GO:0042322

From wiki-pain
Jump to: navigation, search
Name negative regulation of circadian sleep/wake cycle, REM sleep
Categary Process
Go Slim No
Go Link GO:0042322
Unique Molecular Interactions 240
Total Molecular Interactions 378
Total Single Events 2133
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of circadian sleep/wake cycle, REM sleep. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of circadian sleep/wake cycle, REM sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
2 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
3 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
4 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
5 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
6 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
7 INT260897 CRH Positive_regulation of Localization of IL8 1 0.24 0.09 1.51
8 INT109958 Binding of CRH and HPSE 1 0.10 0.72 1.46
9 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
10 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
11 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
12 INT134213 CRH Positive_regulation of Gene_expression of ENG 1 0.13 0.61 1.03
13 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
14 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
15 INT18247 Binding of CRH and GNRH1 1 0.51 1.57 0.95
16 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
17 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
18 INT137563 Ghrl Positive_regulation of Gene_expression of Npy 1 0.59 0 0.87
19 INT5451 CRH Regulation of POMC 2 0.28 0.39 0.85
20 INT260894 CRH Regulation of Localization of MMP3 1 0.21 0.36 0.85
21 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
22 INT90382 Binding of CRH and GH1 1 0.34 0.05 0.81
23 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
24 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76
25 INT353716 Ghrl Positive_regulation of Vta1 1 0.33 0 0.74
26 INT260895 CRH Regulation of MMP1 1 0.11 0.31 0.74
27 INT353722 Rbm39 Positive_regulation of Localization of Ghrl 1 0.01 0 0.65
28 INT167139 Binding of Ghrl and Mln 1 0.04 0.56 0.65
29 INT220145 HPSE Negative_regulation of Gene_expression of CRH 1 0.01 0.92 0.64
30 INT34311 Regulation of CRH Positive_regulation of POMC 1 0.24 0 0.59
31 INT61505 ABAT Negative_regulation of Localization of CRH 1 0.09 0 0.57
32 INT55872 Binding of ADRA1D and CRH 1 0.26 0 0.54
33 INT134214 CRH Regulation of Localization of ENG 1 0.14 0.39 0.53
34 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
35 INT226125 Ghrl Positive_regulation of Cnr1 1 0.44 0.06 0.46
36 INT328385 Binding of GHS and Ghrl 1 0.15 1.89 0.45
37 INT295548 Ghrl Regulation of Regulation of Ghrh 1 0.30 0 0.45
38 INT226126 Negative_regulation of Ghrl Regulation of Prkag1 1 0.06 0.17 0.45
39 INT118208 Ghrl Negative_regulation of Localization of Prl 1 0.39 0 0.44
40 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
41 INT328377 Binding of GAST and Ghrl 1 0.03 0.62 0.43
42 INT25027 CRH Negative_regulation of Negative_regulation of FSHR 1 0.25 0 0.42
43 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42
44 INT295533 Ghrl Regulation of Npy 1 0.23 0.09 0.42
45 INT226116 Ghrl Regulation of Positive_regulation of Npy 1 0.17 0 0.41
46 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
47 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4
48 INT105771 CRH Negative_regulation of Localization of GNRH1 1 0.35 0.56 0.39
49 INT37249 CRH Positive_regulation of PPY 1 0.04 0.34 0.39
50 INT118210 Ghrl Negative_regulation of Prl 1 0.53 0 0.33
51 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33
52 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33
53 INT137561 Ghrl Regulation of Gene_expression of Npy 1 0.53 0 0.32
54 INT260893 CRH Positive_regulation of Gene_expression of IL8 1 0.28 0.05 0.31
55 INT137386 Ghrl Regulation of Gene_expression of Pigm 1 0.00 0.36 0.3
56 INT188288 Ghrl Regulation of Gene_expression of Pou1f1 1 0.07 0 0.3
57 INT111813 CREM Regulation of Regulation of CRH 1 0.12 0 0.3
58 INT137385 Ghrl Negative_regulation of Gene_expression of Pigm 1 0.01 0.36 0.3
59 INT107747 CRH Negative_regulation of HSD17B1 1 0.40 0.41 0.3
60 INT260896 CRH Positive_regulation of Localization of MMP9 1 0.15 0.15 0.3
61 INT35080 CRH Negative_regulation of Localization of FSHR 1 0.03 0 0.29
62 INT295549 Ghrl Positive_regulation of Gene_expression of Ghsr 1 0.29 0 0.29
63 INT295526 Ghrl Positive_regulation of Gene_expression of Fos 1 0.41 0.08 0.29
64 INT35079 CRH Negative_regulation of Localization of PLOD1 1 0.06 0 0.29
65 INT157082 Ghrl Positive_regulation of Localization of Gh1 2 0.22 0.18 0.28
66 INT264782 Binding of CRH and CRHR1 1 0.02 0.06 0.28
67 INT31508 FEM1B Positive_regulation of Gene_expression of CRH 1 0.54 0 0.28
68 INT31505 CRH Positive_regulation of Gene_expression of FEM1B 1 0.54 0 0.28
69 INT137562 Ghrl Positive_regulation of Gene_expression of Agrp 1 0.30 0 0.28
70 INT180194 CRH Positive_regulation of CRHR2 1 0.02 0.24 0.27
71 INT295531 Ghrl Negative_regulation of Gene_expression of Ghrh 1 0.25 0 0.27
72 INT180195 CRH Regulation of CRHR2 1 0.01 0.24 0.27
73 INT157080 Ghrl Positive_regulation of Localization of Gnrhr 2 0.23 0.7 0.26
74 INT295541 Ghrl Positive_regulation of Ghrh 1 0.31 0 0.26
75 INT328378 GH1 Regulation of Gene_expression of Ghrl 1 0.02 0.39 0.25
76 INT118211 Ghrl Positive_regulation of Localization of Prl 1 0.63 0 0.24
77 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
78 INT164251 Ghrl Negative_regulation of Localization of Gnrh1 1 0.34 0 0.22
79 INT139271 Binding of CRH and POMC 1 0.35 1.1 0.22
80 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21
81 INT157083 Ghrl Regulation of Gene_expression of Ppt1 1 0.40 0 0.2
82 INT100084 Binding of CRH and CRHR2 1 0.32 1.11 0.19
83 INT153322 CRH Positive_regulation of Positive_regulation of CRHR1 1 0.31 0.12 0.19
84 INT25495 AVP Positive_regulation of CRH 1 0.14 0 0.19
85 INT297393 TRIM6-TRIM34 Regulation of CRH 1 0.01 1.42 0.19
86 INT25497 AVP Positive_regulation of Localization of CRH 1 0.14 0 0.19
87 INT295542 Ghrl Positive_regulation of Gene_expression of Ghrh 1 0.33 0 0.19
88 INT325390 Binding of Ghrl and Gpr39 1 0.19 0 0.18
89 INT34346 CRH Regulation of DBI 1 0.01 0.25 0.17
90 INT323494 Ghrl Regulation of Ins1 1 0.16 2.12 0.17
91 INT107750 CRH Regulation of Transcription of HSD17B1 1 0.19 0.21 0.17
92 INT328386 GHS Positive_regulation of Localization of Ghrl 1 0.10 0.88 0.17
93 INT328379 Ghrl Positive_regulation of CRH 1 0.16 1.17 0.16
94 INT118209 Ghrl Regulation of Localization of Prl 1 0.56 0 0.15
95 INT57500 CREM Positive_regulation of Regulation of CRH 1 0.39 0 0.14
96 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13
97 INT328384 Ghrl Positive_regulation of ALPL 1 0.01 0.93 0.13
98 INT295540 Binding of Gh and Ghrl 2 0.10 0.13 0.12
99 INT12830 Regulation of CRH Regulation of PENK 1 0.10 0.41 0.12
100 INT226132 Ghrl Positive_regulation of Gene_expression of Prkag1 1 0.06 0 0.12
101 INT12828 CRH Regulation of PENK 1 0.10 0.41 0.12
102 INT226117 Ghrl Positive_regulation of Gene_expression of Mastl 1 0.02 0 0.12
103 INT295545 Ghrl Positive_regulation of Gh 1 0.15 0 0.11
104 INT295551 Ghrl Positive_regulation of Localization of Gh 1 0.15 0 0.1
105 INT293627 GHRL Positive_regulation of EDNRA 1 0.00 0.96 0.1
106 INT328364 Binding of GHRH and Ghrl 1 0.09 0.2 0.1
107 INT328372 Ghrl Positive_regulation of Transcription of GH1 1 0.04 0.27 0.1
108 INT142418 Lep Positive_regulation of Gene_expression of Ghrl 1 0.48 1.66 0.09
109 INT157079 Ghrl Positive_regulation of Gnrhr 1 0.23 0 0.09
110 INT157081 Ghrl Positive_regulation of Gh1 1 0.22 0 0.09
111 INT295527 Gene_expression of Ghrl Positive_regulation of Gene_expression of Fos 1 0.29 0 0.09
112 INT328373 Negative_regulation of Ghrl Positive_regulation of Localization of GH1 1 0.05 0.31 0.08
113 INT188291 Ghrl Regulation of Localization of LH 1 0.03 0 0.08
114 INT325418 Ghrl Positive_regulation of Ghsr 1 0.16 0 0.08
115 INT162762 Ghrl Regulation of Son 1 0.36 0 0.07
116 INT328366 GPR39 Regulation of Localization of Ghrl 1 0.11 0.2 0.07
117 INT323486 Ghrl Regulation of Localization of Ins1 1 0.21 2.07 0.07
118 INT328380 AR Negative_regulation of Gene_expression of Ghrl 1 0.01 0.55 0.07
119 INT295550 Binding of Ghrh and Ghrl 1 0.21 0.06 0.07
120 INT295529 Ghrl Regulation of Localization of Gh 1 0.20 0 0.06
121 INT328387 INS Negative_regulation of Gene_expression of Ghrl 1 0.01 0.6 0.05
122 INT328371 Ghrl Negative_regulation of INS 1 0.03 0.13 0.05
123 INT198620 CRH Negative_regulation of GH1 1 0.05 0.47 0.05
124 INT328376 Ghrl Negative_regulation of SST 1 0.03 0.13 0.05
125 INT328383 Ghrl Negative_regulation of MBOAT4 1 0.26 0 0.05
126 INT198619 CRH Negative_regulation of TRH 1 0.18 0.47 0.05
127 INT323482 Ghrl Negative_regulation of Ins1 1 0.13 0.24 0.05
128 INT229820 Fos Positive_regulation of Gene_expression of Ghrl 1 0.02 0.05 0.05
129 INT328308 CRH Negative_regulation of KISS1 1 0.02 0 0.05
130 INT323503 STARD7 Positive_regulation of Ghrl 1 0.24 1.92 0.05
131 INT198618 CRH Negative_regulation of Localization of SST 1 0.07 0.53 0.05
132 INT328365 Binding of JAG2 and Ghrl 1 0.03 0.07 0.05
133 INT323485 Ghrl Negative_regulation of Localization of Ins1 1 0.15 1.99 0.05
134 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04
135 INT328363 Ghrl Negative_regulation of PLOD1 1 0.02 0.11 0.04
136 INT222497 Negative_regulation of Gh1 Negative_regulation of Ghrl 1 0.01 0.2 0.04
137 INT328332 Ghrl Negative_regulation of Abo 1 0.01 0 0.04
138 INT247080 Binding of CRH and CRHBP 1 0.11 0.2 0.03
139 INT328362 LYPLA1 Regulation of Ghrl 1 0.04 0.07 0.03
140 INT175560 Binding of GPER and GHRL 1 0.01 1.14 0.03
141 INT97896 Ghrl Positive_regulation of Localization of Gh 1 0.48 0.37 0.03
142 INT328381 Ghrl Positive_regulation of NPY 1 0.06 0.15 0.03
143 INT328304 POMC Positive_regulation of Localization of CRH 1 0.07 0.22 0.03
144 INT28372 CPM Regulation of GHRL 2 0.05 0 0
145 INT222536 Ghrl Positive_regulation of Transcription of Pou1f1 1 0.03 0.13 0
146 INT188289 Ghrl Negative_regulation of Gnrh1 1 0.08 0.17 0
147 INT188295 Binding of KITLG and Ghrl 1 0.02 0.09 0
148 INT328369 Ghrl Negative_regulation of CRH 1 0.16 0.15 0
149 INT28371 CPN2 Regulation of GHRL 1 0.00 0 0
150 INT121541 Positive_regulation of Binding of CRH and CCL7 1 0.09 0.07 0
151 INT323489 Ghrl Regulation of Regulation of Ins1 1 0.09 0.07 0
152 INT144261 CRH Positive_regulation of SEMA6A 1 0.56 0 0
153 INT323493 Binding of Ins1 and Ghrl 1 0.12 1.25 0
154 INT121542 Binding of CRH and CCL7 1 0.07 0.07 0
155 INT117795 ABCA1 Regulation of GHRL 1 0.00 0 0
156 INT111768 IL2 Positive_regulation of Localization of CRH 1 0.02 0 0
157 INT323499 Ghrl Positive_regulation of Ins1 1 0.21 0.25 0
158 INT328375 Ghrl Negative_regulation of LEP 1 0.07 0.15 0
159 INT163696 Ghrl Regulation of Efs 1 0.05 0 0
160 INT188292 Ghrl Regulation of Gnrhr 1 0.01 0.19 0
161 INT323500 Ghrl Positive_regulation of Grb2 1 0.13 0.5 0
162 INT233400 COPD Regulation of CRH 1 0.11 1.67 0
163 INT51878 CCBE1 Regulation of CRH 1 0.01 1.06 0
164 INT323495 Ghrl Positive_regulation of Irs1 1 0.20 0.5 0
165 INT188287 Ghrl Regulation of Gh1 1 0.01 0.19 0
166 INT188293 Ghrl Negative_regulation of LH 1 0.03 0.17 0
167 INT188290 Ghrl Regulation of Gene_expression of Kitlg 1 0.02 0.15 0
168 INT323487 Ghrl Positive_regulation of Phosphorylation of Akt1 1 0.09 0.77 0
169 INT328368 Ghrl Positive_regulation of INS 1 0.04 0.22 0
170 INT163697 Ghrl Regulation of Gene_expression of Efs 1 0.09 0 0
171 INT325420 Ghrl Regulation of Mag 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of circadian sleep/wake cycle, REM sleep. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of circadian sleep/wake cycle, REM sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5454 Localization of CRH 124 0.79 79.18 41.53
2 INT7082 Gene_expression of CRH 180 0.78 64.66 31.74
3 INT6441 Positive_regulation of CRH 98 0.69 57.22 24.12
4 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14
5 INT5452 Regulation of CRH 56 0.62 15.32 12.42
6 INT11288 Negative_regulation of CRH 44 0.00 16.69 12.37
7 INT14513 Localization of Ghrl 52 0.78 29.26 11.63
8 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7
9 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68
10 INT224964 Localization of Ghrl 30 0.59 7.71 8.77
11 INT20922 Positive_regulation of Localization of CRH 18 0.67 11.12 6.79
12 INT5455 Negative_regulation of Localization of CRH 16 0.49 7.31 6.41
13 INT57502 Positive_regulation of Gene_expression of CRH 30 0.70 23.37 5.7
14 INT226106 Negative_regulation of Ghrl 12 0.40 3.98 5.39
15 INT117855 Negative_regulation of Ghrl 29 0.57 17.52 5
16 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86
17 INT7559 Transcription of CRH 37 0.69 4.84 3.61
18 INT132317 Positive_regulation of Gene_expression of Ghrl 20 0.49 21 3.57
19 INT226114 Binding of Ghrl 18 0.36 4.34 3.54
20 INT118207 Binding of Ghrl 11 0.47 7.39 3.52
21 INT25029 Positive_regulation of Positive_regulation of CRH 7 0.49 6.77 3.52
22 INT63534 Binding of CRH 23 0.47 6.84 3.43
23 INT23763 Regulation of Localization of CRH 6 0.48 0.22 3.04
24 INT35251 Regulation of Ghrl 21 0.60 8.26 2.6
25 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59
26 INT323469 Negative_regulation of Localization of Ghrl 4 0.29 0.4 2.49
27 INT226105 Regulation of Ghrl 10 0.50 2.36 2.26
28 INT30202 Positive_regulation of GHRL 5 0.44 3.04 2.22
29 INT188282 Regulation of Gene_expression of Ghrl 16 0.31 10.08 1.95
30 INT164017 Negative_regulation of Localization of Ghrl 2 0.53 3.12 1.88
31 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76
32 INT12835 Negative_regulation of Positive_regulation of CRH 6 0.42 3.15 1.76
33 INT97892 Positive_regulation of Gene_expression of Ghrl 31 0.49 13.43 1.7
34 INT115963 Negative_regulation of Gene_expression of CRH 9 0.59 4.53 1.48
35 INT34312 Regulation of Gene_expression of CRH 6 0.46 1.97 1.48
36 INT224947 Positive_regulation of Localization of Ghrl 3 0.34 0.48 1.4
37 INT161750 Transcription of Ghrl 14 0.67 7.05 1.23
38 INT323462 Regulation of Gene_expression of Ghrl 2 0.27 0.15 1
39 INT161751 Positive_regulation of Transcription of Ghrl 3 0.49 3.89 0.81
40 INT323980 Regulation of Localization of Ghrl 5 0.60 3.04 0.8
41 INT97763 Negative_regulation of Binding of CRH 2 0.42 0 0.76
42 INT323979 Negative_regulation of Negative_regulation of Ghrl 2 0.42 0.98 0.76
43 INT166886 Negative_regulation of Gene_expression of Ghrl 3 0.41 4.11 0.66
44 INT163329 Negative_regulation of GHRL 5 0.58 7.34 0.65
45 INT4783 Localization of GHRL 5 0.11 1.28 0.61
46 INT194127 Negative_regulation of Transcription of CRH 2 0.41 0.16 0.51
47 INT202229 Regulation of GHRL 3 0.07 1.8 0.47
48 INT4780 Positive_regulation of Gene_expression of GHRL 2 0.06 1.03 0.45
49 INT12833 Regulation of Regulation of CRH 2 0.27 1.32 0.44
50 INT325380 Positive_regulation of Positive_regulation of Ghrl 2 0.45 1.35 0.35
51 INT7558 Regulation of Transcription of CRH 1 0.60 0.06 0.35
52 INT137559 Negative_regulation of Regulation of Ghrl 1 0.32 0 0.34
53 INT41640 Binding of GHRL 2 0.15 1.78 0.32
54 INT287775 Transcription of Ghrl 3 0.41 1.27 0.31
55 INT295517 Negative_regulation of Gene_expression of Ghrl 2 0.32 0.91 0.28
56 INT67420 Negative_regulation of Negative_regulation of CRH 2 0.43 0.81 0.28
57 INT295520 Regulation of Positive_regulation of Ghrl 1 0.24 0.16 0.26
58 INT28717 Regulation of Positive_regulation of CRH 2 0.29 1.4 0.24
59 INT12834 Positive_regulation of Transcription of CRH 3 0.67 1 0.2
60 INT325379 Regulation of Positive_regulation of Ghrl 1 0.26 0.23 0.17
61 INT293628 Regulation of Transcription of Ghrl 1 0.31 0.96 0.13
62 INT293629 Negative_regulation of Gene_expression of GHRL 1 0.02 0.79 0.13
63 INT323468 Negative_regulation of Negative_regulation of Ghrl 1 0.21 0.14 0.12
64 INT264799 Regulation of Binding of CRH 1 0.04 0 0.11
65 INT328361 Positive_regulation of Negative_regulation of Ghrl 1 0.24 0.12 0.07
66 INT323466 Negative_regulation of Binding of Ghrl 1 0.21 0.36 0.07
67 INT287774 Negative_regulation of Transcription of Ghrl 1 0.02 1.28 0.05
68 INT302734 Negative_regulation of Positive_regulation of Ghrl 2 0.41 1.58 0.04
69 INT226110 Positive_regulation of Binding of Ghrl 1 0.30 0 0.04
70 INT323471 Regulation of Localization of Ghrl 1 0.22 0 0.04
71 INT293630 Regulation of Gene_expression of GHRL 1 0.01 0.54 0.03
72 INT293631 Negative_regulation of Positive_regulation of GHRL 1 0.02 0.89 0.03
73 INT323464 Phosphorylation of Ghrl 1 0.40 0.19 0.03
74 INT328291 Protein_catabolism of Ghrl 1 0.13 0.17 0
75 INT328352 Protein_catabolism of Ghrl 1 0.86 0.15 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox