GO:0042403

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Name thyroid hormone metabolic process
Categary Process
Go Slim No
Go Link GO:0042403
Unique Molecular Interactions 91
Total Molecular Interactions 137
Total Single Events 1447
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for thyroid hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
2 INT74840 Binding of Cacna1a and Cacna1a 5 0.00 4.24 2.36
3 INT122660 Binding of CACNA1A and DNAH8 2 0.28 2.68 2.08
4 INT349608 Binding of DIO2 and LMOD1 1 0.23 0.41 2.01
5 INT355251 Cacna1a Regulation of Gene_expression of Gabrg1 1 0.01 0.06 1.86
6 INT355249 Cacna1a Regulation of Gene_expression of Ltp 1 0.04 0.06 1.86
7 INT355254 Ltp Regulation of Cacna1a 1 0.04 0 1.58
8 INT74843 Binding of Cacna1a and Ea2 3 0.13 3.29 1.55
9 INT355250 Ltp Regulation of Positive_regulation of Cacna1a 1 0.04 0 1.39
10 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
11 INT122659 Binding of CACNA1A and SAR1B 1 0.06 1.38 1.35
12 INT355253 Ltp Positive_regulation of Cacna1a 1 0.05 0 1.34
13 INT355252 Binding of Cacna1a and Cnr1 1 0.04 0 1.31
14 INT74841 Binding of Cacna1a and Ea2 2 0.01 2.33 1.27
15 INT265070 Reln Positive_regulation of Gene_expression of Fos 1 0.02 0.51 1.01
16 INT108729 Binding of CACNA1A and Cacna1a 3 0.13 1.21 0.95
17 INT214410 Binding of ATP1A4 and CACNA1A 1 0.26 0.95 0.7
18 INT31416 Cacna1a Positive_regulation of Gene_expression of Gcg 1 0.03 0 0.65
19 INT166863 Kcnj9 Regulation of Kcnj6 1 0.20 0 0.56
20 INT5112 DIO2 Positive_regulation of Positive_regulation of Gal 1 0.27 0 0.53
21 INT5111 DIO2 Positive_regulation of Drd1a 1 0.04 0 0.53
22 INT166862 Kcnj6 Positive_regulation of Gene_expression of Oprd1 1 0.15 0 0.52
23 INT85565 Oprd1 Regulation of KCNJ6 1 0.00 0 0.51
24 INT354986 Cacna1a Regulation of Localization of Mpo 1 0.01 1.15 0.49
25 INT354981 Cacna1a Negative_regulation of Gene_expression of Nos2 1 0.01 0.99 0.45
26 INT80679 Abat Regulation of Localization of Sult1b1 1 0.01 0 0.44
27 INT155752 Binding of CACNA1A and ATCAY 1 0.04 0.86 0.42
28 INT68526 Binding of ADCY1 and DIO2 1 0.01 0.07 0.41
29 INT354984 Binding of Cacna1a and Tnf 1 0.01 0.83 0.4
30 INT158355 Cacna1a Regulation of Alox5 1 0.01 0.7 0.37
31 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
32 INT354985 Cacna1a Regulation of Nos2 1 0.01 0.73 0.34
33 INT354982 Cacna1a Regulation of Tnf 1 0.00 0.73 0.34
34 INT101551 Binding of CACNA1A and CACNA1F 1 0.07 1.51 0.33
35 INT151258 Binding of Cacna1a and FCMTE1 1 0.00 0.57 0.3
36 INT33977 DIO2 Regulation of PCDHB17 1 0.00 0.44 0.27
37 INT142003 Binding of Cacna1a and Etax2 1 0.00 1.02 0.26
38 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
39 INT142004 Binding of Cacna1a and TGM6 1 0.00 1.02 0.26
40 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
41 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
42 INT336561 Binding of DDC and DIO2 1 0.04 0.27 0.24
43 INT149791 Binding of Lrp8 and Reln 4 0.36 0.38 0.22
44 INT356089 Positive_regulation of Binding of Tg and Rab11a 1 0.00 0.07 0.21
45 INT356099 Binding of Tg and Rab11a 1 0.00 0.07 0.21
46 INT121807 CACNA1A Regulation of CAV2 1 0.01 0.25 0.2
47 INT55809 Binding of Ttr and Fap 1 0.12 2.56 0.19
48 INT71329 Cacna1a Regulation of Ea2 1 0.01 0.71 0.15
49 INT71328 Cacna1a Regulation of Atxn2 1 0.00 0.71 0.15
50 INT149792 Binding of Reln and Vldlr 3 0.51 0.35 0.11
51 INT120559 Binding of Cacna1a and FCMTE1 1 0.02 0.25 0.1
52 INT341004 Reln Positive_regulation of Fabp7 1 0.03 0.12 0.08
53 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
54 INT341019 Binding of VLDLR and Reln 1 0.01 0.1 0.05
55 INT341011 Reln Positive_regulation of Cp 1 0.00 0.15 0.04
56 INT354983 Cacna1a Regulation of Mpo 1 0.02 0.41 0.04
57 INT198917 Lrp8 Negative_regulation of Binding of Reln 1 0.15 0 0.04
58 INT341002 Reln Positive_regulation of Gene_expression of Fabp7 1 0.04 0.32 0.04
59 INT341016 Reln Positive_regulation of Positive_regulation of PIK3CB 1 0.01 0.15 0.04
60 INT149793 Binding of LRP8 and Reln 1 0.03 0.17 0.04
61 INT354987 Cacna1a Regulation of Localization of LDHA 1 0.00 0.23 0.03
62 INT183921 Binding of Crp and Ttr 1 0.00 1.18 0.03
63 INT202573 Binding of DIO2 and DRD4 1 0.07 0.09 0.03
64 INT206429 Binding of PRCP and SULT1B1 1 0.16 0.14 0.03
65 INT206428 Binding of SULT1B1 and ASAP1 1 0.28 0.13 0.03
66 INT341003 Reln Positive_regulation of Positive_regulation of Lrp8 1 0.03 0.11 0
67 INT276136 Binding of DIO2 and HLA-E 1 0.26 0 0
68 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
69 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
70 INT341006 Reln Regulation of Gene_expression of Fabp7 1 0.03 0 0
71 INT261963 Binding of Cacna1a and Tgm2 1 0.08 1.19 0
72 INT302364 Binding of Arx and Reln 1 0.32 1.25 0
73 INT250496 Gopc Regulation of Positive_regulation of Cacna1a 1 0.37 0 0
74 INT275232 DUOX2 Positive_regulation of ROS1 1 0.10 0.33 0
75 INT262515 Positive_regulation of Kcnj6 Positive_regulation of Binding of Bcl2 1 0.00 0.48 0
76 INT341001 Binding of Reln and Vim 1 0.02 0.14 0
77 INT269770 Binding of DIO2 and NOVA2 1 0.07 0 0
78 INT341024 VLDLR Positive_regulation of Reln 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for thyroid hormone metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in thyroid hormone metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT66331 Gene_expression of Cacna1a 101 0.78 49.58 46.32
2 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1
3 INT2499 Positive_regulation of Sult1b1 51 0.43 2.83 32.38
4 INT41487 Negative_regulation of Cacna1a 16 0.57 9.42 25.2
5 INT7258 Localization of Sult1b1 42 0.68 0.17 17.85
6 INT31136 Binding of Cacna1a 28 0.45 30.76 17.35
7 INT35467 Gene_expression of DIO2 37 0.65 9.56 12.61
8 INT90184 Gene_expression of KCNJ6 7 0.67 4.14 12.57
9 INT30101 Regulation of Cacna1a 25 0.45 14.38 12.43
10 INT2496 Gene_expression of Sult1b1 32 0.66 3 10.97
11 INT75765 Positive_regulation of Gene_expression of Cacna1a 17 0.70 17.51 10.91
12 INT31780 Binding of DIO2 17 0.36 10.07 10
13 INT62997 Gene_expression of Kcnj6 17 0.77 2.16 9.44
14 INT68267 Gene_expression of CACNA1A 22 0.75 11.39 8.65
15 INT2500 Negative_regulation of Positive_regulation of Sult1b1 13 0.18 0.6 8.6
16 INT29121 Positive_regulation of DIO2 23 0.67 6.13 8.46
17 INT2501 Positive_regulation of Positive_regulation of Sult1b1 19 0.19 2.38 7.16
18 INT29794 Regulation of DIO2 13 0.44 5.02 6.84
19 INT91821 Binding of Cacna1a 16 0.48 13.1 6.37
20 INT6229 Positive_regulation of Gene_expression of Sult1b1 18 0.22 2.21 6.04
21 INT85563 Positive_regulation of KCNJ6 6 0.50 0.4 5.89
22 INT129508 Localization of Cacna1a 7 0.74 6.47 5.13
23 INT2497 Regulation of Positive_regulation of Sult1b1 7 0.23 0.49 5.11
24 INT110796 Positive_regulation of Positive_regulation of Cacna1a 1 0.49 0.51 4.84
25 INT281850 Binding of KCNJ6 1 0.37 0.93 4.57
26 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51
27 INT23440 Negative_regulation of Sult1b1 12 0.45 1.77 4.33
28 INT28734 Gene_expression of Reln 7 0.74 5.76 4.33
29 INT82731 Transcription of Cacna1a 5 0.56 3.41 4.27
30 INT7257 Positive_regulation of Localization of Sult1b1 8 0.59 0 3.91
31 INT66473 Negative_regulation of Kcnj6 6 0.50 1.26 3.87
32 INT287526 Negative_regulation of Gene_expression of CACNA1A 1 0.42 4.25 3.81
33 INT53516 Binding of CACNA1A 9 0.47 6.86 3.36
34 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33
35 INT142701 Gene_expression of Kcnj6 8 0.78 0.34 3.25
36 INT85564 Negative_regulation of KCNJ6 6 0.25 0 3.24
37 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08
38 INT85572 Gene_expression of Cacna1a 11 0.66 5.72 3.02
39 INT202577 Localization of DIO2 9 0.56 1.3 2.97
40 INT142940 Positive_regulation of Negative_regulation of Cacna1a 3 0.50 1.65 2.97
41 INT7256 Negative_regulation of Localization of Sult1b1 5 0.37 0 2.81
42 INT2502 Regulation of Gene_expression of Sult1b1 5 0.11 0.92 2.8
43 INT355244 Negative_regulation of Negative_regulation of Cacna1a 1 0.04 0 2.67
44 INT62998 Regulation of Kcnj6 4 0.39 0.5 2.57
45 INT39212 Binding of Ttr 14 0.48 9.62 2.31
46 INT229110 Positive_regulation of Positive_regulation of DIO2 3 0.26 1.08 2.31
47 INT161575 Localization of CACNA1A 4 0.75 5.28 2.26
48 INT110795 Regulation of Positive_regulation of Cacna1a 2 0.26 0.65 2.07
49 INT229242 Positive_regulation of Gene_expression of KCNJ6 2 0.50 1.47 2.03
50 INT117396 Binding of Kcnj6 1 0.35 1.58 1.95
51 INT265064 Binding of Reln 1 0.02 2.7 1.83
52 INT281851 Positive_regulation of Binding of KCNJ6 1 0.50 0.4 1.82
53 INT354979 Positive_regulation of Localization of Cacna1a 2 0.05 0.86 1.79
54 INT355239 Negative_regulation of Positive_regulation of Cacna1a 1 0.04 0 1.79
55 INT66469 Negative_regulation of Gene_expression of Kcnj6 3 0.58 0.32 1.77
56 INT122895 Transcription of DIO2 3 0.52 0.91 1.73
57 INT265066 Positive_regulation of Reln 1 0.02 1.59 1.72
58 INT71327 Localization of Cacna1a 3 0.60 2.51 1.7
59 INT28735 Localization of Reln 2 0.12 1.49 1.7
60 INT148853 Transcription of Kcnj6 1 0.72 0 1.66
61 INT12890 Gene_expression of Ttr 15 0.63 7.68 1.6
62 INT355242 Negative_regulation of Binding of Cacna1a 1 0.04 0.17 1.47
63 INT126121 Transcription of Kcnj6 1 0.65 0 1.45
64 INT355245 Regulation of Localization of Cacna1a 1 0.04 0 1.43
65 INT159312 Regulation of Reln 4 0.43 1.79 1.4
66 INT90740 Negative_regulation of Cacna1a 3 0.23 1.43 1.38
67 INT90189 Positive_regulation of Positive_regulation of KCNJ6 1 0.45 0 1.34
68 INT85562 Regulation of KCNJ6 2 0.45 0.27 1.32
69 INT82727 Positive_regulation of Transcription of Cacna1a 1 0.01 1.07 1.25
70 INT17032 Positive_regulation of Ttr 7 0.50 3.87 1.2
71 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18
72 INT55699 Regulation of Binding of DIO2 2 0.24 1.91 1.16
73 INT355243 Negative_regulation of Regulation of Cacna1a 1 0.04 0 1.16
74 INT123643 Gene_expression of Reln 19 0.75 1.85 1.13
75 INT148851 Regulation of Transcription of Kcnj6 1 0.62 0 1.11
76 INT86834 Positive_regulation of Tg 10 0.69 4.9 1.04
77 INT46320 Negative_regulation of Ttr 4 0.15 2.54 1
78 INT140720 Negative_regulation of Reln 5 0.57 2.43 0.95
79 INT321650 Negative_regulation of Gene_expression of Cacna1a 2 0.04 0.13 0.95
80 INT148852 Regulation of Kcnj6 1 0.27 0 0.91
81 INT94046 Protein_catabolism of Cacna1a 1 0.70 0.83 0.9
82 INT23441 Negative_regulation of Gene_expression of Sult1b1 4 0.14 0.3 0.89
83 INT23913 Negative_regulation of Gene_expression of Ttr 3 0.15 2.8 0.87
84 INT131964 Positive_regulation of CACNA1A 5 0.61 0.73 0.85
85 INT83743 Gene_expression of SULT1B1 7 0.76 0.93 0.71
86 INT103336 Transcription of Cacna1a 2 0.69 1.17 0.68
87 INT141227 Phosphorylation of CACNA1A 1 0.55 0.78 0.66
88 INT62302 Regulation of Localization of Sult1b1 2 0.03 0 0.65
89 INT154706 Gene_expression of Tg 9 0.38 4.95 0.64
90 INT335719 Positive_regulation of Gene_expression of DIO2 3 0.23 0.59 0.61
91 INT149788 Binding of Reln 4 0.37 1.41 0.6
92 INT257949 Regulation of Gene_expression of DIO2 1 0.15 0.17 0.6
93 INT66470 Regulation of Gene_expression of Kcnj6 1 0.27 0 0.57
94 INT83814 Positive_regulation of Kcnj6 4 0.16 0.84 0.56
95 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55
96 INT122930 Positive_regulation of Gene_expression of CACNA1A 2 0.49 0.91 0.54
97 INT9799 Regulation of Ttr 3 0.37 1.96 0.52
98 INT257946 Regulation of Positive_regulation of DIO2 1 0.13 0.45 0.49
99 INT39018 Protein_catabolism of DIO2 1 0.02 0 0.49
100 INT349611 Positive_regulation of Localization of DIO2 1 0.26 0 0.46
101 INT36686 Regulation of Tg 7 0.19 3.12 0.45
102 INT80677 Regulation of Sult1b1 1 0.02 0 0.44
103 INT45729 Positive_regulation of Negative_regulation of Sult1b1 1 0.39 0 0.43
104 INT40541 Negative_regulation of Positive_regulation of DIO2 2 0.41 0.86 0.4
105 INT148850 Negative_regulation of Gene_expression of Kcnj6 1 0.59 0 0.35
106 INT148849 Negative_regulation of Kcnj6 1 0.59 0 0.35
107 INT99962 Positive_regulation of Gene_expression of Cacna1a 1 0.01 1.1 0.34
108 INT155753 Regulation of Gene_expression of CACNA1A 1 0.27 0.66 0.32
109 INT149790 Localization of Reln 2 0.79 1.38 0.29
110 INT127711 Negative_regulation of Positive_regulation of Kcnj6 1 0.14 0.27 0.26
111 INT281852 Transcription of KCNJ6 1 0.69 0 0.23
112 INT159314 Positive_regulation of Gene_expression of Reln 1 0.44 0.47 0.2
113 INT206433 Negative_regulation of SULT1B1 3 0.48 1.25 0.18
114 INT23912 Negative_regulation of Positive_regulation of Ttr 1 0.41 0.45 0.17
115 INT349614 Negative_regulation of Binding of DIO2 1 0.27 0.77 0.16
116 INT323465 Regulation of Localization of Kcnj6 1 0.02 0.05 0.13
117 INT340963 Positive_regulation of Positive_regulation of Reln 1 0.08 0.75 0.13
118 INT323474 Localization of Kcnj6 1 0.03 0.05 0.13
119 INT155189 Regulation of Reln 2 0.44 0.94 0.12
120 INT340975 Positive_regulation of Reln 1 0.08 0.78 0.12
121 INT335654 Negative_regulation of Gene_expression of DIO2 1 0.17 0.72 0.1
122 INT62566 Positive_regulation of Negative_regulation of Ttr 1 0.02 0.28 0.09
123 INT265068 Transcription of Reln 1 0.03 0.07 0.09
124 INT74638 Transcription of Ttr 1 0.66 0.64 0.08
125 INT206462 Positive_regulation of SULT1B1 1 0.39 0 0.08
126 INT307408 Gene_expression of DUOX2 1 0.23 1.38 0.08
127 INT62567 Positive_regulation of Gene_expression of Ttr 3 0.05 0.6 0.07
128 INT123644 Negative_regulation of Gene_expression of Reln 2 0.41 0.95 0.07
129 INT196235 Negative_regulation of Transcription of CACNA1A 1 0.36 0.1 0.07
130 INT123646 Transcription of Reln 1 0.52 0.66 0.07
131 INT196229 Transcription of CACNA1A 1 0.60 0.24 0.07
132 INT62565 Positive_regulation of Positive_regulation of Ttr 1 0.01 0.3 0.07
133 INT89933 Negative_regulation of Tg 2 0.04 1.78 0.06
134 INT326140 Transcription of SULT1B1 1 0.17 0.87 0.06
135 INT309389 Phosphorylation of Cacna1a 1 0.01 0.54 0.05
136 INT309386 Positive_regulation of Phosphorylation of Cacna1a 1 0.01 0.54 0.05
137 INT326141 Localization of SULT1B1 1 0.24 0.63 0.04
138 INT340952 Positive_regulation of Localization of Reln 1 0.09 0.24 0.04
139 INT206453 Binding of SULT1B1 1 0.31 0.13 0.03
140 INT184567 Binding of Tg 1 0.07 0.27 0
141 INT184569 Regulation of Positive_regulation of Tg 1 0.09 0 0
142 INT276140 Regulation of Negative_regulation of DIO2 1 0.34 0.07 0
143 INT295910 Regulation of Gene_expression of Ttr 1 0.03 0.3 0
144 INT196237 Positive_regulation of Transcription of CACNA1A 1 0.39 0.14 0
145 INT184570 Transcription of Tg 1 0.12 0.08 0
146 INT166861 Binding of Kcnj6 1 0.37 0 0
147 INT184568 Regulation of Binding of Tg 1 0.08 0.15 0
148 INT262673 Localization of Tg 1 0.13 0 0
149 INT307412 Binding of DUOX2 1 0.14 0.96 0
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