GO:0042359

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Name vitamin D metabolic process
Categary Process
Go Slim No
Go Link GO:0042359
Unique Molecular Interactions 103
Total Molecular Interactions 134
Total Single Events 1283
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for vitamin D metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for vitamin D metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
2 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
3 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
4 INT301166 LRP2 Regulation of TRD@ 1 0.12 1.93 1.21
5 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
6 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
7 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
8 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
9 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
10 INT544 Binding of ALB and GC 1 0.13 0 0.55
11 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51
12 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
13 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
14 INT38269 Binding of TCN1 and CUBN 1 0.00 0.28 0.4
15 INT329086 Binding of Gc and Scly 1 0.03 0.75 0.38
16 INT104932 AHR Positive_regulation of CYP1A1 1 0.43 0.83 0.31
17 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
18 INT137683 Positive_regulation of Binding of Cyp27b1 and Prkca 1 0.03 0 0.29
19 INT137684 Binding of Cyp27b1 and Prkca 1 0.02 0 0.29
20 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
21 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25
22 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
23 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
24 INT262151 Vdr Regulation of Cyp24a1 1 0.24 0.24 0.23
25 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
26 INT335021 Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.53 1.49 0.21
27 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
28 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
29 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
30 INT335020 Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.62 0.82 0.18
31 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
32 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
33 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
34 INT65883 Binding of CYP1A1 and PPP4C 1 0.02 0 0.15
35 INT156837 Binding of CYP24A1 and MED1 1 0.47 0 0.15
36 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
37 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
38 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
39 INT155318 Binding of Calb1 and Fos 1 0.40 0.36 0.14
40 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
41 INT335026 Positive_regulation of Fgf23 Positive_regulation of Gene_expression of Cyp24a1 1 0.45 0.2 0.13
42 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
43 INT335024 Positive_regulation of Fgf23 Negative_regulation of Gene_expression of Cyp27b1 1 0.39 0.19 0.13
44 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
45 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
46 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
47 INT156832 MAPK7 Positive_regulation of Transcription of CYP24A1 1 0.35 0 0.1
48 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
49 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09
50 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
51 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
52 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
53 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
54 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
55 INT156839 Binding of CYP24A1 and MAPK3 1 0.31 0 0.07
56 INT156830 Binding of CYP24A1 and TRPV6 1 0.32 0 0.07
57 INT156828 Positive_regulation of Binding of CYP24A1 and TRPV6 1 0.42 0 0.07
58 INT262145 Positive_regulation of Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.45 0.06
59 INT218009 AHR Positive_regulation of CYP27B1 1 0.16 0.06 0.05
60 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
61 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
62 INT218010 EE Positive_regulation of CYP27B1 1 0.05 0 0.04
63 INT285388 Ahr Positive_regulation of Gene_expression of Cyp27b1 1 0.01 0.14 0.04
64 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
65 INT262221 Nr1i2 Negative_regulation of Cyp24a1 1 0.27 0.15 0.04
66 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
67 INT218011 AHR Positive_regulation of Transcription of CYP27B1 1 0.16 0 0.04
68 INT285386 Ahr Positive_regulation of Binding of Cyp27b1 1 0.01 0.14 0.04
69 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
70 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
71 INT262154 Vdr Negative_regulation of Cyp24a1 1 0.16 0.14 0.04
72 INT316598 Pth Regulation of Fgf23 1 0.10 0.28 0.03
73 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
74 INT262170 Nr1i2 Positive_regulation of Gene_expression of Cyp24a1 1 0.29 0.4 0
75 INT204927 Binding of LGMN and IL33 1 0.00 0.52 0
76 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
77 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
78 INT44023 Binding of Cyp27b1 and Klk1b27 1 0.00 0.1 0
79 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
80 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
81 INT44025 Binding of Cd86 and Cyp27b1 1 0.02 0.1 0
82 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
83 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
84 INT173905 Binding of CD69 and LRP2 1 0.14 0.32 0
85 INT333682 Binding of Gc and Hr 1 0.02 0.5 0
86 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
87 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
88 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
89 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
90 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
91 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
92 INT333683 Hr Negative_regulation of Gene_expression of Gc 1 0.01 0.43 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for vitamin D metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in vitamin D metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
2 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
3 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
4 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
5 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
6 INT102836 Binding of LRP2 12 0.38 11.27 5.58
7 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
8 INT67138 Gene_expression of Gc 19 0.31 17.11 4.1
9 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09
10 INT4739 Gene_expression of Calb1 16 0.78 2.83 4.08
11 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
12 INT55862 Negative_regulation of Calb1 7 0.57 1.4 3.85
13 INT545 Binding of GC 15 0.45 10.74 3.47
14 INT55861 Positive_regulation of Calb1 3 0.67 0.14 3.46
15 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
16 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83
17 INT22212 Gene_expression of CYP1A1 34 0.76 10.11 2.77
18 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
19 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
20 INT61225 Positive_regulation of Cyp27b1 8 0.31 2.32 2.24
21 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
22 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
23 INT36267 Positive_regulation of CYP1A1 29 0.69 11.09 2.01
24 INT262364 Positive_regulation of LRP2 6 0.39 4.44 1.97
25 INT29577 Negative_regulation of Cyp27b1 5 0.37 2.41 1.88
26 INT55864 Negative_regulation of Transcription of Calb1 2 0.42 0.09 1.86
27 INT55865 Transcription of Calb1 2 0.52 0.09 1.82
28 INT37758 Gene_expression of GC 10 0.75 7.09 1.75
29 INT55863 Regulation of Gene_expression of Calb1 1 0.62 0.16 1.63
30 INT37838 Regulation of Cyp27b1 4 0.27 0.67 1.61
31 INT168565 Positive_regulation of Gc 4 0.13 3.74 1.45
32 INT262123 Gene_expression of Cyp24a1 17 0.67 6.67 1.38
33 INT8339 Negative_regulation of GC 12 0.57 4.9 1.37
34 INT24477 Regulation of Calb1 3 0.27 0.19 1.31
35 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
36 INT257952 Positive_regulation of CUBN 1 0.07 0.61 1.22
37 INT173916 Regulation of LRP2 6 0.44 7.96 1.14
38 INT35104 Positive_regulation of GC 6 0.11 4.99 1.08
39 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
40 INT68220 Binding of CYP1A1 8 0.48 0.8 0.99
41 INT67135 Binding of Gc 5 0.10 3.2 0.94
42 INT142495 Regulation of LGMN 2 0.14 0.13 0.91
43 INT71197 Positive_regulation of Gene_expression of Cyp27b1 3 0.20 0.49 0.89
44 INT71194 Transcription of Cyp27b1 4 0.15 0.99 0.84
45 INT243487 Binding of Calb1 1 0.07 0 0.79
46 INT173914 Regulation of Gene_expression of LRP2 3 0.60 6.49 0.78
47 INT130797 Gene_expression of Fgf23 6 0.66 4.73 0.77
48 INT190958 Negative_regulation of Gene_expression of Calb1 5 0.41 2.15 0.77
49 INT294932 Negative_regulation of Gc 6 0.17 3.38 0.71
50 INT257951 Localization of CUBN 1 0.07 0 0.71
51 INT257948 Binding of CUBN 1 0.05 0 0.7
52 INT35705 Regulation of CYP27B1 1 0.23 0 0.66
53 INT320988 Regulation of Gc 3 0.13 2.52 0.62
54 INT24476 Localization of Calb1 3 0.74 0.4 0.61
55 INT44016 Binding of Cyp27b1 3 0.10 0.53 0.59
56 INT73164 Negative_regulation of Gene_expression of GC 1 0.41 0.06 0.52
57 INT71187 Positive_regulation of Transcription of Cyp27b1 1 0.13 0.2 0.51
58 INT71196 Positive_regulation of Binding of Cyp27b1 1 0.13 0.19 0.51
59 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
60 INT329084 Negative_regulation of Gene_expression of Gc 2 0.12 1.63 0.45
61 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
62 INT262095 Positive_regulation of Gene_expression of Cyp24a1 1 0.40 2.58 0.44
63 INT173912 Negative_regulation of LRP2 5 0.57 6.22 0.42
64 INT88678 Gene_expression of CYP27B1 8 0.75 2.11 0.41
65 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
66 INT218020 Positive_regulation of CYP27B1 3 0.49 0.15 0.41
67 INT156845 Negative_regulation of CYP24A1 2 0.41 2.04 0.41
68 INT329082 Positive_regulation of Gene_expression of Gc 1 0.20 1.09 0.41
69 INT173920 Transcription of LRP2 1 0.52 2.63 0.4
70 INT71190 Regulation of Gene_expression of Cyp27b1 1 0.13 0.17 0.39
71 INT71191 Regulation of Positive_regulation of Cyp27b1 1 0.13 0.17 0.39
72 INT262130 Negative_regulation of Gene_expression of Cyp24a1 1 0.33 1.37 0.37
73 INT301168 Localization of LRP2 1 0.59 0.83 0.36
74 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
75 INT137677 Positive_regulation of Positive_regulation of Cyp27b1 2 0.07 0.56 0.32
76 INT204930 Gene_expression of LGMN 1 0.07 0.48 0.31
77 INT11647 Regulation of GC 5 0.60 2.12 0.3
78 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
79 INT130799 Localization of Fgf23 2 0.63 1.94 0.28
80 INT96886 Positive_regulation of Gene_expression of CYP1A1 8 0.64 3.15 0.27
81 INT157409 Negative_regulation of Fgf23 3 0.50 3.21 0.27
82 INT115926 Negative_regulation of Positive_regulation of CYP1A1 1 0.30 0.16 0.27
83 INT294931 Positive_regulation of Negative_regulation of Gc 1 0.05 0.62 0.26
84 INT119707 Gene_expression of CYP24A1 4 0.73 1.11 0.24
85 INT119705 Positive_regulation of CYP24A1 4 0.49 1.11 0.22
86 INT218021 Positive_regulation of Gene_expression of CYP27B1 2 0.67 0.73 0.21
87 INT130798 Positive_regulation of Gene_expression of Fgf23 2 0.59 1.12 0.2
88 INT65885 Negative_regulation of CYP1A1 2 0.18 0.64 0.2
89 INT96884 Regulation of Gene_expression of CYP1A1 2 0.60 0.54 0.2
90 INT96889 Negative_regulation of Gene_expression of CYP1A1 2 0.42 0.9 0.2
91 INT137674 Localization of Cyp27b1 1 0.10 0 0.2
92 INT119702 Transcription of CYP24A1 4 0.69 1.61 0.16
93 INT173909 Positive_regulation of Gene_expression of LRP2 1 0.41 1.05 0.16
94 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
95 INT156862 Positive_regulation of Gene_expression of CYP24A1 2 0.66 0.54 0.15
96 INT227044 Negative_regulation of Gene_expression of Cyp27b1 2 0.06 0.46 0.15
97 INT156858 Regulation of CYP24A1 2 0.58 0.54 0.14
98 INT238489 Negative_regulation of Gene_expression of LRP2 1 0.57 2.74 0.14
99 INT158562 Negative_regulation of Positive_regulation of Cyp24a1 1 0.05 0.6 0.14
100 INT158566 Positive_regulation of Cyp24a1 2 0.27 0.68 0.12
101 INT349935 Transcription of CYP1A1 1 0.47 1.22 0.12
102 INT113367 Positive_regulation of Binding of GC 1 0.05 1 0.12
103 INT88677 Negative_regulation of Gene_expression of CYP27B1 2 0.57 0.91 0.11
104 INT137680 Regulation of Localization of Cyp27b1 1 0.07 0 0.11
105 INT295974 Regulation of Fgf23 1 0.07 2.3 0.11
106 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
107 INT68218 Regulation of Positive_regulation of CYP1A1 3 0.45 2.35 0.1
108 INT84944 Regulation of Negative_regulation of GC 1 0.44 1 0.1
109 INT156849 Phosphorylation of CYP24A1 1 0.59 0 0.1
110 INT156852 Positive_regulation of Transcription of CYP24A1 1 0.44 0 0.1
111 INT119706 Regulation of Transcription of CYP24A1 2 0.44 0.57 0.09
112 INT156844 Regulation of Gene_expression of CYP24A1 1 0.58 0 0.09
113 INT156861 Regulation of Positive_regulation of CYP24A1 1 0.43 0 0.08
114 INT88676 Negative_regulation of CYP27B1 2 0.30 1.96 0.07
115 INT274054 Localization of CYP1A1 1 0.12 0 0.07
116 INT156857 Negative_regulation of Regulation of CYP24A1 1 0.41 0 0.07
117 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
118 INT238496 Negative_regulation of Negative_regulation of LRP2 1 0.42 1.84 0.07
119 INT67136 Negative_regulation of Binding of Gc 1 0.05 0.9 0.06
120 INT274056 Protein_catabolism of CYP1A1 1 0.15 0 0.06
121 INT218026 Localization of CYP27B1 1 0.73 0.07 0.05
122 INT68219 Positive_regulation of Binding of CYP1A1 1 0.50 0 0.05
123 INT262105 Regulation of Gene_expression of Cyp24a1 1 0.35 0.15 0.05
124 INT320989 Phosphorylation of Gc 1 0.07 0.83 0.05
125 INT119704 Transcription of CYP27B1 2 0.69 0.48 0.04
126 INT218025 Positive_regulation of Transcription of CYP27B1 1 0.49 0 0.04
127 INT316595 Transcription of Fgf23 1 0.61 0.44 0.04
128 INT262133 Negative_regulation of Cyp24a1 1 0.24 0.14 0.04
129 INT316589 Negative_regulation of Transcription of Fgf23 1 0.50 0.44 0.04
130 INT226091 Negative_regulation of Binding of GC 1 0.02 0.29 0.03
131 INT316588 Positive_regulation of Fgf23 1 0.43 0.29 0.03
132 INT289834 Positive_regulation of Protein_catabolism of LRP2 1 0.45 0.65 0.03
133 INT289835 Protein_catabolism of LRP2 1 0.96 0.58 0.03
134 INT167112 Regulation of CYP1A1 3 0.26 0.37 0
135 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
136 INT204931 Binding of LGMN 2 0.27 1.64 0
137 INT354644 Gene_expression of CUBN 1 0.65 0.32 0
138 INT150308 Protein_catabolism of Fgf23 1 0.75 0.05 0
139 INT320984 Localization of Gc 1 0.08 0 0
140 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
141 INT294588 Positive_regulation of Positive_regulation of CYP1A1 1 0.07 0.25 0
142 INT330965 Localization of CYP24A1 1 0.51 0.08 0
143 INT330966 Positive_regulation of Localization of CYP24A1 1 0.34 0.08 0
144 INT320987 Transcription of Gc 1 0.07 0.36 0
145 INT167111 Regulation of Binding of CYP1A1 1 0.43 0 0
146 INT150307 Positive_regulation of Protein_catabolism of Fgf23 1 0.52 0.11 0
147 INT277008 Regulation of Transcription of CYP3A4 1 0.41 0.67 0
148 INT320986 Negative_regulation of Localization of Gc 1 0.04 0 0
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