GO:0042418

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Name epinephrine biosynthetic process
Categary Process
Go Slim No
Go Link GO:0042418
Unique Molecular Interactions 140
Total Molecular Interactions 205
Total Single Events 4046
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for epinephrine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for epinephrine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
2 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
3 INT40887 Penk Regulation of Th 1 0.04 0 1.53
4 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36
5 INT60989 Ngf Regulation of Th 1 0.17 0 1.34
6 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
7 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
8 INT90644 Slc6a3 Positive_regulation of Th 1 0.51 0 1.2
9 INT141245 Prkaca Regulation of Gene_expression of Th 1 0.15 0.17 1.17
10 INT141246 Trib3 Regulation of Gene_expression of Th 1 0.02 0.17 1.17
11 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17
12 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14
13 INT88446 Uncx Positive_regulation of Th 1 0.13 0 1.1
14 INT44838 Pitpnm1 Negative_regulation of Th 1 0.02 0 1.09
15 INT31547 Binding of Th and Vip 1 0.31 0 1.08
16 INT221 Chd7 Negative_regulation of Th 1 0.02 0 1.04
17 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
18 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
19 INT184916 Binding of da and Th 1 0.09 1.22 0.87
20 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83
21 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83
22 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83
23 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81
24 INT184918 da Positive_regulation of Negative_regulation of Th 1 0.14 0.14 0.77
25 INT147278 Negative_regulation of Calca Positive_regulation of Th 1 0.41 0.76 0.74
26 INT147277 Calca Positive_regulation of Th 1 0.48 0.76 0.74
27 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7
28 INT313435 Syp Regulation of Th 1 0.43 1.6 0.64
29 INT7958 LOC686180 Positive_regulation of Gene_expression of Th 1 0.02 0 0.64
30 INT228852 Th Positive_regulation of Vta1 1 0.04 0 0.53
31 INT228851 Th Positive_regulation of Mtf2 1 0.02 0 0.52
32 INT184922 Negative_regulation of Th Negative_regulation of da 1 0.12 0.18 0.52
33 INT7957 Calca Positive_regulation of Gene_expression of Th 1 0.39 0 0.47
34 INT249021 Gabrg1 Negative_regulation of Th 1 0.08 0.06 0.44
35 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43
36 INT139487 Oprm1 Positive_regulation of Th 1 0.26 0.1 0.42
37 INT147280 Binding of Pecam1 and Th 1 0.29 0.41 0.41
38 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4
39 INT7625 Man2a2 Regulation of Th 1 0.01 0.07 0.4
40 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38
41 INT173476 Th Regulation of Gene_expression of Bcar1 1 0.10 0 0.34
42 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34
43 INT173478 Th Regulation of Localization of Ins1 1 0.13 0 0.34
44 INT153019 nct Positive_regulation of Transcription of Th 1 0.19 0.61 0.32
45 INT153020 nct Positive_regulation of Gene_expression of Th 1 0.19 0.61 0.32
46 INT290614 Binding of Th and RLS 1 0.21 3.26 0.31
47 INT90643 Negative_regulation of Slc6a3 Positive_regulation of Th 1 0.47 0 0.3
48 INT55404 Binding of ENG and Th 1 0.02 0 0.3
49 INT314484 TH Positive_regulation of RLS 1 0.01 1.66 0.29
50 INT78484 Binding of DBH and TH 1 0.09 0 0.28
51 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
52 INT329432 Binding of CCR6 and TH 1 0.00 0.47 0.23
53 INT329431 Binding of CCL20 and TH 1 0.00 0.47 0.23
54 INT61987 Th Regulation of Penk 1 0.46 0 0.2
55 INT281477 Binding of Pten and Th 1 0.28 0.4 0.19
56 INT349504 Ptpn2 Negative_regulation of Th 1 0.23 2 0.19
57 INT313453 Siglec1 Regulation of Th 1 0.02 0.61 0.17
58 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
59 INT88450 Uncx Regulation of Gene_expression of Th 1 0.06 0 0.17
60 INT349503 Ptpn2 Negative_regulation of Gene_expression of Th 1 0.23 0.7 0.16
61 INT261456 Sftpd Positive_regulation of Gene_expression of Th 1 0.10 0.77 0.13
62 INT313441 Th Regulation of Siglec1 1 0.02 0.22 0.13
63 INT313439 Syp Negative_regulation of Th 1 0.30 0.14 0.13
64 INT197317 Nr4a2 Regulation of Gene_expression of Th 1 0.03 0.07 0.12
65 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
66 INT313454 Negative_regulation of Syp Negative_regulation of Th 1 0.30 0.14 0.1
67 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
68 INT313442 Th Regulation of Phosphorylation of Syp 1 0.32 0 0.08
69 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
70 INT313459 Gene_expression of Syp Negative_regulation of Th 1 0.30 0.49 0.08
71 INT313437 Th Regulation of Phosphorylation of Siglec1 1 0.04 0 0.08
72 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
73 INT125208 Pou4f1 Negative_regulation of Gene_expression of Th 1 0.28 0.67 0.07
74 INT125209 Pou4f1 Positive_regulation of Gene_expression of Th 1 0.33 0.67 0.07
75 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
76 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
77 INT313450 Th Regulation of Syp 1 0.32 0.6 0.06
78 INT242618 Binding of Slc18a3 and Th 1 0.13 0.26 0.05
79 INT313433 53T Regulation of Th 1 0.00 0 0.03
80 INT313448 Gene_expression of Syp Positive_regulation of Th 1 0.28 0 0.03
81 INT313468 Negative_regulation of Syp Regulation of Th 1 0.30 0.3 0.03
82 INT313443 Syp Positive_regulation of Binding of Th 1 0.35 0.31 0
83 INT292968 Fto Regulation of Gene_expression of Th 1 0.30 1.11 0
84 INT313461 Gopc Regulation of Th 1 0.07 0 0
85 INT292970 Fto Regulation of Th 1 0.18 0.48 0
86 INT127058 Vta1 Negative_regulation of Positive_regulation of Th 1 0.33 0 0
87 INT313457 Ppp2ca Regulation of Th 1 0.36 0 0
88 INT49943 Binding of Th and Pdx1 1 0.02 0.17 0
89 INT163744 Binding of Th and Gfra4 1 0.09 0 0
90 INT313438 Mapk1 Regulation of Th 1 0.06 0 0
91 INT313428 Binding of Syp and Th 1 0.25 0.31 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for epinephrine biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in epinephrine biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
2 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
3 INT7327 Regulation of Th 164 0.62 29.67 110.14
4 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
5 INT350 Localization of Th 79 0.80 10.26 41.17
6 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
7 INT7326 Transcription of Th 83 0.72 13.5 35.33
8 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
9 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
10 INT4781 Gene_expression of TH 68 0.73 26.92 24.01
11 INT26719 Negative_regulation of Gene_expression of Th 38 0.58 11.87 22.78
12 INT13643 Phosphorylation of Th 20 0.82 1.9 20.97
13 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18
14 INT219 Negative_regulation of Th 55 0.59 20.88 17.09
15 INT24241 Phosphorylation of Th 35 0.81 8.69 16.06
16 INT13716 Positive_regulation of TH 33 0.68 19.11 16
17 INT109264 Positive_regulation of Transcription of Th 17 0.50 4.73 14.33
18 INT31368 Positive_regulation of Positive_regulation of Th 19 0.51 2.2 12.68
19 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47
20 INT141 Binding of Th 21 0.48 3.53 11.04
21 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75
22 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02
23 INT3922 Negative_regulation of Pnmt 29 0.59 3.18 8.96
24 INT109265 Transcription of Th 18 0.68 4.5 8.21
25 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74
26 INT7624 Positive_regulation of Regulation of Th 7 0.50 2.41 7
27 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88
28 INT109266 Negative_regulation of Transcription of Th 9 0.42 2.5 6.85
29 INT23132 Positive_regulation of Pnmt 17 0.67 2.02 6.84
30 INT66987 Regulation of Th 23 0.61 7.86 6.8
31 INT3506 Localization of TH 12 0.81 0.78 6.66
32 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17
33 INT30317 Regulation of TH 14 0.43 7.27 5.38
34 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16
35 INT14455 Transcription of Pnmt 17 0.72 2.13 4.95
36 INT24236 Positive_regulation of Phosphorylation of Th 12 0.61 3.68 4.87
37 INT37151 Localization of Th 13 0.57 3.11 4.82
38 INT12380 Localization of Pnmt 10 0.80 0.07 4.7
39 INT40620 Regulation of Positive_regulation of Th 9 0.45 2.45 4.69
40 INT30165 Positive_regulation of Phosphorylation of Th 8 0.56 0.75 4.22
41 INT18538 Regulation of Pnmt 11 0.60 1.03 3.84
42 INT77823 Negative_regulation of Negative_regulation of Th 9 0.59 1.56 3.79
43 INT30166 Regulation of Phosphorylation of Th 4 0.50 0.52 3.33
44 INT102901 Regulation of Gene_expression of Th 12 0.60 2.42 3.22
45 INT4782 Positive_regulation of Gene_expression of TH 12 0.47 7.36 2.95
46 INT106066 Negative_regulation of Positive_regulation of TH 1 0.18 0.22 2.6
47 INT106068 Positive_regulation of Positive_regulation of TH 1 0.21 0.22 2.59
48 INT4704 Positive_regulation of Negative_regulation of Th 4 0.50 0.06 2.56
49 INT13644 Negative_regulation of Phosphorylation of Th 2 0.43 0.06 2.51
50 INT184914 Negative_regulation of Gene_expression of Th 15 0.43 9.17 2.46
51 INT15210 Negative_regulation of Transcription of Th 9 0.59 0.47 2.37
52 INT15209 Negative_regulation of Regulation of Th 6 0.51 1.64 2.16
53 INT28468 Positive_regulation of Transcription of Pnmt 4 0.67 0.63 2.04
54 INT1834 Positive_regulation of Binding of Th 1 0.46 0 1.91
55 INT314510 Protein_catabolism of TH 1 0.10 3.28 1.86
56 INT3505 Binding of TH 5 0.39 2.6 1.8
57 INT145545 Transcription of TH 3 0.67 1.48 1.64
58 INT28478 Regulation of Gene_expression of Pnmt 5 0.44 0 1.41
59 INT97869 Negative_regulation of Positive_regulation of Th 3 0.25 0.79 1.23
60 INT26760 Negative_regulation of Localization of Th 2 0.40 0.09 1.14
61 INT50267 Negative_regulation of Negative_regulation of Th 3 0.42 1.57 1.12
62 INT89670 Negative_regulation of Binding of Th 2 0.43 0.28 1.12
63 INT28469 Positive_regulation of Gene_expression of Pnmt 4 0.49 0.73 1.11
64 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94
65 INT198953 Regulation of Regulation of Th 1 0.01 0.1 0.93
66 INT24242 Negative_regulation of Phosphorylation of Th 3 0.38 1.44 0.9
67 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89
68 INT50266 Regulation of Negative_regulation of Th 1 0.42 0.94 0.88
69 INT53309 Regulation of Localization of Th 1 0.39 0 0.84
70 INT47518 Negative_regulation of Positive_regulation of Pnmt 2 0.42 0.32 0.8
71 INT12379 Regulation of Localization of Pnmt 1 0.17 0 0.69
72 INT122934 Negative_regulation of Regulation of TH 1 0.03 0.56 0.63
73 INT13929 Protein_catabolism of Th 3 1.00 0 0.58
74 INT314505 Positive_regulation of Protein_catabolism of TH 1 0.05 1.07 0.56
75 INT314499 Negative_regulation of Protein_catabolism of TH 1 0.04 1.06 0.54
76 INT111304 Regulation of Gene_expression of TH 2 0.17 0.57 0.44
77 INT90640 Positive_regulation of Negative_regulation of Th 2 0.40 0.58 0.39
78 INT314511 Positive_regulation of Binding of TH 1 0.04 0.68 0.38
79 INT349488 Positive_regulation of Localization of Th 1 0.30 0.96 0.34
80 INT277462 Regulation of Positive_regulation of Th 2 0.09 0.23 0.31
81 INT83525 Negative_regulation of Transcription of Pnmt 3 0.57 0 0.27
82 INT40588 Regulation of Negative_regulation of Th 1 0.16 0.26 0.26
83 INT83526 Negative_regulation of Gene_expression of Pnmt 1 0.41 0 0.25
84 INT343976 Negative_regulation of Negative_regulation of TH 1 0.23 0.19 0.23
85 INT237448 Negative_regulation of Binding of TH 1 0.30 0.29 0.22
86 INT140716 Negative_regulation of Protein_catabolism of Th 1 0.59 0 0.19
87 INT140717 Positive_regulation of Protein_catabolism of Th 1 0.47 0 0.19
88 INT16756 Regulation of Transcription of Pnmt 2 0.39 0.08 0.18
89 INT66986 Binding of Th 6 0.45 1.43 0.16
90 INT313420 Positive_regulation of Positive_regulation of Th 1 0.33 0.35 0.12
91 INT66162 Positive_regulation of Binding of Pnmt 1 0.49 0 0.08
92 INT66164 Negative_regulation of Binding of Pnmt 1 0.41 0 0.08
93 INT66163 Binding of Pnmt 1 0.36 0 0.08
94 INT314508 Regulation of Positive_regulation of TH 1 0.04 0.92 0.08
95 INT313408 Regulation of Phosphorylation of Th 1 0.40 0.74 0.07
96 INT76171 Regulation of Regulation of Pnmt 1 0.19 0 0
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