GO:0042288

From wiki-pain
Jump to: navigation, search
Name MHC class I protein binding
Categary Function
Go Slim No
Go Link GO:0042288
Unique Molecular Interactions 137
Total Molecular Interactions 176
Total Single Events 1291
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for MHC class I protein binding. They are ordered first by their pain relevance and then by number of times they were reported for MHC class I protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72755 Tap1 Negative_regulation of TNF 1 0.43 2.45 1.46
2 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72
3 INT209956 Binding of CD8A and RDBP 1 0.01 0.3 0.7
4 INT230532 LILRB1 Positive_regulation of Gene_expression of Mmp2 1 0.14 1.04 0.5
5 INT230533 LILRB1 Positive_regulation of Positive_regulation of Mmp9 1 0.20 1.03 0.5
6 INT330522 Binding of CD8A and TNFSF10 1 0.17 1.24 0.48
7 INT148611 Binding of CD8A and Cr2 1 0.02 0.81 0.44
8 INT330519 Binding of CD8A and DICER1 1 0.08 0.99 0.38
9 INT330516 Binding of CD8A and CCR6 1 0.07 0.99 0.38
10 INT330517 Binding of CD8A and HLA-DRB4 1 0.08 0.99 0.38
11 INT27029 HERPUD1 Regulation of Gene_expression of CD8A 1 0.41 0 0.34
12 INT27035 HERPUD1 Regulation of CD8A 1 0.18 0 0.34
13 INT194621 TNF Positive_regulation of Gene_expression of Klrk1 1 0.05 0.5 0.32
14 INT194614 Il15 Positive_regulation of Gene_expression of Klrk1 1 0.04 0.5 0.32
15 INT141882 Binding of CD8A and HLA-A 1 0.32 0.9 0.29
16 INT202016 Binding of LILRB2 and MRAP 1 0.14 0.38 0.23
17 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
18 INT202017 Negative_regulation of Binding of LILRB2 and MRAP 1 0.13 0.38 0.23
19 INT63202 POMC Positive_regulation of CD8A 1 0.30 0.3 0.23
20 INT63201 PTH Positive_regulation of CD8A 1 0.45 0.29 0.22
21 INT78349 Binding of GALR1 and TUBB 1 0.39 0 0.21
22 INT330520 Positive_regulation of Binding of CD8A and TNFSF10 1 0.19 0.62 0.21
23 INT252817 Binding of CD8A and IL12A 1 0.02 1.36 0.19
24 INT353298 IFNA1 Positive_regulation of CD8A 1 0.04 0.75 0.19
25 INT132267 Binding of SGCG and Tap1 1 0.05 0.24 0.18
26 INT226380 Gene_expression of IL15 Negative_regulation of Positive_regulation of CD8A 1 0.02 1.59 0.18
27 INT350149 SH2B3 Regulation of CD8A 1 0.13 0.86 0.17
28 INT116442 CD8B Negative_regulation of Positive_regulation of NFKB1 1 0.02 0 0.17
29 INT302553 Binding of CD8A and MID1 1 0.01 0.38 0.17
30 INT310937 Binding of CD8A and COPD 1 0.16 1.21 0.16
31 INT252326 Binding of Cx3cl1 and Klrk1 1 0.01 0.23 0.16
32 INT275412 Binding of TYROBP and LILRB2 1 0.02 0.29 0.16
33 INT249685 Binding of CD8A and GRDX 1 0.02 0.46 0.16
34 INT181841 Binding of CD8A and PHB2 1 0.01 0.75 0.13
35 INT181844 Binding of CD8A and HLA-B 1 0.14 1.82 0.12
36 INT317243 Npy Positive_regulation of Tap2 1 0.08 0 0.1
37 INT317260 Pyy Positive_regulation of Tap2 1 0.09 0 0.1
38 INT219155 Binding of HLA-G and LILRB2 1 0.15 0.23 0.1
39 INT181845 Binding of CD8A and IFN1@ 2 0.13 0.65 0.09
40 INT333095 Localization of IL2 Negative_regulation of Negative_regulation of CD8A 1 0.10 0.8 0.09
41 INT337536 Binding of Klrk1 and COPD 1 0.03 3.09 0.09
42 INT163664 Binding of CD8A and KRT20 1 0.27 0.5 0.09
43 INT333121 Pol Positive_regulation of CD8A 1 0.00 0.08 0.09
44 INT333097 ERVW-1 Positive_regulation of CD8A 1 0.02 0.08 0.08
45 INT116439 CD8B Negative_regulation of Gene_expression of CCL2 1 0.02 0 0.08
46 INT210288 Binding of CD8A and ELAVL4 1 0.27 1.21 0.07
47 INT333098 Binding of CD8A and IL2 1 0.01 0.17 0.07
48 INT335712 Binding of FASLG and CD8A 1 0.18 0.9 0.06
49 INT335713 Binding of FAS and CD8A 1 0.32 0.9 0.06
50 INT237151 Binding of Klrk1 and Ulbp1 1 0.05 1.02 0.05
51 INT317257 Binding of Tap2 and Pyy 1 0.06 0 0.05
52 INT317242 Binding of Tap2 and Npy 1 0.05 0 0.05
53 INT237149 Binding of H60a and Klrk1 1 0.24 1.01 0.05
54 INT333090 Localization of IFN1@ Negative_regulation of Negative_regulation of CD8A 1 0.10 0.4 0.05
55 INT237150 Binding of Klrk1 and Rae1 1 0.04 1.14 0.05
56 INT181168 Binding of CD79A and TAPBP 1 0.10 0.7 0.04
57 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04
58 INT225027 Binding of TAPBP and TRERF1 1 0.33 0 0.04
59 INT236235 HLA-A Positive_regulation of CD8A 1 0.01 1 0.03
60 INT92381 Binding of HLA-B and Tap1 1 0.01 0 0
61 INT193696 Binding of CD8A and Trav6-3 1 0.00 0.85 0
62 INT181169 TAPBP Negative_regulation of MALT1 1 0.00 0.48 0
63 INT236246 Binding of CD8A and Birc5 1 0.04 1.34 0
64 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
65 INT181167 TAPBP Negative_regulation of CD79A 1 0.11 0.48 0
66 INT227250 Rtl1 Positive_regulation of CD8A 1 0.20 0.4 0
67 INT189117 TAP1 Positive_regulation of Tap1 1 0.44 0.45 0
68 INT349220 Binding of CASP3 and CD8A 1 0.00 0.18 0
69 INT335240 Binding of CD8A and PMEL 1 0.28 0.81 0
70 INT294883 Binding of CD8A and IGHG3 1 0.03 0 0
71 INT227218 Binding of JAG1 and CD8A 1 0.05 0.5 0
72 INT341485 Binding of CD8A and GZMB 1 0.01 0.7 0
73 INT341486 Positive_regulation of TLR2 Positive_regulation of CD8A 1 0.11 0.3 0
74 INT258923 Binding of CD8A and Atp8a1 1 0.23 0.07 0
75 INT333093 AD5 Regulation of CD8A 1 0.00 0.25 0
76 INT189112 Tap1 Positive_regulation of Gene_expression of Mthfd1 1 0.07 0.3 0
77 INT250952 Binding of TAP1 and USO1 1 0.02 0 0
78 INT181165 TAPBP Regulation of Gene_expression of CD79A 1 0.07 0.35 0
79 INT286501 Binding of PKD1 and LILRB1 1 0.01 1.07 0
80 INT189109 Tap1 Regulation of Tap2 1 0.27 0.29 0
81 INT240410 Gene_expression of CD69 Positive_regulation of CD8A 1 0.10 0 0
82 INT301677 Binding of APC and CD8A 1 0.03 1.48 0
83 INT159710 Binding of Tap1 and ERAP1 1 0.04 0.11 0
84 INT341488 Binding of CD8A and TLR2 1 0.08 0.31 0
85 INT229176 LILRB1 Negative_regulation of KIR3DL1 1 0.02 0.29 0
86 INT343500 Binding of CD8A and ERVW-1 1 0.11 0.13 0
87 INT237148 Negative_regulation of Binding of Klrk1 and Rae1 1 0.05 0.13 0
88 INT210287 Binding of CD8A and GOPC 1 0.07 0.87 0
89 INT189104 Negative_regulation of Binding of Esr1 and Tap1 1 0.08 0.06 0
90 INT189107 Binding of Atp8a1 and Tap1 1 0.39 0 0
91 INT337537 Binding of MICA and Positive_regulation of Klrk1 1 0.07 0.68 0
92 INT258907 Binding of CD8A and HLA-G 1 0.05 0.07 0
93 INT301676 Binding of CD8A and HLA-E 1 0.02 2.24 0
94 INT189113 Gene_expression of Tap1 Positive_regulation of Gene_expression of H2-D1 1 0.05 0.47 0
95 INT286594 Binding of LILRB1 and Pkd1 1 0.01 1.07 0
96 INT189103 Binding of Tap1 and Tap2 1 0.21 0.08 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for MHC class I protein binding. They are ordered first by their pain relevance and then by number of times they were reported in MHC class I protein binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39
2 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44
3 INT101140 Negative_regulation of Tap1 7 0.50 9.08 17.46
4 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15
5 INT10019 Binding of CD8A 57 0.36 31.49 10.08
6 INT56149 Localization of CD8A 56 0.74 30.41 5.75
7 INT16405 Regulation of CD8A 38 0.45 19.04 5.31
8 INT96273 Binding of TAP1 4 0.37 4.27 2.67
9 INT93753 Positive_regulation of Tap2 1 0.57 1.31 2.21
10 INT58691 Positive_regulation of Gene_expression of CD8A 26 0.50 15.19 1.97
11 INT36018 Negative_regulation of Gene_expression of CD8A 12 0.42 6.66 1.85
12 INT8707 Localization of LILRB1 2 0.60 1.5 1.5
13 INT202035 Gene_expression of LILRB1 5 0.75 4.78 1.41
14 INT189092 Gene_expression of Tap1 56 0.76 14.09 1.33
15 INT194611 Gene_expression of Klrk1 28 0.44 19.31 1.28
16 INT132531 Positive_regulation of TAPBP 8 0.49 2.84 1.09
17 INT58692 Regulation of Gene_expression of CD8A 11 0.42 10.16 1
18 INT79115 Binding of Tap1 12 0.47 4.21 0.95
19 INT56151 Positive_regulation of Positive_regulation of CD8A 11 0.34 9.74 0.94
20 INT122101 Negative_regulation of Tap2 4 0.25 0.36 0.82
21 INT140449 Positive_regulation of Tap1 5 0.68 1.84 0.74
22 INT158295 Transcription of CD8A 11 0.53 4.02 0.7
23 INT132528 Gene_expression of TAPBP 17 0.65 5.93 0.69
24 INT48970 Positive_regulation of LILRB1 7 0.67 11.38 0.67
25 INT154772 Positive_regulation of Localization of CD8A 7 0.24 3.58 0.63
26 INT191825 Regulation of Positive_regulation of CD8A 3 0.12 2.5 0.62
27 INT78257 Transcription of Tap2 1 0.28 0.59 0.62
28 INT11458 Binding of Tap2 3 0.39 2.51 0.57
29 INT9688 Localization of Tap1 3 0.73 0.96 0.57
30 INT78254 Gene_expression of Tap2 4 0.54 2.59 0.56
31 INT134418 Regulation of LILRB1 3 0.44 2.7 0.5
32 INT176891 Negative_regulation of Localization of CD8A 4 0.22 2.58 0.49
33 INT8706 Positive_regulation of Localization of LILRB1 1 0.00 0.69 0.47
34 INT139674 Regulation of TAPBP 2 0.44 1.34 0.46
35 INT237144 Binding of Klrk1 3 0.18 3.44 0.34
36 INT78256 Regulation of Gene_expression of Tap2 2 0.28 0.38 0.32
37 INT230527 Regulation of Gene_expression of LILRB1 1 0.44 1.73 0.3
38 INT253647 Phosphorylation of CD8A 3 0.25 0.7 0.29
39 INT143502 Regulation of Tap1 2 0.40 0.75 0.29
40 INT219213 Regulation of Binding of CD8A 1 0.30 0 0.27
41 INT171130 Protein_catabolism of CD8A 1 0.83 0.47 0.27
42 INT115420 Positive_regulation of LILRB2 1 0.15 1.01 0.25
43 INT28247 Negative_regulation of Positive_regulation of CD8A 3 0.14 2.84 0.24
44 INT202027 Negative_regulation of LILRB2 1 0.29 0.38 0.23
45 INT117251 Positive_regulation of Localization of TAPBP 1 0.40 0.8 0.22
46 INT111912 Negative_regulation of TAP1 1 0.04 0.41 0.22
47 INT117250 Localization of TAPBP 1 0.61 0.8 0.22
48 INT132529 Binding of TAPBP 8 0.47 1.43 0.18
49 INT230524 Binding of LILRB1 2 0.35 2.14 0.15
50 INT230522 Regulation of Regulation of LILRB1 1 0.44 0.87 0.15
51 INT159579 Positive_regulation of TUBB 1 0.18 0.09 0.15
52 INT265419 Negative_regulation of Binding of CD8A 2 0.08 0.9 0.14
53 INT219163 Gene_expression of LILRB2 1 0.23 0.23 0.1
54 INT219190 Binding of LILRB2 1 0.14 0.23 0.1
55 INT243261 Gene_expression of TAP1 1 0.05 0.1 0.1
56 INT243262 Localization of TAP1 1 0.06 0.09 0.09
57 INT219617 Negative_regulation of Positive_regulation of Tap1 1 0.27 1.03 0.07
58 INT172369 Negative_regulation of Gene_expression of TAPBP 1 0.09 0.25 0.07
59 INT298569 Negative_regulation of LILRB1 2 0.05 1.97 0.05
60 INT337525 Positive_regulation of Gene_expression of Klrk1 1 0.17 2.32 0.05
61 INT181175 Negative_regulation of TAPBP 1 0.35 0.81 0.05
62 INT230526 Positive_regulation of Positive_regulation of LILRB1 1 0.49 0.67 0.04
63 INT337524 Regulation of Klrk1 1 0.17 2.05 0.03
64 INT189097 Positive_regulation of Gene_expression of Tap1 18 0.68 2.67 0
65 INT303313 Localization of TUBB 2 0.44 0.33 0
66 INT202603 Positive_regulation of Regulation of CD8A 2 0.16 0.27 0
67 INT268691 Gene_expression of TUBB 2 0.38 1.26 0
68 INT282776 Regulation of Localization of CD8A 2 0.42 0.65 0
69 INT189089 Regulation of Binding of Tap1 1 0.38 0 0
70 INT335230 Positive_regulation of TAP1 1 0.01 0.07 0
71 INT323133 Negative_regulation of Phosphorylation of CD8A 1 0.04 0.27 0
72 INT268709 Positive_regulation of Gene_expression of TUBB 1 0.34 1.19 0
73 INT132530 Positive_regulation of Binding of TAPBP 1 0.67 0.08 0
74 INT189094 Positive_regulation of Gene_expression of Tap2 1 0.37 0.14 0
75 INT189099 Localization of Tap2 1 0.39 0.33 0
76 INT288670 Negative_regulation of Negative_regulation of CD8A 1 0.30 0.5 0
77 INT189091 Regulation of Gene_expression of Tap1 1 0.44 0.18 0
78 INT237142 Regulation of Gene_expression of Klrk1 1 0.26 0.12 0
79 INT241873 Binding of TUBB 1 0.03 0.44 0
80 INT189098 Transcription of Tap1 1 0.67 0.32 0
81 INT337527 Positive_regulation of Klrk1 1 0.17 1.64 0
82 INT243348 Regulation of TAP1 1 0.05 0.08 0
83 INT189095 Negative_regulation of Gene_expression of Tap1 1 0.36 0.22 0
84 INT189090 Negative_regulation of Localization of Tap1 1 0.42 0.38 0
85 INT303314 Negative_regulation of TUBB 1 0.16 0.07 0
86 INT132527 Positive_regulation of Gene_expression of TAPBP 1 0.49 0.84 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox