GO:0042415

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Name norepinephrine metabolic process
Categary Process
Go Slim No
Go Link GO:0042415
Unique Molecular Interactions 31
Total Molecular Interactions 53
Total Single Events 323
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for norepinephrine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for norepinephrine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
2 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
3 INT170449 Pax3 Positive_regulation of Spr 1 0.01 0.26 0.99
4 INT170446 Pax3 Positive_regulation of Gene_expression of Spr 1 0.01 0 0.58
5 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
6 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
7 INT288701 Epas1 Regulation of Transcription of Slc11a2 1 0.29 0.38 0.13
8 INT188192 HBE1 Positive_regulation of LY6E 1 0.00 0.14 0.11
9 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
10 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
11 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
12 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
13 INT241400 Epas1 Positive_regulation of Gene_expression of VEGFA 1 0.03 1.09 0.07
14 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
15 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
16 INT200212 Binding of EPAS1 and VHL 3 0.06 4.1 0.05
17 INT308291 LY6E Regulation of EPC1 1 0.00 0 0.05
18 INT224310 EPAS1 Positive_regulation of CXCL12 1 0.02 0.63 0.05
19 INT342726 Binding of Laptm5 and Park2 1 0.03 0.64 0.04
20 INT308290 LY6E Positive_regulation of EPC1 1 0.00 0 0.04
21 INT317301 Binding of Park2 and Park7 1 0.36 0.62 0
22 INT342725 Pink1 Positive_regulation of Phosphorylation of Park2 1 0.29 0.62 0
23 INT351099 EPAS1 Regulation of Gene_expression of CRTC1 1 0.00 0.8 0
24 INT339260 EPAS1 Positive_regulation of VEGFA 1 0.19 3.67 0
25 INT193014 VHL Regulation of EPAS1 1 0.20 0.92 0
26 INT317300 Binding of Park2 and Pink1 1 0.48 1.23 0
27 INT342727 Pink1 Positive_regulation of Park2 1 0.29 0.62 0
28 INT317302 Binding of Park2 and Mul1 1 0.01 0.62 0
29 INT193013 VHL Regulation of Regulation of EPAS1 1 0.14 1.74 0
30 INT351098 MTOR Regulation of Binding of EPAS1 1 0.08 0.95 0
31 INT339262 EPAS1 Positive_regulation of Gene_expression of VEGFA 1 0.14 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for norepinephrine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in norepinephrine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47
2 INT3922 Negative_regulation of Pnmt 29 0.59 3.18 8.96
3 INT23132 Positive_regulation of Pnmt 17 0.67 2.02 6.84
4 INT170443 Gene_expression of Spr 1 0.12 0.07 5.88
5 INT14455 Transcription of Pnmt 17 0.72 2.13 4.95
6 INT12380 Localization of Pnmt 10 0.80 0.07 4.7
7 INT80473 Gene_expression of Spr 5 0.46 2.76 3.86
8 INT18538 Regulation of Pnmt 11 0.60 1.03 3.84
9 INT101406 Regulation of Spr 3 0.25 1.32 2.95
10 INT170439 Positive_regulation of Spr 1 0.10 0.3 2.67
11 INT52865 Positive_regulation of Spr 2 0.49 0.56 2.06
12 INT28468 Positive_regulation of Transcription of Pnmt 4 0.67 0.63 2.04
13 INT200223 Positive_regulation of EPAS1 21 0.17 21.95 1.7
14 INT80469 Negative_regulation of Spr 2 0.30 1.62 1.61
15 INT101405 Binding of Spr 1 0.20 0.43 1.55
16 INT28478 Regulation of Gene_expression of Pnmt 5 0.44 0 1.41
17 INT170440 Positive_regulation of Gene_expression of Spr 1 0.10 0 1.21
18 INT80471 Negative_regulation of Gene_expression of Spr 1 0.22 1.19 1.16
19 INT144782 Gene_expression of LY6E 2 0.01 1.67 1.12
20 INT28469 Positive_regulation of Gene_expression of Pnmt 4 0.49 0.73 1.11
21 INT101402 Positive_regulation of Gene_expression of Spr 1 0.27 0.26 0.88
22 INT101403 Transcription of Spr 1 0.29 0.26 0.88
23 INT101400 Positive_regulation of Transcription of Spr 1 0.25 0.26 0.88
24 INT147867 Localization of Spr 1 0.65 1.16 0.84
25 INT47518 Negative_regulation of Positive_regulation of Pnmt 2 0.42 0.32 0.8
26 INT101404 Regulation of Gene_expression of Spr 1 0.34 0.28 0.8
27 INT183672 Gene_expression of EPAS1 37 0.35 28.68 0.72
28 INT12379 Regulation of Localization of Pnmt 1 0.17 0 0.69
29 INT144969 Binding of EPAS1 3 0.06 4.12 0.44
30 INT147866 Regulation of Localization of Spr 1 0.43 0.49 0.41
31 INT83525 Negative_regulation of Transcription of Pnmt 3 0.57 0 0.27
32 INT83526 Negative_regulation of Gene_expression of Pnmt 1 0.41 0 0.25
33 INT193015 Positive_regulation of Gene_expression of EPAS1 6 0.32 8.77 0.21
34 INT16756 Regulation of Transcription of Pnmt 2 0.39 0.08 0.18
35 INT200220 Positive_regulation of Positive_regulation of EPAS1 2 0.09 2 0.16
36 INT339266 Regulation of Gene_expression of EPAS1 3 0.11 2.92 0.14
37 INT272873 Gene_expression of Epas1 1 0.05 1.57 0.13
38 INT308298 Binding of LY6E 1 0.01 0.72 0.13
39 INT272871 Positive_regulation of Gene_expression of Epas1 1 0.03 1.58 0.13
40 INT183671 Localization of EPAS1 5 0.16 5.41 0.09
41 INT224327 Negative_regulation of EPAS1 5 0.09 4.29 0.08
42 INT66162 Positive_regulation of Binding of Pnmt 1 0.49 0 0.08
43 INT342696 Gene_expression of Park2 1 0.65 1.19 0.08
44 INT66164 Negative_regulation of Binding of Pnmt 1 0.41 0 0.08
45 INT66163 Binding of Pnmt 1 0.36 0 0.08
46 INT308296 Localization of LY6E 1 0.01 0.13 0.07
47 INT241390 Positive_regulation of Epas1 1 0.03 1.03 0.07
48 INT193016 Regulation of EPAS1 9 0.15 7.38 0.06
49 INT317299 Binding of Park2 1 0.36 0.61 0.04
50 INT112351 Negative_regulation of Epas1 2 0.05 0.3 0
51 INT339265 Negative_regulation of Gene_expression of EPAS1 2 0.15 2.67 0
52 INT251998 Protein_catabolism of EPAS1 2 0.03 2.68 0
53 INT342695 Phosphorylation of Park2 1 0.79 0.62 0
54 INT351121 Positive_regulation of Negative_regulation of EPAS1 1 0.09 0.86 0
55 INT252004 Negative_regulation of Regulation of EPAS1 1 0.02 1.17 0
56 INT76171 Regulation of Regulation of Pnmt 1 0.19 0 0
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