GO:0042221

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Name response to chemical stimulus
Categary Process
Go Slim No
Go Link GO:0042221
Unique Molecular Interactions 1174
Total Molecular Interactions 1695
Total Single Events 16319
Pain Genes Associated 34

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported for response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36
2 INT145775 Ngf Positive_regulation of Trpv1 11 0.72 7.71 11.25
3 INT251170 Clu Positive_regulation of Trpv1 1 0.28 2.61 6.49
4 INT122779 Ngf Positive_regulation of Gene_expression of Trpv1 8 0.74 4.31 6.1
5 INT351352 Binding of Trpv1 and Lpar1 1 0.21 5.86 4.62
6 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
7 INT122349 Ngf Regulation of Trpv1 3 0.64 1.55 3.79
8 INT136525 Binding of Prokr1 and Trpv1 1 0.39 2.9 3.76
9 INT141254 Ngf Regulation of Transcription of Trpv1 1 0.53 1.37 3.74
10 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
11 INT158770 Binding of Trpv1 and Trpa1 5 0.34 2.07 3.5
12 INT195931 Binding of OPRM1 and Trpv1 1 0.07 0.87 3.43
13 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
14 INT122780 Ngf Regulation of Gene_expression of Trpv1 4 0.65 3.74 3.11
15 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
16 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
17 INT182564 Binding of Ptger2 and Trpv1 1 0.18 1.77 2.67
18 INT223866 Ltp Positive_regulation of Positive_regulation of Mapk1 2 0.46 0.75 2.61
19 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
20 INT210696 Trpv1 Regulation of Slc12a2 1 0.25 1.97 2.58
21 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
22 INT107165 Binding of Gabrg1 and Trpv1 2 0.01 0.16 2.34
23 INT228454 Ngf Positive_regulation of Phosphorylation of Trpv1 1 0.39 2.97 2.26
24 INT251164 Binding of Clu and Trpv1 1 0.19 0.44 2.23
25 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
26 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
27 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
28 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18
29 INT281084 Prkaca Positive_regulation of Mapk1 2 0.25 0 2.06
30 INT167530 Phax Regulation of Gene_expression of Trpv1 1 0.16 0.86 2.05
31 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
32 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
33 INT137917 Oprm1 Positive_regulation of Kdr 1 0.43 0 1.98
34 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
35 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92
36 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9
37 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9
38 INT166945 Ngf Positive_regulation of Trpv1 1 0.01 0.47 1.88
39 INT338691 Binding of Trpv1 and Aff3 1 0.24 1.21 1.88
40 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
41 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
42 INT23392 Gal Regulation of Trpv1 1 0.05 0.33 1.77
43 INT276863 Gpr65 Regulation of Trpv1 1 0.25 1.78 1.75
44 INT182565 Ptger2 Regulation of Trpv1 1 0.25 1.34 1.73
45 INT276670 Binding of Trpv1 and Nkx1-1 1 0.07 0.68 1.6
46 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
47 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
48 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
49 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
50 INT42000 Trpv1 Positive_regulation of Cck 1 0.04 0 1.49
51 INT41999 Trpv1 Positive_regulation of Vip 1 0.04 0 1.49
52 INT156008 Bcl2 Regulation of Localization of Aifm1 1 0.17 1.92 1.47
53 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
54 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
55 INT169800 Negative_regulation of Adrbk1 Positive_regulation of Positive_regulation of Mapk1 1 0.39 1.04 1.45
56 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44
57 INT180789 Ngf Regulation of Localization of Trpv1 1 0.28 1.22 1.44
58 INT180768 Bdnf Regulation of Localization of Trpv1 1 0.13 1.21 1.43
59 INT180790 Gdnf Regulation of Localization of Trpv1 1 0.15 1.21 1.43
60 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42
61 INT148450 Gene_expression of Inhbe Positive_regulation of Mapk1 1 0.07 1.35 1.41
62 INT161670 H2-M3 Positive_regulation of Positive_regulation of Mapk1 1 0.14 0.73 1.41
63 INT144123 Binding of P2rx6 and Trpv1 1 0.11 0 1.4
64 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
65 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38
66 INT167529 Ppt1 Negative_regulation of Gene_expression of Trpv1 1 0.26 0.49 1.38
67 INT182558 Binding of Ptgir and Trpv1 1 0.16 1.12 1.37
68 INT276673 Nkx1-1 Regulation of Trpv1 1 0.05 0.16 1.37
69 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
70 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
71 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35
72 INT355248 Ltp Positive_regulation of Localization of Trpv1 1 0.51 0 1.35
73 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
74 INT121457 KNG1 Positive_regulation of Trpv1 1 0.16 0.91 1.33
75 INT242605 Gdnf Positive_regulation of Trpv1 1 0.26 0.17 1.3
76 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
77 INT208990 Binding of CALM1 and Trpv1 1 0.10 0.07 1.29
78 INT73597 Positive_regulation of BAX Positive_regulation of Casp1 1 0.06 0.69 1.28
79 INT125950 Syt17 Regulation of Trpv1 1 0.11 0.43 1.28
80 INT73598 BAX Positive_regulation of Casp1 1 0.06 0.63 1.27
81 INT64077 Trpv1 Positive_regulation of Kcnma1 1 0.00 0.37 1.27
82 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
83 INT314198 Mapk14 Positive_regulation of Gene_expression of Trpv1 1 0.48 1.09 1.24
84 INT195926 Prkaca Positive_regulation of Trpv1 1 0.10 0.44 1.24
85 INT168459 Sult1a1 Negative_regulation of Gene_expression of Arr3 1 0.05 2.98 1.23
86 INT166388 Binding of Gnb2l1 and Mapk1 1 0.49 0.49 1.21
87 INT142154 Trpv1 Positive_regulation of Gene_expression of Il2 1 0.22 0 1.21
88 INT166301 Adrbk1 Positive_regulation of Localization of Trpv1 1 0.45 1.17 1.2
89 INT93294 Ngf Regulation of Transcription of Trpv1 1 0.01 0.36 1.19
90 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17
91 INT93290 Ngf Regulation of Transcription of Trpv1 1 0.02 0.34 1.16
92 INT93289 Ngf Regulation of Trpv1 1 0.05 0.34 1.16
93 INT161510 Tlr4 Positive_regulation of Mapk1 1 0.14 0.3 1.16
94 INT121725 Binding of Trpv1 and Pik3cb 1 0.35 0.62 1.15
95 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
96 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
97 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
98 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
99 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
100 INT110669 Binding of Alox5 and Trpv1 1 0.07 0.2 1.13
101 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
102 INT121362 Trpv1 Regulation of Localization of Ins1 1 0.51 0.17 1.12
103 INT182550 Ptger1 Negative_regulation of Trpv1 1 0.35 0.73 1.12
104 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
105 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
106 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
107 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
108 INT121730 Pik3cb Regulation of Trpv1 1 0.58 0.54 1.09
109 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
110 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
111 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
112 INT305734 Binding of Sort1 and Trpv1 1 0.01 0.5 1.08
113 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
114 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
115 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
116 INT154846 Negative_regulation of Mapk14 Negative_regulation of Positive_regulation of Trpv1 1 0.23 0.07 1.05
117 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
118 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
119 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
120 INT349576 Binding of Ugt2b and Sult1a1 1 0.00 0.45 1.03
121 INT114553 Binding of Trpv1 and Col4a4 1 0.01 0.44 1.03
122 INT114554 Binding of St3gal3 and Trpv1 1 0.01 0.44 1.03
123 INT148327 Binding of Pkd1 and Trpv1 1 0.52 2.23 1.01
124 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01
125 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
126 INT283932 Positive_regulation of Mapk14 Regulation of Gene_expression of Trpv1 1 0.14 1.28 0.99
127 INT307100 Trpv1 Regulation of Binding of Trpa1 1 0.31 1.81 0.97
128 INT137920 Binding of Kdr and Oprm1 1 0.23 0 0.97
129 INT307103 Trpa1 Regulation of Binding of Trpv1 1 0.31 1.81 0.97
130 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
131 INT122144 Binding of Trpv1 and Prkd1 1 0.02 0.39 0.96
132 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
133 INT156608 Trpv1 Regulation of Nav1 1 0.51 0.52 0.95
134 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
135 INT144902 Binding of Trpv1 and Pars2 1 0.17 0 0.95
136 INT199396 Prok2 Regulation of Trpv1 1 0.43 1.23 0.94
137 INT223871 Ltp Positive_regulation of Gene_expression of Mapk1 1 0.33 0 0.93
138 INT145853 Casp1 Positive_regulation of Mapk14 1 0.02 0.68 0.93
139 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92
140 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91
141 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
142 INT109842 Prkce Positive_regulation of Localization of Trpv1 1 0.13 1.31 0.91
143 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
144 INT180772 Bdnf Regulation of Trpv1 1 0.11 0.29 0.9
145 INT180777 Bdnf Regulation of Gene_expression of Trpv1 1 0.18 0.29 0.9
146 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
147 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
148 INT326455 Runx1 Positive_regulation of Gene_expression of Trpv1 1 0.45 0 0.88
149 INT251159 Binding of Clu and Positive_regulation of Trpv1 1 0.16 0 0.87
150 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
151 INT152868 Tnf Regulation of Gene_expression of Trpv1 1 0.27 0.25 0.86
152 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86
153 INT150864 RYBP Positive_regulation of Positive_regulation of Bcl2 1 0.01 0.66 0.86
154 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86
155 INT193278 Brs3 Positive_regulation of Gene_expression of Trpv1 1 0.04 0.09 0.86
156 INT114546 Ins1 Positive_regulation of Positive_regulation of Trpv1 1 0.39 0.19 0.86
157 INT182555 Ptgir Regulation of Trpv1 1 0.12 0.61 0.85
158 INT260842 Binding of NRP2 and Kdr 1 0.00 2.28 0.85
159 INT338695 CAP1 Regulation of Trpv1 1 0.01 0.14 0.85
160 INT140660 Phax Negative_regulation of Trpv1 2 0.08 0.58 0.84
161 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
162 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
163 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
164 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
165 INT339293 Casp1 Regulation of Localization of Il1 1 0.07 1.87 0.83
166 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
167 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
168 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
169 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81
170 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
171 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
172 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
173 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8
174 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
175 INT168455 Sult1a1 Negative_regulation of Nos2 1 0.08 1.99 0.79
176 INT192134 Ngf Positive_regulation of Trpv1 1 0.18 1.22 0.79
177 INT125353 Binding of Sst and Trpv1 1 0.36 0.5 0.79
178 INT281651 Phax Positive_regulation of Gene_expression of Trpv1 1 0.09 0.89 0.79
179 INT161520 H2-M3 Regulation of Positive_regulation of Mapk1 1 0.09 0.47 0.79
180 INT132977 Tac1 Positive_regulation of Mapk1 1 0.06 0.17 0.79
181 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79
182 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
183 INT168457 Sult1a1 Positive_regulation of Cat 1 0.15 1.56 0.78
184 INT145430 oh Positive_regulation of Trpv1 1 0.05 0.15 0.78
185 INT351364 LPA Positive_regulation of Trpv1 1 0.02 1.15 0.78
186 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
187 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
188 INT152869 Tnf Positive_regulation of Gene_expression of Trpv1 1 0.46 0.48 0.77
189 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
190 INT114547 Ins1 Positive_regulation of Trpv1 1 0.36 0.19 0.77
191 INT129415 KNG1 Positive_regulation of Trpv1 1 0.05 0.39 0.76
192 INT108671 Positive_regulation of ras Positive_regulation of Positive_regulation of Trpv1 1 0.04 0.26 0.76
193 INT276865 Regulation of Trpv1 Regulation of Gene_expression of Gpr65 1 0.25 0.62 0.76
194 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
195 INT278490 Negative_regulation of Faah Positive_regulation of Trpv1 1 0.38 0.6 0.76
196 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
197 INT23681 Negative_regulation of Binding of Stx3 and Chrna7 1 0.00 0 0.75
198 INT23680 Binding of Stx3 and Chrna7 1 0.00 0 0.75
199 INT193276 Brs3 Negative_regulation of Gene_expression of Trpv1 1 0.03 0.14 0.75
200 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to chemical stimulus. They are ordered first by their pain relevance and then by number of times they were reported in response to chemical stimulus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59
2 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42
3 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42
4 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59
5 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94
6 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4
7 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75
8 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
9 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03
10 INT38731 Localization of Trpv1 138 0.81 52.73 90.49
11 INT4830 Binding of Trpv1 158 0.48 45.11 84.2
12 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46
13 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7
14 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
15 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23
16 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
17 INT87686 Positive_regulation of Gene_expression of Trpv1 101 0.70 72.41 69.15
18 INT96622 Localization of Trpv1 110 0.81 59.82 63.25
19 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72
20 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
21 INT98498 Binding of Trpv1 75 0.48 33.67 44.4
22 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
23 INT92437 Positive_regulation of Phosphorylation of Mapk1 113 0.70 32.19 40.29
24 INT114751 Gene_expression of Mapk1 137 0.76 60.14 39.98
25 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37
26 INT58062 Negative_regulation of Gene_expression of Trpv1 66 0.59 22.34 38.02
27 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38
28 INT80075 Regulation of Gene_expression of Trpv1 55 0.62 32.42 36.88
29 INT23330 Binding of Chrna7 79 0.48 10.06 35.5
30 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77
31 INT96624 Positive_regulation of Positive_regulation of Trpv1 62 0.70 20.5 34.28
32 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05
33 INT48925 Gene_expression of Mapk1 95 0.74 42.21 32.91
34 INT9347 Localization of Il1b 58 0.81 26.13 31.53
35 INT117112 Negative_regulation of Mapk1 87 0.56 40.34 31.18
36 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
37 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
38 INT95788 Positive_regulation of Positive_regulation of Mapk1 83 0.69 24.75 25.84
39 INT112036 Phosphorylation of Trpv1 51 0.82 18.59 25.6
40 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
41 INT103320 Positive_regulation of Positive_regulation of Trpv1 44 0.70 27.73 25.28
42 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01
43 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
44 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
45 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2
46 INT48081 Localization of Il1b 46 0.80 21.59 22.4
47 INT89056 Phosphorylation of Trpv1 46 0.82 13.52 22.16
48 INT96511 Negative_regulation of Positive_regulation of Trpv1 35 0.59 10.95 19.79
49 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
50 INT90937 Negative_regulation of Gene_expression of Trpv1 34 0.59 22.74 18.12
51 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
52 INT95790 Regulation of Mapk1 55 0.61 21.17 16.31
53 INT80972 Gene_expression of Tp53 104 0.78 102.74 16.02
54 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59
55 INT128401 Positive_regulation of Positive_regulation of Mapk1 39 0.70 10.88 15.38
56 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
57 INT97848 Positive_regulation of Localization of Trpv1 18 0.50 7.66 13.36
58 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18
59 INT101494 Regulation of Positive_regulation of Trpv1 18 0.62 6.57 12.9
60 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
61 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
62 INT150676 Positive_regulation of Gene_expression of Mapk1 30 0.45 10.06 12.37
63 INT119396 Regulation of Positive_regulation of Mapk1 22 0.61 7.88 12.25
64 INT145515 Positive_regulation of Localization of Trpv1 23 0.50 10.12 12.08
65 INT81640 Positive_regulation of Gene_expression of Bcl2 106 0.69 84.58 11.63
66 INT23675 Negative_regulation of Binding of Chrna7 18 0.37 0.5 10.74
67 INT69035 Positive_regulation of Casp1 43 0.69 25.18 10.67
68 INT112037 Negative_regulation of Positive_regulation of Trpv1 19 0.59 8.9 10.55
69 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
70 INT48921 Regulation of Mapk1 25 0.49 19.51 10.41
71 INT134625 Gene_expression of Kdr 116 0.71 53.13 10.09
72 INT169997 Positive_regulation of Gene_expression of Tp53 37 0.70 47.3 9.85
73 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
74 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51
75 INT89053 Positive_regulation of Phosphorylation of Trpv1 16 0.70 8.89 9.39
76 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98
77 INT50767 Positive_regulation of Nanog 14 0.67 3.63 8.56
78 INT70848 Gene_expression of Casp1 24 0.77 10.97 8.52
79 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
80 INT126848 Positive_regulation of Phosphorylation of Mapk1 30 0.50 15.94 8.34
81 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86
82 INT28358 Gene_expression of Nanog 25 0.70 3.52 7.85
83 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
84 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71
85 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
86 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
87 INT69033 Negative_regulation of Casp1 21 0.58 13.15 7.52
88 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
89 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
90 INT48928 Positive_regulation of Gene_expression of Mapk1 19 0.48 9.38 6.59
91 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
92 INT81586 Negative_regulation of Casp1 11 0.57 6.55 6.45
93 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
94 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42
95 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
96 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
97 INT90077 Gene_expression of Casp1 29 0.76 20.79 6.26
98 INT139964 Regulation of Phosphorylation of Mapk1 12 0.58 10.04 6.1
99 INT103319 Regulation of Positive_regulation of Trpv1 11 0.45 8.37 5.99
100 INT80750 Binding of Il1b 11 0.47 7.97 5.95
101 INT71220 Positive_regulation of Casp1 15 0.38 10.23 5.84
102 INT125187 Positive_regulation of Transcription of Trpv1 9 0.69 8.98 5.77
103 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
104 INT268043 Gene_expression of Abcc8 30 0.71 3.05 5.61
105 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
106 INT10705 Binding of Il1b 9 0.36 2.8 5.53
107 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
108 INT213741 Gene_expression of Kdr 60 0.75 44.24 5.35
109 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25
110 INT94357 Positive_regulation of Transcription of Trpv1 11 0.50 3.63 5.05
111 INT134610 Positive_regulation of Phosphorylation of Trpv1 9 0.69 4.51 4.74
112 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
113 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
114 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
115 INT158416 Localization of Mapk1 19 0.67 5.32 4.18
116 INT133244 Regulation of Positive_regulation of Mapk1 11 0.43 3.52 4.03
117 INT41942 Gene_expression of A2m 9 0.36 9.98 3.96
118 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92
119 INT113924 Binding of Mapk1 27 0.38 8.64 3.84
120 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
121 INT74684 Gene_expression of Mmp12 8 0.31 5.69 3.68
122 INT64203 Positive_regulation of Negative_regulation of Trpv1 5 0.47 3.39 3.67
123 INT141253 Regulation of Transcription of Trpv1 7 0.62 3.54 3.62
124 INT64825 Negative_regulation of Nanog 8 0.57 2.59 3.47
125 INT58063 Negative_regulation of Binding of Trpv1 6 0.59 1.54 3.21
126 INT81642 Regulation of Gene_expression of Bcl2 20 0.44 16.93 3.19
127 INT148190 Positive_regulation of Transcription of Nanog 1 0.49 0.2 3.17
128 INT64234 Regulation of Bcl2 41 0.54 31.88 3.16
129 INT138350 Regulation of Phosphorylation of Trpv1 6 0.58 1.87 3.16
130 INT171368 Regulation of Phosphorylation of Mapk1 14 0.61 4.77 3.14
131 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
132 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11
133 INT105884 Binding of Bcl2 19 0.35 15.67 3
134 INT196872 Negative_regulation of Localization of Trpv1 4 0.42 1.47 2.98
135 INT114263 Negative_regulation of Negative_regulation of Trpv1 6 0.43 2.71 2.92
136 INT178457 Positive_regulation of LIFR 12 0.56 3.98 2.9
137 INT200895 Localization of Mapk1 6 0.67 2.08 2.82
138 INT122787 Transcription of Nanog 4 0.67 0.78 2.81
139 INT122782 Negative_regulation of Positive_regulation of Nanog 3 0.57 1.15 2.81
140 INT169112 Negative_regulation of Positive_regulation of Mapk1 9 0.59 1.84 2.78
141 INT145821 Negative_regulation of Gene_expression of Mapk1 16 0.41 8.05 2.77
142 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
143 INT152927 Negative_regulation of Mapk1 16 0.41 5.85 2.73
144 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
145 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65
146 INT49473 Gene_expression of MSR1 14 0.75 7.28 2.64
147 INT107433 Localization of Casp1 6 0.56 2.44 2.64
148 INT118888 Regulation of Localization of Trpv1 5 0.44 1.43 2.64
149 INT125191 Regulation of Transcription of Trpv1 6 0.45 4.54 2.62
150 INT27412 Regulation of Nanog 7 0.58 0.81 2.59
151 INT156876 Positive_regulation of Gene_expression of Casp1 10 0.50 10.25 2.58
152 INT108691 Regulation of Binding of Trpv1 3 0.58 1.91 2.51
153 INT178458 Negative_regulation of LIFR 13 0.47 8.75 2.48
154 INT205692 Positive_regulation of Positive_regulation of Casp1 5 0.46 3 2.44
155 INT108395 Positive_regulation of Binding of Trpv1 5 0.50 1.26 2.39
156 INT147349 Localization of Bcl2 13 0.65 7.83 2.31
157 INT134626 Positive_regulation of Gene_expression of Kdr 20 0.63 14.63 2.29
158 INT195917 Regulation of Phosphorylation of Trpv1 2 0.52 1.86 2.29
159 INT262548 Regulation of Localization of Trpv1 2 0.45 0.73 2.25
160 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24
161 INT219180 Gene_expression of TLR7 13 0.68 9.51 2.21
162 INT116784 Regulation of Regulation of Trpv1 5 0.60 1.76 2.18
163 INT54969 Binding of Sult1a1 4 0.35 1.4 2.18
164 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13
165 INT261812 Positive_regulation of Negative_regulation of Trpv1 3 0.46 1.26 2.11
166 INT170482 Regulation of Gene_expression of Mapk1 5 0.43 5.73 2.1
167 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
168 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
169 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
170 INT146793 Positive_regulation of Tp53 30 0.70 32.93 1.94
171 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
172 INT188678 Binding of Tlr7 14 0.32 6.6 1.89
173 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
174 INT47425 Localization of Chrna7 11 0.81 6.7 1.86
175 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
176 INT62692 Localization of Nanog 3 0.73 0.82 1.85
177 INT51584 Regulation of KCNQ1 10 0.44 3.21 1.84
178 INT126539 Negative_regulation of Transcription of Trpv1 9 0.59 1.52 1.8
179 INT162725 Binding of Kdr 13 0.42 8.86 1.79
180 INT178188 Positive_regulation of Tlr7 12 0.40 6.33 1.77
181 INT41639 Positive_regulation of A2m 7 0.46 4.52 1.74
182 INT89008 Gene_expression of Lepr 2 0.65 5.39 1.66
183 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
184 INT135447 Transcription of Abcc8 5 0.63 1.55 1.64
185 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63
186 INT169461 Regulation of Gene_expression of Mapk1 7 0.44 1.64 1.61
187 INT113189 Gene_expression of Slc10a3 6 0.30 2.95 1.6
188 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57
189 INT174689 Gene_expression of Tlr7 11 0.67 8.24 1.56
190 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51
191 INT149510 Negative_regulation of Transcription of Trpv1 5 0.56 3.74 1.5
192 INT120004 Transcription of Tp53 8 0.72 4.92 1.48
193 INT190646 Regulation of Regulation of Mapk1 1 0.30 1.16 1.43
194 INT74683 Positive_regulation of Gene_expression of Mmp12 3 0.23 2.02 1.41
195 INT153627 Binding of Mapk1 5 0.36 2.88 1.4
196 INT330442 Negative_regulation of Regulation of Trpv1 1 0.37 1.69 1.38
197 INT145221 Binding of Tp53 10 0.37 8.59 1.37
198 INT69034 Regulation of Casp1 3 0.27 3.56 1.36
199 INT199567 Binding of Kdr 18 0.47 13.81 1.34
200 INT219159 Positive_regulation of TLR7 8 0.55 2.37 1.32
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