 0.42 2.57 3.78
118 INT120715 Positive_regulation of Egfr 15 0.68 5.53 3.77
119 INT133550 Negative_regulation of Gene_expression of Rela 14 0.40 4.64 3.73
120 INT121986 Phosphorylation of Grin2a 5 0.76 0.83 3.71
121 INT119506 Negative_regulation of Egfr 32 0.55 23.75 3.67
122 INT65210 Positive_regulation of Binding of Prkcg 6 0.70 2.71 3.65
123 INT74374 Negative_regulation of Phosphorylation of Prkcg 7 0.41 1.28 3.57
124 INT195527 Binding of Rela 17 0.25 4.42 3.56
125 INT163832 Negative_regulation of Gene_expression of EGFR 50 0.59 39.71 3.45
126 INT209221 Regulation of Gene_expression of Grin2a 5 0.24 2.81 3.45
127 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
128 INT129752 Regulation of Phosphorylation of Prkcg 8 0.31 1.43 3.41
129 INT61952 Negative_regulation of Transcription of Nos2 17 0.54 5.1 3.34
130 INT126223 Binding of Nos2 17 0.37 6 3.22
131 INT133557 Transcription of Rela 6 0.52 3.86 3.2
132 INT116235 Negative_regulation of Transcription of Nos2 23 0.58 7.91 3.14
133 INT124954 Gene_expression of Egfr 26 0.75 15.08 3.12
134 INT120562 Negative_regulation of Egfr 108 0.59 79.38 3.11
135 INT161863 Positive_regulation of Regulation of Prkcg 4 0.27 1.63 3.1
136 INT117348 Regulation of EGFR 75 0.61 47.73 3.09
137 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
138 INT130616 Positive_regulation of Negative_regulation of Prkcg 5 0.48 1.6 3.08
139 INT181668 Protein_catabolism of Prkcg 8 0.77 2.59 3.06
140 INT94687 Binding of Prkcc 5 0.37 0.34 3.02
141 INT95779 Positive_regulation of Gene_expression of Prkcc 5 0.69 5.66 3.02
142 INT90611 Positive_regulation of Positive_regulation of Grin2a 4 0.63 1.89 3
143 INT89133 Transcription of NOS2 13 0.71 6.84 2.93
144 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
145 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
146 INT221171 Positive_regulation of Localization of Flna 1 0.39 0.05 2.9
147 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
148 INT59878 Negative_regulation of Transcription of Prkcg 3 0.43 2.15 2.85
149 INT85750 Regulation of Positive_regulation of Nos2 10 0.54 7.78 2.83
150 INT59877 Regulation of Regulation of Prkcg 2 0.45 1.17 2.81
151 INT153221 Positive_regulation of Rela 5 0.16 2.16 2.72
152 INT72757 Negative_regulation of Negative_regulation of Nos2 8 0.42 4.23 2.68
153 INT99550 Regulation of FLNA 51 0.54 27.88 2.58
154 INT89852 Localization of Nos2 22 0.78 14.89 2.56
155 INT105730 Localization of Grin2a 7 0.67 0.64 2.56
156 INT46646 Localization of FLNA 19 0.73 18.83 2.53
157 INT259224 Negative_regulation of Flna 1 0.23 0.15 2.51
158 INT141075 Transcription of Grin2a 5 0.49 1.89 2.46
159 INT141195 Negative_regulation of Rela 14 0.29 8.61 2.44
160 INT130476 Phosphorylation of Fyn 8 0.80 2.99 2.44
161 INT148166 Positive_regulation of Phosphorylation of Prkcc 2 0.68 0 2.44
162 INT79609 Positive_regulation of Negative_regulation of Nos2 5 0.49 3.6 2.43
163 INT162518 Positive_regulation of Localization of Rela 12 0.47 1.96 2.41
164 INT76094 Localization of NOS2 8 0.72 2.76 2.34
165 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
166 INT221177 Negative_regulation of Gene_expression of Flna 2 0.33 0 2.22
167 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
168 INT103917 Positive_regulation of Phosphorylation of Egfr 12 0.68 7.23 2.18
169 INT89130 Positive_regulation of Transcription of NOS2 7 0.50 3.32 2.14
170 INT145196 Gene_expression of Irak3 5 0.23 4.23 2.13
171 INT145195 Positive_regulation of Irak3 4 0.15 3.65 2.12
172 INT221179 Regulation of Flna 1 0.24 0.13 2.04
173 INT138095 Gene_expression of Grin2c 3 0.63 0.36 2.03
174 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
175 INT70174 Negative_regulation of Regulation of Prkcg 3 0.42 0.88 1.98
176 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
177 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
178 INT74595 Regulation of Transcription of Grin2a 2 0.42 0.66 1.92
179 INT103624 Negative_regulation of Gene_expression of Grin2a 5 0.56 1.58 1.9
180 INT65545 Localization of EGFR 35 0.79 20.8 1.88
181 INT144649 Negative_regulation of Positive_regulation of Rela 11 0.26 8.27 1.87
182 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
183 INT112131 Positive_regulation of Positive_regulation of Egfr 10 0.49 9.95 1.85
184 INT120563 Positive_regulation of Gene_expression of Egfr 56 0.70 46.19 1.82
185 INT151174 Negative_regulation of Transcription of Grin2a 3 0.40 0 1.8
186 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
187 INT124953 Negative_regulation of Gene_expression of Egfr 6 0.42 1.97 1.75
188 INT135332 Positive_regulation of Negative_regulation of Prkcc 1 0.46 0.74 1.75
189 INT55169 Binding of RELA 40 0.36 4.91 1.74
190 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
191 INT79063 Regulation of Gene_expression of NOS2 6 0.43 3.68 1.7
192 INT221166 Positive_regulation of Flna 2 0.39 0.09 1.7
193 INT256341 Positive_regulation of Phosphorylation of Rela 5 0.46 2.12 1.62
194 INT181574 Phosphorylation of Nos2 9 0.70 2.92 1.55
195 INT118292 Negative_regulation of Phosphorylation of EGFR 27 0.59 13.62 1.54
196 INT259219 Negative_regulation of Negative_regulation of Flna 1 0.23 0 1.47
197 INT61951 Regulation of Negative_regulation of Nos2 5 0.58 3.08 1.39
198 INT121297 Positive_regulation of Positive_regulation of Prkcc 1 0.50 0 1.38
199 INT96993 Positive_regulation of Phosphorylation of EGFR 15 0.59 5.44 1.37
200 INT133552 Negative_regulation of Transcription of Rela 2 0.23 2.43 1.34
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