GO:0042310

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Name vasoconstriction
Categary Process
Go Slim No
Go Link GO:0042310
Unique Molecular Interactions 770
Total Molecular Interactions 1107
Total Single Events 7776
Pain Genes Associated 30

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vasoconstriction. They are ordered first by their pain relevance and then by number of times they were reported for vasoconstriction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
2 INT87891 Agt Regulation of Cck 1 0.28 0 1.97
3 INT149470 Oxt Regulation of Gene_expression of Avp 1 0.46 1.2 1.92
4 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
5 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78
6 INT10202 Agt Positive_regulation of Avp 3 0.70 0 1.69
7 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
8 INT31772 Ednra Positive_regulation of Nppa 1 0.05 0.13 1.33
9 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
10 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
11 INT162482 Binding of Agt and Vta1 1 0.23 0 1.27
12 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25
13 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
14 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
15 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2
16 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
17 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
18 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09
19 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
20 INT277192 SUGT1 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.86 1.04
21 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03
22 INT352295 Binding of P2RY2 and Agtr1a 1 0.01 0.08 1.02
23 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97
24 INT149471 Avp Regulation of Gene_expression of Crh 1 0.45 0.6 0.96
25 INT149474 Avp Regulation of Gene_expression of Oxt 1 0.27 0.6 0.96
26 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
27 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
28 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
29 INT123023 Ednra Regulation of Adarb1 1 0.00 0 0.93
30 INT123024 Csf2 Regulation of Ednra 1 0.06 0 0.92
31 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
32 INT12050 Agt Positive_regulation of Localization of Oxt 1 0.29 0 0.91
33 INT61587 Agt Negative_regulation of REN 1 0.00 0.42 0.91
34 INT333303 Zic2 Regulation of Gene_expression of Slc6a4 1 0.60 0.47 0.91
35 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84
36 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84
37 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84
38 INT41863 Avp Regulation of Cck 1 0.00 0 0.84
39 INT41865 Avp Regulation of Cpe 1 0.00 0 0.84
40 INT41857 Avp Regulation of Vip 1 0.01 0 0.84
41 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
42 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
43 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
44 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
45 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
46 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
47 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
48 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
49 INT47143 Negative_regulation of Agt Positive_regulation of Avp 1 0.22 0 0.79
50 INT243024 Binding of Dcpp1 and Slc6a4 1 0.08 0.42 0.76
51 INT243025 Dcpp1 Regulation of Slc6a4 1 0.10 0.43 0.76
52 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74
53 INT333296 Gtf3a Regulation of Gene_expression of Slc6a4 1 0.01 0 0.74
54 INT39095 Negative_regulation of Agt Positive_regulation of Localization of Ren 1 0.38 0 0.73
55 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
56 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
57 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
58 INT77689 Binding of Ace and Tenc1 1 0.28 0.65 0.7
59 INT129919 IFNA2 Positive_regulation of Gene_expression of SLC6A4 1 0.02 0.38 0.69
60 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
61 INT391 Binding of Agt and Ace 2 0.33 1.5 0.68
62 INT141063 Agt Regulation of Agtr1a 1 0.28 1.18 0.68
63 INT74727 Binding of Slc6a4 and Hpic1 1 0.00 0.49 0.68
64 INT74728 Binding of Slc6a4 and Ptprj 1 0.01 0.48 0.68
65 INT129921 IL4 Positive_regulation of Gene_expression of SLC6A4 1 0.01 0.38 0.68
66 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
67 INT134286 PLD2 Regulation of Regulation of EDNRA 1 0.10 0 0.67
68 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
69 INT47145 Penk Negative_regulation of Agt 1 0.06 0 0.66
70 INT162878 Agt Regulation of Ang 1 0.21 1.15 0.66
71 INT333305 Zic2 Positive_regulation of Transcription of Slc6a4 1 0.68 0 0.66
72 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66
73 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
74 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
75 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
76 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
77 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
78 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
79 INT219921 EDNRA Negative_regulation of Trpv1 1 0.13 0.36 0.63
80 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
81 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
82 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
83 INT144107 Binding of SLC6A2 and SLC6A4 1 0.00 0.18 0.62
84 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62
85 INT57421 Oprd1 Regulation of Agt 1 0.29 0 0.62
86 INT230734 Negative_regulation of Binding of EDNRA and Pah 1 0.02 3.26 0.61
87 INT74395 Htr2b Negative_regulation of Pdyn 1 0.03 0 0.61
88 INT230735 Binding of EDNRA and Pah 1 0.02 3.22 0.6
89 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
90 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
91 INT56116 Agt Positive_regulation of Lhb 1 0.15 0 0.58
92 INT144864 Htr2b Positive_regulation of Localization of Gh1 1 0.48 0 0.58
93 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
94 INT333302 Zic2 Positive_regulation of Slc6a4 1 0.68 0.11 0.57
95 INT149473 Avp Positive_regulation of Localization of Pomc 4 0.48 2.64 0.56
96 INT56117 Agt Positive_regulation of Positive_regulation of CGA 1 0.00 0 0.56
97 INT202157 Binding of CSF1R and SLC6A4 1 0.08 0.9 0.54
98 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
99 INT73367 Agt Negative_regulation of Localization of Calca 1 0.43 0.26 0.54
100 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53
101 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
102 INT128431 SLC6A4 Regulation of S100A4 1 0.48 0.65 0.53
103 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
104 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
105 INT256019 Agt Negative_regulation of Lnpep 1 0.23 1.76 0.53
106 INT130157 Pomc Regulation of Gene_expression of Ednrb 1 0.14 0 0.52
107 INT47745 Binding of Slc6a4 and Htr2a 1 0.33 0.09 0.52
108 INT271191 Bdnf Regulation of Slc6a4 1 0.03 0.29 0.51
109 INT235870 Bdnf Regulation of Gene_expression of Slc6a4 1 0.09 0.77 0.5
110 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
111 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
112 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
113 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
114 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
115 INT39078 Binding of Agt and Penk 1 0.24 0.42 0.48
116 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
117 INT47144 Negative_regulation of Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
118 INT47146 Creg2-ps1 Positive_regulation of Agt 1 0.01 0 0.48
119 INT280826 Il6 Positive_regulation of Localization of Avp 1 0.01 0.64 0.47
120 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
121 INT37599 Ace Regulation of Localization of Insr 1 0.18 0 0.46
122 INT39077 Agt Negative_regulation of Prss12 1 0.05 0.44 0.46
123 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
124 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
125 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
126 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
127 INT151958 Negative_regulation of Agt Positive_regulation of Agtrap 1 0.39 0 0.44
128 INT94093 Pnoc Positive_regulation of EDNRA 1 0.03 0.1 0.44
129 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
130 INT113248 Olr1259 Negative_regulation of Slc6a4 1 0.00 0.23 0.44
131 INT151959 Agt Positive_regulation of Agtrap 1 0.63 0 0.44
132 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
133 INT114341 Agt Positive_regulation of AGT 3 0.01 1.15 0.43
134 INT184543 Agt Positive_regulation of Ccl2 1 0.16 3.18 0.43
135 INT36459 Binding of Agt and Positive_regulation of Localization of Avp 1 0.38 0.19 0.43
136 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
137 INT242992 Binding of Agt and Ppara 1 0.20 1.44 0.42
138 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
139 INT126975 Penk Negative_regulation of Localization of Avp 1 0.00 0 0.41
140 INT334763 Ednra Positive_regulation of Gabrg1 1 0.01 0 0.4
141 INT36460 Binding of Agt and Avp 1 0.28 0.16 0.4
142 INT275156 Agt Positive_regulation of Rac1 1 0.03 2.89 0.4
143 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
144 INT278932 Binding of Agtr1a and H3 1 0.00 0 0.39
145 INT64384 Agt Negative_regulation of Son 1 0.26 0 0.39
146 INT114067 Ace Regulation of Insr 1 0.09 0.31 0.39
147 INT77683 Ednra Negative_regulation of LH 1 0.03 0.23 0.39
148 INT273617 Gene_expression of Slc6a4 Positive_regulation of Pah 1 0.02 0.93 0.38
149 INT354062 Avp Regulation of Lyz2 1 0.00 0.12 0.38
150 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
151 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
152 INT185530 Binding of AGT and EDNRA 1 0.00 0.31 0.38
153 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
154 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
155 INT154782 Binding of SLC6A4 and Ndst2 1 0.01 0 0.37
156 INT39092 Agt Negative_regulation of Ren 1 0.39 0 0.37
157 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
158 INT152315 Ifng Regulation of Ednrb 1 0.19 0.22 0.36
159 INT152313 Il18 Regulation of Ednrb 1 0.30 0.22 0.36
160 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
161 INT53257 CALCRL Negative_regulation of Binding of Agt 1 0.00 0 0.36
162 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
163 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
164 INT44112 Agt Regulation of Penk 1 0.08 0 0.35
165 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
166 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34
167 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
168 INT330122 Agt Positive_regulation of Gene_expression of Agtr1a 1 0.03 0.69 0.34
169 INT140667 IFNG Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
170 INT330121 Agtr1a Positive_regulation of Gene_expression of Bdkrb1 1 0.05 0.68 0.34
171 INT140666 TNF Regulation of Gene_expression of SLC6A4 1 0.40 0.41 0.34
172 INT330119 Agt Positive_regulation of Gene_expression of Bdkrb1 1 0.37 0.63 0.34
173 INT162157 Binding of SGCG and Agt 1 0.33 0.35 0.33
174 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
175 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
176 INT147436 Agt Positive_regulation of Gene_expression of Ros1 1 0.02 0.5 0.33
177 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
178 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32
179 INT201484 Negative_regulation of Prkcg Negative_regulation of Positive_regulation of Ednrb 1 0.34 0.96 0.32
180 INT303030 Binding of Ednra and MCPH1 1 0.00 1.02 0.32
181 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
182 INT44127 Agt Negative_regulation of DSPP 1 0.02 0 0.32
183 INT119603 H2-Ab1 Regulation of EDNRA 1 0.00 0.07 0.32
184 INT119602 EDNRA Regulation of H2-Ab1 1 0.00 0.07 0.32
185 INT303005 Binding of Ednra and Pah 1 0.06 1.02 0.32
186 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
187 INT56115 Agt Regulation of Lhb 1 0.16 0 0.32
188 INT235869 Binding of Slc6a4 and Ppp2ca 1 0.04 0.21 0.31
189 INT115597 Avp Positive_regulation of Crh 1 0.56 0.79 0.31
190 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
191 INT99843 Edn3 Negative_regulation of Localization of Ren 1 0.25 0.42 0.31
192 INT69365 Binding of EDNRA and Pnoc 1 0.00 0 0.31
193 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
194 INT235877 Prkaca Regulation of Transcription of Slc6a4 1 0.06 0.13 0.31
195 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
196 INT284137 EDNRB Regulation of EDNRA 1 0.07 0.09 0.3
197 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
198 INT117588 Binding of C5AR1 and EDNRA 1 0.40 0.38 0.3
199 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
200 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29

Single Events

The table below shows the top 100 pain related interactions that have been reported for vasoconstriction. They are ordered first by their pain relevance and then by number of times they were reported in vasoconstriction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64
2 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
3 INT385 Gene_expression of Agt 182 0.78 63.62 37.91
4 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
5 INT390 Positive_regulation of Agt 170 0.70 61.47 36.08
6 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
7 INT1159 Negative_regulation of Agt 133 0.59 40.14 31.67
8 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
9 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
10 INT1158 Regulation of Agt 106 0.61 29.4 30.29
11 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
12 INT91775 Gene_expression of Slc6a4 102 0.78 26.45 28.23
13 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84
14 INT15089 Regulation of SLC6A4 48 0.62 17.87 25.6
15 INT76743 Gene_expression of Slc6a4 55 0.76 13.53 24.9
16 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67
17 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
18 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88
19 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
20 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
21 INT5048 Binding of Edn1 55 0.47 18.86 19.16
22 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09
23 INT27670 Negative_regulation of Ace 122 0.57 79.21 18.08
24 INT6728 Gene_expression of Ednra 43 0.65 13.41 17.38
25 INT2066 Localization of Agt 56 0.80 9.95 16.25
26 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42
27 INT9191 Localization of EDN1 94 0.81 57.01 14.78
28 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
29 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
30 INT6365 Localization of Edn1 56 0.81 18.84 13.83
31 INT79703 Gene_expression of Agtr1a 46 0.76 14.18 13.77
32 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
33 INT4199 Binding of Agt 76 0.48 21.06 12.66
34 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
35 INT100096 Regulation of Slc6a4 24 0.62 7.25 12.28
36 INT47743 Negative_regulation of Slc6a4 22 0.59 6.23 12.23
37 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79
38 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
39 INT53038 Positive_regulation of Agtr1a 35 0.67 23.76 11.68
40 INT66303 Regulation of Slc6a4 10 0.45 4.82 10.55
41 INT10982 Negative_regulation of Agtr1a 42 0.58 22.42 10.29
42 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
43 INT6361 Localization of Edn1 30 0.81 19.09 9.7
44 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68
45 INT47744 Binding of Slc6a4 21 0.48 5.52 9.45
46 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
47 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
48 INT10879 Positive_regulation of Avp 39 0.65 14.01 8.76
49 INT386 Positive_regulation of Gene_expression of Agt 37 0.70 15.92 8.73
50 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71
51 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
52 INT10237 Binding of EDN1 40 0.48 16 8.48
53 INT30382 Negative_regulation of Ednra 21 0.42 12.06 8.19
54 INT389 Gene_expression of Ace 21 0.67 10.31 8.1
55 INT77804 Regulation of Ednra 9 0.39 2.71 7.94
56 INT25958 Regulation of Ace 26 0.59 11.88 7.87
57 INT54978 Binding of EDNRA 36 0.41 14.97 7.86
58 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
59 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
60 INT67170 Gene_expression of Ednra 22 0.65 9.35 7.57
61 INT1771 Positive_regulation of Ace 31 0.68 10.47 7.46
62 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
63 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
64 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
65 INT119651 Binding of Slc6a4 12 0.32 4.65 7.07
66 INT19806 Regulation of Avp 29 0.53 14.17 6.94
67 INT167049 Binding of Ednra 3 0.07 3.47 6.84
68 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
69 INT15092 Positive_regulation of SLC6A4 17 0.67 7.32 6.7
70 INT40962 Localization of Avp 40 0.80 20.5 6.38
71 INT78178 Gene_expression of Ednrb 21 0.75 7.1 6.37
72 INT109714 Transcription of SLC6A4 7 0.72 3.8 6.19
73 INT19805 Negative_regulation of Avp 18 0.59 4.57 5.87
74 INT5762 Negative_regulation of Gene_expression of Agt 18 0.57 6.09 5.84
75 INT119523 Gene_expression of EDNRB 32 0.75 26.47 5.75
76 INT70907 Negative_regulation of EDNRA 30 0.36 19.68 5.49
77 INT60776 Regulation of EDNRA 20 0.51 16.62 5.36
78 INT137593 Regulation of Gene_expression of SLC6A4 7 0.60 2.59 5.23
79 INT119711 Positive_regulation of Slc6a4 16 0.69 4.44 5.21
80 INT92858 Negative_regulation of Ednra 6 0.57 1.25 4.81
81 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
82 INT122675 Negative_regulation of Gene_expression of Slc6a4 14 0.59 6.4 4.69
83 INT246315 Localization of Ednra 22 0.15 2.73 4.64
84 INT21953 Binding of Ednra 12 0.33 4.72 4.56
85 INT29519 Gene_expression of Ednrb 8 0.66 1.99 4.55
86 INT92133 Negative_regulation of Ednrb 8 0.42 1.7 4.44
87 INT29327 Positive_regulation of Ace 13 0.67 8.79 4.33
88 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
89 INT387 Regulation of Ace 18 0.45 5.24 4.24
90 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
91 INT53040 Binding of Agtr1a 22 0.47 7.36 4.15
92 INT79343 Positive_regulation of Slc6a4 10 0.50 1.77 4.05
93 INT152312 Positive_regulation of Ednrb 7 0.49 1.46 4.04
94 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
95 INT28983 Regulation of Htr2b 3 0.22 0.26 3.96
96 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
97 INT140670 Negative_regulation of Gene_expression of SLC6A4 4 0.51 2.7 3.88
98 INT103021 Transcription of Slc6a4 16 0.70 3.93 3.77
99 INT5782 Gene_expression of Edn3 17 0.67 3.38 3.65
100 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
101 INT115203 Negative_regulation of Positive_regulation of Ednra 5 0.33 1.27 3.32
102 INT99291 Transcription of Slc6a4 7 0.46 1.16 3.28
103 INT84222 Regulation of Ednrb 4 0.45 2.24 3.25
104 INT127455 Positive_regulation of Gene_expression of Slc6a4 9 0.59 5.62 3.2
105 INT111195 Negative_regulation of Gene_expression of Agtr1a 7 0.58 3.2 3.16
106 INT100190 Regulation of Gene_expression of Slc6a4 5 0.39 1.8 3.14
107 INT49971 Regulation of Ednra 10 0.35 2.4 3.06
108 INT55033 Localization of Edn3 7 0.80 1.4 3.05
109 INT53374 Binding of Edn1 17 0.43 11.66 2.98
110 INT124438 Regulation of Gene_expression of Slc6a4 9 0.62 3.5 2.97
111 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
112 INT93058 Positive_regulation of Gene_expression of Ednra 8 0.28 4.11 2.88
113 INT58166 Regulation of Gene_expression of Avp 13 0.57 2.63 2.76
114 INT8652 Protein_catabolism of Ace 10 0.94 4.7 2.74
115 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
116 INT76836 Positive_regulation of Ednra 6 0.55 2.65 2.72
117 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
118 INT11300 Positive_regulation of Gene_expression of Avp 24 0.50 10.18 2.69
119 INT80320 Negative_regulation of Gene_expression of Slc6a4 4 0.42 0.85 2.6
120 INT128774 Regulation of Gene_expression of Ednrb 3 0.46 1 2.56
121 INT53780 Binding of Avp 19 0.48 6.16 2.55
122 INT148071 Gene_expression of Agt 42 0.74 44.9 2.43
123 INT4270 Negative_regulation of Negative_regulation of Agt 10 0.43 1.08 2.43
124 INT63418 Regulation of Agtr1a 8 0.44 3.67 2.43
125 INT120726 Positive_regulation of Gene_expression of Slc6a4 4 0.68 0.51 2.34
126 INT74695 Gene_expression of Ace 41 0.73 53.33 2.33
127 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
128 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
129 INT10201 Positive_regulation of Localization of Agt 8 0.50 0.97 2.21
130 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
131 INT152554 Regulation of Transcription of SLC6A4 3 0.62 1.52 2.18
132 INT78177 Negative_regulation of Gene_expression of Ednrb 4 0.41 1.04 2.16
133 INT388 Positive_regulation of Gene_expression of Ace 4 0.42 1.04 2.13
134 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
135 INT12005 Negative_regulation of Localization of Agt 6 0.57 1.49 2.06
136 INT156677 Regulation of Gene_expression of Ednra 4 0.15 0.25 2.05
137 INT195430 Regulation of Positive_regulation of SLC6A4 1 0.42 1.01 1.98
138 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
139 INT125974 Localization of Slc6a4 5 0.66 2.27 1.97
140 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
141 INT79915 Positive_regulation of Agt 27 0.56 12.97 1.96
142 INT12801 Negative_regulation of Regulation of Agt 4 0.43 1.2 1.96
143 INT45646 Protein_catabolism of Ace 5 0.98 3.14 1.95
144 INT43084 Binding of Ace 10 0.46 4.7 1.93
145 INT43944 Negative_regulation of Positive_regulation of Agt 4 0.42 1.44 1.93
146 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
147 INT243017 Negative_regulation of Binding of Slc6a4 1 0.25 0.22 1.89
148 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
149 INT178130 Binding of EDNRB 12 0.36 6.18 1.84
150 INT55606 Binding of Ace 14 0.37 10.73 1.82
151 INT141937 Negative_regulation of Regulation of SLC6A4 1 0.41 0.27 1.8
152 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
153 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
154 INT15980 Positive_regulation of Positive_regulation of Agt 6 0.50 2.99 1.76
155 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
156 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
157 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
158 INT3152 Transcription of Agt 7 0.72 5.09 1.68
159 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
160 INT201475 Negative_regulation of Positive_regulation of Ednrb 6 0.42 3.74 1.66
161 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
162 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
163 INT161217 Positive_regulation of Htr2b 1 0.67 2.55 1.58
164 INT147808 Positive_regulation of Gene_expression of SLC6A4 4 0.50 1.03 1.57
165 INT72021 Localization of Ednra 7 0.58 3.13 1.53
166 INT139514 Localization of EDNRB 7 0.73 4.63 1.52
167 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
168 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
169 INT24768 Negative_regulation of Gene_expression of Edn1 10 0.43 2.85 1.48
170 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
171 INT65640 Positive_regulation of Localization of Edn1 2 0.42 2.16 1.48
172 INT23938 Positive_regulation of Gene_expression of EDNRA 8 0.45 9.82 1.47
173 INT129488 Regulation of Gene_expression of EDNRA 5 0.51 3.39 1.44
174 INT114298 Positive_regulation of Gene_expression of Ednrb 4 0.36 0.79 1.42
175 INT60772 Negative_regulation of Ednrb 8 0.41 4.56 1.39
176 INT83553 Positive_regulation of Positive_regulation of Agtr1a 3 0.59 4.12 1.37
177 INT239215 Binding of Agt 9 0.38 6.75 1.35
178 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
179 INT44145 Negative_regulation of Gene_expression of Ace 5 0.40 4.5 1.33
180 INT11306 Regulation of Gene_expression of Agt 7 0.45 3.29 1.31
181 INT131977 Positive_regulation of Localization of Avp 6 0.55 4.9 1.31
182 INT155662 Positive_regulation of Localization of P2rx1 2 0.47 1.92 1.26
183 INT141862 Binding of Cav1 11 0.36 1.32 1.25
184 INT19319 Negative_regulation of Binding of Agt 9 0.42 3.42 1.24
185 INT79916 Negative_regulation of Agt 14 0.47 6 1.22
186 INT132283 Regulation of P2rx1 3 0.13 0 1.2
187 INT17802 Transcription of Edn1 6 0.24 6.31 1.18
188 INT161216 Positive_regulation of Gene_expression of Htr2b 1 0.49 1.87 1.16
189 INT28594 Positive_regulation of Transcription of Agt 2 0.47 1.3 1.15
190 INT160652 Positive_regulation of Binding of P2rx1 1 0.36 0.67 1.15
191 INT161219 Gene_expression of Htr2b 4 0.75 2.01 1.14
192 INT47839 Localization of Slc6a4 4 0.79 0.96 1.14
193 INT148072 Gene_expression of Agtr1a 5 0.75 9.41 1.13
194 INT147286 Negative_regulation of Regulation of Slc6a4 1 0.21 0 1.13
195 INT49258 Negative_regulation of Positive_regulation of EDN1 10 0.43 7.24 1.12
196 INT88948 Localization of Ace 9 0.69 9.18 1.11
197 INT61123 Localization of Edn2 1 0.55 0.27 1.05
198 INT128444 Phosphorylation of SLC6A4 2 0.61 0.49 1.02
199 INT69803 Regulation of Localization of Edn1 3 0.62 0.79 0.98
200 INT267071 Positive_regulation of Gene_expression of P2rx1 2 0.49 1.77 0.98
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