GO:0042321

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Name negative regulation of circadian sleep/wake cycle, sleep
Categary Process
Go Slim No
Go Link GO:0042321
Unique Molecular Interactions 113
Total Molecular Interactions 150
Total Single Events 1378
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of circadian sleep/wake cycle, sleep. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of circadian sleep/wake cycle, sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
3 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
4 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
5 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
6 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
7 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
8 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
9 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
10 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
11 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
12 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
13 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
14 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
15 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
16 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
17 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
18 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
19 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
20 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
21 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
22 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
23 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
24 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
25 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
26 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
27 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
28 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
29 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
30 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
31 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
32 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
33 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
34 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
35 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
36 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
37 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
38 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
39 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
40 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
41 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
42 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
43 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
44 INT99938 Drd1a Regulation of Transcription of Qrfp 1 0.03 0 0.69
45 INT71988 Drd1a Regulation of Npr1 1 0.10 0 0.68
46 INT99939 Drd1a Regulation of Qrfp 1 0.03 0 0.68
47 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
48 INT317638 Ins1 Positive_regulation of Gene_expression of Drd1a 1 0.14 0.86 0.59
49 INT317634 Ins1 Positive_regulation of Drd1a 1 0.14 0.86 0.59
50 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
51 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
52 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
53 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
54 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
55 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
56 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
57 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
58 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
59 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
60 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
61 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
62 INT223925 Drd1a Positive_regulation of Gene_expression of Serpina1 1 0.01 0 0.51
63 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
64 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
65 INT317635 Positive_regulation of Drd1a Positive_regulation of Phosphorylation of Gtf3a 1 0.01 0.53 0.43
66 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
67 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
68 INT331675 Binding of Drd1a and Sptan1 1 0.03 0.33 0.4
69 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
70 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
71 INT32244 Slc3a1 Positive_regulation of Localization of Drd1a 1 0.15 0 0.39
72 INT32243 Drd1a Positive_regulation of Localization of Slc3a1 1 0.15 0 0.39
73 INT344103 Positive_regulation of Drd1a Positive_regulation of Obfc1 1 0.00 0 0.38
74 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
75 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
76 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
77 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
78 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
79 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
80 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
81 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
82 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
83 INT97595 Penk Regulation of Gene_expression of Drd1a 1 0.25 0.1 0.28
84 INT73385 Cfp Regulation of Drd1a 1 0.10 0 0.25
85 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
86 INT73384 Positive_regulation of Cfp Regulation of Drd1a 1 0.18 0 0.25
87 INT261465 Binding of Drd1a and Ptgdr 1 0.03 0.1 0.23
88 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
89 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
90 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
91 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
92 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
93 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
94 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
95 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
96 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
97 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
98 INT241070 Klf16 Positive_regulation of Drd1a 1 0.05 0.13 0.12
99 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
100 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
101 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
102 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07
103 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
104 INT261454 Akr1d1 Regulation of Drd1a 1 0.00 0.71 0.06
105 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
106 INT89016 Oprd1 Negative_regulation of Drd1a 1 0.06 0 0
107 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
108 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
109 INT69256 Drd2 Regulation of Regulation of Pomc 1 0.29 0 0
110 INT69255 Drd2 Regulation of Transcription of Pomc 1 0.29 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of circadian sleep/wake cycle, sleep. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of circadian sleep/wake cycle, sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
2 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
3 INT13501 Binding of Drd2 65 0.48 23.76 35.6
4 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
5 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
6 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
7 INT12484 Binding of Drd2 45 0.48 15.17 24.72
8 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
9 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
10 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
11 INT49774 Binding of DRD2 48 0.48 17.42 20.73
12 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
13 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
14 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
15 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
16 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
17 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
18 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
19 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
20 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
21 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
22 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
23 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
24 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
25 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
26 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
27 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
28 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
29 INT9167 Binding of Adora1 6 0.40 0.53 6.9
30 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
31 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
32 INT24460 Localization of Drd2 12 0.73 2.96 6.46
33 INT86772 Localization of Drd2 14 0.80 1.93 6.17
34 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
35 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
36 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
37 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
38 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
39 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
40 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
41 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
42 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
43 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
44 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
45 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
46 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
47 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
48 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
49 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
50 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
51 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
52 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
53 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
54 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
55 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
56 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
57 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
58 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
59 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
60 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
61 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
62 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
63 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
64 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
65 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
66 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
67 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
68 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
69 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
70 INT77216 Localization of DRD2 3 0.75 0 1.19
71 INT184839 Localization of Drd1a 4 0.73 0.84 1.03
72 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
73 INT64690 Negative_regulation of Localization of Drd1a 2 0.09 0 0.95
74 INT74183 Positive_regulation of Localization of Drd1a 1 0.32 0.06 0.95
75 INT99668 Positive_regulation of Binding of Drd1a 2 0.43 0.89 0.87
76 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
77 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
78 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
79 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
80 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
81 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
82 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
83 INT153157 Regulation of Regulation of Drd1a 2 0.25 0.2 0.66
84 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
85 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
86 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65
87 INT140306 Regulation of Binding of Drd1a 1 0.20 0.36 0.64
88 INT72516 Regulation of Binding of Drd1a 2 0.44 0.4 0.63
89 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
90 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
91 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
92 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
93 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
94 INT48566 Regulation of Transcription of Drd1a 1 0.32 0 0.37
95 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27
96 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
97 INT186700 Localization of Adora1 1 0.23 0 0.23
98 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
99 INT337102 Protein_catabolism of Drd2 1 0.88 0 0
100 INT263506 Regulation of Regulation of Drd2 1 0.26 0.34 0
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