GO:0042277

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Name peptide binding
Categary Function
Go Slim No
Go Link GO:0042277
Unique Molecular Interactions 587
Total Molecular Interactions 758
Total Single Events 8657
Pain Genes Associated 72

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for peptide binding. They are ordered first by their pain relevance and then by number of times they were reported for peptide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7190 Syt17 Positive_regulation of Ctsb 1 0.16 0 3.23
2 INT7193 Abl2 Positive_regulation of Ctsb 1 0.21 0 3.21
3 INT324927 Syt17 Positive_regulation of Bdkrb1 1 0.04 4.29 2.96
4 INT7195 Negative_regulation of Syt17 Positive_regulation of Ctsb 1 0.10 0 2.25
5 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
6 INT227543 Mtx1 Positive_regulation of Prep 1 0.22 1.19 1.92
7 INT227542 Mtx1 Positive_regulation of Binding of Prep 1 0.23 1.2 1.92
8 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
9 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68
10 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
11 INT187175 Binding of BSG and PPIA 1 0.14 2.23 1.64
12 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
13 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
14 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
15 INT237286 Dlat Regulation of Prep 1 0.01 0 1.57
16 INT66713 Binding of BDKRB1 and KNG1 2 0.22 0.39 1.53
17 INT166360 Negative_regulation of Crhr1 Negative_regulation of Positive_regulation of Pomc 1 0.02 0.36 1.5
18 INT201950 IFNA1 Positive_regulation of Binding of DPP4 1 0.12 2.17 1.47
19 INT201946 IFNA1 Positive_regulation of DPP4 1 0.17 2.16 1.46
20 INT356317 Crhr1 Regulation of Gene_expression of Cea 1 0.18 0.65 1.33
21 INT356326 Crhr1 Regulation of Gene_expression of Helt 1 0.01 0.65 1.32
22 INT330124 Positive_regulation of Bdkrb1 Positive_regulation of RT1-O2-ps 1 0.02 1.97 1.3
23 INT201942 DPP4 Negative_regulation of CXCL10 1 0.33 0.9 1.3
24 INT118784 Thop1 Positive_regulation of Protein_catabolism of Pax3 1 0.07 0.07 1.25
25 INT162343 Positive_regulation of KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
26 INT162344 KCNMA1 Positive_regulation of ACE 1 0.06 1.25 1.23
27 INT7186 Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
28 INT7184 Negative_regulation of Trib3 Negative_regulation of Positive_regulation of Ctsb 1 0.03 0 1.21
29 INT165929 Binding of MME and WSN 1 0.01 0.99 1.16
30 INT24796 ACE Positive_regulation of Localization of HMMR 1 0.00 0.58 1.16
31 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16
32 INT60134 MME Negative_regulation of GRP 1 0.20 0 1.12
33 INT60133 MME Negative_regulation of SST 1 0.10 0 1.12
34 INT209088 Binding of Ceacam3 and Crhr1 1 0.34 1.26 1.11
35 INT172757 Rnpep Positive_regulation of Hps4 1 0.00 0 1.08
36 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06
37 INT7191 Negative_regulation of Abl2 Positive_regulation of Ctsb 1 0.13 0 1.04
38 INT45665 Fpr1 Negative_regulation of Mme 1 0.13 0 1
39 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99
40 INT90385 EXTL3 Regulation of Ctsl 1 0.00 1.1 0.98
41 INT240457 Binding of Ppyr1 and Grina 1 0.06 0.42 0.96
42 INT227545 Hspa9 Positive_regulation of Prep 1 0.18 0.59 0.96
43 INT66714 Negative_regulation of Binding of BDKRB1 and KNG1 1 0.13 0.22 0.96
44 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92
45 INT72917 Binding of Crh and Crhr1 4 0.32 0.73 0.91
46 INT92423 EC3 Negative_regulation of Mme 1 0.02 0.28 0.86
47 INT308495 Pcsk5 Regulation of CFI 1 0.01 0.22 0.85
48 INT105282 Thop1 Positive_regulation of Protein_catabolism of Pnoc 1 0.17 0.1 0.85
49 INT105281 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Pnoc 1 0.16 0.09 0.84
50 INT129881 Binding of Calr and Cbll1 1 0.00 0.58 0.84
51 INT127240 Bdkrb1 Regulation of Ssr1 1 0.01 0.08 0.84
52 INT105280 Negative_regulation of Thop1 Negative_regulation of Positive_regulation of Pnoc 1 0.14 0.09 0.83
53 INT19299 ANG Regulation of AVP 1 0.25 0 0.82
54 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
55 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
56 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8
57 INT84466 DPP4 Regulation of Localization of Naga 1 0.00 0.87 0.78
58 INT110578 PENK Positive_regulation of Gene_expression of MME 1 0.35 0.1 0.76
59 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75
60 INT46916 Binding of Thop1 and Positive_regulation of Penk 1 0.14 0 0.74
61 INT201947 IFNA1 Positive_regulation of Gene_expression of DPP4 1 0.11 1.09 0.74
62 INT4875 TNF Regulation of MME 1 0.51 0.71 0.74
63 INT316673 Binding of CALR and LRP1 1 0.39 1.89 0.74
64 INT46920 Thop1 Regulation of Vom1r1 1 0.03 0 0.74
65 INT46918 Binding of Thop1 and Positive_regulation of Vom1r1 1 0.03 0 0.74
66 INT290548 Positive_regulation of Crhr1 Positive_regulation of Etf1 1 0.01 0.38 0.72
67 INT36219 Mme Positive_regulation of Protein_catabolism of Penk 1 0.39 0 0.72
68 INT31243 Binding of Mme and Cpe 1 0.01 0 0.72
69 INT29380 Binding of gp and Mme 1 0.01 0 0.71
70 INT110577 MME Positive_regulation of Protein_catabolism of POMC 1 0.49 0.06 0.71
71 INT12052 Xcl1 Negative_regulation of Rnpep 1 0.01 0 0.71
72 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
73 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
74 INT253759 Hmgb1 Positive_regulation of Apex1 1 0.09 4.53 0.69
75 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
76 INT215093 Tlr4 Positive_regulation of Localization of Hmgb1 1 0.32 2.9 0.68
77 INT122190 Binding of Crhr1 and Ucn 4 0.49 0.65 0.67
78 INT28079 POMC Regulation of ANPEP 1 0.08 0.16 0.66
79 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
80 INT14613 Negative_regulation of MME Negative_regulation of Positive_regulation of POMC 1 0.06 0.24 0.65
81 INT29381 gp Regulation of Mme 1 0.01 0 0.65
82 INT29382 Positive_regulation of gp Regulation of Mme 1 0.02 0 0.65
83 INT14614 Negative_regulation of MME Negative_regulation of POMC 1 0.06 0.24 0.65
84 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64
85 INT356329 Crhr1 Regulation of Cea 1 0.09 0.31 0.64
86 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64
87 INT255994 Binding of Ang and Il1rn 1 0.09 1.21 0.63
88 INT356314 Binding of Crhr1 and ORF61 1 0.00 0 0.63
89 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
90 INT237285 Dlat Negative_regulation of Prep 1 0.01 0 0.62
91 INT79210 Hps4 Negative_regulation of Mme 1 0.00 0 0.62
92 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
93 INT36320 PDYN Negative_regulation of Ctsb 1 0.00 0 0.61
94 INT227544 Hspa9 Regulation of Gene_expression of Prep 1 0.15 0.57 0.61
95 INT21607 ACE Positive_regulation of ANGPT2 1 0.03 0.13 0.61
96 INT324925 Ros1 Positive_regulation of Bdkrb1 1 0.08 0.67 0.6
97 INT253760 Hmgb1 Positive_regulation of Gene_expression of Apex1 1 0.10 3.53 0.58
98 INT181619 ACE Positive_regulation of KNG1 1 0.33 0.97 0.58
99 INT120349 Binding of BDKRB1 and DES 1 0.05 0.17 0.58
100 INT47284 Binding of Mme and Ctsa 1 0.21 0 0.57
101 INT73368 Ang1 Negative_regulation of Fabp6 1 0.00 0.44 0.56
102 INT356321 Positive_regulation of Crhr1 Positive_regulation of Cea 1 0.19 0.37 0.56
103 INT323611 Il1 Regulation of Hmgb1 1 0.17 2.36 0.55
104 INT215101 Hmgb1 Positive_regulation of Localization of Il6 4 0.16 1.18 0.54
105 INT19690 Enpep Regulation of Negative_regulation of Penk 1 0.28 0 0.54
106 INT356322 Positive_regulation of Crhr1 Positive_regulation of ORF61 1 0.00 0 0.54
107 INT54239 Binding of Mme and Nts 1 0.21 0 0.54
108 INT255999 Binding of Ang and H7 1 0.00 0.38 0.54
109 INT192160 Cxcl9 Negative_regulation of Furin 1 0.02 0.8 0.54
110 INT55445 Positive_regulation of Ahr Regulation of Mme 1 0.23 0 0.53
111 INT192162 Furin Positive_regulation of Mmp14 1 0.10 0.79 0.53
112 INT253767 Binding of Hmgb1 and Tlr9 2 0.12 1.78 0.52
113 INT303721 KNG1 Positive_regulation of Bdkrb1 1 0.05 0.75 0.52
114 INT130161 IgG-2a Positive_regulation of Gene_expression of Crhr1 1 0.01 0 0.52
115 INT292075 FSCN1 Positive_regulation of Gene_expression of Csnk1a1 1 0.03 0.57 0.52
116 INT130158 Pomc Regulation of Gene_expression of Crhr1 1 0.20 0 0.52
117 INT130163 Pomc Positive_regulation of Gene_expression of Crhr1 1 0.15 0 0.52
118 INT130159 IgG-2a Regulation of Gene_expression of Crhr1 1 0.01 0 0.52
119 INT303720 Prkaca Regulation of Bdkrb1 1 0.02 0.33 0.52
120 INT205030 Crh Positive_regulation of Crhr1 2 0.54 1.33 0.51
121 INT253770 Hmgb1 Positive_regulation of Localization of Apex1 1 0.08 0.71 0.49
122 INT254638 Bdkrb2 Positive_regulation of Positive_regulation of Bdkrb1 1 0.09 0.96 0.48
123 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
124 INT88696 Tac1 Regulation of Regulation of Mme 1 0.00 0.39 0.48
125 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48
126 INT145954 Binding of BSG and MME 1 0.00 0.81 0.47
127 INT261648 BDKRB1 Regulation of PRKCA 1 0.03 1.9 0.47
128 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
129 INT19297 ANG Positive_regulation of AVP 1 0.28 0 0.46
130 INT342633 ACE Regulation of Gene_expression of AGT 1 0.01 0.14 0.46
131 INT242401 Negative_regulation of Bdkrb1 Negative_regulation of Gene_expression of Mcpt1 1 0.16 1.45 0.46
132 INT41039 Thop1 Positive_regulation of Mme 1 0.01 0 0.45
133 INT242402 Negative_regulation of Bdkrb1 Positive_regulation of Hmox1 1 0.17 1.44 0.45
134 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
135 INT321293 Binding of Nr1h4 and Nr0b2 1 0.18 0.31 0.43
136 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 0.02 0.25 0.43
137 INT92422 Mme Negative_regulation of EC3 1 0.01 0.14 0.43
138 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43
139 INT189309 Binding of MME and PENK 1 0.15 1.16 0.42
140 INT201943 Regulation of Binding of DPP4 and CXCL10 1 0.20 0.58 0.42
141 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
142 INT346238 PREP Negative_regulation of IL1B 1 0.04 0.99 0.41
143 INT335643 CTSB Positive_regulation of PAR4 1 0.01 1.3 0.41
144 INT19298 ANG Regulation of OXT 1 0.07 0 0.41
145 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
146 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
147 INT201948 Binding of DPP4 and CXCL10 1 0.27 0.54 0.39
148 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39
149 INT266530 Ppyr1 Positive_regulation of Fig4 1 0.01 0 0.38
150 INT330120 Bdkrb2 Regulation of Bdkrb1 1 0.19 1.26 0.38
151 INT262153 Binding of Clta and Nr1i2 1 0.05 0.65 0.38
152 INT316675 Binding of CALR and SFTPD 1 0.35 0.96 0.37
153 INT4876 Regulation of TNF Regulation of MME 1 0.37 0.36 0.37
154 INT229222 Negative_regulation of ACE Negative_regulation of Protein_catabolism of KNG1 1 0.06 0.53 0.37
155 INT324823 Tlr4 Positive_regulation of Gene_expression of Hmgb1 1 0.21 0.51 0.37
156 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
157 INT324818 Hmgb1 Positive_regulation of Gene_expression of Tlr4 1 0.21 0.51 0.37
158 INT324819 Hmgb1 Positive_regulation of Gene_expression of Maob 1 0.09 0.44 0.37
159 INT122189 Binding of Crhr1 and Ucn2 2 0.08 0.27 0.36
160 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
161 INT127099 Memo1 Negative_regulation of Nfkb1 1 0.11 0.57 0.36
162 INT77494 PREP Positive_regulation of TRH 1 0.16 0 0.36
163 INT262189 Binding of Nr1i2 and Nr1h4 1 0.14 0.18 0.36
164 INT127100 Memo1 Negative_regulation of Binding of Nfkb1 1 0.11 0.57 0.36
165 INT242403 INSR Positive_regulation of Gene_expression of Bdkrb1 1 0.45 0.88 0.35
166 INT230786 Binding of AGT and ACE 4 0.15 2.53 0.34
167 INT37328 Binding of PDYN and Mme 1 0.02 0 0.34
168 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
169 INT346229 PREP Positive_regulation of MAPK14 1 0.13 0.63 0.34
170 INT262218 Nr1h4 Regulation of Nr1i2 1 0.10 0.15 0.34
171 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
172 INT24127 Cast Positive_regulation of Mme 1 0.15 0 0.33
173 INT14062 Binding of POMC and RNPEP 1 0.01 0 0.33
174 INT110350 Positive_regulation of Arigg3 Positive_regulation of Positive_regulation of Dpp4 1 0.01 0 0.33
175 INT59602 Crhr1 Positive_regulation of Localization of LH 1 0.25 0 0.33
176 INT33581 Thop1 Positive_regulation of Cpe 1 0.01 0 0.33
177 INT230852 ACE Regulation of KNG1 2 0.03 0.72 0.32
178 INT39594 TPO Positive_regulation of CALR 1 0.30 0.91 0.32
179 INT356323 Binding of ac and Crhr1 1 0.01 0 0.32
180 INT15141 MME Negative_regulation of IL1B 1 0.39 0.19 0.32
181 INT253762 Binding of Apex1 and Hmgb1 1 0.09 1.29 0.32
182 INT35216 Binding of KNG1 and Thop1 1 0.01 0 0.32
183 INT311228 DPP4 Negative_regulation of Localization of GLP1R 1 0.31 1.25 0.32
184 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
185 INT150050 Mtor Positive_regulation of Rps6kb1 3 0.49 1.44 0.3
186 INT40219 Ang Negative_regulation of REN 1 0.00 0 0.3
187 INT80304 Nrd1 Negative_regulation of Furin 1 0.01 0 0.3
188 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
189 INT265826 Binding of ACE and SERPINE1 1 0.24 1.08 0.3
190 INT50107 Ei24 Positive_regulation of Localization of CTSB 3 0.00 0.6 0.29
191 INT126696 Binding of Crhr1 and Crh 3 0.50 0.44 0.29
192 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
193 INT200639 Ace Positive_regulation of Gene_expression of TGFB1 1 0.06 1.36 0.29
194 INT262208 Clta Positive_regulation of Nr1i2 1 0.09 0.59 0.29
195 INT134927 CYP19A1 Positive_regulation of Gene_expression of MME 1 0.30 1.04 0.28
196 INT264782 Binding of CRH and CRHR1 1 0.02 0.06 0.28
197 INT214615 FOXC1 Positive_regulation of Gene_expression of Ang 1 0.01 0.29 0.28
198 INT15142 MME Regulation of IL1B 1 0.40 0.16 0.28
199 INT134930 MME Positive_regulation of Gene_expression of CYP19A1 1 0.30 1.04 0.28
200 INT258858 CTSB Positive_regulation of Gene_expression of IL8 1 0.00 0.64 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for peptide binding. They are ordered first by their pain relevance and then by number of times they were reported in peptide binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
2 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
3 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59
4 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
5 INT49643 Gene_expression of Bdkrb1 39 0.78 46.49 40.21
6 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
7 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
8 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
9 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89
10 INT5232 Negative_regulation of Enpep 56 0.57 3.25 26.7
11 INT4877 Gene_expression of MME 184 0.78 122.82 24.78
12 INT114362 Localization of Hmgb1 127 0.78 120.28 23.26
13 INT292049 Gene_expression of Csnk1a1 1 0.59 28.22 19.53
14 INT9490 Regulation of Mme 44 0.56 6.69 19.21
15 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
16 INT84464 Gene_expression of DPP4 101 0.78 56.15 17.53
17 INT30517 Negative_regulation of Bdkrb1 16 0.58 16.52 16.88
18 INT15237 Protein_catabolism of Mme 31 0.96 10.26 16.69
19 INT15166 Positive_regulation of Mme 40 0.70 13.01 16.24
20 INT3926 Regulation of Bdkrb1 22 0.61 16.72 16.1
21 INT59987 Gene_expression of BDKRB1 25 0.77 11.95 15.93
22 INT78827 Gene_expression of Bdkrb1 34 0.78 18.48 15.81
23 INT9751 Localization of Crhr1 26 0.78 10.47 15.69
24 INT61301 Positive_regulation of Gene_expression of Bdkrb1 7 0.68 16.95 15.44
25 INT14453 Localization of Mme 44 0.80 2.46 14.75
26 INT20665 Gene_expression of ACE 87 0.78 51.71 14.19
27 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79
28 INT3623 Negative_regulation of CTSB 49 0.55 27.39 13.52
29 INT39553 Gene_expression of Hmgb1 50 0.75 51.18 12.21
30 INT7350 Negative_regulation of Anpep 30 0.59 2.89 11.28
31 INT104039 Positive_regulation of Crhr1 15 0.70 8.34 10.99
32 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63
33 INT11205 Gene_expression of Prep 65 0.77 8.11 10.12
34 INT29740 Gene_expression of ANG 55 0.78 24.53 9.86
35 INT132036 Negative_regulation of DPP4 126 0.59 63.24 9.51
36 INT18941 Regulation of Enpep 17 0.55 2.56 9.38
37 INT47301 Gene_expression of Ctsl 27 0.76 7.72 9.32
38 INT20664 Binding of ACE 60 0.48 35.27 9.16
39 INT7104 Binding of Bdkrb1 6 0.37 6.54 9.02
40 INT7572 Regulation of Crhr1 8 0.45 5.6 8.93
41 INT38173 Gene_expression of Ang 40 0.75 32.63 8.86
42 INT3622 Regulation of CTSB 34 0.58 16.08 8.76
43 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61
44 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31
45 INT4880 Regulation of MME 17 0.61 7.78 8.2
46 INT88919 Positive_regulation of Casp9 39 0.70 28.64 8.18
47 INT114363 Positive_regulation of Hmgb1 50 0.67 48.92 8.15
48 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
49 INT113038 Positive_regulation of Gene_expression of Bdkrb1 12 0.69 7.11 7.93
50 INT25958 Regulation of Ace 26 0.59 11.88 7.87
51 INT8603 Binding of Mme 28 0.48 1.42 7.64
52 INT7570 Transcription of Crhr1 7 0.66 6.6 7.6
53 INT7168 Positive_regulation of Ctsb 9 0.70 0.3 7.58
54 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51
55 INT74326 Gene_expression of Crhr1 25 0.66 9.7 7.48
56 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
57 INT81378 Negative_regulation of Dpp4 18 0.59 7.87 7.42
58 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41
59 INT80161 Positive_regulation of Crhr1 13 0.67 9.66 7.33
60 INT3928 Localization of Bdkrb1 15 0.75 4.06 7.23
61 INT42038 Localization of ACE 26 0.80 8.88 7.06
62 INT14865 Regulation of Prep 20 0.55 4.21 6.75
63 INT98260 Negative_regulation of Gene_expression of Bdkrb1 4 0.57 5.98 6.7
64 INT70139 Regulation of Bdkrb1 6 0.52 8.41 6.66
65 INT9753 Positive_regulation of Localization of Crhr1 8 0.49 1.72 6.55
66 INT65772 Positive_regulation of Positive_regulation of Bdkrb1 6 0.49 8.34 6.54
67 INT292062 Negative_regulation of Csnk1a1 1 0.44 7.57 6.52
68 INT85655 Gene_expression of Crhr1 17 0.68 9.34 6.31
69 INT24504 Localization of Anpep 19 0.80 3.44 6.23
70 INT168446 Gene_expression of Prep 25 0.64 15.17 5.94
71 INT52464 Negative_regulation of Bdkrb1 9 0.57 8.71 5.87
72 INT190520 Negative_regulation of Hmgb1 24 0.53 20.08 5.6
73 INT15143 Protein_catabolism of MME 16 1.00 4.56 5.54
74 INT3768 Negative_regulation of ANPEP 16 0.59 4.96 5.52
75 INT81326 Positive_regulation of Gene_expression of Ang 17 0.67 18.5 5.46
76 INT33291 Protein_catabolism of Enpep 15 0.85 0.51 5.41
77 INT292072 Positive_regulation of Gene_expression of Csnk1a1 1 0.53 9.76 5.39
78 INT11062 Positive_regulation of MME 24 0.63 14.37 5.26
79 INT50105 Localization of CTSB 29 0.78 10.98 5.21
80 INT125396 Positive_regulation of Positive_regulation of Bdkrb1 5 0.69 5.14 5.2
81 INT8653 Protein_catabolism of Thop1 13 0.92 0.73 5.16
82 INT34358 Binding of MME 13 0.37 7.25 5.14
83 INT59983 Regulation of BDKRB1 12 0.45 10.69 5.11
84 INT71841 Negative_regulation of Thop1 7 0.48 0.41 5.08
85 INT14027 Positive_regulation of Prep 29 0.69 3.63 4.99
86 INT71243 Negative_regulation of Ppyr1 12 0.36 1.46 4.91
87 INT113037 Transcription of Bdkrb1 4 0.69 3.89 4.82
88 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81
89 INT7568 Negative_regulation of Crhr1 8 0.43 4.63 4.77
90 INT7170 Positive_regulation of Positive_regulation of Ctsb 1 0.40 0 4.76
91 INT81761 Negative_regulation of Prep 12 0.55 8.48 4.73
92 INT94453 Gene_expression of ITGB1 50 0.75 18.41 4.72
93 INT17103 Negative_regulation of Prep 15 0.38 4.95 4.71
94 INT292060 Positive_regulation of Csnk1a1 1 0.53 6.03 4.57
95 INT113039 Binding of Bdkrb1 9 0.48 5.71 4.51
96 INT24619 Regulation of Thop1 11 0.44 1.24 4.5
97 INT26477 Regulation of ACE 26 0.45 16.31 4.33
98 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
99 INT103037 Transcription of Bdkrb1 8 0.70 4.76 4.33
100 INT292057 Regulation of Csnk1a1 1 0.34 3.52 4.33
101 INT9456 Gene_expression of Anpep 9 0.78 1.69 4.26
102 INT387 Regulation of Ace 18 0.45 5.24 4.24
103 INT21817 Binding of Thop1 9 0.48 0.88 4.19
104 INT48518 Gene_expression of ANPEP 51 0.78 22.88 4.18
105 INT215071 Positive_regulation of Localization of Hmgb1 34 0.63 22.03 4.15
106 INT215085 Positive_regulation of Gene_expression of Hmgb1 17 0.63 16.81 4.13
107 INT110348 Negative_regulation of Dpp4 28 0.46 22.39 4.12
108 INT47298 Localization of Ctsl 13 0.79 3.77 4.08
109 INT215074 Negative_regulation of Localization of Hmgb1 28 0.57 15.09 4
110 INT11872 Protein_catabolism of Rnpep 6 0.87 0 4
111 INT1722 Protein_catabolism of ACE 10 0.88 2.61 3.76
112 INT133788 Negative_regulation of Gene_expression of Bdkrb1 7 0.58 3.49 3.75
113 INT61300 Negative_regulation of Binding of Bdkrb1 3 0.42 3 3.69
114 INT76229 Binding of BDKRB1 5 0.33 1.46 3.66
115 INT13451 Positive_regulation of DPP4 23 0.68 9.33 3.62
116 INT85537 Regulation of Crhr1 4 0.45 1.64 3.53
117 INT20265 Gene_expression of Ctsb 3 0.47 1.01 3.52
118 INT59984 Regulation of Gene_expression of BDKRB1 2 0.45 2.08 3.47
119 INT59986 Localization of BDKRB1 5 0.61 1.69 3.45
120 INT122997 Phosphorylation of Rps6kb1 46 0.72 9.92 3.43
121 INT201959 Positive_regulation of Gene_expression of DPP4 13 0.53 6.24 3.4
122 INT46513 Gene_expression of Ppyr1 2 0.56 2.14 3.4
123 INT30238 Positive_regulation of Anpep 14 0.66 2.77 3.38
124 INT61341 Positive_regulation of Prep 12 0.63 6.08 3.37
125 INT11616 Gene_expression of Thop1 10 0.74 0.32 3.34
126 INT12388 Negative_regulation of Crhr1 17 0.59 9.47 3.33
127 INT227524 Positive_regulation of Gene_expression of Prep 13 0.48 7.69 3.28
128 INT18477 Protein_catabolism of ANPEP 7 0.79 0.41 3.26
129 INT29333 Positive_regulation of Enpep 8 0.70 3.22 3.25
130 INT22492 Binding of Enpep 10 0.47 0.7 3.2
131 INT127336 Positive_regulation of Transcription of Crhr1 3 0.48 3.37 3.19
132 INT292056 Localization of Csnk1a1 1 0.57 3.99 3.17
133 INT35910 Binding of Mme 8 0.37 4.79 3.16
134 INT37111 Regulation of Negative_regulation of Mme 7 0.44 2.61 3.13
135 INT116143 Positive_regulation of Casp9 32 0.67 30.34 3.04
136 INT66716 Negative_regulation of BDKRB1 4 0.48 1.31 3
137 INT228677 Negative_regulation of Phosphorylation of Rps6kb1 24 0.51 3.88 2.97
138 INT35548 Regulation of Mme 9 0.45 10.62 2.97
139 INT12887 Positive_regulation of Mme 9 0.60 15.41 2.93
140 INT201952 Binding of DPP4 11 0.37 8.81 2.91
141 INT37734 Positive_regulation of Ang 18 0.46 9.17 2.87
142 INT30228 Protein_catabolism of Anpep 3 0.42 0.82 2.87
143 INT9752 Regulation of Localization of Crhr1 3 0.44 0.36 2.82
144 INT11291 Positive_regulation of Gene_expression of Mme 6 0.61 5.93 2.81
145 INT321310 Positive_regulation of Nr1h4 1 0.49 1.75 2.75
146 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
147 INT7148 Negative_regulation of Negative_regulation of Mme 6 0.42 2.19 2.74
148 INT110980 Gene_expression of CTSB 17 0.45 8.02 2.69
149 INT12051 Negative_regulation of Rnpep 7 0.36 0.42 2.59
150 INT70380 Transcription of Prep 7 0.62 0.43 2.54
151 INT73028 Positive_regulation of Transcription of Ctsb 1 0.55 1.53 2.54
152 INT59135 Positive_regulation of CTSB 15 0.67 7.53 2.53
153 INT81377 Gene_expression of Dpp4 8 0.71 5.15 2.51
154 INT8512 Gene_expression of PREP 17 0.65 7.98 2.5
155 INT292070 Binding of Csnk1a1 1 0.28 3.18 2.5
156 INT61805 Positive_regulation of Dpp4 4 0.44 0.41 2.49
157 INT9455 Negative_regulation of Rnpep 5 0.31 0.52 2.47
158 INT4879 Positive_regulation of Gene_expression of MME 17 0.69 12.48 2.46
159 INT141183 Gene_expression of Casp9 9 0.75 11.96 2.46
160 INT169073 Positive_regulation of Nr1h4 8 0.47 2.44 2.45
161 INT303703 Positive_regulation of Transcription of Bdkrb1 2 0.21 2.91 2.41
162 INT54555 Negative_regulation of CALR 10 0.41 4.41 2.4
163 INT133789 Regulation of Gene_expression of Bdkrb1 5 0.39 3 2.38
164 INT6404 Gene_expression of Thop1 3 0.64 0.18 2.36
165 INT149975 Negative_regulation of Ppif 1 0.41 0.44 2.36
166 INT24997 Protein_catabolism of Anpep 6 0.96 0 2.34
167 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
168 INT37427 Positive_regulation of Gene_expression of Ctsb 2 0.37 1.02 2.33
169 INT31796 Gene_expression of Enpep 5 0.65 0.42 2.32
170 INT61340 Regulation of Prep 7 0.50 6.13 2.31
171 INT26434 Localization of MME 17 0.81 8.67 2.3
172 INT84465 Localization of DPP4 8 0.75 7.28 2.29
173 INT7173 Regulation of Positive_regulation of Ctsb 1 0.49 0 2.29
174 INT28833 Localization of Bdkrb1 3 0.81 2.17 2.28
175 INT26514 Regulation of Gene_expression of Mme 2 0.41 1.18 2.27
176 INT129280 Gene_expression of Casp9 9 0.68 5.48 2.25
177 INT30137 Negative_regulation of TPP1 5 0.37 0.96 2.2
178 INT169072 Gene_expression of Nr1h4 7 0.60 6.23 2.18
179 INT21819 Localization of Thop1 7 0.79 0.36 2.14
180 INT18480 Positive_regulation of ANPEP 9 0.59 5.18 2.13
181 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
182 INT39134 Positive_regulation of Ace2 3 0.14 0.57 2.13
183 INT37733 Negative_regulation of Ang 11 0.41 3.23 2.09
184 INT51980 Protein_catabolism of Mme 6 0.89 2.49 2.06
185 INT47303 Regulation of Ctsl 10 0.56 2.64 2.04
186 INT28832 Negative_regulation of Positive_regulation of Bdkrb1 3 0.23 1.36 2.04
187 INT333132 Negative_regulation of Gene_expression of Ppyr1 1 0.42 1.81 2.04
188 INT71870 Positive_regulation of Gene_expression of Mme 6 0.48 4.27 2
189 INT51570 Regulation of Anpep 6 0.43 1.7 2
190 INT62556 Positive_regulation of Gene_expression of BDKRB1 3 0.46 0.65 1.98
191 INT70526 Binding of CALR 11 0.35 7.09 1.97
192 INT21941 Regulation of CALR 7 0.53 3.88 1.96
193 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
194 INT149761 Negative_regulation of MAS1 5 0.29 1.91 1.95
195 INT43084 Binding of Ace 10 0.46 4.7 1.93
196 INT33096 Negative_regulation of Gene_expression of ACE 9 0.43 2.84 1.93
197 INT58208 Negative_regulation of Ctsl 8 0.53 3.49 1.91
198 INT39133 Binding of Ace2 3 0.30 0.8 1.89
199 INT148917 Positive_regulation of Transcription of Bdkrb1 4 0.50 0.88 1.83
200 INT55606 Binding of Ace 14 0.37 10.73 1.82
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